ZG0Cr26Ni5Mo3Cu3 Duplex Stainless Steel(DSS) was solution treated at 1,060 ℃ for 3 h, followed by water cooling. Tempering treatments were conducted at 720, 750 and 780 ℃, respectively, for 16 h, followed by air coo...ZG0Cr26Ni5Mo3Cu3 Duplex Stainless Steel(DSS) was solution treated at 1,060 ℃ for 3 h, followed by water cooling. Tempering treatments were conducted at 720, 750 and 780 ℃, respectively, for 16 h, followed by air cooling. The microstructures of ZG0Cr26Ni5Mo3Cu3 duplex stainless steel samples treated at different tempering temperatures were observed by scanning electron microscope(SEM) and energy dispersal spectroscopy(EDS), and the phase consitutions were analyzed using X-ray diffraction(XRD). The effects of the precipitation of sigma(σ) phase on the duplex phase percentage, hardness, impact toughness and corrosion resistance of the DSS were studied. Results showed that microstructures of ZG0Cr26Ni5Mo3Cu3 after solution treatment consists of ferrite(α) phase and austenite(γ) phase; after being tempered at different temperatures, σ phase appeared due to a eutectoid-type reaction of α→σ+γ2 during tempering treatment. It was observed that σ phase distributed along the grain boundary. The volume fraction of σ and γ phases increased with increasing tempering temperature in the range of 720 to 780 ℃, whereas the volume fraction of α phase showed the opposite trend. When the percentage of σ phase increased, the hardness of steel also increased. In the solution treated steel, hardness was measured to be only 244.0 HB, because σ phase did not appear. However, it increased to 391.8 HB when the DSS was tempered at 780℃because a great of deal of σ phase appeared. The impact toughness and corrosion resistance of DSS decreased when the percentage of σ phase increased.展开更多
BACKGROUND Nearly 10%of patients undergoing primary total knee arthroplasty(TKA)have valgus deformity(VD)of the knee.For severe VD of the knee,a more lateral structural release is needed to achieve balance between med...BACKGROUND Nearly 10%of patients undergoing primary total knee arthroplasty(TKA)have valgus deformity(VD)of the knee.For severe VD of the knee,a more lateral structural release is needed to achieve balance between medial and lateral space and neutral femorotibial mechanical axis(FTMA),which is challenging and technical.AIM To introduce a new surgical technique of resection,soft tissue release,and FTMA for Ranawat type-Ⅱ VD with a 5-year follow-up.METHODS A retrospective study was conducted on patients who underwent TKA from December 2011 to December 2014.Hip-knee-ankle(HKA),range of motion(ROM),Oxford knee score(OKS),and knee society score(KSS)were used to assess the joint activity of patients in the new theory TKA group(NT-TKA)and were compared with those of the conventional TKA group(C-TKA).RESULTS A total of 103 people(103 knees)were included in this study,including 42 patients with an average follow-up period of 83 mo in the C-TKA group and 61 patients with an average follow-up period of 76 mo in the NT-TKA group.Six patients had constrained prosthesis,one had common peroneal nerve injury,and two had joint instability in the C-TKA group,but none of these occurred in the NT-TKA group.There were significant statistical differences in constrained prosthesis usage and complications between the groups(P=0.002 and P=0.034,respectively).The KSS at 1 mo post-operation for the C-TKA and NT-TKA groups were 11.2±3.8 and 13.3±2.9,respectively,with a significant difference(P=0.007).However,the data of HKA,ROM,OKS KSS,and prosthesis survival rate were insignificant(P>0.05)in both the preoperative and follow-up periods.CONCLUSION Adopting 5°-7°valgus cut angle for VD and sacrificing 2°neutral FTMA for severe VD which cannot be completely corrected during TKA can reduce the need for soft tissue release,maintain early joint stability,reduce the use of constrained prostheses,and minimize postoperative complications.展开更多
Objective:The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase(MTHFR) C677T excision repair cross-complementation group 1(ERCC1) genetic polymorphisms and the clinical ...Objective:The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase(MTHFR) C677T excision repair cross-complementation group 1(ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer(NSCLC).Methods:A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regimens.The polymorphisms of MTHFR C677T,ERCC1 C8092A,and ERCC1 C118T were genotyped using the TaqMan methods.Results:The overall response rate was 28.9%.Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype(TT or CT)(41.2% versus 19.1%,P=0.01).Median time to progression(TTP) of patients with MTHFR CC genotype was longer than that of patients with variant genotype(7.6 months versus 5.0 months,P=0.003).No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival.Conclusions:Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.展开更多
Transition metal dichalcogenides(TMDs)have emerged as a promising electrocatalyst for hydrogen evo-lution reaction(HER)due to its excellent conductivity and abundant electrocatalytic active sites of its edges.TMDs nan...Transition metal dichalcogenides(TMDs)have emerged as a promising electrocatalyst for hydrogen evo-lution reaction(HER)due to its excellent conductivity and abundant electrocatalytic active sites of its edges.TMDs nanowall can expose abundant of edges so that they tend to show better catalytic performance for hydrogen evolution reaction.Herein,PtSe_(2) nanowall films with morphology controlled at centimeters level are synthesized by selenizing Pt film.The dynamic and thermodynamics of selenation reaction are investigated.The nanowall structure can be obtained by controlling the growth temperature,and the thickness of nanowall can be tuned by the original thickness of Pt film.The Pt atoms can be rearranged into ordered distribution at 550℃ and can be induced to well-ordered PtSe_(2) nanowalls finally.The well-ordered PtSe_(2) nanowall films show excellent HER performance,with an overpotential of 0.3 V at-10 mA·cm^(-2) and a Tafel slope of~52 mV·dec^(-1).This work demonstrates the great potential of activated 2D PtSe_(2) as an ultrathin film catalyst for the HER,which is valuable to provide instruction and afford experience for further application at industrial level.展开更多
An efficient method for mono-phosphorylation of 2 (KRP203) using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P (KRP203-P) was developed. We applied the present method to the synthesis of KRP20...An efficient method for mono-phosphorylation of 2 (KRP203) using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P (KRP203-P) was developed. We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.展开更多
A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2- halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, Cul catalyzed system, which spontane...A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2- halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, Cul catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields. This synthetic protocol provides a concise and efficient access to a wide variety of dibenzodiazepinone, including biologically active molecules.展开更多
基金Project(51674230) supported by the National Natural Science Foundation of ChinaProject(2018YFC1900505) supported by the National Key R&D Program of China
基金The authors acknowledge the funding support from the Key Deployment Projects of Chinese Academy of Sciences(ZDRW_CN_2020-1)the Sino-German Cooperation Research Project under the Natural Science Foundation of China(51761135108)+1 种基金the German Research Foundation(392417756)the CAS Interdisciplinary Innovation Team.
基金This work was supported by the grants from National Natural Science Foundation of China (project 81170286 to FAN XH, project 81300184 to WANG XJ). We thank the patients for their participations in our study.
基金financially supported by National Key R&D Program of China(No.2017YFB0305100)Science&Technology Research Project of Guangdong Province(No.2015B090926012+1 种基金2015A0404040232014B090907005)
文摘ZG0Cr26Ni5Mo3Cu3 Duplex Stainless Steel(DSS) was solution treated at 1,060 ℃ for 3 h, followed by water cooling. Tempering treatments were conducted at 720, 750 and 780 ℃, respectively, for 16 h, followed by air cooling. The microstructures of ZG0Cr26Ni5Mo3Cu3 duplex stainless steel samples treated at different tempering temperatures were observed by scanning electron microscope(SEM) and energy dispersal spectroscopy(EDS), and the phase consitutions were analyzed using X-ray diffraction(XRD). The effects of the precipitation of sigma(σ) phase on the duplex phase percentage, hardness, impact toughness and corrosion resistance of the DSS were studied. Results showed that microstructures of ZG0Cr26Ni5Mo3Cu3 after solution treatment consists of ferrite(α) phase and austenite(γ) phase; after being tempered at different temperatures, σ phase appeared due to a eutectoid-type reaction of α→σ+γ2 during tempering treatment. It was observed that σ phase distributed along the grain boundary. The volume fraction of σ and γ phases increased with increasing tempering temperature in the range of 720 to 780 ℃, whereas the volume fraction of α phase showed the opposite trend. When the percentage of σ phase increased, the hardness of steel also increased. In the solution treated steel, hardness was measured to be only 244.0 HB, because σ phase did not appear. However, it increased to 391.8 HB when the DSS was tempered at 780℃because a great of deal of σ phase appeared. The impact toughness and corrosion resistance of DSS decreased when the percentage of σ phase increased.
基金the Project of Excellent Young Talents of Traditional Chinese Medicine of Zhejiang Province,No.2019ZQ016the Zhejiang Medical and Health Science and Technology Young Talents Program,No.2019RC059.
文摘BACKGROUND Nearly 10%of patients undergoing primary total knee arthroplasty(TKA)have valgus deformity(VD)of the knee.For severe VD of the knee,a more lateral structural release is needed to achieve balance between medial and lateral space and neutral femorotibial mechanical axis(FTMA),which is challenging and technical.AIM To introduce a new surgical technique of resection,soft tissue release,and FTMA for Ranawat type-Ⅱ VD with a 5-year follow-up.METHODS A retrospective study was conducted on patients who underwent TKA from December 2011 to December 2014.Hip-knee-ankle(HKA),range of motion(ROM),Oxford knee score(OKS),and knee society score(KSS)were used to assess the joint activity of patients in the new theory TKA group(NT-TKA)and were compared with those of the conventional TKA group(C-TKA).RESULTS A total of 103 people(103 knees)were included in this study,including 42 patients with an average follow-up period of 83 mo in the C-TKA group and 61 patients with an average follow-up period of 76 mo in the NT-TKA group.Six patients had constrained prosthesis,one had common peroneal nerve injury,and two had joint instability in the C-TKA group,but none of these occurred in the NT-TKA group.There were significant statistical differences in constrained prosthesis usage and complications between the groups(P=0.002 and P=0.034,respectively).The KSS at 1 mo post-operation for the C-TKA and NT-TKA groups were 11.2±3.8 and 13.3±2.9,respectively,with a significant difference(P=0.007).However,the data of HKA,ROM,OKS KSS,and prosthesis survival rate were insignificant(P>0.05)in both the preoperative and follow-up periods.CONCLUSION Adopting 5°-7°valgus cut angle for VD and sacrificing 2°neutral FTMA for severe VD which cannot be completely corrected during TKA can reduce the need for soft tissue release,maintain early joint stability,reduce the use of constrained prostheses,and minimize postoperative complications.
基金This study was funded by the National Natural Science Foundation of China {No.81572098) and Natural Science Foundation of Shanxi Province of China (No. 2008012011-3).
基金supported by the National Natural Science Foundation of China (No.30900654)the Medical Scientific Research Foundation of Zhejiang Province (Nos.2007B025,2010KYA036,and 2010KYA032)+1 种基金the Science and Technology Department of Zhejiang Province(Nos.2011c23017 and 2012c23081)the Zhejiang Major Science and Technology Special Project (No.2009C13018),China
文摘Objective:The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase(MTHFR) C677T excision repair cross-complementation group 1(ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer(NSCLC).Methods:A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regimens.The polymorphisms of MTHFR C677T,ERCC1 C8092A,and ERCC1 C118T were genotyped using the TaqMan methods.Results:The overall response rate was 28.9%.Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype(TT or CT)(41.2% versus 19.1%,P=0.01).Median time to progression(TTP) of patients with MTHFR CC genotype was longer than that of patients with variant genotype(7.6 months versus 5.0 months,P=0.003).No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival.Conclusions:Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.
基金the National Natural Science Foundation of China(No.51802266)Shaanxi’s Key Project of Research and Development Plan(No.2021GY-217)+1 种基金the Research Funds for Interdisciplinary Subject of NWPU(No.19SH0304)the Fundamental Research Funds for the Central Universities(No.3102017jc01001)。
文摘Transition metal dichalcogenides(TMDs)have emerged as a promising electrocatalyst for hydrogen evo-lution reaction(HER)due to its excellent conductivity and abundant electrocatalytic active sites of its edges.TMDs nanowall can expose abundant of edges so that they tend to show better catalytic performance for hydrogen evolution reaction.Herein,PtSe_(2) nanowall films with morphology controlled at centimeters level are synthesized by selenizing Pt film.The dynamic and thermodynamics of selenation reaction are investigated.The nanowall structure can be obtained by controlling the growth temperature,and the thickness of nanowall can be tuned by the original thickness of Pt film.The Pt atoms can be rearranged into ordered distribution at 550℃ and can be induced to well-ordered PtSe_(2) nanowalls finally.The well-ordered PtSe_(2) nanowall films show excellent HER performance,with an overpotential of 0.3 V at-10 mA·cm^(-2) and a Tafel slope of~52 mV·dec^(-1).This work demonstrates the great potential of activated 2D PtSe_(2) as an ultrathin film catalyst for the HER,which is valuable to provide instruction and afford experience for further application at industrial level.
基金financially supported by National Natural Science Foundation of China(No.81102322)
文摘An efficient method for mono-phosphorylation of 2 (KRP203) using cbz-protection, dibenzylphosphoryl chloride and TMSI affording 2-P (KRP203-P) was developed. We applied the present method to the synthesis of KRP203 phosphate analogs which were difficult to produce through tradition procedures.
基金National Natural Science Foundation of China(No.81102322)the Global Alliance for TB Drug Development(TB alliance)for their financial supports
文摘A one pot protocol for the synthesis of dibenzodiazepinones was developed. The substituted ethyl 2- halobenzoates are cross-coupled with o-phenylenediamine utilizing a ligand-free, Cul catalyzed system, which spontaneously undergo an intramolecular N-acylation in ethylene glycol to give the corresponding products in high yields. This synthetic protocol provides a concise and efficient access to a wide variety of dibenzodiazepinone, including biologically active molecules.