BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal...BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal involvement is rare,with only 11 reported cases in the literature.We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal and present a literature review.CASE SUMMARY A 27-year-old man presented with acute-onset neck pain,numbness,and weakness in his extremities.Magnetic resonance imaging showed an epidural mass in the cervicothoracic(C6-T1)spinal canal and vertebral hemangioma(VH)involving the C7 vertebral body.C6-T1 Laminectomy and radical excision of the mass were performed.Histopathological examinations revealed papillary proliferation of vascular endothelial cells with thrombus formation,and an IPEH diagnosis was made.By his 6-mo follow-up appointment,his symptoms were relieved without recurrence.The possible pathogenesis,clinical and imaging features,differential diagnosis,and management of IPEH were reviewed.CONCLUSION We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal,treated via complete resection,and showing a favorable outcome.We found a causal relationship between spinal IPEH and VH;this partly explains the mechanism of IPEH.展开更多
Inspired by the concept of content-addressable retrieval from cognitive science,we propose a novel fragment-based Chinese named entity recognition(NER)model augmented with a lexicon-based memory in which both characte...Inspired by the concept of content-addressable retrieval from cognitive science,we propose a novel fragment-based Chinese named entity recognition(NER)model augmented with a lexicon-based memory in which both character-level and word-level features are combined to generate better feature representations for possible entity names.Observing that the boundary information of entity names is particularly useful to locate and classify them into pre-defined categories,position-dependent features,such as prefix and suffix,are introduced and taken into account for NER tasks in the form of distributed representations.The lexicon-based memory is built to help generate such position-dependent features and deal with the problem of out-of-vocabulary words.Experimental results show that the proposed model,called LEMON,achieved state-of-the-art performance with an increase in the Fl-score up to 3.2%over the state-of-the-art models on four different widely-used NER datasets.展开更多
The thioredoxin system plays a role in a variety of physiological functions, including cell growth, differenti- ation, apoptosis, tumorigenesis, and immunity. We previously confirmed that butaselen (BS), a novel thi...The thioredoxin system plays a role in a variety of physiological functions, including cell growth, differenti- ation, apoptosis, tumorigenesis, and immunity. We previously confirmed that butaselen (BS), a novel thioredoxin reductase inhibitor, can inhibit the growth of various human cancer cell lines, yet the underlying mechanism remains elusive. In this study, we investigated the anti-tumor effect of BS in vivo through regulating the immune system of KM mice. We found that BS inhibits tumor proliferation by promoting the activation of splenic lymphocytes in mice. BS can elevate the percentage of CD^4-CD8^+ T lymphocytes and the secretion of downstream cytokines in mice via downregulating the expression of programmed death-ligand 1 (PD-L1) on the tumor cells' surface in vivo. Further study in HepG2 and BEL-7402 cells showed that decrease of PD-L1 level after BS treatment was achieved by inhibiting signal transducer and activator of transcription 3 (STAT3) phosphorylation. Taken together, our results suggest that BS has a role in promoting the immune response by reducing PD-L1 expression via the STAT3 pathway, and subsequently suppresses tumorigenesis.展开更多
基金Guangdong Medical Science and Technology Research Fund Project,No.A2021454.
文摘BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal involvement is rare,with only 11 reported cases in the literature.We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal and present a literature review.CASE SUMMARY A 27-year-old man presented with acute-onset neck pain,numbness,and weakness in his extremities.Magnetic resonance imaging showed an epidural mass in the cervicothoracic(C6-T1)spinal canal and vertebral hemangioma(VH)involving the C7 vertebral body.C6-T1 Laminectomy and radical excision of the mass were performed.Histopathological examinations revealed papillary proliferation of vascular endothelial cells with thrombus formation,and an IPEH diagnosis was made.By his 6-mo follow-up appointment,his symptoms were relieved without recurrence.The possible pathogenesis,clinical and imaging features,differential diagnosis,and management of IPEH were reviewed.CONCLUSION We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal,treated via complete resection,and showing a favorable outcome.We found a causal relationship between spinal IPEH and VH;this partly explains the mechanism of IPEH.
基金supported by the National Key Research and Development Program of China under Grant No.2018YFC0830900the National Natural Science Foundation of China under Grant No.62076068Shanghai Municipal Science and Technology Project under Grant No.21511102800。
文摘Inspired by the concept of content-addressable retrieval from cognitive science,we propose a novel fragment-based Chinese named entity recognition(NER)model augmented with a lexicon-based memory in which both character-level and word-level features are combined to generate better feature representations for possible entity names.Observing that the boundary information of entity names is particularly useful to locate and classify them into pre-defined categories,position-dependent features,such as prefix and suffix,are introduced and taken into account for NER tasks in the form of distributed representations.The lexicon-based memory is built to help generate such position-dependent features and deal with the problem of out-of-vocabulary words.Experimental results show that the proposed model,called LEMON,achieved state-of-the-art performance with an increase in the Fl-score up to 3.2%over the state-of-the-art models on four different widely-used NER datasets.
基金Project supported by the National Natural Science Foundation of China(No.81372266)the National Science and Technology Major Project(No.2011zx09101-001-03)China
文摘The thioredoxin system plays a role in a variety of physiological functions, including cell growth, differenti- ation, apoptosis, tumorigenesis, and immunity. We previously confirmed that butaselen (BS), a novel thioredoxin reductase inhibitor, can inhibit the growth of various human cancer cell lines, yet the underlying mechanism remains elusive. In this study, we investigated the anti-tumor effect of BS in vivo through regulating the immune system of KM mice. We found that BS inhibits tumor proliferation by promoting the activation of splenic lymphocytes in mice. BS can elevate the percentage of CD^4-CD8^+ T lymphocytes and the secretion of downstream cytokines in mice via downregulating the expression of programmed death-ligand 1 (PD-L1) on the tumor cells' surface in vivo. Further study in HepG2 and BEL-7402 cells showed that decrease of PD-L1 level after BS treatment was achieved by inhibiting signal transducer and activator of transcription 3 (STAT3) phosphorylation. Taken together, our results suggest that BS has a role in promoting the immune response by reducing PD-L1 expression via the STAT3 pathway, and subsequently suppresses tumorigenesis.