Development and evaluation of a new curriculum based on the Delphi method for master of nursing progranls in China

Objective： To develop a new curriculum for a master＇s degree in nursing and provide a reference for nursing education in China. Methods： After a comprehensive literature review and item consolidation, an expert panel developed the initial version of the master＇s degree program objective and curriculum. A three-round Delphi study was subsequently conducted to revise and validate the curriculum. Results： Twenty-six experts participated in the evaluation and validation process. The authority coef- ficient was 0.88, and the Kendall coordination coefficient was statistically significant （X2 test, P 〈 0.01）. The final training objective contained 9 items, covering knowledge, skills and humanistic quality. The final established curriculum contained 22 courses, including 5 public compulsory courses, 5 specialized basic compulsory courses and 12 elective courses for professional development. Conclusions： The present study provided an operational curriculum for a master＇s degree in nursing in China.

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired immunity.The molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been elusive.Here,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in colon.Nevertheless,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and migration.Notably,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA models.CD8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune surveillance.The dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC patients.Our findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.