鞭虫感染致腹痛1例

鞭虫病常无特异性临床表现,多数患者仅表现为慢性腹痛,临床较易漏诊、误诊。现将典型病例报道如下。1临床资料男性患者,15岁,因反复腹痛50 d,加重1 d,晕厥2次就诊于遵义医学院附属医院。50 d前患者出现脐周及右下腹疼痛,腹痛后突发晕厥1次,外院胃镜检查示慢性胃窦炎,期间腹痛仍反复发作,可自行缓解,未重视。1 d前腹痛再发伴晕厥1次,急诊入本院。查体:贫血貌,右下腹压痛。入院查血常规示:血红蛋白98 g/L,肝功能:总蛋白56.4 g/L,大便隐血及虫卵检查阴性。

Potential model for differential diagnosis between Crohn's disease and primary intestinal lymphoma

AIM To evaluate the usefulness of different parameters to differentiate Crohn's disease(CD) from primary intestinal lymphoma(PIL).METHODS The medical records of 85 patients with CD and 56 patients with PIL were reviewed retrospectively. Demographic, clinical, laboratory, endoscopic, and computed tomographic enterography(CTE) parameters were collected. The univariate value of each parameter was analyzed. A differentiation model was established by pooling all the valuable parameters. Diagnostic efficacy was analyzed, and a receiver operating characteristic(ROC) curve was plotted.RESULTS The demographic and clinical parameters that showed significant values for differentiating CD from PIL included age of onset, symptom duration, presence of diarrhea, abdominal mass, and perianal lesions(P < 0.05). Elevated lactate dehydrogenase and serum β2-microglobulin levels suggested a PIL diagnosis(P < 0.05). The endoscopic parameters that showed significant values for differentiating CD from PIL included multiple-site lesions, longitudinal ulcer, irregular ulcer,and intraluminal proliferative mass(P < 0.05). The CTE parameters that were useful in the identification of the two conditions included involvement of ≤ 3 segments, circular thickening of the bowel wall, wall thickness > 8 mm, aneurysmal dilation, stricture with proximal dilation, "comb sign", mass showing the "sandwich sign", and intussusceptions(P < 0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the differentiation model were 91.8%, 96.4%, 93.6%, 97.5%, and 88.5%, respectively. The cutoff value was 0.5. The area under the ROC curve was 0.989.CONCLUSION The differentiation model that integrated the various parameters together may yield a high diagnostic efficacy in the differential diagnosis between CD and PIL.

Adjustable half-skyrmion chains induced by SU(3)spin-orbit coupling in rotating Bose-Einstein condensates

The ground state properties of the rotating Bose–Einstein condensates(BECs) with SU(3) spin–orbit coupling(SOC)in a two-dimensional harmonic trap are studied. The results show that the ferromagnetic and antiferromagnetic systems present three half-skyrmion chains at an angle of 120°to each other along the coupling directions. With the enhancement of isotropic SU(3) SOC strength, the position of the three chains remains unchanged, in which the number of half-skyrmions increases gradually. With the increase of rotation frequency and atomic density–density interaction, the number of halfskyrmions on the three chains and in the regions between two chains increases gradually. The relationships of the total number of half-skyrmions on the three chains with the increase of SU(3) SOC strength, rotation frequency and atomic density–density interaction are also given. In addition, changing the anisotropic SU(3) SOC strength can regulate the number and morphology of the half-skyrmion chains.

Controllable laning phase for oppositely driven disk systems

A two-dimensional binary driven disk system embedded by impermeable tilted plates is investigated through nonequilibrium computer simulations. It is well known that a binary disk system in which two particle species are driven in opposite directions exhibits jammed, phase separated, disordered, and laning states. The presence of tilted plates can not only advance the formation of laning phase, but also effectively stabilize laning phase by suppressing massively drifting behavior perpendicular to the driving force. The lane width distribution can be controlled easily by the interplate distance. The collective behavior of driven particles in laning phase is guided by the funnel-shaped confinements constituted by the neighboring tilted plates. Our results provide the important clues for investigating the mechanism of laning formation in driven system.

Effect of intense pulsed light autopulse combined with oral metronidazole on serum inflammatory mediators in patients with mild and moderate acne

Objective:To study the effect of intense pulsed light autopulse combined with oral metronidazole on serum inflammatory mediators in patients with mild and moderate acne. Methods: A total of 84 patients who were diagnosed with mild-to-moderate acne in our hospital between May 2013 and December 2015 were selected and randomly divided into laser group and metronidazole group who received intense pulsed light autopulse combined with oral metronidazole therapy and oral metronidazole monotherapy respectively. Before treatment as well as 1 week and 2 weeks after treatment, the serum was collected, fluorescent quantitative PCR kits were used to determine the expression of TLR molecules and NLRP inflammasome, and enzyme-linked immunosorbent assay kits were used to determine the levels of inflammatory cytokines.Results: 2 weeks and 4 weeks after treatment, serum IL-1β, IL-8, IL-12 and IL-18 levels as well as TLR2, TLR4, NLRP3, ASC and Caspase-1 mRNA expression of both groups of patients were significantly lower than those before treatment, and serum IL-1β, IL-8, IL-12 and IL-18 levels as well as TLR2, TLR4, NLRP3, ASC and Caspase-1 mRNA expression of laser group were significantly lower than those of metronidazole group.Conclusion: Intense pulsed light autopulse combined with oral metronidazole has significant inhibitory effect on the inflammatory response mediated by pattern recognition receptors TLR2, TLR4 and NLRP3 in patients with mild and moderate acne.

Matrix metalloproteinase 2 degrades collagen I to regulate ovarian development by association with an insulin-like peptide

The ovary generally undergoes tissue remodeling during larval to pupal transition,which includes membrane degeneration and ovariole growth.At the same time,the hormones produced by insects significantly change during metamorphosis.However,the regulatory mechanism for ovarian development and hormones is not fully understood in insects.Herein,we found that matrix metalloproteinase 2(MMP2)was highly expressed in the ovarian capsules and ovarioles,and the development was abnormal after knocking out MMP2 in Bombyx mori.The process of abnormal degradation of collagen I due to MMP2 deletion,which resulted in abnormal development of ovarioles and eggs,was analyzed in detail.The proteomics of ovaries in the MMP2-knock out and wild type strains showed a critically significant difference in the expression of a protein,insulin-like peptide(ILP).Additional analysis revealed significant alteration of ILP during ovarian development,and abnormal expression of ILP significantly affected ovarian development in vivo and MMP2 expression in vitro and in vivo.These results showed that MMP2 regulation of ovarian tissue remodeling is closely related to ILP expression.Our study provides new insights into the regulatory mechanism of MMP2 and ovarian development in B.mori.

Animal model-based simulation training for three emergent and urgent operations of penetrating thoracic injuries

Purpose:To develop animal models of penetrating thoracic injuries and to observe the effects of the animal model-based training on improving the trainees’performance for emergent and urgent thoracic surgeries.Methods:With a homemade machine,animal models of lung injuries and penetrating heart injuries were produced in porcine and used for training of chest tube drainage,urgent sternotomy,and emergent thoracotomy.Coefficient of variation of abbreviated injury scale and blood loss was calculated to judge the reproducibility of animal models.Five operation teams from basic-level hospitals(group A)and five operation teams from level III hospitals(group B)were included to be trained and tested.Testing standards for the operations were established after thorough literature review,and expert questionnaires were employed to evaluate the scientificity and feasibility of the testing standards.Tests were carried out after the training.Pre-and post-training performances were compared.Post-training survey using 7-point Likert scale was taken to evaluate the feelings of the trainees to these training approaches.Results:Animal models of the three kinds of penetrating chest injuries were successfully established and the coefficient of variation of abbreviated injury scale and blood loss were all less than 25%.After literature review,testing standards were established,and expert questionnaire results showed that the scientific score was 7.30±1.49,and the feasibility score was 7.50±0.89.Post-training performance was significantly higher in both group A and group B than pre-training performance.Post-training survey showed that all the trainees felt confident in applying the operations and were generally agreed that the training procedure were very helpful in improving operation skills for thoracic penetrating injury.Conclusions:Animal model-based simulation training established in the current study could improve the trainees’performance for emergent and urgent thoracic surgeries,especially of the surgical teams from basic-level hospitals.

Gold nanoparticles/carbon nanotubes composite microspheres for catalytic reduction of 4-nitrophenol

The layer-by-layer assembly of polyethyleneimine and carbon nanotubes is carried out through the electrostatic interactions on colloidal polystyrene templates. The successful spherical growth of polyethyleneimine/carbon nanotube multilayers could be investigated by SEM. The subsequent in situ preparation and deposition of gold nanoparticles on the core–shell composites could yield novel microsphere complexes, which are characterized by SEM, TEM, EDX and XRD. The functional hierarchical microspheres with gold nanoparticles exhibit good catalytic activity in the reaction of reducing 4-nitrophenol to 4-aminophenol.