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低价锆氧化物Zr_(3)O的结构、热力学和弹性性质第一性原理研究
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作者 周虹伶 陈莉君 +3 位作者 杨晓玲 刘许旸 孙超 栾佰峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第3期952-965,共14页
采用第一性原理系统地研究3种Zr_(3)O晶形(空间群分别为R3c(斜方六面体)、R32(斜方六面体)和P6322(六面体))的晶格动力学及其与温度相关的热力学和力学性质。计算得到的3种Zr_(3)O晶形的晶体结构参数与实验结果一致。此外,证明3种Zr_(3)... 采用第一性原理系统地研究3种Zr_(3)O晶形(空间群分别为R3c(斜方六面体)、R32(斜方六面体)和P6322(六面体))的晶格动力学及其与温度相关的热力学和力学性质。计算得到的3种Zr_(3)O晶形的晶体结构参数与实验结果一致。此外,证明3种Zr_(3)O结构在动力学和热力学上均具有稳定性。获得了3种Zr_(3)O晶形在0~1500 K温度范围内的熵、焓、吉布斯自由能、比热容、热膨胀系数和弹性模量等性质。发现3种Zr_(3)O晶形在0K时的相对稳定性顺序为Zr_(3)O(R3c)>Zr_(3)O(R32)>Zr_(3)O(P6_(3)22);然而,在50 K时Zr_(3)O(R3c)转变成Zr_(3)O(R32),在540K时转变为Zr_(3)O(P6_(3)22)。相较于其他2种Zr_(3)O相,Zr_(3)O(R32)表现出更优越的力学性能。 展开更多
关键词 第一性原理 Zr_(3)O 晶格动力学 热力学性质 弹性模量
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Subretinal recombinant human tissue plasminogen activator injection using a 41G needle for the management of submacular hemorrhages:a 3-case report 被引量:1
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作者 Dan Jiang Zhi-Xiang Hu +2 位作者 xiao-ling yang Qi-Fei Shang Rong-Han Wu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第4期663-667,共5页
Dear Editor,Submacular hemorrhage(SMH)is the accumulation of blood in the macular region caused by changes in retinal or choroidal circulation[1].SMH may be caused by age-related macular degeneration(AMD),pathological... Dear Editor,Submacular hemorrhage(SMH)is the accumulation of blood in the macular region caused by changes in retinal or choroidal circulation[1].SMH may be caused by age-related macular degeneration(AMD),pathological myopia,polypoid choroidal angiopathy(PCV)or retinal macroaneurysm[2]. 展开更多
关键词 NEEDLE INJECTION DEGENERATION
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同型半胱氨酸对FABP4启动子活性的影响 被引量:1
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作者 熊建团 李旭生 +8 位作者 杨安宁 杨松昊 邓梅 王磊 高源 李南 杨晓玲 贾月霞 姜怡邓 《中国现代医学杂志》 CAS 2018年第29期25-30,共6页
目的通过克隆脂肪酸结合蛋白4(FABP4)基因启动子,确定其活性核心区和功能片段,分析心血管疾病独立危险因子同型半胱氨酸(Hcy)对FABP4启动子活性的影响。方法应用生物信息学预测FABP4基因启动子区顺式转录作用元件和反式作用因子,以pGL3-... 目的通过克隆脂肪酸结合蛋白4(FABP4)基因启动子,确定其活性核心区和功能片段,分析心血管疾病独立危险因子同型半胱氨酸(Hcy)对FABP4启动子活性的影响。方法应用生物信息学预测FABP4基因启动子区顺式转录作用元件和反式作用因子,以pGL3-Basic为载体,采用基因重组法构建启动子截取片段,转染HEK-293A细胞,观察不同截取片段的荧光素酶活性变化,确定活性最强的片段。进一步将核心启动子片段(-2000/-1)转染巨噬细胞,观察不同浓度Hcy和DNA甲基化抑制剂5-氮杂胞苷(AZC)对FABP4基因启动子活性的影响。结果不同长度截取片段转染HEK-293A细胞后检测荧光素酶活性结果显示,与pGL3对照组比较,-2000/-1片段转录活性最强。将核心启动子片段(-2000/-1)转染巨噬细胞并用不同浓度Hcy干预后,与0μmol/L Hcy组比较,100和200μmol/L Hcy组启动活性升高;与100μmol/L Hcy组比较,在100μmol/L Hcy基础上用AZC干预后,FABP4基因启动活性升高(P <0.05)。结论成功克隆FABP4启动子的4个片段,且确定FABP4基因核心启动子位于-2000/-1片段;Hcy可以促进FABP4基因核心启动子片段活性,补充AZC后可以进一步促进Hcy引起的FABP4启动子活性升高。 展开更多
关键词 FABP4 启动子活性 同型半胱氨酸
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Evidence of human papilloma virus infection and its epidemiology in esophageal squamous cell carcinoma 被引量:15
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作者 Pin-Fang Yao Guang-Can Li +7 位作者 Jin Li He-Shun Xia xiao-ling yang Huan-Yuan Huang You-Gao Fu Rui-Qin Wang Xi-Yin Wang Ju-Wei Sha 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第9期1352-1355,共4页
瞄准:在食道的有鳞的房间癌(ESCC ) 寻找病毒(HPV ) 感染人的乳突淋瘤的证据并且在河南省移民在食道的癌的致病调查 HPV 感染的潜在的角色和传染病学。方法:乳突淋瘤病毒(PV ) 和 HPV 被 Ultrasensive S-P 免疫组织化学(IHC ) 和原位... 瞄准:在食道的有鳞的房间癌(ESCC ) 寻找病毒(HPV ) 感染人的乳突淋瘤的证据并且在河南省移民在食道的癌的致病调查 HPV 感染的潜在的角色和传染病学。方法:乳突淋瘤病毒(PV ) 和 HPV 被 Ultrasensive S-P 免疫组织化学(IHC ) 和原位杂交(ISH ) 在食道的癌纸巾(82 个案例) 和正常粘膜(40 个案例) 决定。结果:当时, IHC 表明 PV 的积极的率分别地是 75.0% , 68.18% 和 72.5% 积极的率是的 HPV (16/18-E6 )45.0%,36.36% , 37.5% ,分别地在从在湖北癌症的河南省移民,本地公民和病人的食道的癌组织标本医院。PV 和 HPV (16/18-E6 ) 在所有正常食道的粘膜标本是否定的。没有关联在食道的有鳞的房间癌纸巾并且在等级 1-3 在 HPV 之间被发现食道的有鳞的房间癌房间。原位杂交证明 HPV (16/18 ) DNA 积极的率是 30.0% , 31.8% , 25.0% ,分别地在 3 组样品。没有积极杂交信号在 40 个正常食道的粘膜标本被发现。在食道的癌标本的 HPV (16/18 ) DNA 的积极的率在正常粘膜标本(P【0.05 ) 比那显著地高。积极的率不在 3 组食道的癌组织标本(P】0.05 ) 之中是不同的。结论:HPV 感染在在湖北癌症 Hospital.HPV 的河南省移民,本地居民和病人的食道的癌高仔细与食道的有鳞的房间癌被联系。HPV 感染可以在食道的有鳞的房间癌起一个重要作用。 展开更多
关键词 乳头状瘤病毒 流行病学 食管鳞状细胞癌 病理机制
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气囊面罩结合气管插管通气对急救心肺复苏结局及预后的影响 被引量:11
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作者 杨晓玲 胡谊容 江秀 《中国现代医学杂志》 CAS 北大核心 2021年第17期91-95,共5页
目的探讨气囊面罩结合气管插管通气对急救心肺复苏结局及预后的影响。方法选取2015年1月—2017年5月在重庆医科大学附属大学城医院接受急救心肺复苏患者102例,采用随机数字表法将分为观察组和对照组,每组51例。对照组给予气管插管通气治... 目的探讨气囊面罩结合气管插管通气对急救心肺复苏结局及预后的影响。方法选取2015年1月—2017年5月在重庆医科大学附属大学城医院接受急救心肺复苏患者102例,采用随机数字表法将分为观察组和对照组,每组51例。对照组给予气管插管通气治疗,观察组给予气囊面罩结合气管插管通气治疗。比较两组患者治疗前后的pH、氧分压(PO_(2))、二氧化碳分压(PCO_(2))水平变化;记录两组患者治疗后气道开放、呼吸恢复、心跳恢复及意识改善时间;比较两组患者治疗后生命体征指标恢复情况、复苏成功率、最终存活率及满意度情况。结果治疗前,两组患者的pH、PO_(2)、PCO_(2)比较无统计学意义(P>0.05)。治疗后,两组患者的pH、PO_(2)均有所升高,但是观察组pH(7.29±0.12)mmHg低于对照组(7.53±0.22)mmHg(P<0.05),观察组PO_(2)(89.34±7.69)mmHg高于对照组(71.56±6.98)mmHg(P<0.05);两组患者的PCO_(2)均有所降低,但是观察组的PCO_(2)(37.43±5.25)mmHg低于对照组(44.32±6.51)mmHg(P<0.05)。观察组气道开放、呼吸恢复、心跳恢复及意识改善时间都短于对照组(P<0.05)。观察组血氧饱和度(85.32±11.76)%高于对照组(43.54±9.12)%(P<0.05),平均动脉(72.32±9.56)mmHg高于对照组(36.78±7.32)mmHg(P<0.05)。观察组复苏成功率(52.94%VS 25.49%)、最终存活率均高于对照组(33.33%VS 11.76%)(P<0.05)。观察组总满意率高于对照组(86.27%VS 62.75%)(P<0.05)。结论采用气囊面罩与气管插管通气结合进行急救心肺复苏,能有效改善患者的pH、PO_(2)、PCO_(2),促进患者的各项生命体征的恢复,缩短患者气道开放、呼吸恢复、心跳恢复及意识改善时间,提高复苏成功率及最终存活率,从而提高患者的满意度。治疗效果显著,值得推广使用。 展开更多
关键词 急救心肺复苏 气囊面罩 气管插管通气 复苏结局及预后
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视网膜内微血管异常及其来源的新生血管的临床特征 被引量:3
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作者 杨小玲 方海珍 +1 位作者 周挺业 潘建东 《国际眼科杂志》 CAS 北大核心 2021年第1期164-168,共5页
目的:观察糖尿病性视网膜病变(DR)患者视网膜内微血管异常(IRMA)及由IRMA来源的视网膜新生血管的临床特征。方法:本研究为前瞻性、观察性的研究。于2016-10/2017-12期间,经荧光素血管造影(FFA)检查明确有IRMA或者视网膜新生血管的未经... 目的:观察糖尿病性视网膜病变(DR)患者视网膜内微血管异常(IRMA)及由IRMA来源的视网膜新生血管的临床特征。方法:本研究为前瞻性、观察性的研究。于2016-10/2017-12期间,经荧光素血管造影(FFA)检查明确有IRMA或者视网膜新生血管的未经治疗的DR患者36例39眼纳入研究。在FFA引导下,对IRMA及视网膜新生血管进行光相干断层扫描血流成像(OCTA)检查。记录并比较IRMA及IRMA来源的新生血管的形态特征、血管来源层次、无灌注区面积、与无灌注区位置关系及病灶在FFA中的渗漏情况。无灌注区面积采用Image J软件进行测量。结果:OCTA成功扫描到IRMA病灶20个,IRMA来源的新生血管22个。20个IRMA病灶均来源并回流于视网膜静脉,血管分支较少,表现为“经修剪过的树干”样外观;IRMA均从无灌注区的边缘长出,位于视网膜静脉的无灌注区一侧,并且在无灌注区内生长;IRMA均位于视网膜内,没有突破内界膜向玻璃体腔内生长。22个IRMA来源的新生血管病灶,血管分支较多,表现为“海扇”样外观;IRMA来源的新生血管往往横跨视网膜静脉,向视网膜静脉的两侧生长、延伸;其主要部分在视网膜内,有个别分支突破内界膜沿着玻璃体后皮质生长,与视网膜紧密黏连。IRMA来源的新生血管20个(91%)位于无灌注区当中,2个(9%)位于无灌注区的边缘。IRMA来源的新生血管病灶旁的无灌注区面积为26.1±4.2mm2,大于IRMA旁的无灌注区面积12.9±4.7mm2(P<0.05)。IRMA及其来源的新生血管的来源层次无差异(P>0.05)。结论:OCTA是IRMA及增殖期糖尿病性视网膜病变(PDR)新生血管的有效检查手段。IRMA及IRMA来源的新生血管具有明显不同的临床特征,OCTA能够有效地对两者进行鉴别,从而为DR患者的诊断及随访治疗提供重要的临床依据。 展开更多
关键词 视网膜内微血管异常 新生血管 光相干断层扫描血流成像 临床特征
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Sampling Survey of Disability in 0-6 Year-old Children in China
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作者 HUI ZHANG SHAO-HUA BO +9 位作者 XI-TAN ZHANG MIN LIU ZHI-XIANG ZHANG xiao-ling yang SHU-RONG JI HUA YAN XIU-LI SUI XIN NA SHAO-HUA GUO ZHENG-LAI WU 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2006年第5期380-384,共5页
Objective To investigate the current status of disabled children and prevalence of disabilities in children aged 0-6 years and their risk factors, and to provide scientific evidence for making relevant policies for di... Objective To investigate the current status of disabled children and prevalence of disabilities in children aged 0-6 years and their risk factors, and to provide scientific evidence for making relevant policies for disabled children. Metlmds In a community-based cross-sectional study, multi-phase, stratified, unequal proportional and cluster sampling was adopted to survey 60 124 children aged 0-6 years. All the investigated children were screened for disabilities, and those with positive screening tests were further diagnosed by various specialties. Results A total of 819 children were diagnosed as disabled with an overall prevalence of 1,362%, 0.155% for hearing disability, 0.160% for visual disability, 0.931% for intelligent disability, 0.424% for limb disability, and 0.101% for mental disability. Prevalence of disability in children was higher in rural areas, and in families with two or more children, low educational level or in divorced families. Conclusion The prevalence of disability can be reduced by economic development, improvement of health care and quality of population, as well as harmonious familial relationship, early prevention of disability, and preschool education for disabled children. 展开更多
关键词 CHILDREN DISABILITY PREVALENCE Risk factor
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Anti-tumor Immunity of Gene Vaccine with Nucleofection Technology
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作者 Tao GUAN Qiu XIE +4 位作者 xiao-ling yang Guo-liang WANG Zhi-qiang ZHU Jian-hua WANG Bo NIU 《Clinical oncology and cancer resexreh》 CAS CSCD 2011年第2期92-99,共8页
关键词 肿瘤免疫 基因疫苗 技术 WESTERN印迹 质粒DNA 树突状细胞 疫苗使用 免疫反应
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Anti-Tumor Efficacy of Gene Vaccine Expressing PSMA
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作者 xiao-ling yang Jing LV +1 位作者 Yue-hong ZHANG Bo NIU 《Clinical oncology and cancer resexreh》 CAS CSCD 2010年第6期347-351,共5页
关键词 抗肿瘤作用 基因疫苗 疗效评价 免疫小鼠 细胞毒性 预防接种 哺乳动物 免疫接种
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Clinical utility of characterizing intestinal flora in septic kidney injury 被引量:8
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作者 Jiao-Jiao Yuan Xue-Ni Chang +3 位作者 Min Li Qi-Xi Yuan xiao-ling yang Chen-Ming Dong 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第7期842-846,共5页
The incidence of septic acute kidney injury(AKI)is increasing,it has become a major threat to human health because of its acute onset,poor prognosis,and high hospital costs.The most common cause of AKI in critical-car... The incidence of septic acute kidney injury(AKI)is increasing,it has become a major threat to human health because of its acute onset,poor prognosis,and high hospital costs.The most common cause of AKI in critical-care units is sepsis.Septic AKI is a complex and multi-factorial process;its pathogenesis is not fully understood.In sepsis,the destruction of mucosal barriers,intestinal flora disorders,intestinal ischemia/reperfusion injury,use of antibiotics,and lack of intestinal nutrients lead to an inflammatory reactions that in turn affects the metabolism and immunity of the host.Such changes further influence the occurrence and development of AKI.New technology is enabling various detection methods for intestinal flora.Clinical application of these methods in septic renal injury is expected to clarify the relationship among pathogenesis,disease progression mechanism,and intestinal flora. 展开更多
关键词 INTESTINAL FLORA KIDNEY INJURY SEPSIS
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A deep learning approach to the classification of 3D CAD models 被引量:12
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作者 Fei-wei QIN Lu-ye LI +2 位作者 Shu-ming GAO xiao-ling yang Xiang CHEN 《Journal of Zhejiang University-Science C(Computers and Electronics)》 SCIE EI 2014年第2期91-106,共16页
Model classification is essential to the management and reuse of 3D CAD models.Manual model classification is laborious and error prone.At the same time,the automatic classification methods are scarce due to the intri... Model classification is essential to the management and reuse of 3D CAD models.Manual model classification is laborious and error prone.At the same time,the automatic classification methods are scarce due to the intrinsic complexity of 3D CAD models.In this paper,we propose an automatic 3D CAD model classification approach based on deep neural networks.According to prior knowledge of the CAD domain,features are selected and extracted from 3D CAD models first,and then preprocessed as high dimensional input vectors for category recognition.By analogy with the thinking process of engineers,a deep neural network classifier for 3D CAD models is constructed with the aid of deep learning techniques.To obtain an optimal solution,multiple strategies are appropriately chosen and applied in the training phase,which makes our classifier achieve better performance.We demonstrate the efficiency and effectiveness of our approach through experiments on 3D CAD model datasets. 展开更多
关键词 CAD model classification Design reuse Machine learning Neural network
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Arithmetic-analytical Expression of the Koch-type Curves and Their Generalizations (Ⅰ)
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作者 xiao-ling yang Guang-jun yang 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2015年第4期1167-1180,共14页
In this paper, by constructing the one-to-one correspondence between its IFS and the quaternary fractional expansion, the n-th iteration analytical expression and the limit representation of the family of the Koch-typ... In this paper, by constructing the one-to-one correspondence between its IFS and the quaternary fractional expansion, the n-th iteration analytical expression and the limit representation of the family of the Koch-type curves with arbitrary angles are obtained. The distinction between our method and that of H. Sagan is that we provide the generation process analytically and represent it as a graph of a series function which looks like the Weierstrass function. With these arithmetic expressions, we further analyze and prove some of the fractal properties of the Koch-type curves such as the self-similarity, the HSlder exponent and with the property of continuous everywhere but differentiable nowhere. Then, we will show that the Koch- type curves can be approximated by different constructed generators. Based on the analytic transformation of the Koch-type curves, we also constructed more continuous but nowhere-differentiable curves represented by arithmetic expressions. This result implies that the analytical expression of a fractal has theoretical and practical significance. 展开更多
关键词 the family of Koch-type curves arithmetic-analytical expression binary expansion series analyt-ical transformation stitched curve
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