Objective: To study the correlation of PI3K/Akt signaling pathway with cell apoptosis and invasion in mantle cell lymphoma. Methods: A total of 38 patients who were diagnosed with mantle cell lymphoma in Xijing Hospit...Objective: To study the correlation of PI3K/Akt signaling pathway with cell apoptosis and invasion in mantle cell lymphoma. Methods: A total of 38 patients who were diagnosed with mantle cell lymphoma in Xijing Hospital Affiliated to the Fourth Military Medical University between June 2014 and March 2017 were selected as the MCL group of the research, 55 patients who were diagnosed with reactive lymphoid hyperplasia in Xijing Hospital Affiliated to the Fourth Military Medical University during the same period were selected as the control group of the research, and lymph node tissue was collected to detect the protein expression of p-PI3K and p-AKT as well as the mRNA expression of apoptosis genes and invasion genes. Results: p-PI3K and p-AKT protein expression as well as SOX11, cyclinD1, TNFAIP3, XIAP, PCNA, MMP2, MMP7, MMP9 and VEGF mRNA expression in lymph node of MCL group were significantly higher than those of control group while TNFAIP3 mRNA expression was significantly lower than that of control group;SOX11, cyclinD1, XIAP, PCNA, MMP2, MMP7, MMP9 and VEGF mRNA expression in MCL lymph node with high p-PI3K expression were significantly higher than those in MCL lymph node with low p-PI3K expression while TNFAIP3 mRNA expression was significantly lower than that in MCL lymph node with low p-PI3K expression. Conclusion: The activation of PI3K/Akt signaling pathway in mantle cell lymphoma is closely related to the tumor cell apoptosis disorder and invasion enhancement.展开更多
文摘Objective: To study the correlation of PI3K/Akt signaling pathway with cell apoptosis and invasion in mantle cell lymphoma. Methods: A total of 38 patients who were diagnosed with mantle cell lymphoma in Xijing Hospital Affiliated to the Fourth Military Medical University between June 2014 and March 2017 were selected as the MCL group of the research, 55 patients who were diagnosed with reactive lymphoid hyperplasia in Xijing Hospital Affiliated to the Fourth Military Medical University during the same period were selected as the control group of the research, and lymph node tissue was collected to detect the protein expression of p-PI3K and p-AKT as well as the mRNA expression of apoptosis genes and invasion genes. Results: p-PI3K and p-AKT protein expression as well as SOX11, cyclinD1, TNFAIP3, XIAP, PCNA, MMP2, MMP7, MMP9 and VEGF mRNA expression in lymph node of MCL group were significantly higher than those of control group while TNFAIP3 mRNA expression was significantly lower than that of control group;SOX11, cyclinD1, XIAP, PCNA, MMP2, MMP7, MMP9 and VEGF mRNA expression in MCL lymph node with high p-PI3K expression were significantly higher than those in MCL lymph node with low p-PI3K expression while TNFAIP3 mRNA expression was significantly lower than that in MCL lymph node with low p-PI3K expression. Conclusion: The activation of PI3K/Akt signaling pathway in mantle cell lymphoma is closely related to the tumor cell apoptosis disorder and invasion enhancement.
