Objective: To observe the lipid-lowering effect of Typha angustifolia extract(TAE) in Sprague Dawley rats.Methods: The rats were randomly divided into six groups, including the hypercholesterolemic diet(HYD)group. Ad ...Objective: To observe the lipid-lowering effect of Typha angustifolia extract(TAE) in Sprague Dawley rats.Methods: The rats were randomly divided into six groups, including the hypercholesterolemic diet(HYD)group. Ad libitum food was given to the animals for 60 d to establish dyslipidemia models. The rats were received an ig administration of 1 mL medicine daily. After 120 d the animals were sacrificed by cervical dislocation; Blood was collected to measure total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein-cholesterol(HDL-C), nitric oxide(NO), and endothelin(ET) plasma concentration; Livers were collected to measure ApoE mRNA and protein expression; Morphologic changes of aorta ventralis tissue were also observed.Results: Compared with HYD group, TAE had the ability of reducing TC, TG, LDL-C, NO, and ET(P < 0.01),thereby increasing ApoE mRNA and protein expression of the liver(P < 0.01).Conclusion: These results suggested that TAE was capable of effectively decreasing the circulating lipids levels and enhancing the protective effects of artery.展开更多
基金supported by Research Fund and Natural Science Foundation of Yichang City in Hubei Province,China(Nos.KFJ2013009A14301-06)
文摘Objective: To observe the lipid-lowering effect of Typha angustifolia extract(TAE) in Sprague Dawley rats.Methods: The rats were randomly divided into six groups, including the hypercholesterolemic diet(HYD)group. Ad libitum food was given to the animals for 60 d to establish dyslipidemia models. The rats were received an ig administration of 1 mL medicine daily. After 120 d the animals were sacrificed by cervical dislocation; Blood was collected to measure total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein-cholesterol(HDL-C), nitric oxide(NO), and endothelin(ET) plasma concentration; Livers were collected to measure ApoE mRNA and protein expression; Morphologic changes of aorta ventralis tissue were also observed.Results: Compared with HYD group, TAE had the ability of reducing TC, TG, LDL-C, NO, and ET(P < 0.01),thereby increasing ApoE mRNA and protein expression of the liver(P < 0.01).Conclusion: These results suggested that TAE was capable of effectively decreasing the circulating lipids levels and enhancing the protective effects of artery.
