Dear editor,Lactic acidosis is a commonly encountered condition in the emergency department,and the most common causes of lactic acidosis are hypoperfusion and hypoxia induced by sepsis.A number of other diseases can ...Dear editor,Lactic acidosis is a commonly encountered condition in the emergency department,and the most common causes of lactic acidosis are hypoperfusion and hypoxia induced by sepsis.A number of other diseases can also cause hyperlactatemia,such as hematological malignancies,which can sometimes be life-threatening.Treatment of hyperlactatemia is largely dependent on underlying conditions.Therefore,an accurate diagnosis is important,and prompt treatment could be lifesaving.Despite the advances in medical sciences,lactic acidosis and malignancy have been linked only in a small number of cases,[1]and hypoglycemia and dyslipidemia were rare findings.We report a case of an elderly woman who had persistent lactic acidosis and hypoglycemia with dyslipidemia and was finally diagnosed with B-cell lymphoma.The aim of this case is to highlight the importance of considering hematological malignancies when presented with persistent lactic acidosis and identify a diagnosis for appropriate and timely treatment.展开更多
Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The ...Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3-5 min vs. 40 min); the peak concentration became higher (1.32-4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.展开更多
Currently,the combination of photothermal therapy（PTT） and photodynamic therapy（PDT） has emerged as a powerful technique for cancer treatment.However,most examples of combined PTT and PDT reported use multi-compon...Currently,the combination of photothermal therapy（PTT） and photodynamic therapy（PDT） has emerged as a powerful technique for cancer treatment.However,most examples of combined PTT and PDT reported use multi-component nanocomposites under excitation of separate wavelength,resulting in complex treatment process.In this work,a novel theranostic nanoplatform（SiNcOH-DSPE-PEG（NH2）NPs） has been successfully developed by coating silicon 2,3-naphthalocyanine dihydroxide（SiNcOH）with DSPE-PEG and DSPE-PEG-NH2 for photoacoustic（PA） imaging-guided PTT and PDT tumor ablation for the first time.The as-prepared single-agent SiNcOH-DSPE-PEG（NH2） NPs not only have good water solubility and biocompatibility,but also exhibit high photothermal conversion efficiency and singlet oxygen generation capability upon 808 nm NIR laser irradiation.In addition,owing to their high absorption at NIR region,the SiNcOH-DSPE-PEG（NH2） NPs can also be employed as an effective diagnostic nanoagent for photoacoustic（PA） imaging.In vitro and in vivo experimental results clearly indicated that the simultaneously combined PTT and PDT under the guidance of PA imaging with single NIR laser excitation can effectively kill cancer cells or eradicate tumor tissues.Taking facile synthesis and high efficiency in cancer treatment by SiNcOH-DSPE-PEG（NH2） NPs into consideration,our study provides a promising strategy to realize molecular imaging-guided combination therapy.展开更多
基金Acknowledgments We thank Dr Boja Emily S （NHLBI, NIH, USA） for expert technical assistance in mass spectrometry analyses, and our colleagues Drs Bin Lu, Zhao-Qiu Wu for helpful comments. This work was supported by a National Basic Research Program grant from the Ministry of Science and Technology of China （G2003CB515401）, National Science Fund for Distinguished Young Scholar from the National Natural Science Foundation of China （30425002） and a fund supported by the ＂100 Talents Project＂ of Chinese Academy of Sciences （J-G Liu）.
文摘Dear editor,Lactic acidosis is a commonly encountered condition in the emergency department,and the most common causes of lactic acidosis are hypoperfusion and hypoxia induced by sepsis.A number of other diseases can also cause hyperlactatemia,such as hematological malignancies,which can sometimes be life-threatening.Treatment of hyperlactatemia is largely dependent on underlying conditions.Therefore,an accurate diagnosis is important,and prompt treatment could be lifesaving.Despite the advances in medical sciences,lactic acidosis and malignancy have been linked only in a small number of cases,[1]and hypoglycemia and dyslipidemia were rare findings.We report a case of an elderly woman who had persistent lactic acidosis and hypoglycemia with dyslipidemia and was finally diagnosed with B-cell lymphoma.The aim of this case is to highlight the importance of considering hematological malignancies when presented with persistent lactic acidosis and identify a diagnosis for appropriate and timely treatment.
基金supported by the National Natural Science Foundation of China (No. 81073057)the Key New Drug Creation and Development Programme of China (Nos. 2009ZX09502-008 and 2009ZX09308-003)the Doctoral Fund of the Ministry of Education of China(No. 20090013110007)
文摘Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3-5 min vs. 40 min); the peak concentration became higher (1.32-4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%-237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.
基金supported by the National Natural Science Foundation of China(No.21101131)National Basic Research Foundation(973)of China(No.2014CB932004)Natural Science Foundation of Fujian Province(No.2016J01073)
文摘Currently,the combination of photothermal therapy（PTT） and photodynamic therapy（PDT） has emerged as a powerful technique for cancer treatment.However,most examples of combined PTT and PDT reported use multi-component nanocomposites under excitation of separate wavelength,resulting in complex treatment process.In this work,a novel theranostic nanoplatform（SiNcOH-DSPE-PEG（NH2）NPs） has been successfully developed by coating silicon 2,3-naphthalocyanine dihydroxide（SiNcOH）with DSPE-PEG and DSPE-PEG-NH2 for photoacoustic（PA） imaging-guided PTT and PDT tumor ablation for the first time.The as-prepared single-agent SiNcOH-DSPE-PEG（NH2） NPs not only have good water solubility and biocompatibility,but also exhibit high photothermal conversion efficiency and singlet oxygen generation capability upon 808 nm NIR laser irradiation.In addition,owing to their high absorption at NIR region,the SiNcOH-DSPE-PEG（NH2） NPs can also be employed as an effective diagnostic nanoagent for photoacoustic（PA） imaging.In vitro and in vivo experimental results clearly indicated that the simultaneously combined PTT and PDT under the guidance of PA imaging with single NIR laser excitation can effectively kill cancer cells or eradicate tumor tissues.Taking facile synthesis and high efficiency in cancer treatment by SiNcOH-DSPE-PEG（NH2） NPs into consideration,our study provides a promising strategy to realize molecular imaging-guided combination therapy.
