Effects of Danshen Chuanxiongqin therapy on TXA2/PGI2, bone metabolism and stress levels after proximal femoral fracture surgery

Objective:To study the effects of Danshen Chuanxiongqin therapy on TXA2/PGI2, bone metabolism and stress levels after proximal femoral fracture surgery.Methods:A total of 80 patients with proximal femoral fractures who received open reduction and internal fixation treatment in the First Affiliated Hospital of the Fourth Military Medical University between January 2015 and December 2016 were selected as the research subjects and randomly divided into the experimental group who received postoperative adjuvant Danshen Chuanxiongqin therapy and the control group who received postoperative conventional therapy. The levels of TXA2/PGI2 balance-related indicators, bone metabolism indicators and stress hormones in serum as well as the expression levels of stress molecules in peripheral blood were measured before surgery and 3 d after surgery.Results:Compared with those of same group before surgery, serum 6-keto-PGF1α, t-PA, PICP, BALP and OCN levels of both groups of patients were significantly lower whereas serum TXB2, PAI-1, D-D,β-CTX, RANKL, NE, COR and ANG-Ⅱ levels as well as peripheral blood NF-κB and HSP70 expression were significantly higher after surgery, and serum 6-keto-PGF1α, t-PA, PICP, BALP and OCN levels of experimental group after surgery were higher than those of control group whereas serum TXB2, PAI-1, D-D,β-CTX, RANKL, NE, COR and ANG-Ⅱ levels as well as peripheral blood NF-κB and HSP70 expression were lower than those of control group.Conclusion:Danshen Chuanxiongqin therapy after proximal femoral fracture surgery can adjust the TXA2/PGI2 balance, improve the bone metabolism and reduce the stress level.

小儿蛛网膜囊肿术后单侧动眼神经麻痹案

The paper reports a successful case of unilateral oculomotor palsy treated with acupuncture in a Chinese boy aged 5 years and 3 months.Filiform needles were applied for ptosis,ocular motility impairment and blurred vision of the left oculomotor palsy after arachnoid cyst surgery.Two stages of treatment with acupuncture were composed.Acupuncture in the first stage focused on resolving stasis,unblocking meridians and activating qi and blood circulation,especially at the acupoints around the eye,combined with the distal points(four gate points)to enhance qi movement and activate blood circulation,once daily.Besides,the western medicines for nerve nutrition were added.One month later,all the symptoms were alleviated,and the eyelid could be lifted.Then,the second stage of acupuncture started,during which,the western medicine for nerve nutrition was withdrawal,acupuncture was continued with the same acupoints as the first stage,once every two days.Besides,the thumb-tack needle was used to maintain the effect of filiform needle,and Zusanli(ST36)was added to replenish qi of spleen and stomach and promote circulation of meridians.Another month later,the lift of the left eyelid and the ocular motility were basically symmetrical to the right eye,and the left eye vision returned normal.Follow-up until the time of publication,the motility and function of the affected eye were basically the same as those of the healthy side.This case suggests that the staged intervention with acupuncture could be effective in child with unilateral oculomotor palsy after arachnoid cyst surgery and were acceptable for child.Further studies are needed to confirm the effect and mechanism of acupuncture intervention on postoperative oculomotor palsy.

Alacrimia after child traumatic brain injury

Objective: To report the clinical effects of acupuncture on alacrimia after child traumatic brain injury.Methods: One child with the alacrimia on the right eye after traumatic injury, aged 2 years and 3 months, was treated with acupuncture. The acupoint selection: Yángbái(阳白 GB 14), Cuánzhú(攒竹 BL2), T6 ngzǐliáo(瞳子髎 GB 1), Sìbái(四白 ST 2), Yingxiāng(迎香 LI 20), Yìfēng(翳风 TE 17) and Fēngchí(风池 GB 20) on the right side, as well as bilateral Hégǔ((合谷 LI 4) and Tàichōng(太冲 LR 3). The quick needling technique was applied to GB 20, LI 4 and LR 3 and the needles were retained for 20 min in the rest acupoints. In the embedding needle therapy, one group of acupoints was selected in each treatment,(Group No.1: BL 2, Sizhúkōng(丝竹空 TE 23), ST 2 and Shàngyíngxiāng(上迎香 EX-HN 8);Group No. 2:Tàiyáng(太阳EX-HN 5), TE 17, LI 20 and GB 14)The embedding needle therapy was provided after the routine acupuncture treatment and the thumb-tack needles were embedded subcutaneously for 48 hours.The treatment with acupuncture was given once every other day. three times a week.Results: After 5 treatments, a full of tears was visible on the right eye when crying. After 10 treatments,there was a large amount of tears on the eyes and nasal discharge when crying. After 15 treatments, the lacrimal secretion and nasal secretion were normal when crying, without differences from the condition before traumatic brain injury.Conclusion: Acupuncture achieves the significant therapeutic effects on alacrimia after the child traumatic brain injury.