Element W can effectively improve the density of energetic structural materials. However, W is an inert element and does not combust in air. To change the reaction characteristics of W, 60 at.% Al was introduced into ...Element W can effectively improve the density of energetic structural materials. However, W is an inert element and does not combust in air. To change the reaction characteristics of W, 60 at.% Al was introduced into W through mechanical alloying. XRD analysis shows that after 50 h of ball milling, the diffraction peak of Al completely disappears and W(Al60) super-saturated solid solution powder is obtained. Further observation by HAADF and HRTEM reveals that the W(Al60) super-saturated solid solution powder is a mixture of solid solution and amorphous phase. Based on the good thermal stability of W(Al60) alloy powder below 1000℃, W(Al60)-Al composite was synthesized by hot pressing process.Impact initiation experiments suggest that the W(Al60)-Al composite has excellent reaction characteristics, and multiple types of tungsten oxides are detected in the reaction products, showing that the modified W is combustible in air. Due to the combustion of tungsten, the energy release rate of the W(Al60)-Al composite at speed of 1362 m/s reaches 2.71 kJ/g.展开更多
Multiple myeloma(MM)is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells.In many countries,it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.Althoug...Multiple myeloma(MM)is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells.In many countries,it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.Although treatment methods for MM have been continuously improved and the survival of patients has been dramatically prolonged,MM remains an incurable disease with a high probability of recurrence.As such,there are still many challenges to be addressed.One promising approach is singlecell RNA sequencing(scRNA-seq),which can elucidate the transcriptome heterogeneity of individual cells and reveal previously unknown cell types or states in complex tissues.In this review,we outlined the experimental workflow of scRNA-seq in MM,listed some commonly used scRNA-seq platforms and analytical tools.In addition,with the advent of scRNA-seq,many studies have made new progress in the key molecular mechanisms during MM clonal evolution,cell interactions and molecular regulation in the microenvironment,and drug resistance mechanisms in target therapy.We summarized the main findings and sequencing platforms for applying scRNA-seq to MM research and proposed broad directions for targeted therapies based on these findings.展开更多
基金supported by the National Natural Science Foundation of China, [Award number: 11972372] and [Award number: U20A20231]。
文摘Element W can effectively improve the density of energetic structural materials. However, W is an inert element and does not combust in air. To change the reaction characteristics of W, 60 at.% Al was introduced into W through mechanical alloying. XRD analysis shows that after 50 h of ball milling, the diffraction peak of Al completely disappears and W(Al60) super-saturated solid solution powder is obtained. Further observation by HAADF and HRTEM reveals that the W(Al60) super-saturated solid solution powder is a mixture of solid solution and amorphous phase. Based on the good thermal stability of W(Al60) alloy powder below 1000℃, W(Al60)-Al composite was synthesized by hot pressing process.Impact initiation experiments suggest that the W(Al60)-Al composite has excellent reaction characteristics, and multiple types of tungsten oxides are detected in the reaction products, showing that the modified W is combustible in air. Due to the combustion of tungsten, the energy release rate of the W(Al60)-Al composite at speed of 1362 m/s reaches 2.71 kJ/g.
基金supported by the Shanghai Shenkang Hospital Development Center(No.SHDC2020CR2070B).
文摘Multiple myeloma(MM)is a malignant neoplasm characterized by clonal proliferation of abnormal plasma cells.In many countries,it ranks as the second most prevalent malignant neoplasm of the hematopoietic system.Although treatment methods for MM have been continuously improved and the survival of patients has been dramatically prolonged,MM remains an incurable disease with a high probability of recurrence.As such,there are still many challenges to be addressed.One promising approach is singlecell RNA sequencing(scRNA-seq),which can elucidate the transcriptome heterogeneity of individual cells and reveal previously unknown cell types or states in complex tissues.In this review,we outlined the experimental workflow of scRNA-seq in MM,listed some commonly used scRNA-seq platforms and analytical tools.In addition,with the advent of scRNA-seq,many studies have made new progress in the key molecular mechanisms during MM clonal evolution,cell interactions and molecular regulation in the microenvironment,and drug resistance mechanisms in target therapy.We summarized the main findings and sequencing platforms for applying scRNA-seq to MM research and proposed broad directions for targeted therapies based on these findings.
