Wrist-ankle acupuncture combined with pain nursing for the treatment of urinary calculi with acute pain

BACKGROUND Urological calculi often cause renal colic,which is characterized by paroxysmal or persistent severe pain in the upper abdomen or lumbar region.Development of methods to quickly relieve these pain symptoms has garnered clinical attention.Wrist-ankle acupuncture is a type of floating acupuncture therapy administered at selected points in the carpal and ankle areas,and it has good pain-relieving effects.We used wrist-ankle acupuncture combined with pain nursing for pain intervention in patients with renal calculi to confirm its application and safety.AIM To study the effect of wrist-ankle acupuncture combined with pain nursing in the treatment of urinary calculi with acute pain.METHODS Eighty-two patients with urinary calculi with acute pain as the first symptom followed at our hospital from November 2019 to June 2021 were enrolled in the study and classified into two groups according to the odd and even numbers of the visit sequences,each with 41 cases.The control group received a routine nursing intervention and intramuscular injection of nonsteroidal anti-inflammatory drugs,whereas the observation group received pain management nursing and wrist-ankle acupuncture.Subsequently,the pain-relieving effect was compared between the two groups.RESULTS The score on the visual analog scale(VAS)at 24,48,and 72 h postintervention was decreased in both groups compared with the baseline data;moreover,the observation group scored significantly lower than the control group on the VAS at each time point after the intervention(P<0.05).The clinical efficacy at 24 h postintervention was not significantly different between the two groups(P>0.05).In turn,the pain recurrence rate at 72 h postintervention was lower in the observation group compared with the control group(P<0.05).Finally,the nursing satisfaction rate in the observation group was significantly higher than that observed in the control group(P<0.05).No serious adverse reactions occurred during the treatment and the safety of treatment was high in both groups.CONCLUSION Wrist-ankle acupuncture combined with pain nursing for treating urolithiasis with acute pain effectively alleviated the degree of pain and reduced the recurrence rate,which was worthy of clinical application.

Effect of rhPDGF gel on wound healing as well as inflammation and angiogenesis in the wound of rats with diabetes ulcer

Objective:To study the effect of recombinant human platelet-derived growth factor (rhPDGF) gel on wound healing as well as inflammation and angiogenesis in the wound of rats with diabetes ulcer. Methods:Clean male Wistar rats were selected as the research objects, made into diabetes ulcer models and then divided into model group, low dose group and high dose group who received blank gel, 30μg/g rhPDGF gel and 100μg/g rhPDGF gel respectively for intervention. 4, 6, 8 and 10 d after intervention, the area of ulcer wound was observed;6 and 10 d after intervention, wound tissue was collected to detect the expression of inflammation and angiogenesis molecules. Results:4, 6, 8 and 10 d after intervention, ulcer wound area of low dose group and high dose group were significantly less than those of model group (P<0.05), and ulcer wound area of high dose group were significantly less than those of low dose group (P<0.05);6 and 10 d after intervention, TNF-αand IL-2 levels in ulcer wounds of low dose group and high dose group were significantly lower than those of model group (P<0.05) while VEGF, eNOS and NO levels were significantly higher than those of model group (P<0.05);TNF-αand IL-2 levels in ulcer wounds of high dose group were significantly lower than those of low dose group (P<0.05) while VEGF, eNOS and NO levels were significantly higher than those of low dose group (P<0.05). Conclusions:rhPDGF gel has promoting effect on the wound healing in rats with diabetes ulcer, and can also inhibit inflammation and promote angiogenesis.