A transition edge sensor(TES)is extremely sensitive to changes in temperature,and combined with a high-Z metal of a certain thickness,it can realize high-energy resolution measurements of particles such as X-rays.X-ra...A transition edge sensor(TES)is extremely sensitive to changes in temperature,and combined with a high-Z metal of a certain thickness,it can realize high-energy resolution measurements of particles such as X-rays.X-rays with energies below 10 keV have a weak penetrating ability,hence,only gold or bismuth of a few micrometers in thickness can guarantee a quantum efficiency higher than 70%.Therefore,the entire structure of the TES X-ray detector in this energy range can be realized using a microfabrication process.However,for X-rays or γ-rays from 10 keV to 200 keV,submillimeter absorber layers are required,which cannot be realized using the microfabrication process.This paper first briefly introduces a set of TES X-ray detectors and their auxiliary systems,and then focuses on the introduction of the TES γ-ray detector with an absorber based on a submillimeter lead-tin alloy sphere.The detector achieved a quantum efficiency above 70% near 100 keV and an energy resolution of approximately 161.5 eV at 59.5 keV.展开更多
Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,l...Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,low nucleus pulposus(NP)-specific differentiation potential,and inability to avoid pyroptosis caused by the acidic IDD microenvironment after transplantation.To address these challenges,embryo-derived long-term expandable nucleus pulposus progenitor cells(NPPCs)and esterase-responsive ibuprofen nano-micelles(PEG-PIB)were prepared for synergistic transplantation.In this study,we propose a biomaterial pre-modification cell strategy;the PEG-PIB were endocytosed to pre-modify the NPPCs with adaptability in harsh IDD microenvironment through inhibiting pyroptosis.The results indicated that the PEG-PIB pre-modified NPPCs exhibited inhibition of pyroptosis in vitro;their further synergistic transplantation yielded effective functional recovery,histological regeneration,and inhibition of pyroptosis during IDD regeneration.Herein,we offer a novel biomaterial pre-modification cell strategy for synergistic transplantation with promising therapeutic effects in IDD regeneration.展开更多
In this paper, the existence of a uniform exponential attractor for a second order non-autonomous lattice dynamical system with quasiperiodic symbols acting on a closed bounded set is considered. Firstly, the existenc...In this paper, the existence of a uniform exponential attractor for a second order non-autonomous lattice dynamical system with quasiperiodic symbols acting on a closed bounded set is considered. Firstly, the existence and uniqueness of solutions for the considered systems which generate a family of continuous processes is shown, and the existence of a uniform bounded absorbing sets for the processes is proved. Secondly, a semigroup defined on a extended space is introduced, and the Lipschitz continuity, a-contraction and squeezing property of this semigroup are proved. Finally, the existence of a uniform exponential attractor for the family of processes associated with the studied lattice dynamical systems is obtained.展开更多
基金supported by the National major scientific research instrument development project(No.11927805)National Natural Science Foundation of China Young Scientists Fund(No.12005134)+2 种基金Shanghai-XFEL Beamline Project(SBP)(No.31011505505885920161A2101001)Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX02)Shanghai Pujiang Program(No.20PJ1410900).
文摘A transition edge sensor(TES)is extremely sensitive to changes in temperature,and combined with a high-Z metal of a certain thickness,it can realize high-energy resolution measurements of particles such as X-rays.X-rays with energies below 10 keV have a weak penetrating ability,hence,only gold or bismuth of a few micrometers in thickness can guarantee a quantum efficiency higher than 70%.Therefore,the entire structure of the TES X-ray detector in this energy range can be realized using a microfabrication process.However,for X-rays or γ-rays from 10 keV to 200 keV,submillimeter absorber layers are required,which cannot be realized using the microfabrication process.This paper first briefly introduces a set of TES X-ray detectors and their auxiliary systems,and then focuses on the introduction of the TES γ-ray detector with an absorber based on a submillimeter lead-tin alloy sphere.The detector achieved a quantum efficiency above 70% near 100 keV and an energy resolution of approximately 161.5 eV at 59.5 keV.
基金Nature Science Foundation of Zhejiang Province(Y20H060063,LY19H060005,LQ18H060003,LZ22H090003)National Natural Science Foundation of China(NO.82072465,NO.81772379,NO.81972096,NO.82172457,NO.82002327)+1 种基金China Postdoctoral Science Foundation(2017M612011)Scientific Research Fund of Zhejiang Provincial Education Department(Y201941476).
文摘Stem cell-based transplantation is a promising therapeutic approach for intervertebral disc degeneration(IDD).Current limitations of stem cells include with their insufficient cell source,poor proliferation capacity,low nucleus pulposus(NP)-specific differentiation potential,and inability to avoid pyroptosis caused by the acidic IDD microenvironment after transplantation.To address these challenges,embryo-derived long-term expandable nucleus pulposus progenitor cells(NPPCs)and esterase-responsive ibuprofen nano-micelles(PEG-PIB)were prepared for synergistic transplantation.In this study,we propose a biomaterial pre-modification cell strategy;the PEG-PIB were endocytosed to pre-modify the NPPCs with adaptability in harsh IDD microenvironment through inhibiting pyroptosis.The results indicated that the PEG-PIB pre-modified NPPCs exhibited inhibition of pyroptosis in vitro;their further synergistic transplantation yielded effective functional recovery,histological regeneration,and inhibition of pyroptosis during IDD regeneration.Herein,we offer a novel biomaterial pre-modification cell strategy for synergistic transplantation with promising therapeutic effects in IDD regeneration.
基金supported by Hunan Provincial Natural Science Foundation of China(No.2015JJ2144)National Natural Science Foundation of China(No.11671343 and No.11171280)+1 种基金the General Project of The Education Department of Hunan Province(No.12C0408)Zhejiang Natural Science Foundation(No.LY14A010012)
文摘In this paper, the existence of a uniform exponential attractor for a second order non-autonomous lattice dynamical system with quasiperiodic symbols acting on a closed bounded set is considered. Firstly, the existence and uniqueness of solutions for the considered systems which generate a family of continuous processes is shown, and the existence of a uniform bounded absorbing sets for the processes is proved. Secondly, a semigroup defined on a extended space is introduced, and the Lipschitz continuity, a-contraction and squeezing property of this semigroup are proved. Finally, the existence of a uniform exponential attractor for the family of processes associated with the studied lattice dynamical systems is obtained.