Resistance mechanisms of rho-associated kinase（ROCK） inhibitors are associated with the enhanced expression of cyclooxygenase-2（COX-2）. The therapeutic effects of ROCK on nervous system diseases might be enhanced ...Resistance mechanisms of rho-associated kinase（ROCK） inhibitors are associated with the enhanced expression of cyclooxygenase-2（COX-2）. The therapeutic effects of ROCK on nervous system diseases might be enhanced by COX-2 inhibitors. This study investigated the synergistic effect of the combined use of the ROCK inhibitor fasudil and a COX-2 inhibitor celecoxib on spinal cord injury in a rat model established by transecting the right half of the spinal cord at T11. Rat models were orally administrated with celecoxib（20 mg/kg） and/or intramuscularly with fasudil（10 mg/kg） for 2 weeks. Results demonstrated that the combined use of celecoxib and fasudil significantly decreased COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury, improved the pathomorphology of the injured spinal cord, and promoted the recovery of motor function. Moreover, the effects of the drug combination were better than celecoxib or fasudil alone. This study demonstrated that the combined use of fasudil and celecoxib synergistically enhanced the functional recovery of injured spinal cord in rats.展开更多
BACKGROUND The outbreak of the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 has been the most important clinical challenge worldwide since January 2020.COVID-19 inact...BACKGROUND The outbreak of the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 has been the most important clinical challenge worldwide since January 2020.COVID-19 inactivated vaccines play a crucial role in reducing the rates of morbidity and mortality.CASE SUMMARY We presented a 48-year-old woman from Haidian District,Beijing,China who developed ischemic colitis after receiving the second dose of COVID-19 inactivated vaccine.Computed tomography of the abdomen showed edema and bowel wall thickening with hypodensity in the sigmoid colon and descending colon.Colonoscopy revealed hyperemia,edema and erosion of the mucosa with superficial ulceration and a yellow-white coating at the descending colon and sigmoid colon.The symptoms were relieved after 1 wk of receiving pinaverium bromide(50 mg,tid)and aspirin enteric-coated tablets(0.1 g,qd).CONCLUSION The possible occurrence of ischemic colitis should be considered after administration of the COVID-19 inactivated vaccines.展开更多
Uplink non-orthogonM multiple access （NOMA） is a promising technique to meet the requirements of the fifth generation （5G） and beyond systems. Various NOMA schemes have been proposed in both academia and industry....Uplink non-orthogonM multiple access （NOMA） is a promising technique to meet the requirements of the fifth generation （5G） and beyond systems. Various NOMA schemes have been proposed in both academia and industry. However, most existing schemes assume equal average received power, which limits the performance. We propose three enhancements of uplink NOMA to achieve the requirements of massive connectivity and high reliability in 5G, where unequal average received power is exploited as part of the multiple access signature. First, the optimal sequences targeting to generalized Welch-bound equality （GWBE） are obtained for unequal average received power. Then user grouping with multi-level received powers is proposed for better successive interference cancellation （SIC） at the receiver. Finally, sequence grouping based on the cross-correlation properties of sequences is proposed to reduce inter-and intra-group interference. Simulation results show that by incorporating multi-level received powers and sequence grouping into existing NOMA schemes, for an NOMA system with 400% overloading and fixed signature allocation, 3 dB and 10 dB signal-to-noise ratio （SNR） gains at 0.1 block error rate （BLER） target can be achieved compared with existing NOMA schemes and orthogonal multiple access （OMA）, respectively. Besides, 0.01 BLER target can be achieved while an error floor exists in existing NOMA schemes. Under random sequence selection, collision probability is reduced by multi-level powers. In addition, GWBE sequences achieve lower BLER than existing sequences and the gain is large especially for low BLER requirements. This shows that the proposed scheme can support larger connectivity and higher reliability.展开更多
基金supported by the National Natural Science Foundation of ChinaNo.81060109+1 种基金a grant from the Yunnan Provincial Department of Science&Technology in ChinaNo.2008CD150
文摘Resistance mechanisms of rho-associated kinase（ROCK） inhibitors are associated with the enhanced expression of cyclooxygenase-2（COX-2）. The therapeutic effects of ROCK on nervous system diseases might be enhanced by COX-2 inhibitors. This study investigated the synergistic effect of the combined use of the ROCK inhibitor fasudil and a COX-2 inhibitor celecoxib on spinal cord injury in a rat model established by transecting the right half of the spinal cord at T11. Rat models were orally administrated with celecoxib（20 mg/kg） and/or intramuscularly with fasudil（10 mg/kg） for 2 weeks. Results demonstrated that the combined use of celecoxib and fasudil significantly decreased COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury, improved the pathomorphology of the injured spinal cord, and promoted the recovery of motor function. Moreover, the effects of the drug combination were better than celecoxib or fasudil alone. This study demonstrated that the combined use of fasudil and celecoxib synergistically enhanced the functional recovery of injured spinal cord in rats.
文摘BACKGROUND The outbreak of the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 has been the most important clinical challenge worldwide since January 2020.COVID-19 inactivated vaccines play a crucial role in reducing the rates of morbidity and mortality.CASE SUMMARY We presented a 48-year-old woman from Haidian District,Beijing,China who developed ischemic colitis after receiving the second dose of COVID-19 inactivated vaccine.Computed tomography of the abdomen showed edema and bowel wall thickening with hypodensity in the sigmoid colon and descending colon.Colonoscopy revealed hyperemia,edema and erosion of the mucosa with superficial ulceration and a yellow-white coating at the descending colon and sigmoid colon.The symptoms were relieved after 1 wk of receiving pinaverium bromide(50 mg,tid)and aspirin enteric-coated tablets(0.1 g,qd).CONCLUSION The possible occurrence of ischemic colitis should be considered after administration of the COVID-19 inactivated vaccines.
文摘Uplink non-orthogonM multiple access （NOMA） is a promising technique to meet the requirements of the fifth generation （5G） and beyond systems. Various NOMA schemes have been proposed in both academia and industry. However, most existing schemes assume equal average received power, which limits the performance. We propose three enhancements of uplink NOMA to achieve the requirements of massive connectivity and high reliability in 5G, where unequal average received power is exploited as part of the multiple access signature. First, the optimal sequences targeting to generalized Welch-bound equality （GWBE） are obtained for unequal average received power. Then user grouping with multi-level received powers is proposed for better successive interference cancellation （SIC） at the receiver. Finally, sequence grouping based on the cross-correlation properties of sequences is proposed to reduce inter-and intra-group interference. Simulation results show that by incorporating multi-level received powers and sequence grouping into existing NOMA schemes, for an NOMA system with 400% overloading and fixed signature allocation, 3 dB and 10 dB signal-to-noise ratio （SNR） gains at 0.1 block error rate （BLER） target can be achieved compared with existing NOMA schemes and orthogonal multiple access （OMA）, respectively. Besides, 0.01 BLER target can be achieved while an error floor exists in existing NOMA schemes. Under random sequence selection, collision probability is reduced by multi-level powers. In addition, GWBE sequences achieve lower BLER than existing sequences and the gain is large especially for low BLER requirements. This shows that the proposed scheme can support larger connectivity and higher reliability.
