Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological func-tions after acute ischemic stroke. Because of its inconvenient application and toxic components （Cinnabaris andRealgar）, we u...Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological func-tions after acute ischemic stroke. Because of its inconvenient application and toxic components （Cinnabaris andRealgar）, we used transdermal enhancers to deliverAngong Niuhuang pill by modern technology, which expanded the safe dose range and clinical indications. In this study, Angong Niuhuang stickers administered at different point application doses （1.35, 2.7, and 5.4 g/kg） were administered to theDazhui （DU14）, Qihai（RN6） andMingmen （DU4） of rats with chronic cerebral ischemia, for 4 weeks. The Morris water maze was used to determine the learning and memory ability of rats. Hematoxylin-eosin staining and Nissl staining were used to observe neuronal damage of the cortex and hippocampal CA1 region in rats with chronic cerebral ischemia. The middle- and high-dose point application ofAngong Niuhuangstickers attenuated neuronal damage in the cortex and hippocampal CA1 region, and improved the memory of rats with chronic cerebral ischemia with an efifcacy similar to interventions by electroacupuncture at Dazhui （DU14）,Qihai （RN6） andMingmen （DU4）. Our experimental ifndings indicate that point application withAngong Niuhuang stickers can improve cognitive function after chronic cerebral ischemia in rats and is neuroprotective with an equivalent efifcacy to acupuncture.展开更多
Covalent organic frameworks(COFs) have broad application prospects in adsorption and separation.Yet,as COFs are generally in powder form,their superior performance at the laboratory scale is difficult to transfer into...Covalent organic frameworks(COFs) have broad application prospects in adsorption and separation.Yet,as COFs are generally in powder form,their superior performance at the laboratory scale is difficult to transfer into pilot-or industrial-scale use.Thus,there is a strong and urgent need to structure COFs into monolithic materials.Herein,a facile strategy was developed to prepare COFs@alginate composite beads.Three composite beads comprising different COFs including TpPa-1(2,4,6-triformylphloroglucinol(Tp) and p-phenylenediamine(Pa-1)as monomers),TpDb(Tp and 2,5-diaminobenzonitrile(Db)as monomers) and TpTt(Tp and 1,3,5-triazine-2,4,6-triamine(Tt) as monomers) with controlled COF loading and product size have been facilely achieved via this strategy,validating the applicability of this method.Furthermore,the representative TpDb@alginate composite beads showed good adsorption performance of uranium(VI) in aqueous solution with high adsorption capacity(635 mg·g^(-1)),good interference immunity and recyclability.This work offers a practical approach for incorporation of COFs into polymer matrix,which can serve as potential adsorbents for radioactive wastewater treatment.展开更多
基金supported by the National Natural Science Foundation of China,No.81403458a grant from Cultivation Project Foundation for Youth Technological Talents of Southern Medical University,No.B1012015
文摘Angong Niuhuang pill, a Chinese materia medica preparation, can improve neurological func-tions after acute ischemic stroke. Because of its inconvenient application and toxic components （Cinnabaris andRealgar）, we used transdermal enhancers to deliverAngong Niuhuang pill by modern technology, which expanded the safe dose range and clinical indications. In this study, Angong Niuhuang stickers administered at different point application doses （1.35, 2.7, and 5.4 g/kg） were administered to theDazhui （DU14）, Qihai（RN6） andMingmen （DU4） of rats with chronic cerebral ischemia, for 4 weeks. The Morris water maze was used to determine the learning and memory ability of rats. Hematoxylin-eosin staining and Nissl staining were used to observe neuronal damage of the cortex and hippocampal CA1 region in rats with chronic cerebral ischemia. The middle- and high-dose point application ofAngong Niuhuangstickers attenuated neuronal damage in the cortex and hippocampal CA1 region, and improved the memory of rats with chronic cerebral ischemia with an efifcacy similar to interventions by electroacupuncture at Dazhui （DU14）,Qihai （RN6） andMingmen （DU4）. Our experimental ifndings indicate that point application withAngong Niuhuang stickers can improve cognitive function after chronic cerebral ischemia in rats and is neuroprotective with an equivalent efifcacy to acupuncture.
基金the Natural Science Foundation of Hainan Province(No.2019RC005)the National Natural Science Foundation of China(Nos.22061014 and 21761010)Hainan University Start-Up Fund(No.KYQD(ZR)1806)。
文摘Covalent organic frameworks(COFs) have broad application prospects in adsorption and separation.Yet,as COFs are generally in powder form,their superior performance at the laboratory scale is difficult to transfer into pilot-or industrial-scale use.Thus,there is a strong and urgent need to structure COFs into monolithic materials.Herein,a facile strategy was developed to prepare COFs@alginate composite beads.Three composite beads comprising different COFs including TpPa-1(2,4,6-triformylphloroglucinol(Tp) and p-phenylenediamine(Pa-1)as monomers),TpDb(Tp and 2,5-diaminobenzonitrile(Db)as monomers) and TpTt(Tp and 1,3,5-triazine-2,4,6-triamine(Tt) as monomers) with controlled COF loading and product size have been facilely achieved via this strategy,validating the applicability of this method.Furthermore,the representative TpDb@alginate composite beads showed good adsorption performance of uranium(VI) in aqueous solution with high adsorption capacity(635 mg·g^(-1)),good interference immunity and recyclability.This work offers a practical approach for incorporation of COFs into polymer matrix,which can serve as potential adsorbents for radioactive wastewater treatment.
