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JMJD3 promotes esophageal squamous cell carcinoma pathogenesis through epigenetic regulation of MYC 被引量:1
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作者 Shu-Man Li Li-Ru He +7 位作者 Jie-Wei Chen Jie Zhou Run-Cong Nie xiao-han jin Xin Wang Jian-Hua Fu Feng-Wei Wang Dan Xie 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期1043-1045,共3页
Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC... Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC patients are greatly needed.The dysregulation of epigenetic control is one of the common features in cancer.JMJD3 is a histone demethylase specific for H3K27me3/me2 that switches a gene from its repressive state to an active form.1 The dysregulation of JMJD3 is reported to play key roles in many cancer progressions.Recently,JMJD3 was reported to be overexpressed in ESCC,2 but the potential mechanism of JMJD3 in ESCC remains poorly understood. 展开更多
关键词 JMJD3 SQUAMOUS EPIGENETIC
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