BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative treatments.However,the se...BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative treatments.However,the severity of its adverse effects may have been underestimated.The most serious adverse effect is hemolysis,which may result in acute kidney injury or death.Although glucose-6-phosphate dehydrogenase(G6PD)deficiency is considered to be the main cause,the probability and pathological mechanism are not completely understood,leading to a lack of effective and standardized treatment methods.CASE SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg HVCT.In contrast to previous cases,the lowest hemoglobin level in the two cases was<50 g/L,which was lower than previously reported.This may be because Case 1 had chronic hepatitis B for many years,which caused abnormal liver reserve function,and Case 2 had grade II bone marrow suppression.Both patients improved and were discharged after blood replacement therapy.Our cases had the most severe degree of hemolysis but the best prognosis,suggesting that our treatment may be helpful for rescue of drug-induced hemolysis.This is the first review of the literature on hemolysis caused by HVCT,and we found that all patients with G6PD deficiency developed hemolysis after HVCT.CONCLUSION G6PD deficiency should be considered as a contraindication to HVCT,and it is not recommended for patients with bone marrow suppression,moderate-tosevere anemia,hematopoietic abnormalities,or abnormal liver and kidney function.Early blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.展开更多
The obstacles of inferior microstructure and poor magnetic properties of(La,Ce)-Fe-B type magnets stand in the way of expanding their applications.In this work,(La,Ce)-Fe-B melt-spun ribbons were prepared with differe...The obstacles of inferior microstructure and poor magnetic properties of(La,Ce)-Fe-B type magnets stand in the way of expanding their applications.In this work,(La,Ce)-Fe-B melt-spun ribbons were prepared with different La/Ce ratios and rare earth contents.The microstructure and magnetic properties of these ribbons were investigated.With the La/Ce ratio increased,the fraction of the CeFe_(2)phase decreased and the β-La phase segregated among matrix grains,which deteriorated the coercivity of the ribbons.Reducing the rare earth content effectively suppressed the β-La phase and improved the proportion of the matrix phase in the ribbons.Here,the optimal alloy composite(La_(15)Ce_(85))_(14)Fe_(80)B_(6) has been obtained with modified microstructure and inhibited secondary phases.Good ribbon performance was tested,with H_(cj)=4.51 kOe,B_(r)=6.29 kG and(BH)_(max)=6.81 MGOe.展开更多
Abstract A method of Baotou mixed rare earth concen- trate leaching was investigated. According to the principle of complex leaching, the quadratic orthogonal regression experiment was used to investigate effect of si...Abstract A method of Baotou mixed rare earth concen- trate leaching was investigated. According to the principle of complex leaching, the quadratic orthogonal regression experiment was used to investigate effect of six factors. An optimal condition of low energy and environment friendly was determined as follows: HCl acidity is 4 mol.L-1, AlCl3 concentration is 2 mol.L-l, reaction temperature is 85 ℃, reaction time is 90 rain, liquid to solid ratio is 35 ml.g-1, and stirring speed is 100 r.min-1. According to this condition, the leaching ratio of mixed rare earth con- centrate is 76.5 %. The analyses of X-ray diffraction shows that bastnasite disappears, and the main peaks of filter residue is monazite and cheralite after leaching of HCl- AlCl3 solution. The result indicates that REFCO3 of the mixed rare earth concentrate can be dissolved, but REPO4 remains in the leaching residue. This method provides a way to separate and extract rare earth.展开更多
The estimated ultimate recovery(EUR)of shale gas wells is influenced by many factors,and the accurate prediction still faces certain challenges.As an artificial intelligence algorithm,deep learning yields notable adva...The estimated ultimate recovery(EUR)of shale gas wells is influenced by many factors,and the accurate prediction still faces certain challenges.As an artificial intelligence algorithm,deep learning yields notable advantages in nonlinear regression.Therefore,it is feasible to predict the EUR of shale gas wells based on a deep-learning algorithm.In this paper,according to geological evaluation data,hydraulic fracturing data,production data and EUR evaluation results of 282 wells in the WY shale gas field,a deep-learning-based algorithm for EUR evaluation of shale gas wells was designed and realized.First,the existing EUR evaluation methods of shale gas wells and the deep feedforward neural network algorithm was systematically analyzed.Second,the technical process of a deep-learning-based algorithm for EUR prediction of shale gas wells was designed.Finally,by means of real data obtained from the WY shale gas field,several different cases were applied to testify the validity and accuracy of the proposed approach.The results show that the EUR prediction with high accuracy.In addition,the results are affected by the variety and number of input parameters,the network structure and hyperparameters.The proposed approach can be extended to other shale fields using the similar technic process.展开更多
Spinal cord injury usually leads to permanent disability, which could cause a huge financial problem to the patient. Up to now there is no effective method to treat this disease. The key of the treatment is to enable ...Spinal cord injury usually leads to permanent disability, which could cause a huge financial problem to the patient. Up to now there is no effective method to treat this disease. The key of the treatment is to enable the damage zone axonal regeneration and luckily it could go through the damage zone; last a connection can be established with the target neurons. This study attempts to combine stem cell, material science and genetic modification technology together, by preparing two genes modified adipose-derived stem cells and inducing them into neuron direction; then by compositing them on the silk fibroin/chitosan scaffold and implanting them into the spinal cord injury model, seed cells can have features of neuron cells. At the same time, it could stably express the brain-derived neurotrophic factor and neurotrophin-3, both of which could produce synergistic effects, which have a positive effect on the recovery of spinal cord. The spinal cord scaffold bridges the broken end of the spinal cord and isolates with the surrounding environment, which could avoid a scar effect on the nerve regeneration and provide three-dimensional space for the seed cell growth, and at last we hope to provide a new treatment for spinal cord injury with the tissue engineering technique.展开更多
AIM To perform a meta-analysis to investigate the association between cyclooxygenase-2(COX-2)-1195G>A gene polymorphism and gastrointestinal cancers. METHODS Publications related to the COX-2-1195G>A gene polymo...AIM To perform a meta-analysis to investigate the association between cyclooxygenase-2(COX-2)-1195G>A gene polymorphism and gastrointestinal cancers. METHODS Publications related to the COX-2-1195G>A gene polymorphism and gastrointestinal cancers published before July 2016 were retrieved from Pub Med, EMBASE, Web of Science, China Biological Medicine Database, China National Knowledge Infrastructure, and CQVIP Database. Meta-analysis was performed using Stata11.0 software. The strength of the association was evaluated by calculating the combined odds ratios(ORs) and the corresponding 95%CIs. The retrieved publications were excluded or included one by one for sensitivity analysis. In addition, the funnel plot, Begg's rank correlation test, and Egger's linear regression method were applied to analyse whether the included publications had publication bias. RESULTS A total of 24 publications related to the COX-2-1195G>A gene polymorphism were included, including 28 studies involving 11043 cases and 18008 controls. The meta-analysis results showed that the COX-2-1195G>A gene polymorphism significantly correlated with an increased risk of gastrointestinal cancers, particularly gastric cancer(A vs G: OR = 1.35; AA/AG vs GG: OR = 1.54; AA vs GG/AG: OR = 1.43; AA vs GG: OR = 1.80; AG vs GG: OR = 1.35). Compared to the Caucasian population in America and Europe, the COX-2-1195G>A gene polymorphism in the Asian population(A vs G: OR = 1.30; AA/AG vs GG: OR= 1.50; AA vs GG/AG: OR = 1.35; AA vs GG: OR = 1.71; AG vs GG: OR = 1.37) significantly increased gastrointestinal cancer risk. The sensitivity analysis(P < 0.05) and the false positive report probability(P < 0.2) confirmed the reliability of the results. CONCLUSION The results showed that the COX-2-1195G>A gene polymorphism might be a potential risk factor for gastrointestinal cancers. Further validation by a large homogeneous study is warranted.展开更多
Low frequency flicker,high frequency flicker,strong light,strong blue light,infrared,ultraviolet,electromagnetic radiation,ripple flicker and dimming flicker produced by different lamps have negative impact on vision,...Low frequency flicker,high frequency flicker,strong light,strong blue light,infrared,ultraviolet,electromagnetic radiation,ripple flicker and dimming flicker produced by different lamps have negative impact on vision,eyes and health. Negative impact on eyes resulting in myopia or cataract etc: the solution is to remove all the negative factors by applying upright lighting technology and that is optimum to vision,eyes and health.展开更多
Recent years,huge progress of first-principles methods has been witnessed in calculating the quasiparticle band gaps,with many-body perturbation theory in the GW approximation being the standard choice,where G refers ...Recent years,huge progress of first-principles methods has been witnessed in calculating the quasiparticle band gaps,with many-body perturbation theory in the GW approximation being the standard choice,where G refers to Green’s function and W denotes the dynamically screened Coulomb interaction.Numerically,the completeness of the basis set has been extensively discussed,but in practice far from carefully addressed.Beyond the static description of the nuclei,the electron–phonon interactions(EPIs)are ubiquitous,which cause zero-point renormalization(ZPR)of the band gaps.Therefore,to obtain high quality band gaps,one needs both accurate quasiparticle energies and accurate treatments of EPIs.In this article,we review methods on this.The completeness of the basis set is analyzed in the framework of linearized augmented plane waves,by adding high-energy local orbitals(HLOs).The electron–phonon matrix elements and self-energy are discussed,followed by the temperature dependence of the band gaps in both perturbative and non-perturbative methods.Applications of such an analysis on bulk wurtzite BeO and monolayer honeycomb BeO are given.Adding HLOs widens their GW_(0) band gaps by∼0.4 eV while ZPR narrows them by similar amount.These influences cancel each other,which explains the fortuitous agreement between experiment and theory when the basis set is incomplete and the EPIs are absent.The phonon-induced renormalization,a term often neglected in calculations of the band gaps,is also emphasized by its large magnitude.展开更多
Anthocyanins are secondary metabolites induced by environmental stimuli and developmental signals.The positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been neg...Anthocyanins are secondary metabolites induced by environmental stimuli and developmental signals.The positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been neglected.Although the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be investigated.In this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA signals.MdbHLH162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin biosynthesis.MdbHLH162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and MdbHLH33.The GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 complex.The JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 complex.Our findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin biosynthesis.This study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.展开更多
Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-t...Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.Based on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each category.According to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on PG-SGA.Based on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,respectively.The sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and 0.975.The Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,respectively.The area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,respectively.The IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with cancer.The missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,respectively.AIWW showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool for this population.展开更多
In order to solve the problem of large temperature difference between the center and ends of the metallic rod in the purification process of solid-state electrotransport(SSE),three types of electrode connections of ta...In order to solve the problem of large temperature difference between the center and ends of the metallic rod in the purification process of solid-state electrotransport(SSE),three types of electrode connections of tantalum and the corresponding rods of metallic lanthanum were designed,the temperature distributions of three kinds of rod were measured,and the influence of temperature difference on the purification effect of solid-state electrotransport was investigated.The results indicate that the maximum temperature difference of the rod will be significantly reduced through decreasing the cross section of electrode connection to make its unit length resistance close to that of rod,or increasing the unit length resistance of the section at both ends of the rod.When these two measures are adopted at the same time,the effect of decreasing rod temperature difference is the best in the present study,and the maximum temperature difference of the rod can be reduced to 29℃when the maximum temperature of the rod is 820℃.The migration velocity of the impurities at rod ends can be obviously improved after the rod temperature difference is reduced,which enables the purification effect and efficiency of solid-state electrotransport to be greatly raised;it is also found that the major impurities iron in metallic lanthanum migrates more easily than oxygen and carbon during the purification of metal lanthanum with solid-state electrotransport.展开更多
This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal latt...This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal lattice deformation on a double-crystal monochromator at different incident powers.The nanoscale thermal lattice deformation of the monochromator first crystal was obtained by analyzing the intensity of the distorted DuMond diagrams.DuMond diagrams of the 333 diffraction index,sensitive to lattice deformation,were obtained directly using a 2D detector and an analyzer crystal orthogonal to the monochromator.With increasing incident power and power density,the maximum height of the lattice deformation increased from 3.2 to 18.5 nm,and the deformation coefficient of the maximum height increased from 1.1 to 3.2 nm/W.The maximum relative standard deviation was 4.2%,and the maximum standard deviation was 0.1 nm.Based on the measured thermal deformations,the flux saturation phenomenon and critical point for the linear operation of the monochromator were predicted with increasing incident power.This study provides a simple solution to the problem of the lower precision of synchrotron radiation monochromator characterizations compared to simulations.展开更多
Background: At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial micr...Background: At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA (miRNA) signatures for impaired endometrial receptivity by microarray analysis. Methods: A total of 12 repeated implantation failure (RIF) patients and I0 infertile patients, who conceived and delivered after one embryo transfer attempt, were recruited as RIF and control groups, respectively. Endometrial specimens from the window of implantation (WOI) were collected from these two groups. MiRNA microarray was conducted on seven and five samples from the RIF and control groups, respectively. Comparative, functional, and network analyses were performed for the microarray results. Quantitative real-time polymerase chain reaction (PCR) was performed on other samples to validate the expression of specific miRNAs. Results: Compared with those in the control group, the expression levels of 105 miRNAs in the RIF group were found to be significantly up- or down-regulated (at least 2-fold) by microarray analysis. The most relevant miRNA functional sets of these dysregulated miRNAs were miR-30 family, human embryonic stern cell regulation, epithelial-mesenchymal transition, and miRNA tumor suppressors by tool for annotations ofmicroRNA analysis. Network regulatory analysis found 176 miRNA-mRNA interactions, and the top 3 core miRNAs were has-miR-4668-5p, has-miR-429, and has-miR-5088. Expression levels of the 18 selected miRNAs in new samples by real-time PCR were found to be regulated with the same trend, as the result ofmicroarray analysis. Conclusions: There is a significant different expression of certain miRNAs in the WOI endometrium for RIF patients. These miRNAs may contribute to impaired endometrial receptivity.展开更多
Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological paralneters best...Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological paralneters best predict the outcomes of single blastocyst transfer. In addition. most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozcn euploid blastocysts. Methods: The study retrospectively analyzed 914 single euploid blastocyst transfer cycles that were performed at the Peking U laivcrsity Third Hospital Reproductive Medical Center between June 2011 and May 2016. The expansion, trophectoderm (TE). and inner cell mass (ICM) quality of the blastocysts were assessed based on blastocyst parameters, and used to differentiate between "excellent", "good", "average", and "poor"-quality embryos. The relationship between these embryo grades and the achieved pregnancy outcomes was then analyzed via the Chi-square and logistic regression tests. Results: For embryo grades of excellent, good, average and poor, the clinical pregnancy rates were 65.0%. 50.3%, 50.3% and 33.3%. respectively; and the live-birth rates were 50.0%, 49.7%, 42.3% and 25.0%, respectively. Both the clinical pregnancy ratc (x2= 21.28. P = 0.001) and live-birth rate (x2 = 13.50, P 〈 0.001) increased with the overall blastocyst grade. Both rates were significanlly higher after the transfer era blastocyst that exhibited either an A-grade or B-grade TE, and similarly, an A-grade ICM. than after the transfer el a blastocyst that exhibited a C-grade TE and/or ICM. The degree of blastocysl expansion had no apparent effect on the clinical pregnancy or live-birth rate. All odds ratio were adjusted for patient age, body mass index, length (years) of infertility history, and infertility type. Conclusions: A higher overall euploid blastocyst quality is shown to correlate most strongly with optimal pregnancy outcomes. The study thus supports the use of the described TE and ICM morphological grades to augment current embryo selection criteria.展开更多
Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus ca...Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.展开更多
Background: Postmenopausal women with metabolic syndrome (MetS) have increased cardiovascular morbidity and left ventricular diastolic dysfunction (LVDD). The various protective effects ofastragalus membranaceus ...Background: Postmenopausal women with metabolic syndrome (MetS) have increased cardiovascular morbidity and left ventricular diastolic dysfunction (LVDD). The various protective effects ofastragalus membranaceus (AM) have been described in previous studies. Therefore, this study aimed to evaluate the effects of different doses of AM on diastolic function in postmenopausal hypertensive women with MetS. Methods: This was a prospective, randomized controlled study. The postmenopausal hypertensive patients with MetS were enrolled from Lanzhou University Second Hospital from March 2014 to April 2015. Patients were divided into three groups: control group (received conventional medical treatment), AM Group 1 (received AM capsules at 5 g/d additionally), and AM Group 2 (received AM capsules at 10 g/d additionally). Echocardiographic and clinical characteristics were evaluated before and 12 months after treatment. Quantitative data were analyzed using unpaired t-test, analysis of variance, and multiple linear regression analysis. Results: A total of 154 patients were subjected to final analysis. In the AM Group 2, significant improvements were noted in diastolic function 12 months after treatment than those of the control group, including the early diastolic mitral annular velocity (E'; 0.065±0.007 m/s vs. 0.061 ± 0.008 m/s, P = 0.014), the ratio of the early diastolic mitral peak flow velocity to the late diastolic mitral peak flow velocity (E/A; 0.81± 0.05 vs. 0.80± 0.06, P = 0.012), the ratio of E' to the late diastolic mitral annular velocity (EVA'; 0.56 ± 0.12 vs. 0.51 ± 0.13, P 0.048), and the ratio of the early diastolic mitral peak flow velocity (E) to E' (E/E'; 10.70 ± 1.30 vs. 11.37 ± 1.73, P = 0.031). After treatment, E/E' ( 10.70 ± 1.30 vs. 11.24± 1.56, P = 0.021 ), deceleration time (DT; 261.49 ± 44.41 ms vs. 268.74 ±53.87 ms P = 0.046), and EVA' (0.56 ± 0.12 vs. 0.52 ±0.13, P = 0.019) values improved more significantly than those of AM Group 2 before treatment. Besides, waist circumference was positively correlated with E' (r = 0.472, P = 0.003) and E'/N (r = 0.321 ; P- 0.047). In addition, the waist-to-hip ratio was a significant predictor ofDT (r = 0.276; P = 0.041), E' (r= 0.590; P 〈 0.001 ), E/E' (r = 0.454; P=0.004), and EVA' (r= 0.377; P = 0.018). Conclusions: Conventional medical plus AM therapy improved diastolic function. Moreover, WC and WH R might be risk ihctors tbr LVDD.展开更多
基金Supported by The National Natural Science Foundation of China,No.82074061The National Key Research and Development Program of China,No.2022YFC2009600.
文摘BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative treatments.However,the severity of its adverse effects may have been underestimated.The most serious adverse effect is hemolysis,which may result in acute kidney injury or death.Although glucose-6-phosphate dehydrogenase(G6PD)deficiency is considered to be the main cause,the probability and pathological mechanism are not completely understood,leading to a lack of effective and standardized treatment methods.CASE SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg HVCT.In contrast to previous cases,the lowest hemoglobin level in the two cases was<50 g/L,which was lower than previously reported.This may be because Case 1 had chronic hepatitis B for many years,which caused abnormal liver reserve function,and Case 2 had grade II bone marrow suppression.Both patients improved and were discharged after blood replacement therapy.Our cases had the most severe degree of hemolysis but the best prognosis,suggesting that our treatment may be helpful for rescue of drug-induced hemolysis.This is the first review of the literature on hemolysis caused by HVCT,and we found that all patients with G6PD deficiency developed hemolysis after HVCT.CONCLUSION G6PD deficiency should be considered as a contraindication to HVCT,and it is not recommended for patients with bone marrow suppression,moderate-tosevere anemia,hematopoietic abnormalities,or abnormal liver and kidney function.Early blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.
基金Project supported by the fifth batch of major scientific and technological research projects in the Panxi Experimental Zone of Sichuan Province,the new functional materials and applications of rare earth vanadium titanium(Grant No.2020SCUNG201).
文摘The obstacles of inferior microstructure and poor magnetic properties of(La,Ce)-Fe-B type magnets stand in the way of expanding their applications.In this work,(La,Ce)-Fe-B melt-spun ribbons were prepared with different La/Ce ratios and rare earth contents.The microstructure and magnetic properties of these ribbons were investigated.With the La/Ce ratio increased,the fraction of the CeFe_(2)phase decreased and the β-La phase segregated among matrix grains,which deteriorated the coercivity of the ribbons.Reducing the rare earth content effectively suppressed the β-La phase and improved the proportion of the matrix phase in the ribbons.Here,the optimal alloy composite(La_(15)Ce_(85))_(14)Fe_(80)B_(6) has been obtained with modified microstructure and inhibited secondary phases.Good ribbon performance was tested,with H_(cj)=4.51 kOe,B_(r)=6.29 kG and(BH)_(max)=6.81 MGOe.
基金Project(51504036) supported by the National Natural Science Foundation of ChinaProject(2012CBA01207) supported by the National Basic Research Program of ChinaProject(2011AA03A409) supported by the National High-Tech Research and Development Program of China
基金financially supported by the National Nature Science Foundation of China (No. 51174115)National Outstanding Youth Science Foundation of China (No. 51025416)Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1065)
文摘Abstract A method of Baotou mixed rare earth concen- trate leaching was investigated. According to the principle of complex leaching, the quadratic orthogonal regression experiment was used to investigate effect of six factors. An optimal condition of low energy and environment friendly was determined as follows: HCl acidity is 4 mol.L-1, AlCl3 concentration is 2 mol.L-l, reaction temperature is 85 ℃, reaction time is 90 rain, liquid to solid ratio is 35 ml.g-1, and stirring speed is 100 r.min-1. According to this condition, the leaching ratio of mixed rare earth con- centrate is 76.5 %. The analyses of X-ray diffraction shows that bastnasite disappears, and the main peaks of filter residue is monazite and cheralite after leaching of HCl- AlCl3 solution. The result indicates that REFCO3 of the mixed rare earth concentrate can be dissolved, but REPO4 remains in the leaching residue. This method provides a way to separate and extract rare earth.
基金supported by the funding of National Science and Technology Major Projects of China(2016ZX05037-006-005,2016ZX05037-006,2016ZX05035-004)。
文摘The estimated ultimate recovery(EUR)of shale gas wells is influenced by many factors,and the accurate prediction still faces certain challenges.As an artificial intelligence algorithm,deep learning yields notable advantages in nonlinear regression.Therefore,it is feasible to predict the EUR of shale gas wells based on a deep-learning algorithm.In this paper,according to geological evaluation data,hydraulic fracturing data,production data and EUR evaluation results of 282 wells in the WY shale gas field,a deep-learning-based algorithm for EUR evaluation of shale gas wells was designed and realized.First,the existing EUR evaluation methods of shale gas wells and the deep feedforward neural network algorithm was systematically analyzed.Second,the technical process of a deep-learning-based algorithm for EUR prediction of shale gas wells was designed.Finally,by means of real data obtained from the WY shale gas field,several different cases were applied to testify the validity and accuracy of the proposed approach.The results show that the EUR prediction with high accuracy.In addition,the results are affected by the variety and number of input parameters,the network structure and hyperparameters.The proposed approach can be extended to other shale fields using the similar technic process.
文摘Spinal cord injury usually leads to permanent disability, which could cause a huge financial problem to the patient. Up to now there is no effective method to treat this disease. The key of the treatment is to enable the damage zone axonal regeneration and luckily it could go through the damage zone; last a connection can be established with the target neurons. This study attempts to combine stem cell, material science and genetic modification technology together, by preparing two genes modified adipose-derived stem cells and inducing them into neuron direction; then by compositing them on the silk fibroin/chitosan scaffold and implanting them into the spinal cord injury model, seed cells can have features of neuron cells. At the same time, it could stably express the brain-derived neurotrophic factor and neurotrophin-3, both of which could produce synergistic effects, which have a positive effect on the recovery of spinal cord. The spinal cord scaffold bridges the broken end of the spinal cord and isolates with the surrounding environment, which could avoid a scar effect on the nerve regeneration and provide three-dimensional space for the seed cell growth, and at last we hope to provide a new treatment for spinal cord injury with the tissue engineering technique.
文摘AIM To perform a meta-analysis to investigate the association between cyclooxygenase-2(COX-2)-1195G>A gene polymorphism and gastrointestinal cancers. METHODS Publications related to the COX-2-1195G>A gene polymorphism and gastrointestinal cancers published before July 2016 were retrieved from Pub Med, EMBASE, Web of Science, China Biological Medicine Database, China National Knowledge Infrastructure, and CQVIP Database. Meta-analysis was performed using Stata11.0 software. The strength of the association was evaluated by calculating the combined odds ratios(ORs) and the corresponding 95%CIs. The retrieved publications were excluded or included one by one for sensitivity analysis. In addition, the funnel plot, Begg's rank correlation test, and Egger's linear regression method were applied to analyse whether the included publications had publication bias. RESULTS A total of 24 publications related to the COX-2-1195G>A gene polymorphism were included, including 28 studies involving 11043 cases and 18008 controls. The meta-analysis results showed that the COX-2-1195G>A gene polymorphism significantly correlated with an increased risk of gastrointestinal cancers, particularly gastric cancer(A vs G: OR = 1.35; AA/AG vs GG: OR = 1.54; AA vs GG/AG: OR = 1.43; AA vs GG: OR = 1.80; AG vs GG: OR = 1.35). Compared to the Caucasian population in America and Europe, the COX-2-1195G>A gene polymorphism in the Asian population(A vs G: OR = 1.30; AA/AG vs GG: OR= 1.50; AA vs GG/AG: OR = 1.35; AA vs GG: OR = 1.71; AG vs GG: OR = 1.37) significantly increased gastrointestinal cancer risk. The sensitivity analysis(P < 0.05) and the false positive report probability(P < 0.2) confirmed the reliability of the results. CONCLUSION The results showed that the COX-2-1195G>A gene polymorphism might be a potential risk factor for gastrointestinal cancers. Further validation by a large homogeneous study is warranted.
文摘Low frequency flicker,high frequency flicker,strong light,strong blue light,infrared,ultraviolet,electromagnetic radiation,ripple flicker and dimming flicker produced by different lamps have negative impact on vision,eyes and health. Negative impact on eyes resulting in myopia or cataract etc: the solution is to remove all the negative factors by applying upright lighting technology and that is optimum to vision,eyes and health.
基金Project supported by the National Key Research and Development Program of China (Grand Nos. 2016YFA0300900 and 2017YFA0205003)the National Natual Science Foundation of China (Grant Nos. 11934003, 11774003, and 11634001)+3 种基金the Beijing Natural Science FoundationChina (Grant No. Z200004)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB33010400)supported by the High-performance Computing Platform of Peking University,China
文摘Recent years,huge progress of first-principles methods has been witnessed in calculating the quasiparticle band gaps,with many-body perturbation theory in the GW approximation being the standard choice,where G refers to Green’s function and W denotes the dynamically screened Coulomb interaction.Numerically,the completeness of the basis set has been extensively discussed,but in practice far from carefully addressed.Beyond the static description of the nuclei,the electron–phonon interactions(EPIs)are ubiquitous,which cause zero-point renormalization(ZPR)of the band gaps.Therefore,to obtain high quality band gaps,one needs both accurate quasiparticle energies and accurate treatments of EPIs.In this article,we review methods on this.The completeness of the basis set is analyzed in the framework of linearized augmented plane waves,by adding high-energy local orbitals(HLOs).The electron–phonon matrix elements and self-energy are discussed,followed by the temperature dependence of the band gaps in both perturbative and non-perturbative methods.Applications of such an analysis on bulk wurtzite BeO and monolayer honeycomb BeO are given.Adding HLOs widens their GW_(0) band gaps by∼0.4 eV while ZPR narrows them by similar amount.These influences cancel each other,which explains the fortuitous agreement between experiment and theory when the basis set is incomplete and the EPIs are absent.The phonon-induced renormalization,a term often neglected in calculations of the band gaps,is also emphasized by its large magnitude.
基金financially supported by grants from the Natural Science Foundation of Shandong Province(ZR2022YQ24)the Development Plan of the Youth Innovation Team of the Higher Education Institutions in Shandong Province(2022KJ326)Wuhan Botanical Garden Scientific Research Support Project(E3559901)。
文摘Anthocyanins are secondary metabolites induced by environmental stimuli and developmental signals.The positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been neglected.Although the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be investigated.In this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA signals.MdbHLH162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin biosynthesis.MdbHLH162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and MdbHLH33.The GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 complex.The JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 complex.Our findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin biosynthesis.This study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.
基金This work was supported by NSFC-Yunnan United fund(U2102221)the National Science Fund for Distinguished Young Scholars(31325005)+1 种基金the National Natural Science Foundation of China(31270433,31370408,32070453)Wenner-Gren Foundations.
基金supported by the Key Research and Development Program of Beijing Municipal Science and Technology Commission(D181100000218004)General Surgery Clinical Medical Center of Yunnan Province(ZX2019-03-03)the National Key Research and Development Program of China(2022YFC2009600)。
文摘Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.Based on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each category.According to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on PG-SGA.Based on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,respectively.The sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and 0.975.The Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,respectively.The area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,respectively.The IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with cancer.The missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,respectively.AIWW showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool for this population.
基金financially supported by the National Basic Research Program of China(No.2012CBA01207)the National High Technology Research and Development Program of China(No.2011AA03A409)。
文摘In order to solve the problem of large temperature difference between the center and ends of the metallic rod in the purification process of solid-state electrotransport(SSE),three types of electrode connections of tantalum and the corresponding rods of metallic lanthanum were designed,the temperature distributions of three kinds of rod were measured,and the influence of temperature difference on the purification effect of solid-state electrotransport was investigated.The results indicate that the maximum temperature difference of the rod will be significantly reduced through decreasing the cross section of electrode connection to make its unit length resistance close to that of rod,or increasing the unit length resistance of the section at both ends of the rod.When these two measures are adopted at the same time,the effect of decreasing rod temperature difference is the best in the present study,and the maximum temperature difference of the rod can be reduced to 29℃when the maximum temperature of the rod is 820℃.The migration velocity of the impurities at rod ends can be obviously improved after the rod temperature difference is reduced,which enables the purification effect and efficiency of solid-state electrotransport to be greatly raised;it is also found that the major impurities iron in metallic lanthanum migrates more easily than oxygen and carbon during the purification of metal lanthanum with solid-state electrotransport.
基金National Natural Science Foundation of China(No.12205360)Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(No.JCYJ-SHFY-2021-010).
文摘This study presents a new method for characterizing the thermal lattice deformation of a monochromator with high precision under service conditions and first reports the operando measurements of nanoscale thermal lattice deformation on a double-crystal monochromator at different incident powers.The nanoscale thermal lattice deformation of the monochromator first crystal was obtained by analyzing the intensity of the distorted DuMond diagrams.DuMond diagrams of the 333 diffraction index,sensitive to lattice deformation,were obtained directly using a 2D detector and an analyzer crystal orthogonal to the monochromator.With increasing incident power and power density,the maximum height of the lattice deformation increased from 3.2 to 18.5 nm,and the deformation coefficient of the maximum height increased from 1.1 to 3.2 nm/W.The maximum relative standard deviation was 4.2%,and the maximum standard deviation was 0.1 nm.Based on the measured thermal deformations,the flux saturation phenomenon and critical point for the linear operation of the monochromator were predicted with increasing incident power.This study provides a simple solution to the problem of the lower precision of synchrotron radiation monochromator characterizations compared to simulations.
文摘Background: At present, a diagnostic tool with high specificity for impaired endometrial receptivity, which may lead to implantation failure, remains to be developed. We aimed to assess the different endometrial microRNA (miRNA) signatures for impaired endometrial receptivity by microarray analysis. Methods: A total of 12 repeated implantation failure (RIF) patients and I0 infertile patients, who conceived and delivered after one embryo transfer attempt, were recruited as RIF and control groups, respectively. Endometrial specimens from the window of implantation (WOI) were collected from these two groups. MiRNA microarray was conducted on seven and five samples from the RIF and control groups, respectively. Comparative, functional, and network analyses were performed for the microarray results. Quantitative real-time polymerase chain reaction (PCR) was performed on other samples to validate the expression of specific miRNAs. Results: Compared with those in the control group, the expression levels of 105 miRNAs in the RIF group were found to be significantly up- or down-regulated (at least 2-fold) by microarray analysis. The most relevant miRNA functional sets of these dysregulated miRNAs were miR-30 family, human embryonic stern cell regulation, epithelial-mesenchymal transition, and miRNA tumor suppressors by tool for annotations ofmicroRNA analysis. Network regulatory analysis found 176 miRNA-mRNA interactions, and the top 3 core miRNAs were has-miR-4668-5p, has-miR-429, and has-miR-5088. Expression levels of the 18 selected miRNAs in new samples by real-time PCR were found to be regulated with the same trend, as the result ofmicroarray analysis. Conclusions: There is a significant different expression of certain miRNAs in the WOI endometrium for RIF patients. These miRNAs may contribute to impaired endometrial receptivity.
文摘Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological paralneters best predict the outcomes of single blastocyst transfer. In addition. most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozcn euploid blastocysts. Methods: The study retrospectively analyzed 914 single euploid blastocyst transfer cycles that were performed at the Peking U laivcrsity Third Hospital Reproductive Medical Center between June 2011 and May 2016. The expansion, trophectoderm (TE). and inner cell mass (ICM) quality of the blastocysts were assessed based on blastocyst parameters, and used to differentiate between "excellent", "good", "average", and "poor"-quality embryos. The relationship between these embryo grades and the achieved pregnancy outcomes was then analyzed via the Chi-square and logistic regression tests. Results: For embryo grades of excellent, good, average and poor, the clinical pregnancy rates were 65.0%. 50.3%, 50.3% and 33.3%. respectively; and the live-birth rates were 50.0%, 49.7%, 42.3% and 25.0%, respectively. Both the clinical pregnancy ratc (x2= 21.28. P = 0.001) and live-birth rate (x2 = 13.50, P 〈 0.001) increased with the overall blastocyst grade. Both rates were significanlly higher after the transfer era blastocyst that exhibited either an A-grade or B-grade TE, and similarly, an A-grade ICM. than after the transfer el a blastocyst that exhibited a C-grade TE and/or ICM. The degree of blastocysl expansion had no apparent effect on the clinical pregnancy or live-birth rate. All odds ratio were adjusted for patient age, body mass index, length (years) of infertility history, and infertility type. Conclusions: A higher overall euploid blastocyst quality is shown to correlate most strongly with optimal pregnancy outcomes. The study thus supports the use of the described TE and ICM morphological grades to augment current embryo selection criteria.
基金National Key Research and Development Program of China,Grant/Award Number:2017YFC1308900The clinical research and cultivation project of shanghai Shenkang hospital development center,Grant/Award Number:SHDC12017×01Sun Yat-sen University Xie Tong Chuang Xin Program,Grant/Award Number:ZLYXXTCX201504。
文摘Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.
文摘Background: Postmenopausal women with metabolic syndrome (MetS) have increased cardiovascular morbidity and left ventricular diastolic dysfunction (LVDD). The various protective effects ofastragalus membranaceus (AM) have been described in previous studies. Therefore, this study aimed to evaluate the effects of different doses of AM on diastolic function in postmenopausal hypertensive women with MetS. Methods: This was a prospective, randomized controlled study. The postmenopausal hypertensive patients with MetS were enrolled from Lanzhou University Second Hospital from March 2014 to April 2015. Patients were divided into three groups: control group (received conventional medical treatment), AM Group 1 (received AM capsules at 5 g/d additionally), and AM Group 2 (received AM capsules at 10 g/d additionally). Echocardiographic and clinical characteristics were evaluated before and 12 months after treatment. Quantitative data were analyzed using unpaired t-test, analysis of variance, and multiple linear regression analysis. Results: A total of 154 patients were subjected to final analysis. In the AM Group 2, significant improvements were noted in diastolic function 12 months after treatment than those of the control group, including the early diastolic mitral annular velocity (E'; 0.065±0.007 m/s vs. 0.061 ± 0.008 m/s, P = 0.014), the ratio of the early diastolic mitral peak flow velocity to the late diastolic mitral peak flow velocity (E/A; 0.81± 0.05 vs. 0.80± 0.06, P = 0.012), the ratio of E' to the late diastolic mitral annular velocity (EVA'; 0.56 ± 0.12 vs. 0.51 ± 0.13, P 0.048), and the ratio of the early diastolic mitral peak flow velocity (E) to E' (E/E'; 10.70 ± 1.30 vs. 11.37 ± 1.73, P = 0.031). After treatment, E/E' ( 10.70 ± 1.30 vs. 11.24± 1.56, P = 0.021 ), deceleration time (DT; 261.49 ± 44.41 ms vs. 268.74 ±53.87 ms P = 0.046), and EVA' (0.56 ± 0.12 vs. 0.52 ±0.13, P = 0.019) values improved more significantly than those of AM Group 2 before treatment. Besides, waist circumference was positively correlated with E' (r = 0.472, P = 0.003) and E'/N (r = 0.321 ; P- 0.047). In addition, the waist-to-hip ratio was a significant predictor ofDT (r = 0.276; P = 0.041), E' (r= 0.590; P 〈 0.001 ), E/E' (r = 0.454; P=0.004), and EVA' (r= 0.377; P = 0.018). Conclusions: Conventional medical plus AM therapy improved diastolic function. Moreover, WC and WH R might be risk ihctors tbr LVDD.