A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plas...A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plastic flow behavior during thermomechanical processing.The driving force for the nucleation and growth of dynamically recrystallized grain is the volume free energy due to the stored dislocation density of a deformation matrix.The growth terminates the impingement.The model is capable of simulating kinetics,microstructure and texture evolution during recrystallization.The predictions of microstructural evolution agree with the experimental results.展开更多
Aim To establish a sensitive and specific liquid chromatography-mass spectrometry method for determination of mirtazapine in human plasma and evaluation of its relative bioavailability. Methods After being alkalized...Aim To establish a sensitive and specific liquid chromatography-mass spectrometry method for determination of mirtazapine in human plasma and evaluation of its relative bioavailability. Methods After being alkalized by 25% ammonia, mirtazapine in the plasma was extracted with n-hexane. Desloratadine was used as internal standard (IS). Solu-tes were separated on a C_(18) column with a mobile phase of methanol-ammonium acetate buffer (pH 3.5) (75∶25). The flow rate of the mobile phase was 1 mL·min^(-1). Detection was performed on an electrospray ionization (ESI) mass spectrometer and operated in selected ion monitoring (SIM) and positive-ionization mode using target ionsat m/z 266.2 for mirtazapine and m/z 311.2 for the IS. The fragmentor voltage was 90 V. A randomized cross-over study was performed in 20 healthy volunteers. In the two study periods, twenty healthy Chinese male subjects received a single oral dose of mirtazapine 30 mg. Results The calibration curve was linear over the range of 0.3-200 ng·mL^(-1). The limit of quantitation was 0.1 ng·mL^(-1). The parameters for mirtazapine test tablet and reference tablet were as follows: T_(1/2)(24.7±4.1) and (23.6±4.3) h, T_(max)(1.6±0.8) and (1.5±0.8) h, C_(max)(95.9±29.8) and (91.9±26.7) ng·mL^(-1), respectively. Conclusion The established HPLC-MS method is rapid, sensitive and specific for the determination of mirtazapine in human plasma. The relative bioavailability was 100.0%±10.8%.展开更多
Mesoporous transition metal oxide catalysts are well-used in the elimination of volatile organic compounds.In this study,we developed an efficient method for the preparation of mesoporous-Mn_(3)O_(4)(mMn_(3)O_(4))with...Mesoporous transition metal oxide catalysts are well-used in the elimination of volatile organic compounds.In this study,we developed an efficient method for the preparation of mesoporous-Mn_(3)O_(4)(mMn_(3)O_(4))without the use of templates or surfactants.In this method,KCl protects oxygen defects on the surface of fresh Mn_(3)O_(4) crystallites.m-Mn_(3)O_(4) shows higher ameliorative catalytic activity than bulk-Mn_(3)O_(4)(b-Mn_(3)O_(4)) and calcined-Mn_(3)O_(4)(c-Mn_(3)O_(4)),achieving toluene catalytic oxidation of T_(10) and T_(90)(the temperature at a conversion rate of about 10%and 90%)at 191℃and 230℃,respectively(WHSV=40,000 ml·g^(-1)·h^(-1)).Based on various characterizations,the prepared m-Mn_(3)O_(4)has large specific surface area and abundant oxygen defects,and thus can provide more surface active sites,which give it superior toluene combustion activity.展开更多
Flatness and profile are important quality indexes of strip. Combining the influence function method to solve the elastic deformation of roll system with the variational method to solve the lateral flow of metal, the ...Flatness and profile are important quality indexes of strip. Combining the influence function method to solve the elastic deformation of roll system with the variational method to solve the lateral flow of metal, the flatness and profile of the strip during cold continuous rolling were simulated. The B 3 spline function was used to analogize the lateral distribution of strip thickness. The transverse distributions of the exit thickness and the front tension stress for each pass were obtained. Compared with the measured results, it is proved that using the spline function to analogize the lateral distribution of strip thickness can improve the calculation accuracy of flatness and profile largely.展开更多
Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs a...Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs are transported out of the nucleus and serve as templates for the translation of viral proteins or alternatively as the full-length viral genome to be packaged into virus particles.Antisense展开更多
When crossing the streets of Jingdezhen City of east China's jiangxi Province, it used to be hard to avoid stepping on fragments of porcelain dating back hundreds of years. While such an occurrence became increasi...When crossing the streets of Jingdezhen City of east China's jiangxi Province, it used to be hard to avoid stepping on fragments of porcelain dating back hundreds of years. While such an occurrence became increasingly rare as the city updated its town planning in the early 1990s,展开更多
In a country where for tens of centuries agriculture was commonly translated as """"the lower breed of society"""", the obvious wealth of contemporary farmers in some parts of C...In a country where for tens of centuries agriculture was commonly translated as """"the lower breed of society"""", the obvious wealth of contemporary farmers in some parts of China can be surprising to many outsiders. Last year, Huaxi Village, in east China's Jiangsu Province, announced that it gained some z6 billion yuan (US$3.14 billion) through tourism and sales of local products ranging from garments to tobacco,展开更多
基金Sponsored by National Natural Science Foundation of China(50275130)
文摘A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plastic flow behavior during thermomechanical processing.The driving force for the nucleation and growth of dynamically recrystallized grain is the volume free energy due to the stored dislocation density of a deformation matrix.The growth terminates the impingement.The model is capable of simulating kinetics,microstructure and texture evolution during recrystallization.The predictions of microstructural evolution agree with the experimental results.
文摘Aim To establish a sensitive and specific liquid chromatography-mass spectrometry method for determination of mirtazapine in human plasma and evaluation of its relative bioavailability. Methods After being alkalized by 25% ammonia, mirtazapine in the plasma was extracted with n-hexane. Desloratadine was used as internal standard (IS). Solu-tes were separated on a C_(18) column with a mobile phase of methanol-ammonium acetate buffer (pH 3.5) (75∶25). The flow rate of the mobile phase was 1 mL·min^(-1). Detection was performed on an electrospray ionization (ESI) mass spectrometer and operated in selected ion monitoring (SIM) and positive-ionization mode using target ionsat m/z 266.2 for mirtazapine and m/z 311.2 for the IS. The fragmentor voltage was 90 V. A randomized cross-over study was performed in 20 healthy volunteers. In the two study periods, twenty healthy Chinese male subjects received a single oral dose of mirtazapine 30 mg. Results The calibration curve was linear over the range of 0.3-200 ng·mL^(-1). The limit of quantitation was 0.1 ng·mL^(-1). The parameters for mirtazapine test tablet and reference tablet were as follows: T_(1/2)(24.7±4.1) and (23.6±4.3) h, T_(max)(1.6±0.8) and (1.5±0.8) h, C_(max)(95.9±29.8) and (91.9±26.7) ng·mL^(-1), respectively. Conclusion The established HPLC-MS method is rapid, sensitive and specific for the determination of mirtazapine in human plasma. The relative bioavailability was 100.0%±10.8%.
基金supported by the National Natural Science Foundation of China(Nos.21306026,21576054)Natural Science Foundation of Guangdong Province(No.2018A030310563)the Foundation of Higher Education of Guangdong Province(2018KZDXM031)。
文摘Mesoporous transition metal oxide catalysts are well-used in the elimination of volatile organic compounds.In this study,we developed an efficient method for the preparation of mesoporous-Mn_(3)O_(4)(mMn_(3)O_(4))without the use of templates or surfactants.In this method,KCl protects oxygen defects on the surface of fresh Mn_(3)O_(4) crystallites.m-Mn_(3)O_(4) shows higher ameliorative catalytic activity than bulk-Mn_(3)O_(4)(b-Mn_(3)O_(4)) and calcined-Mn_(3)O_(4)(c-Mn_(3)O_(4)),achieving toluene catalytic oxidation of T_(10) and T_(90)(the temperature at a conversion rate of about 10%and 90%)at 191℃and 230℃,respectively(WHSV=40,000 ml·g^(-1)·h^(-1)).Based on various characterizations,the prepared m-Mn_(3)O_(4)has large specific surface area and abundant oxygen defects,and thus can provide more surface active sites,which give it superior toluene combustion activity.
基金Item Sponsored by National Natural Science Foundation of China(50275130)Provincial Natural Science Foundation of Hebei of China(E200400223)
文摘Flatness and profile are important quality indexes of strip. Combining the influence function method to solve the elastic deformation of roll system with the variational method to solve the lateral flow of metal, the flatness and profile of the strip during cold continuous rolling were simulated. The B 3 spline function was used to analogize the lateral distribution of strip thickness. The transverse distributions of the exit thickness and the front tension stress for each pass were obtained. Compared with the measured results, it is proved that using the spline function to analogize the lateral distribution of strip thickness can improve the calculation accuracy of flatness and profile largely.
基金supported by National Natural Science Foundation of China (81371820)
文摘Dear Editor,In the late stages of the retroviral life cycle,the transcription of viral pre-m RNA is initiated at the 5′long terminal repeat(5′LTR)and terminated at the 3′LTR;the full-length and spliced viral RNAs are transported out of the nucleus and serve as templates for the translation of viral proteins or alternatively as the full-length viral genome to be packaged into virus particles.Antisense
文摘When crossing the streets of Jingdezhen City of east China's jiangxi Province, it used to be hard to avoid stepping on fragments of porcelain dating back hundreds of years. While such an occurrence became increasingly rare as the city updated its town planning in the early 1990s,
文摘As one of the country's leading economic performers, it is not surprising that Suzhou is now being seen as a breeding ground for potential provincial
文摘In a country where for tens of centuries agriculture was commonly translated as """"the lower breed of society"""", the obvious wealth of contemporary farmers in some parts of China can be surprising to many outsiders. Last year, Huaxi Village, in east China's Jiangsu Province, announced that it gained some z6 billion yuan (US$3.14 billion) through tourism and sales of local products ranging from garments to tobacco,