炔雌醇环丙孕酮片联合二甲双胍对多囊卵巢综合征患者血清DHEA、AMH及SHBG水平的影响

目的探讨多囊卵巢综合征(PCOS)患者血清硫酸脱氢表雄酮(DHEA)、抗缪勒管激素(AMH)、性激素结合球蛋白(SHBG)水平及经炔雌醇环丙孕酮片联合二甲双胍治疗后的变化。方法选取2018年12月—2019年10月在重庆三峡中心医院妇产科就诊的PCOS患者52例作为观察组。另取同期有规律月经周期、卵巢功能正常的育龄期女性55例作为对照组。观察组应用炔雌醇环丙孕酮片联合二甲双胍治疗,疗程3个月。比较两组治疗前血清DHEA、AMH及SHBG水平和观察组治疗前后血清DHEA、AMH及SHBG水平。采用Pearson法分析血清DHEA、AMH、SHBG与PCOS病情严重程度的关系。结果观察组治疗前DHEA、AMH较对照组高(P<0.05),SHBG较对照组低(P<0.05)。1型组治疗前血清DHEA、AMH水平高于3型组、4型组(P<0.05),SHBG水平低于3型组、4型组(P<0.05),2型组患者治疗前血清DHEA、AMH水平高于4型组(P<0.05),SHBG水平低于4型组(P<0.05)。血清DHEA、AMH与PCOS病情严重程度呈正相关(r=0.827和0.764,P<0.05),SHBG与PCOS病情严重程度呈负相关(r=-0.852,P<0.05)。观察组治疗后血清DHEA、AMH较治疗前低(P<0.05),SHBG较治疗前高(P<0.05)。结论PCOS患者血清DHEA、AMH水平升高,SHBG水平降低。血清DHEA、AMH及SHBG均能有效反映PCOS患者的病情严重程度。炔雌醇环丙孕酮片联合二甲双胍对PCOS患者具有良好的疗效,能有效改善患者血清DHEA、AMH及SHBG水平。

海军某部新兵角膜屈光手术后视觉相关生活质量调查分析

目的:调查分析海军某部入伍新兵行角膜屈光手术后的视觉相关生活质量。方法:在2014/2016年海军某部入伍新兵查体眼科复检过程中,采用问卷调查入伍新兵的一般资料及视觉相关生活质量(NEI-VFQ-25量表),并详细记录每位受检者视力、电脑验光、对比敏感度等眼科检查结果。结果:本研究纳入入伍新兵2760人,其中接受过近视角膜屈光手术者340例(12.32%),手术方式包括角膜基质切削术(89.71%)和角膜表层切削术(10.29%)。根据术前等效球镜度将已行近视角膜屈光手术的受检者分为低度近视组(≤-3.00D,134例)、中度近视组(>-3.00D~<-6.00D,159例)和高度近视组(≥-6.00D,47例),三组受检者术后屈光度在±1.0D范围内者分别为128例(95.52%)、153例(96.23%)、38例(80.85%),低、中度近视组明显高于高度近视组(均P<0.0167)。三组受检者自然光线和眩光条件下各空间频率对比敏感度均有差异(P<0.05),低、中度近视组均高于高度近视组(P<0.05)。三组受检者术后视觉相关生活质量评分具有差异(P<0.05),低度近视组(6.25±8.61分)、中度近视组(6.87±8.51分)显著低于高度近视组(9.84±9.76分)(均P<0.05)。结论:新兵角膜屈光手术后视觉相关生活质量与术前屈光度数有关,术前屈光度低的新兵术后视觉相关生活质量好于术前屈光度高的近视新兵。

Cutting-balloon angioplasty before drug-eluting stent implantation for the treatment of severely calcified coronary lesions

BackgroundSeverely 钙化的冠的损害对汽球 angioplasty 糟糕作出回应，导致不完全、不均匀的 stent 扩大。因此，在 drug-eluting stent (DES ) 以前的足够的匾修正培植是为钙化的损害治疗的钥匙。这研究是评估为严重地钙化的冠的 lesions.MethodsNinety 切汽球 angioplasty 的安全和功效 -- 有严重地钙化的损害的二个连续病人(定义为钙弧 ≥；180 °；钙长度比率 ≥；0.5 ) 在 DES 培植随机基于汽球类型被划分成二个组以前，与汽球膨胀对待：在常规汽球 angioplasty (BA ) 的 45 个病人组织，在切的汽球 angioplasty (CB ) 的 47 个病人组织。在 BA 组的七个盒子令人满意地没完成膨胀并且被变成 CB 组。 Intravascular 超声( IVUS )在汽球膨胀前并且在 stent 培植以后被执行获得质、量的损害特征并且评估 stent ，包括最小的腔代表性的区域( CSA )，钙化的弧和长度，最小的 stent CSA ， stent 并置， stent 对称， stent 扩大，容器解剖，并且分叉容器监狱。在里面医院， 1 月、 6 月的主要不利心脏的事件(向) 是 reported.ResultsThere 不是在在二个组之间的临床的特征的统计差别，包括钙弧(222.2 °；±；22.2 °；对 235.0 °；±；22.1 °；， P = 0.570 ) ，钙长度比率(0.67 ±；0.06 对 0.77 ±；0.05， P = 0.130 ) ，并且在一种总线标准前的最小的腔 CSA (2.59 ±；0.08 公里 2 对 2.52 ±；0.08 公里 2, P = 0.550 ) 。在 stent 培植以后，最后的最小的 stent CSA (6.26 ±；0.40 公里 2 对 5.03 ±；0.33 公里 2 ；P = 0.031 ) 并且尖锐的腔获得(3.74 ±；0.38 公里 2 对 2.44 ±；0.29 公里 2, P = 0.015 ) 比 BA 组的在 CB 组是显著地更大的。没有统计上在在二个组之间的 stent 扩大， stent 对称，不完全的 stent 并置，容器解剖和分支容器监狱的差别。在在严重地钙化的损害的 DES 培植看起来是包括显著地更大的最后的 stent CSA 和更大的尖锐的腔获得的更多的功效以前， 30 天、 6 月的向率也不是 different.ConclusionsCutting 汽球 angioplasty，没有增加在操作和 MACE 率在期间的复杂并发症 6 月。

Numerical and Experimental Evaluation of Shine-Through Loss and Beam Heating Due to Neutral Beam Injection on EAST

This research applies experimental measurements and NUBEAM,ONETWO and TRANSP modules to investigate the shine-through(ST)loss ratio and beam heating percentage of neutral beam injection on EAST.Measurements and simulations confirm that the ST loss ratio increases linearly with beam energy,and decreases exponentially with plasma density.Moreover,using the multi-step fitting method,we present analytical quantitative expressions of ST loss ratio and beam heating percentage,which are valuable for the high parameter long-pulse experiments of EAST.

不同灸量艾灸治疗寒凝血瘀型原发性痛经:随机对照试验

Objective:To explore the clinical effect differences of moxibustion with different doses on primary dysmenorrhea with cold congelation and blood stasis type.Methods:A total of 60 patients of primary dysmenorrhea were randomized into an intensified dose group and a conventional dose group.All of the patients were treated with moxibustion.In the intensified dose group,the treatment was given three times daily(once every morning,afternoon and at bedtime successively) and during the trial,1 case was dropped out and 29 cases were included in the statistical analysis finally.In the conventional dose group,the treatment was given once daily and 1 case was dropped out during trial and 29 cases were included in the statistical analysis.The score of visual analogue scale(VAS) at the worst painful time point,the score of dysmenorrhea symptoms and recurrence rate were observed and compared before and after treatment in the patients between the two groups.The clinical therapeutic effects were observed in the two groups too.Results:VAS difference value(D-value) and dysmenorrhea symptoms D-valuebefore and after treatment in the intensified dose group were higher than those in the conventional dose group respectively(both P<0.05).The recurrence rate was 14.29% in the intensified dose group,lower than 42.31% in the conventional dose group,with the statistical significance(P<0.05).The total clinical effective rate was 96.55%in the intensified dose group,higher than 89.66% in the conventional dose group,with the statistical significance(P<0.05).Conclusion:Compared with the conventional dose moxibustion,moxibustion with intensified dose achieves satisfactory therapeutic effect on primary dysmenorrhea of cold congelation and blood stasis type.This therapy is low in recurrent rate and convenient in manipulation,thus it deserves to be promoted in clinical application.

基于数据挖掘探析慢性胃炎古代针灸选穴规律

Objective:To explore the experiences of ancient acupuncture physicians in acupoint combination with meridians and body regions involved in treatment of chronic gastritis through data mining technology so as to provide the evidences for the clinical application of acupuncture for chronic gastritis in the modem time.Methods:Firstly,the ancient literature(database),searching words,inclusion and exclusion criteria were determined.Secondly,the database was organized through computer and manual retrieval.Finally,using data mining techniques,such as frequency analysis and association analysis,the experiences of ancient acupuncture physicians were explored in meridian selection and acupoint combination in treatment of chronic gastritis.Results:A total of 2243 items in compliance with the relevant requirements were included,covering224 acupoints for the treatment of chronic gastritis.Of them,the involved meridians were closely related to the stomach,especially to bladder,spleen and stomach meridians as well as Conception Vessel.The acupoints selected not only focus on the local acupoints related to lesions,but also on the distal ones,especially those located in the lower limbs.The most common acupoints for any symptom were Zusanli(足三里ST36),Neiguan(内关PC6),Zhongwan(中脘CV12),Gongsun(公孙SP4)and Taibai(太白SP3).For epigastric pain,Liangmen(梁门ST21)and Xiangu(陷谷ST43)were the representatives as the combination of acupoints from the same meridian.For the disorders with upward reversion of qi,PC6 and SP4 were generally combined.Among the specific points,the five-shu points were the most common,followed by the front-mu points.In the combination with the specific points involved,PC4 and SP4 were highly associated.The acupoint combination was particular for each category of main symptoms.Conclusion:In treatment of chronic gastritis with acupuncture,the ancient physicians give the great consideration to symptom differentiation and meridian differentiation relevant with gastric disorders,as well as the combination of the distal and nearby acupoints.Besides,the specific points are of the best choice.

Detailed Structures and Formation Mechanisms of Well-Known Al_(10)RE_2Mn_7 Phase in Die-Cast Mg-4Al-4RE-0.3Mn Alloy

The detailed structures and the corresponding formation mechanisms of the well-known Al_(10)RE_2Mn_7 phase in the conventional die-cast Mg–4Al–4RE–0.3Mn alloy were thoroughly investigated using transmission electron microscopy(TEM). The results indicate that the Al_(10)RE_2Mn_7 phase ordinarily contains both normal (111) twins and orientation twins.Both detailed TEM observations and density functional theory calculations indicate that the Al_(10)RE_2Mn_7 phase is transferred from the Al_8REMn_4 phase following an orientation relationship as [010]_(Al_8REMn_4)//[101]_(Al_(10)RE_2Mn_7) and (101)_(Al_8REMn_4)//(110)_(Al_(10)RE_2Mn_7). Moreover, forming orientation twins in the Al_(10)RE_2Mn_7 phase is attributed to the blurry regions at incoherent twin boundaries in the Al_8REMn_4 phase. Finally, these formed orientation twins result in the (111) twins in the Al_(10)RE_2Mn_7 phase.

Effects of Glycerol on the Fluorescence Spectra and Chloroplast Ultrastructure of Phaeodactylum tricornutum(Bacillariophyta)

Responses of the photosynthetic activity of Phaeodactylum tricornutum （Bacillariophyta） to organic carbon glycerol were investigated. The growth rate, photosynthetic pigments, 77 K fluorescence spectra, and chloroplast ultrastructure of P. tricornutum were examined under photoautotrophic, mixotrophic, and photoheterotrophic conditions. The results showed that the specific growth rate was the fastest under mixotrophic conditions. The cell photosynthetic pigment content and values of Chl a/Chl c were reduced under mixotrophic and photoheterotrophic conditions. The value of carotenoid/Chl a was enhanced under mixotrophic conditions, but was decreased under photoheterotrophic conditions. In comparison with photoautotrophic conditions, the fluorescence emission peaks and fluorescence excitation peaks were not shifted. The relative fluorescence of photosystem （PS） Ⅰ and PS Ⅱ and the values of F685/F710 and F685/F738 were decreased. Chloroplast thylakoid pairs were less packed under mixotrophic and photoheterotrophic conditions. There was a strong correlation between degree of chloroplast thylakoid packing and the excitation energy kept in PS Ⅱ. These results suggested that the PS Ⅱ activity was reduced by glycerol under mixotrophic conditions, thereby leading to repression of the photosynthetic activity.

β-CuGaO_(2):a ferroelectric semiconductor with narrow band gap as degradation catalyst for wastewater environmental remediation

As a narrow band gap semiconductor,wurtziteβ-CuGaO_(2)has drawn increasing attention in the area of solar energy.Althoughβ-CuGaO_(2)has been theoretically predicted to possess ferroelectric polarization,its experi-mental ferroelectric characterization and practical appli-cations have not yet been presented.Herein,firstly we experimentally confirmed its ferroelectric property via hysteresis loop measurement.The result showed a rema-nent polarization value of 10.20μC·cm^(-2) with low coer-cive electricfield of 6.45 kV·cm^(-1) at 20 Hz at room temperature,while the leakage current density(J)value was found to be 1.188 A·cm^(-2),which suggested the property of a larger remnant polarization with low coercive electricfield than current value if the compactness was strengthened.Then,the synergistic effect of ferroelectric and semiconductor was comparatively highlighted by the experiment of pollutant degradation.Within 30 min,methyl orange degradation efficiency had reached 30.73%only in the case of spontaneous polarization(electricity),while it could reach 67.58%under the effect of pre-po-larizedβ-CuGaO_(2)powder due to the modulating orienta-tion of ferroelectric domains.Once irradiated(light),it was up to 92%within 30 min;in comparison,it merely took 16 min up to 92%degradation efficiency under both illu-mination and pre-polarization.If without illumination,it was 92.01%with 30 min in the condition of ordinary ultrasonic vibration(force)while under both illumination and ultrasonic vibration,only 11 min was spent to reach 92.79%degradation efficiency.All these results felici-tously indicated thatβ-CuGaO_(2)had fascinating potential in energy harvesting(such as electricity,light,force)and transformation as wastewater environment remediation catalyst.