Dear Editor,Corneal endotheliitis,first reported in 1982 as an autoimmune disorder by Khodadoust and Attarzadeh[1],is now recognized to be frequently induced by viral infections,including varicella zoster virus(VZV),c...Dear Editor,Corneal endotheliitis,first reported in 1982 as an autoimmune disorder by Khodadoust and Attarzadeh[1],is now recognized to be frequently induced by viral infections,including varicella zoster virus(VZV),cytomegalovirus(CMV)and herpes simplex virus(HSV),that can cause inflammatory and immune-related injuries or direct damages to corneal endothelial cells[2-3].In cases with this type of endotheliitis of viral origin,manifestations may include conjunctival ciliary congestion or mixed congestion,corneal subepithelial bulla,localized corneal edema,keratic precipitates(KP)characteristic to the edema area,puckered posterior elastic lamina,mild anterior chamber reaction,intraocular pressure(IOP)elevation in presence of inflammation in trabecular meshwork,and endothelial decompensation[3-4].Accurate diagnosis of viral corneal endotheliitis is challenging due to its complex presentation,leading to a high misdiagnosis rate.To the best of our knowledge,there was no previous report of viral corneal endotheliitis presenting with corneal endothelial defects in the English literature.展开更多
目的:探究蠕形螨感染对睑板腺功能障碍(MGD)患者眼表功能的影响作用。方法:选取2018-04/09南方医科大学附属珠江医院眼科门诊MGD患者94例94眼,入组患者检查以下指标:眼表疾病指数(OSDI)、Schirmer I试验(SⅠt)、泪膜破裂时间(BUT)、角...目的:探究蠕形螨感染对睑板腺功能障碍(MGD)患者眼表功能的影响作用。方法:选取2018-04/09南方医科大学附属珠江医院眼科门诊MGD患者94例94眼,入组患者检查以下指标:眼表疾病指数(OSDI)、Schirmer I试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光染色(FL)、泪河高度、上睑板腺缺失评分、下睑板腺缺失评分、睑板腺缺失总评分、蠕形螨计数,对比蠕形螨检出阳性组和阴性组以上指标有无差异并分析蠕形螨检出阳性组蠕形螨计数与以上指标相关性。结果: MGD患者94眼中54眼蠕形螨阳性,检出阳性率57%,与年龄无明显相关,男性中检出率高于女性。蠕形螨检出阳性组上睑板腺缺失评分及睑板腺缺失总评分高于蠕形螨检出阴性组[2.00(1.00,2.00) vs 1.00(1.00,1.50)分, P =0.02;3.00(2.00,4.00) vs 2.00(1.00,3.00)分, P =0.04],OSDI、S I t、BUT、FL、下睑板腺缺失评分无差异( P >0.05)。蠕形螨检出阳性的MGD患者中蠕形螨计数与上睑板腺缺失分级评分(rs =0.37, P =0.03)、睑板腺缺失总评分(rs =0.44, P =0.01)呈正相关,与其他检查指标无明显相关性。结论:蠕形螨在睑板腺功能障碍患者眼表功能有一定影响作用,与睑板腺缺失呈正相关,蠕形螨感染数量增加,睑板腺缺失加重,进而加重眼部不适症状。展开更多
AIMTo evaluate the incidence of spontaneous regression of changes in the retina and vitreous in active stage of retinopathy of prematurity(ROP) and identify the possible relative factors during the regression.
文摘Dear Editor,Corneal endotheliitis,first reported in 1982 as an autoimmune disorder by Khodadoust and Attarzadeh[1],is now recognized to be frequently induced by viral infections,including varicella zoster virus(VZV),cytomegalovirus(CMV)and herpes simplex virus(HSV),that can cause inflammatory and immune-related injuries or direct damages to corneal endothelial cells[2-3].In cases with this type of endotheliitis of viral origin,manifestations may include conjunctival ciliary congestion or mixed congestion,corneal subepithelial bulla,localized corneal edema,keratic precipitates(KP)characteristic to the edema area,puckered posterior elastic lamina,mild anterior chamber reaction,intraocular pressure(IOP)elevation in presence of inflammation in trabecular meshwork,and endothelial decompensation[3-4].Accurate diagnosis of viral corneal endotheliitis is challenging due to its complex presentation,leading to a high misdiagnosis rate.To the best of our knowledge,there was no previous report of viral corneal endotheliitis presenting with corneal endothelial defects in the English literature.
文摘目的:探究蠕形螨感染对睑板腺功能障碍(MGD)患者眼表功能的影响作用。方法:选取2018-04/09南方医科大学附属珠江医院眼科门诊MGD患者94例94眼,入组患者检查以下指标:眼表疾病指数(OSDI)、Schirmer I试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光染色(FL)、泪河高度、上睑板腺缺失评分、下睑板腺缺失评分、睑板腺缺失总评分、蠕形螨计数,对比蠕形螨检出阳性组和阴性组以上指标有无差异并分析蠕形螨检出阳性组蠕形螨计数与以上指标相关性。结果: MGD患者94眼中54眼蠕形螨阳性,检出阳性率57%,与年龄无明显相关,男性中检出率高于女性。蠕形螨检出阳性组上睑板腺缺失评分及睑板腺缺失总评分高于蠕形螨检出阴性组[2.00(1.00,2.00) vs 1.00(1.00,1.50)分, P =0.02;3.00(2.00,4.00) vs 2.00(1.00,3.00)分, P =0.04],OSDI、S I t、BUT、FL、下睑板腺缺失评分无差异( P >0.05)。蠕形螨检出阳性的MGD患者中蠕形螨计数与上睑板腺缺失分级评分(rs =0.37, P =0.03)、睑板腺缺失总评分(rs =0.44, P =0.01)呈正相关,与其他检查指标无明显相关性。结论:蠕形螨在睑板腺功能障碍患者眼表功能有一定影响作用,与睑板腺缺失呈正相关,蠕形螨感染数量增加,睑板腺缺失加重,进而加重眼部不适症状。
基金Guangdong Provincial Science and Technology Projects,China (No.2011B031800105)
文摘AIMTo evaluate the incidence of spontaneous regression of changes in the retina and vitreous in active stage of retinopathy of prematurity(ROP) and identify the possible relative factors during the regression.
