Ferroptosis is a form of regulated cell death characterized by iron-dependent overaccumulation of lipid peroxides,which causes membrane damage and cell lysis.Ferroptosis can be prevented by cellular antioxidant mechan...Ferroptosis is a form of regulated cell death characterized by iron-dependent overaccumulation of lipid peroxides,which causes membrane damage and cell lysis.Ferroptosis can be prevented by cellular antioxidant mechanisms such as glutathione peroxidase 4(GPX4)-mediated elimination of the lipid peroxides at the cost of glutathione(GSH).As the rate-limiting step of GSH synthesis,the availability of intracellular cystine is controlled by the cell membrane-located cystine/glutamate antiporter system xc−.Indeed,the initially identified small molecule inducers of ferroptosis,RSL3 and erastin,turned out to be inhibitors of GPX4 and system xc−,respectively.展开更多
基金supported by the National Key R&D Plan of China(2018YFA0107802)(to X-JS)the National Natural Science Foundation of China(NSFC)General Program(No.81670094 and 81470316)(to X-JS)+3 种基金the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine(China)(No.20152506)(to X-JS)Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(China)(No.2019CXJQ01)(to S-JC and X-JS)the Samuel Waxman Cancer Research Foundation,and the Shanghai Guangci Translational Medical Research Development FoundationX-JS was supported by the 1000 Talents Program for Young Scholars(China).
文摘Ferroptosis is a form of regulated cell death characterized by iron-dependent overaccumulation of lipid peroxides,which causes membrane damage and cell lysis.Ferroptosis can be prevented by cellular antioxidant mechanisms such as glutathione peroxidase 4(GPX4)-mediated elimination of the lipid peroxides at the cost of glutathione(GSH).As the rate-limiting step of GSH synthesis,the availability of intracellular cystine is controlled by the cell membrane-located cystine/glutamate antiporter system xc−.Indeed,the initially identified small molecule inducers of ferroptosis,RSL3 and erastin,turned out to be inhibitors of GPX4 and system xc−,respectively.
