Protective role of metalloproteinase inhibitor(AE-941) on ulcerative colitis in rats

AIM:To evaluate the protective role of AE-941,a matrix metalloproteinase(MMP) inhibitor,on ulcerative colitis(UC) in rats.METHODS:Sprague Dawley(SD) rats were randomly divided into three groups:a control group,an AE-941 treatment group,and an UC model group.Rats were sacrificed on days 7,21,or 56 following administration of treatment by enema and the disease activity index(DAI),colonic mucosa damage index(CMDI) and colonic expression of MMP-2 and MMP-9 were assessed.RESULTS:DAI and CDMI scores in the UC model group increased significantly compared to the control group at all timepoints(P < 0.001),and also increased significantly at the 21-and 56-d timepoints compared to the AE-941-treated group(DAI:21-and 56-d = 2.09 ± 0.25,1.52 ± 0.30 vs 1.55 ± 0.28,0.59 ± 0.19,respectively,P = 0.040 and 0.007,CMDI:21-and 56-d = 3.03 ± 0.42,1.60 ± 0.35 vs 2.08 ± 0.46,0.86 ± 0.37,respectively,P = 0.040 and 0.005).Furthermore,the colonic expression of MMP-2 and MMP-9 in the UC model group increased significantly compared to the control group(P < 0.001),and also increased compared to the AE-941-treated group on the 21-and 56-d timepoints(MMP-2:21-and 56-d = 0.6048 ± 0.0522,0.4163 ± 0.0330vs 0.3983 ± 0.0218,0.1093 ± 0.0072,respectively,P = 0.010;MMP-9:21-and 56-d = 0.6873 ± 0.0472,0.4328 ± 0.0257vs 0.5179 ± 0.0305,0.2673 ± 0.0210,respectively,P = 0.010 and 0.040).CONCLUSION:Expression of MMP-2 and MMP-9 increased significantly in rats with UC.AE-941 can reduce colonic mucosal damage by downregulating the expression of MMP-2 and MMP-9.

Relationship between lipidslevelsand right ventricular volume overload in congestive heart failure

在类脂化合物和冠的动脉疾病之间的 BackgroundThe 关系很好被建立了。然而，这在类脂化合物和心失败之间不是事实。讽刺地，高类脂化合物层次充分在心失败与更好的结果被联系，但是位于现象下面的机制不是理解。这研究被执行到由于静脉的拥挤减少了肠的类脂化合物吸收的假设可以导致的测试低类脂化合物 levels.MethodsWe 与充血的心失败在 442 个 unselected 病人收集了临床的特征， echocardiograph，和类脂化合物侧面的数据。在类脂化合物层次之间的关联[包括的全部的胆固醇( TCL )，高密度的脂蛋白胆固醇(高级数据链路控制)，低密度的脂蛋白胆固醇( LDL-C )，和 triglycerides ( TG )]并且正确的室结束心脏舒张的直径( RVEDD )，左室结束心脏舒张的直径( LVEDD )，正确中庭直径( RA )，左中庭直径( LA )，或左室喷射部分( LVEF )用皮尔森关联和部分关联被分析。RVEDD， LVEDD， RA，和 LA 被索引到身体表面 area.ResultsThere 是在 TCL 层次和 RVEDD 之间的显著地反的关联(r =&#x02212； 0.34， P &#x0003c；0.001 ) 并且 RA (r =&#x02212； 0.36， P &#x0003c；0.001 ) 。象 LDL-C，高级数据链路控制，和 TG 那样的另外的类脂化合物与 RVEDD 和 RA 有类似的反的关联。在好久调整以后未改变的仍然是的所有这些关联，性，吸烟地位，物理活动层次， comorbidities，和药 use.ConclusionsLipid 层次相反地与充血的心失败在病人被相关到 RVEDD；然而，因为这是观察研究，进一步的调查被需要验证我们的结果以及如果有的话识别一种原因的关系。