Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xe...Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.展开更多
Pestaloamides A and B(1 and 2),two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone]scaffold,were obtained from the cultures of an endophytic fungus Pestalotiopsis sp.HS30...Pestaloamides A and B(1 and 2),two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone]scaffold,were obtained from the cultures of an endophytic fungus Pestalotiopsis sp.HS30 which inhabited the stems of Isodon xerophilus.Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography.In addition,both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2 D ligands involving MICA/B and ULBP1 in HCT116 cells.展开更多
基金supported financially by the National Natural Science Foundation of China(No.81874298)the CAS“Light of West China”program(Pema-Tenzin Puno)the Yunnan Science Fund for Distinguished Young Scholars(2019FJ002).
文摘Arthrinins E-G(1-3),three new sesquiterpenoids possessing non-isoprenoid botryane skeleton,were isolated from the fermentation of an endophytic fungus named Arthrinium sp.HS66 which colonized in the stems of Isodon xerophilus.Their structures were determined by extensive spectroscopic methods.Furthermore,the structure of 1 was unambiguously confirmed by X-ray diffraction,while those of 2 and 3 were verified through quantum chemical calculation of NMR data and ECD spectra.
基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program(2019QZKK0502)the National Natural Science Foundation of China(81874298)+1 种基金the CAS“Light of West China”Program(Pema-Tenzin Puno)the Yunnan Science Fund for Distinguished Young Scholars(2019FJ002)。
文摘Pestaloamides A and B(1 and 2),two novel alkaloids featuring an unprecedented spiro[imidazothiazoledione-alkylidenecyclopentenone]scaffold,were obtained from the cultures of an endophytic fungus Pestalotiopsis sp.HS30 which inhabited the stems of Isodon xerophilus.Their planar structures and absolute configurations were fully determined by extensive spectroscopic analysis and X-ray crystallography.In addition,both compounds 1 and 2 showed the latent tumor immunotherapy activity through markedly promoting the cell surface engagement of NKG2 D ligands involving MICA/B and ULBP1 in HCT116 cells.
