Objective:To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients.Methods:A retrospective investigation was conducted in 25 pediatric patients with cutaneou...Objective:To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients.Methods:A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders,including 19 infantile hemangiomas(IHs)(12 superficial/7 mixed type),5 nevus flammeus(NF),and 1 pyogenic granuloma(PG).Imiquimod 5% cream was applied every other day for 4 to 16 weeks(average 9.6 weeks).Results:Of the 19 IHs treated,an overall efficacy of 52.6% was achieved,with a clinical resolution rate of 15.8%,excellent rate of 26.3%,and moderate rate of 10.5%.The superficial type responded the best at 66.7%,while the mixed type showed only 28.6% effectiveness,which was predominantly from their superficial parts.No obvious response was noted in the 5 patients with NF.Side effects were observed in 78.9% of the patients,mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration.Systemic side events were observed in 4 IH patients including fever and digestive tract reactions.No recurrence was observed during the follow-up examination.Conclusions:Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.展开更多
To date,comparing and visualizing genome sequences remain challenging due to the large genome size.Existing approaches take advantage of the stable property of oligonucleotides and exhibit the main characteristics of ...To date,comparing and visualizing genome sequences remain challenging due to the large genome size.Existing approaches take advantage of the stable property of oligonucleotides and exhibit the main characteristics of the whole genome,yet they commonly fail to show progression patterns of the genome adjustably.This paper presents a novel visual encoding technique,which not only supports the binning process (phylogenetic analysis),but also allows the sequential analysis of the genome.The key idea is to regard the combination of each k-nucleotide and its reverse complement as a visual word,and to represent a long genome sequence with a list of local statistical feature vectors derived from the local frequency of the visual words.Experimental results on a variety of examples demonstrate that the presented approach has the ability to quickly and intuitively visualize DNA sequences,and to help the user identify regions of differences among multiple datasets.展开更多
基金Project (No. 2009B076) supported by the Medical Science Research Foundation of Zhejiang Province,China
文摘Objective:To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients.Methods:A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders,including 19 infantile hemangiomas(IHs)(12 superficial/7 mixed type),5 nevus flammeus(NF),and 1 pyogenic granuloma(PG).Imiquimod 5% cream was applied every other day for 4 to 16 weeks(average 9.6 weeks).Results:Of the 19 IHs treated,an overall efficacy of 52.6% was achieved,with a clinical resolution rate of 15.8%,excellent rate of 26.3%,and moderate rate of 10.5%.The superficial type responded the best at 66.7%,while the mixed type showed only 28.6% effectiveness,which was predominantly from their superficial parts.No obvious response was noted in the 5 patients with NF.Side effects were observed in 78.9% of the patients,mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration.Systemic side events were observed in 4 IH patients including fever and digestive tract reactions.No recurrence was observed during the follow-up examination.Conclusions:Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.
基金supported by the National Natural Science Foundation of China (Nos.60873123 and 60903085)the National Basic Research Program (973) of China (No.2010CB732504)+1 种基金the Natural Science Foundation of Zhejiang Province (No.Y1080618)the Open Project Program of the State Key Lab of CAD & CG,Zhejiang University,China (No.A0905)
文摘To date,comparing and visualizing genome sequences remain challenging due to the large genome size.Existing approaches take advantage of the stable property of oligonucleotides and exhibit the main characteristics of the whole genome,yet they commonly fail to show progression patterns of the genome adjustably.This paper presents a novel visual encoding technique,which not only supports the binning process (phylogenetic analysis),but also allows the sequential analysis of the genome.The key idea is to regard the combination of each k-nucleotide and its reverse complement as a visual word,and to represent a long genome sequence with a list of local statistical feature vectors derived from the local frequency of the visual words.Experimental results on a variety of examples demonstrate that the presented approach has the ability to quickly and intuitively visualize DNA sequences,and to help the user identify regions of differences among multiple datasets.
