Malignant form of hidroacanthoma simplex:A case report

BACKGROUND This paper presents a case of malignant hidroacanthoma simplex(HAS)and review the literature of previous cases to summarize the histopathological and immunohistochemical features and display the dermoscopic features of malignant HAS.CASE SUMMARY We present an 88-year-old Asian female with malignant HAS.The diagnosis was made according to the histopathological and immunohistochemical results after biopsy.Previous case reports of malignant HAS were retrieved from PubMed to characterize the histopathological and immunohistochemical features.We also display the dermoscopic features of malignant HAS that have not been reported.CONCLUSION Our findings demonstrate that prompt surgical treatment is an effective strategy for malignant HAS.Histopathology and immunohistochemistry are valuable diagnostic tools.This is the first case report to display the dermoscopic features of malignant HAS,and we speculate that dermoscopy may contribute to the diagnosis of malignant HAS.

Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients:Potential role in clinical practice

AIM To evaluate the clinical properties of three subpopulations of circulating tumor cells(CTCs) undergoing epithelial-mesenchymal transition(EMT) in pancreatic ductal adenocarcinoma(PDAC) patients.METHODS We identified CTCs for expression of the epithelial cell marker cytokeratin or epithelial cell adhesion molecule(EpCAM)(E-CTC), the mesenchymal cell markers vimentin and twist(M-CTC), or both(E/M-CTC) using the CanPatrol system. Between July 2014 and July 2016, 107 patients with PDAC were enrolled for CTC evaluation. CTC enumeration and classification were correlated with patient clinicopathological features and outcomes.RESULTS CTCs were detected in 78.5% of PDAC patients. The number of total CTCs ranged from 0 to 26 across all 107 patients, with a median value of six. CTC status correlated with lymph node metastasis, TNM stage, distant metastasis, blood lymphocyte counts, and neutrophil-to-lymphocyte ratio(NLR). Kaplan-Meier survival analysis showed that patients with ≥ 6 total CTCs had significantly decreased overall survival and progression-free survival compared with patients with < 6 total CTCs. The presence of M-CTCs was positively correlated with TNM stage(P < 0.01) and distant metastasis(P < 0.01). Additionally, lymphocyte counts and NLR in patients without CTCs were significantly different from those in patients testing positive for each CTC subpopulation(P < 0.01).CONCLUSION Classifying CTCs by EMT markers helps to identify the more aggressive CTC subpopulations and provides useful evidence for determining a suitable clinical approach.

Fabrication of long-length ion beam-assisted deposited MgO templates for YBCO-coated conductors

The biaxially textured ion beam-assisted deposited(IBAD)-MgO templates were successfully prepared on polycrystalline Hastelloy metal substrate with reel-to-reel system for YB2Cu3O7-d(YBCO)-coated conductors.By the solution deposition planarization technique,amorphous Y2O3films were coated on untreated Hastelloy substrate as the bed layer to obtain smooth,dense,and crack-free surface for subsequent IBAD-MgO deposition.The 50 m long IBAD-MgO and homo-epitaxial(epi)-MgO buffer layers deposited on Y2O3films exhibit excellent crystallographic consistency along the scope with full width half maximum(FWHM)values of(110)DU and(200)Dx in the range of 5.5°–6.0°and3.0°–3.5°,respectively.To match the lattice constant of YBCO material,LaMnO3cap layer was fabricated on IBAD-MgO templates by radio frequency(rf)magnetron sputtering with the FWHM values of in-plane and out-ofplane of 6.8°and 3.7°,respectively,indicating excellent biaxial texture.

Combined phacoemulsification and anterior vitrectomy in a case of anterior megalophthalmos with open-angle glaucoma and high myopia

Dear Editor,I am Dr.Cai-Xuan Huang,from the Eye Center,Renmin Hospital of Wuhan University,Hubei Province,China.I write to present a case report of bilateral anterior megalophthalmos with open-angle glaucoma,which was treated by combined phacoemulsification and anterior vitrectomy.

In-plane oriented CH_(3)NH_(3)PbI_(3) nanowire suppression of the interface electron transfer to PCBM

One-dimensional nanowire is an important candidate for lead-halide perovskite-based photonic detectors and solar cells. Its surface population, diameter, and growth direction, etc., are critical for device performance. In this research,we carried out a detailed study on electron transfer process at the interface of nanowire CH_(3) NH_(3) PbI_(3)(N-MAPbI_(3))/Phenyl C61 butyric acid methyl-ester synonym(PCBM), as well as the interface of compact CH_(3) NH_(3) PbI_(3)(C-MAPbI_(3))/PCBM by transient absorption spectroscopy. By comparing the carrier recombination dynamics of N-MAPbI_(3), N-MAPbI_(3)/PCBM,C-MAPbI_(3), and C-MAPbI_(3)/PCBM from picosecond(ps) to hundred nanosecond(ns) time scale, it is demonstrated that electron transfer at N-MAPbI_(3)/PCBM interface is less efficient than that at C-MAPbI_(3)/PCBM interface. In addition, electron transfer efficiency at C-MAPbI_(3)/PCBM interface was found to be excitation density-dependent, and it reduces with photo-generation carrier concentration increasing in a range from 1.0 × 1018 cm^(-3)–4.0 × 1018 cm^(-3). Hot electron transfer,which leads to acceleration of electron transfer between the interfaces, was also visualized as carrier concentration increases from 1.0 × 10^(18) cm^(-3)–2.2 × 10^(18) cm^(-3).

Enhanced thermoelectric property and stability of NiCr–NiSi thin film thermocouple on superalloy substrate

Thin film thermocouples（TFTCs） can provide fast and accurate surface temperature measurement with minimal impact on the physical characteristics of the supporting components. In this study, NiCr and NiSi films were prepared with radio frequency（RF） magnetron sputtering and the influences of vacuum annealing on the resistivity of the films were investigated. Afterward, NiCr-NiSi films were deposited on Ni-based superalloy substrates to form TFTCs. The overall dimension of the thermocouple is 64 mm in length, 8 mm in width and 30 lm in thickness. Compared with those of as-deposited sample, the thermoelectric property and stability of the TFTC are significantly improved by vacuum annealing of NiCr and NiSi films. The variation of the Seebeck coefficient of TFTC was discussed based on the size effect of NiCr and NiSi films. And a lower Seebeck coefficient of TFTC of 38.4 μV·℃^-1 is obtained.

Epitaxial growth of MOCVD-derived YBCO films by modulation of Cu(tmhd)_2 concentration

Metal-organic chemical vapor deposition was applied to fabricate YBa2Cu3OT-a （YBCO） films on singlecrystal LaA103 （001） substrates for its high deposition rate, easy adjustment on film composition, and low requirement on vacuum apparatus. The effects of Cu（tmhd）2 concentra- tion in the precursor on the properties of YBCO films were systematically investigated. X-ray diffraction （XRD） reveals that the mole ratio of Cu/Ba in the precursor from 0.77 to 0.97 is helpful to improve the crystallization and out-of-plane orientation of YBCO films; however, it hardly affects the inplane texture. Scanning electron microscope （SEM） shows the dense, crack-free but rough surface, on which there are Cu-O and Ba-Cu-O outgrowths identified by energy-dispersive spectrometer （EDS）. As the mole ratio of Cu/Ba increasing, the average size of Ba-Cu-O precipitates keeps increasing and the film composition becomes inhomoge- neous at the mole ratio of Cu/Ba of 0.97. The 250 nm thick YBCO film prepared at the mole ratio of Cu/Ba of 0.91 shows the critical current density （Jc） of 4.0 MA.cm-2 （77 K, 0 T）.

A facile synthesis of a novel energetic surfactant1-amino-3-dodecyl-1,2,3-triazolium nitrate

1-Amino-3-dodecyl-1,2,3-triazolium nitrate, as a novel energetic surfactant, has been synthesized in four steps, namely addition-elimination, cyclization, alkylation and metathesis. Its structure was confirmed by 1H NMR, IR, and MS. The effects of various reaction parameters, including stoichiometry, reaction temperature and time, were investigated in details. In addition, the physical and chemical properties of this energetic surfactant were measured.

Polymer assisted thick single-layer YBa_2Cu_3O_(7-δ)films prepared with modified TFA-MOD method

Single-layer YBa2Cu3O7-δ（YBCO） films with the thickness of over 600 nm were fabricated by modified metal organic deposition using trifluoroacetate metal organic deposition（TFA-MOD） method on LaAlO3（LAO） substrates. Polyvinylbutyral（PVB） was added into the precursor solution to enhance the thickness of the single layer. The pyrolysis process was shortened to about 3 h due to the reduction of the fluorine content in the precursor solution.The effects of heating rate during the crystallization process on the microstructure and Jcvalues of YBCO films were investigated. The α-axis-oriented YBCO crystals dominate when the heating rate is lower than 20 °C·min^-1, while faster heating rate of 43 °C·min^-1 results in pure c-axis epitaxial growth. The Jcvalues of YBCO films increase linearly with heating rate increasing due to the increase of c-axis YBCO growth, and the critical current（Ic） value of 100 A·cm^-1 within a single-layer YBCO film is achieved.

In-stent Anchoring Facilitating Side-branch Balloon Delivery for Final Kissing： A Prospective, Single-center Registry Study

Background：Recrossing the compromised side branch （SB） with a balloon is sometimes technically challenging.The aim of this study was to evaluate whether in-stent anchoring （ISA） is safe and effective to facilitate SB balloon delivery for final kissing.Methods：One hundred and fifty-nine consecutive patients were included （166 bifurcation lesions） in this prospective,single-center registry.ISA was used as a bailout method after unsuccessful SB crossing using conventional techniques,including low-profile balloons.Technique success was defined as SB balloon delivery and final kissing.Results：Kissing-balloon delivery was successfully performed with conventional strategies in 149 of 166 lesions （89.8%）.In the remaining 17 lesions （10.2%）,recrossing of the main vessel stent strut was not successful;therefore,ISA was attempted.The balloon successfully crossed the stent struts,and final kissing was achieved in 15 of 17 lesions （88.2%）.Total final kissing was achieved in 164 of 166 lesions （98.8%）,with success rates of 100% in the single-stent group and 97.6% in the two-stent group.Two cases without balloon delivery had complex bifurcation lesions with severe calcification.There was no vessel dissection in the anchoring zone.Conclusions：ISA is safe and effective for recrossing stent struts when conventional low-profile balloons have failed.However,large-scale trials are warranted for further evaluation.