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Limitations of Lightning Rods in Preventing Direct Lightning Strikes 被引量:1
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作者 Zhen CHEN Xiaofeng LUO +5 位作者 Jixi LIU Ziqin GAO Yixian QIU xiaoning zhang Lingjin KONG Chunliang zhang 《Meteorological and Environmental Research》 CAS 2023年第4期59-62,共4页
Since ancient times,lightning disasters have undoubtedly been an unstoppable threat to humanity.During thunderstorms,lightning often damages objects on the ground,such as buildings and structures.Since Franklin invent... Since ancient times,lightning disasters have undoubtedly been an unstoppable threat to humanity.During thunderstorms,lightning often damages objects on the ground,such as buildings and structures.Since Franklin invented the lightning rod in 1752,lightning rods have been used worldwide to prevent direct lightning strikes in various fields such as high-voltage power transmission lines,outdoor chemical sites,highways,land and sea wind farms,and forest lightning fire protection.It has been proven that lightning accidents still occur frequently in places where lightning rods are installed and the protective angle method is used.In order to further study the protective effect of lightning rods and identify the shortcomings of lightning rod protection,negative lightning strikes are taken as the research object,to analyze the limitations of lightning rods in preventing direct lightning strikes from the working principle of lightning rods. 展开更多
关键词 Lightning rod Direct lightning strike Protective angle method LIMITATION
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SFC Design and VNF Placement Based on Traffic Volume Scaling and VNF Dependency in 5G Networks
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作者 Zhihao Zeng Zixiang Xia +1 位作者 xiaoning zhang Yexiao 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第3期1791-1814,共24页
The development of Fifth-Generation(5G)mobile communication technology has remarkably promoted the spread of the Internet of Things(IoT)applications.As a promising paradigm for IoT,edge computing can process the amoun... The development of Fifth-Generation(5G)mobile communication technology has remarkably promoted the spread of the Internet of Things(IoT)applications.As a promising paradigm for IoT,edge computing can process the amount of data generated by mobile intelligent devices in less time response.Network Function Virtualization(NFV)that decouples network functions from dedicated hardware is an important architecture to implement edge computing,deploying heterogeneous Virtual Network Functions(VNF)(such as computer vision,natural language processing,intelligent control,etc.)on the edge service nodes.With the NFV MANO(Management and Orchestration)framework,a Service Function Chain(SFC)that contains a set of ordered VNFs can be constructed and placed in the network to offer a customized network service.However,the procedure of NFV orchestration faces a technical challenge in minimizing the network cost of VNF placement due to the complexity of the changing effect of traffic volume and the dependency on theVNFrelationship.To this end,we jointly optimize SFC design and VNF placement to minimize resource cost while taking account of VNF dependency and traffic volume scaling.First,the problem is formulated as an Integer Linear Programming(ILP)model and proved NPhard by reduction from Hamiltonian Cycle problem.Then we proposed an efficient heuristic algorithm called Traffic Aware and Interdependent VNF Placement(TAIVP)to solve the problem.Compared with the benchmark algorithms,emulation results show that our algorithm can reduce network cost by 10.2%and increase service request acceptance rate by 7.6%on average. 展开更多
关键词 Network function virtualization virtual network function service function chain resource allocation routing
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Three Core Technical Systems and Engineering Application of Regional Lightning Protection
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作者 Zhen CHEN Yu HUANG +4 位作者 Ziqin GAO Yixian QIU Xiaofeng LUO xiaoning zhang Jixi LIU 《Meteorological and Environmental Research》 CAS 2023年第3期48-53,共6页
Regional lightning protection is a complete theoretical system,mainly including:lightning interception technology(LIPT),lightning strong electromagnetic pulse high-energy absorption technology(MSPD),and regional light... Regional lightning protection is a complete theoretical system,mainly including:lightning interception technology(LIPT),lightning strong electromagnetic pulse high-energy absorption technology(MSPD),and regional lightning activity law analysis technology(RLLA).Lightning interception technology uses dispersive waveguide resonant cavity technology to achieve the functions of 46.55 m longer than upward leader of ordinary lightning rod,significantly reducing lightning strike point current by 40%,optimizing space electromagnetic field environment,and effectively intercepting overhead and side lightning strikes,and overcome the limitations of traditional lightning rod.The lightning strong electromagnetic pulse high-energy absorption technology uses distributed parameter balance technology,special disconnector for short circuit current,and parity pairing technology to achieve stronger surge absorption capacity than traditional single pulse SPD and international advanced technical indicators such as timely breaking under power frequency short circuit current,and good energy and time coordination.The analysis technology of regional lightning activity laws accurately identifies lightning strike points through comprehensive analysis of regional lightning activity laws,physical parameters of ion clouds,and the impact on ground electric fields.The three core technology systems complement each other,achieving all-round protection against direct lightning strike and lightning electromagnetic pulse.Several projects achieved zero lightning damage,effectively ensuring the safety of buildings and electronic and electrical equipment in the protected area. 展开更多
关键词 Regional lightning protection Lightning interception technology Multi-pulse high-energy absorption technology Lightning point identification technology
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Relationship between the -455G/A and -148C/T polymorphisms in the beta-fibrinogen gene and cerebral infarction in the Xinjiang Uygur and Han Chinese populations 被引量:13
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作者 xiaoning zhang Yanyun Li +2 位作者 Xuebing Guo Lei Du Jianhua Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第7期546-551,共6页
We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinj... We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A + AA. 展开更多
关键词 UYGUR HAN cerebral infarction β-fibrinogen gene polymorphism neural regeneration
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IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling 被引量:6
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作者 Zhili Rong Anan Wang +8 位作者 Zhiyong Li Yongming Ren Long Cheng Yinghua Li Yinyin Wang Fangli Ren xiaoning zhang Jim Hu Zhijie Chang 《Cell Research》 SCIE CAS CSCD 2009年第2期208-215,共8页
Interleukin-17 (IL-17 or IL-17A) production is a hallmark of TH17 cells, a new unique lineage of CD4^+ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor... Interleukin-17 (IL-17 or IL-17A) production is a hallmark of TH17 cells, a new unique lineage of CD4^+ T lymphocytes contributing to the pathogenesis of multiple autoimmune and inflammatory diseases. IL-17 receptor (IL-17R or IL-17RA) is essential for IL-17 biological activity. Emerging data suggest that the formation of a heteromeric and/or homomeric receptor complex is required for IL-17 signaling. Here we show that the orphan receptor IL-17RD (Sef, similar expression to FGF genes or IL-17RLM) is associated and colocalized with IL-17R. Importantly, IL-17RD mediates IL-17 signaling, as evaluated using a luciferase reporter driven by the native promoter of 24p3, an IL-17 target gene. In addition, an IL-17RD mutant lacking the intraeellnlar domain dominant-negatively suppresses IL-17R- mediated IL-17 signaling. Moreover, IL-17RD as well as IL-17R is associated with TRAF6, an IL-17R downstream molecule. These results indicate that IL-17RD is a part of the IL-17 receptor signaling complex, therefore providing novel evidence for IL-17 signaling through a heteromeric and/or homomeric receptor complex. 展开更多
关键词 IL-17RD SEF IL-17 IL-17R IL-17 signaling heteromeric receptor complex TH17
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Theoretical and experimental study of the pulling force of jet bits in radial drilling technology 被引量:5
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作者 Ruichang Guo Gensheng Li +3 位作者 Zhongwei Huang Shouceng Tian xiaoning zhang Wei Wu 《Petroleum Science》 SCIE CAS CSCD 2009年第4期395-399,共5页
Radial drilling technology, of which the jet bit is the key device, is a research focus in the field of oil drilling and production. This paper establishes mechanical equations for jet bits and analyzes the hydroseal ... Radial drilling technology, of which the jet bit is the key device, is a research focus in the field of oil drilling and production. This paper establishes mechanical equations for jet bits and analyzes the hydroseal of backward jets in bottom holes. Meanwhile this paper establishes a mechanical equation for a high pressure hose and analyzes the axial force distribution. Laboratory experiments indicate that the flow rate, the angle between the backward nozzle axis and the jet bit axis, and the hole diameter are the major influencing factors; the generation of the pulling force is mainly due to the inlet pressure of the jet bit; the backward jets can significantly increase not only the pulling force but also the stability of jet bits. The pulling force would reach 8,376 N under experimental conditions, which can steadily pull the high-pressure hose forward. 展开更多
关键词 Radial drilling water jet jet bit depression effect pulling force
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经济刑法理念的转向:保障市场自律机制的健全 被引量:13
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作者 张小宁 《青少年犯罪问题》 2021年第1期52-66,共15页
近年来,金融商品交易等领域频繁发生大案要案的根本原因在于:我国经济刑法的立法、司法及研究范式仍然桎梏于统制经济刑法思维之中,无法应对自由经济体制的要求,市场自律机制始终难以健全,因而很难为"发挥市场在资源配置中的基础作... 近年来,金融商品交易等领域频繁发生大案要案的根本原因在于:我国经济刑法的立法、司法及研究范式仍然桎梏于统制经济刑法思维之中,无法应对自由经济体制的要求,市场自律机制始终难以健全,因而很难为"发挥市场在资源配置中的基础作用"提供有效的辅助。在统制经济体制转变为自由经济体制的背景下,经济刑法的根本理念应当是保障市场自律机制的健全。为此,建构经济秩序的机能应当服从于保护国民经济权益的机能;应当依据保护法益的实质内涵来区分制度依存型经济刑法与权益保障型经济刑法;应当放弃刑法优先主义的规制思维,转而构建起以企业自律为主轴,行政处分与民事追责为辅助,刑事制裁为补充的新型规制机制;应当突出违法性认识可能性作为出罪事由的积极意义,并将违法性认识可能性的对象限定为刑事违法性。 展开更多
关键词 经济刑法 经济犯罪 市场自律 自治机制
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A case study on Landscape Component Niche based on Landscape Pattern Indices: Yanchi,Ningxia Province, China 被引量:1
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作者 xiaoning zhang XueLu Liu +4 位作者 Ghanney Philip XiaoDan Li QuanXi Wang YaNan Xu TingTing Hui 《Research in Cold and Arid Regions》 CSCD 2020年第1期22-33,共12页
Yanchi County is located in the agro-pastoral ecotone and belongs to the ecologically fragile area of Northwest China.It is important to study the evolution of landscape pattern to curb its environmental degradation.I... Yanchi County is located in the agro-pastoral ecotone and belongs to the ecologically fragile area of Northwest China.It is important to study the evolution of landscape pattern to curb its environmental degradation.In order to intuitively show how the landscape pattern of the study area changes over time,Landsat Thematic Mappers(TM)and Landsat Operational Land Imager(OLI)data of 1991,2000,2010 and 2017 were used.This paper attempts to apply niche theories and methods into landscape ecology,and constructs a niche model of landscape components by using"n-dimentional hypervolume niche theory"and landscape pattern indices.By evaluating the spatial and temporal evolution of niche from the perspective of two-dimensional space to reflect the changes of landscape pattern in the study area over the past 26 years,new theories and methods were introduced for the characterization of landscape pattern.The results indicate that:1)The larger the attribute and dominance value of landscape components,the higher the ecological niche and the stronger the control effect on the overall landscape.2)The ecological niche of each landscape component was significantly different,just as its control effect on the overall landscape.3)The dynamic change of the ecological niche of each landscape component was different,with grassland,unused land and arable land always in a high dominant position,although the ecological niche of construction land and water area was always low.In general,the introduction of niche theory into the landscape ecology provided a new method to study the changes in regional landscape pattern. 展开更多
关键词 landscape pattern landscape component niche landscape stability landscape dominance
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GMA material design and construction quality control for asphalt pavement of steel box girder: Case study of the Hong Kong–Zhuhai–Macao Bridge 被引量:2
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作者 xiaoning zhang 《Journal of Road Engineering》 2021年第1期63-72,共10页
To improve the quality of the Hong Kong–Zhuhai–Macao Bridge paving project,a new paving layer material,Guss-mastic asphalt(GMA),was proposed in this paper by combining the advantages of two types of cast asphalt mix... To improve the quality of the Hong Kong–Zhuhai–Macao Bridge paving project,a new paving layer material,Guss-mastic asphalt(GMA),was proposed in this paper by combining the advantages of two types of cast asphalt mixtures:mastic asphalt(MA)and Guss asphalt(GA).Based on the characteristics of GMA,to simulate its actual production process,this study developed a small-simulated cooker mixing equipment.Moreover,the flow degree,60C dynamic stability,and impact toughness were proposed to be used to evaluate the construction and ease,high temperature stability,and fatigue resistance of GMA cast asphalt mixtures,respectively.Moreover,the quality control standards for GMA paving materials by indoor tests,field trial mix GMA material performance tests,and accelerated loading tests were finalized.The study showed that the developed simulated cooker yielded consistent mixing results in the same working environment as the engineering cooker device.Increasing the coarse aggregate incorporation rate,coarsening the mastic epure(ME)gradation composition,and using a smaller oil to stone ratio can reduce the flowability of the GMA materials to varying degrees.The four-point bending fatigue life and impact toughness of the different GMA materials are correlated well.A mobility of<20 s,60C dynamic stability of 400–800 times/mm,15C impact toughness of400 N⋅mm,and cooker car mixing temperature control standard of 210C–230C form an appropriate control index system for the design and production of GMA cast asphalt mixtures.Simultaneously,accelerated loading tests verified the accuracy and reliability of the quality control index system that has been used in the GMA paving project of the Hong Kong–Zhuhai–Macao Bridge deck and has achieved good application results. 展开更多
关键词 Asphalt pavement Material design GMA Steel box girder Construction quality control
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Experimental and numerical studies on the receiving gain enhancement modulated by a sub-wavelength plasma layer
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作者 Fanrong KONG Qiuyue NIE +3 位作者 Guangye XU xiaoning zhang Shu LIN Binhao JIANG 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第9期133-139,共7页
A novel technique based on sub-wavelength plasma structure effects on enhancement of RF communication signals on a receiving antenna is carried out in this paper in laboratory experiments and analyzed by corresponding... A novel technique based on sub-wavelength plasma structure effects on enhancement of RF communication signals on a receiving antenna is carried out in this paper in laboratory experiments and analyzed by corresponding numerical simulations.Considerable intensification on receiving signal gain up to -10 d B in comparison with that without the plasma modulation is observed experimentally in -1 GHz RF band,with an effective enhancement bandwidth of -340 MHz and the fractional bandwidth of -34%.Then,the optimal modulation parameters of plasma are further studied by a numerical simulation.It is shown that the number density,the layer thickness,and the collision frequency of the plasma,as well as the relative distance between the plasma layer and antenna synergistically affect the modulation.Compared to the metallic antenna with the same overall dimension,the modulated antenna covered by the subwavelength plasma structure features higher receiving efficiency and lower radar cross section in the studied RF band.The mechanism of the reception enhancement is further revealed by analyzing characteristics of electromagnetic scattering and electric field distribution in the subwavelength plasma layer.The results then exhibit scientific significance and application potential of sub-wavelength plasma modulation on compact receiving antennas with higher performance and better feature of radar stealth. 展开更多
关键词 sub-wavelength plasma structure electromagnetic radiation modulation receiving gain enhancement local surface plasmon resonance
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Cranberry cultivated in China:UPLC-Q-TOF-MS analysis of its acidic ethanol extract and assessment of its anti-bacterial and anti-tumor activities in vitro
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作者 Changhua Li Lin Wang +6 位作者 Dianwen Wei Gaosheng Hu xiaoning zhang Zhihong Lou Qiong zhang Jingming Jia Yongsheng Hou 《Journal of Polyphenols》 2019年第1期50-61,共12页
Cranberry,the fruit of Vaccinium macrocarpon Aiton,is becoming popular all over the world,due to its pleasant taste,nutraceutical value and biological activities.For a long time,98%of its yield has been from America.S... Cranberry,the fruit of Vaccinium macrocarpon Aiton,is becoming popular all over the world,due to its pleasant taste,nutraceutical value and biological activities.For a long time,98%of its yield has been from America.Since being introduced to China as an import in recent decades,cranberry has become a rapid success in the food industry even with the high transportation cost.Recently,V.macrocarpon was cultivated in the Northeast of China,and the area of cultivation has increased dramatically.Therefore,it is important to systematically determine the useful compounds and their activity in this“Made-in-China”cranberry.In the present study,the content of total phenolics,anthocyanins,proanthocyanidins,sugars and organic acids was determined.Our results demonstrated that domestic cranberry is a rich source of phenolics,anthocyanins,proanthocyanidins,sugars and organic acids.Analysis of the chemical composition of an acidic ethanol extract by UPLC-QTOF-MS identified 21 compounds as well as the contents determination of catechin and cyanidin-3-O-glucoside using RPHPLC.Furthermore,cranberry extract was tested for its anti-bacterial activity against five clinically important pathogens,as well as its inhibitory effect on the proliferation and migration of cancer cells in vitro.Our results demonstrated that cranberry produced in Chinese cultivation areas is a rich source of bioactive compounds and exhibited in vitro anti-microbial and anti-tumor activities.Our work provides essential information about the quality of domestic cranberry and facilitates the development of related industries. 展开更多
关键词 Vaccinium macrocarpon UPLC-Q-TOF-MS content determination proanthocyanidin total phenolics Chinese cranberry anti-cancer activity anti-bacterial activity
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Systematic study on size and temporal dependence of micro-LED arrays for display applications 被引量:2
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作者 JUNYANG NIE ZHI zhang +8 位作者 KONGJIE CHEN YIFENG LIU SHUANG HE ZHONGHANG HUANG xiaoning zhang JIE SUN FAN zhang YONGSHENG WU QUN YAN 《Photonics Research》 SCIE EI CAS CSCD 2023年第4期549-557,共9页
Micro-LEDs are one of the most promising candidates for next-generation displays,yet they are inconvenienced by the efficiency reduction induced by the sidewall defects when pursuing further scaled-down device dimensi... Micro-LEDs are one of the most promising candidates for next-generation displays,yet they are inconvenienced by the efficiency reduction induced by the sidewall defects when pursuing further scaled-down device dimensions.We have systematically investigated both the size and temporal dependence of micro-LEDs.Micro-LED arrays with a mesa size ranging from 7 to 100μm were prepared for display purposes.The luminance and external quantum efficiency(EQE)were measured and discussed.Surprisingly,micro-LED arrays with a smaller mesa size exhibit a higher EQE under 100 ns pulse duration operation when compared with longer pulse duration operations.Under certain short-pulsed excitation,a 7×7μm^(2)micro-LED array even exhibits a>20%higher EQE as compared to the direct current(DC)or the long duration pulse operation condition.We thus concluded that the notorious efficiency reduction induced by sidewall defects in small-sized micro-LED arrays could be significantly reduced by applying short-pulse voltages. 展开更多
关键词 ARRAYS PULSE SIZE
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中性粒细胞在基底上迁移过程中曳尾形成的理论模型 被引量:1
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作者 张晓宁 胡文慧 +2 位作者 高文博 章燕 龙勉 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2023年第6期166-178,共13页
中性粒细胞通过头部前伸和尾部收缩可以在内皮细胞或细胞外基质上快速迁移.这些细胞在迁移的过程中会遗留下大量富含整合素的膜结构,但目前尚不清楚曳尾的形成与细胞迁移之间的定量关系以及在这一过程中起关键作用的调控因素.本文将多... 中性粒细胞通过头部前伸和尾部收缩可以在内皮细胞或细胞外基质上快速迁移.这些细胞在迁移的过程中会遗留下大量富含整合素的膜结构,但目前尚不清楚曳尾的形成与细胞迁移之间的定量关系以及在这一过程中起关键作用的调控因素.本文将多层级力学-化学耦合模型与细胞迁移的马达-离合器模型相结合,对中性粒细胞在基质上的趋化迁移进行了数值模拟.结果表明,随着PAK1和其下游信号分子Rac和RhoA的极化分布,细胞膜上的整合素倾向于在细胞前后两端产生极化积聚,当Arp2/3和myosin分别在细胞的头尾极化时,细胞会在整合素的作用下增大迁移速度并提高曳尾的数量.这些关于整合素极化以及曳尾形成的预测与典型的实验结果一致.参数分析进一步表明,虽然细胞迁移速度与基底硬度和“马达”空载速度呈现双相依赖关系,但是曳尾形成的数量随着基底硬度、整合素-配体分子键的结合率、“马达”空载速度、“马达”空载拉力和“离合器”数量的增加而单调增加,随着趋化因子浓度和整合素-配体分子键的解离率的增加而减少.上述工作为阐明中性粒细胞迁移的力学-化学-生物学耦合过程和探究调节中性粒细胞迁移过程中影响曳尾形成的关键因素提供了一种解释. 展开更多
关键词 中性粒细胞 细胞迁移 曳尾 迁移过程 细胞外基质 迁移速度 内皮细胞 趋化因子
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A Practical Approach to Improve the MODIS MCD43A Products in Snow-Covered Areas 被引量:1
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作者 Anxin Ding Ziti Jiao +4 位作者 xiaoning zhang Yadong Dong Alexander AKokhanovsky Jing Guo Hailan Jiang 《Journal of Remote Sensing》 2023年第1期231-246,共16页
The MODerate Resolution Imaging Spectroradiometer(MODIS)MCD43A products have been extensively applied in the remote sensing field,but recent researchers have demonstrated that these products still had the potential to... The MODerate Resolution Imaging Spectroradiometer(MODIS)MCD43A products have been extensively applied in the remote sensing field,but recent researchers have demonstrated that these products still had the potential to be further improved by using the latest development of the kernel-driven model[RossThick-LiSparseReciprocal-Snow(RTLSRS)]in snow-covered areas,since the MCD43A product algorithm[RossThick-LiSparseReciprocal(RTLSR)]needed to be improved for the accurate simulation of snow bidirectional reflectance distribution function(BRDF)signatures.In this paper,we proposed a practical approach to improve the MCD43A products,which used the Polarization and Directionality of the Earth's Reflectance(POLDER)observations and random forest algorithm to establish the relationship between the BRDF parameters(MCD43A1)estimated by the RTLSR and RTLSRS models.We applied this relationship to correct the MCD43A1 product and retrieve the corresponding albedo(MCD43A3)and nadir reflectance(MCD43A4).The results obtained highlight several aspects:(a)The proposed approach can perform well in correcting BRDF parameters[root mean square error(RMSE)=~0.04].(b)The corrected BRDF parameters were then used to retrieve snow albedo,which matched up quite well with the results of the RTLSRS model.(c)Finally,the snow albedo retrieved by the proposed approach was assessed using ground-based albedo observations.Results indicated that the retrieved snow albedo showed a higher accuracy as compared to the station measurements(RMSE=0.055,bias=0.005),which was better than the results of the MODIS albedo product(RMSE=0.064,bias=-0.018),especially at large angles.These results demonstrated that this proposed approach presented the potential to further improve the MCD43A products in snow-covered areas. 展开更多
关键词 BRDF reflectance SIGNATURE
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Prevalence and risk factors for minimal hepatic encephalopathy in cirrhotic patients with different etiologies
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作者 Xiaoyan Li Shanghao Liu +37 位作者 Huiling Xiang Qingge zhang Ying Guo Hongmei Zu Jing Wang Jiaojian Lv xiaoning zhang Fanping Meng Jiahuan Li Jie Li Yangzhen Bianba Jia Shang Guo zhang Fei Liu Zhaowei Tong Chuang Lei Wei Ye Qiaohua Yang Ningning Wang Ying Song Wei Fu Ziyue Li Yanjing Gao Yongping zhang Jiafang Chen Caiyun Wu Qi Zheng Fang Wang Jiali Yu Lianjie Lin Chuanlong Yang Xiaoting Yang Xiaomin Ye Xiangmei Wang Xuelan Zhao Xiaolong Qi Fusheng Wang Junliang Fu 《Portal Hypertension & Cirrhosis》 2023年第4期171-180,共10页
Aims:Minimal hepatic encephalopathy(MHE)significantly affects the prognosis of patients with cirrhosis.This study was performed to determine whether there is a difference in the prevalence of MHE among patients with c... Aims:Minimal hepatic encephalopathy(MHE)significantly affects the prognosis of patients with cirrhosis.This study was performed to determine whether there is a difference in the prevalence of MHE among patients with cirrhosis of different etiologies and whether the etiology directly influences the occurrence of MHE.Methods:This multicenter,cross-sectional study enrolled 1879 patients with confirmed cirrhosis at 40 hospitals from October 25,2021,to January 10,2023(Trial registration:https://clinicaltrials.gov/[NCT05140837]).The patients'demographics,etiologies of cirrhosis,and laboratory test results were collected.The psychometric hepatic encephalopathy score(PHES)was determined in all patients to screen for MHE.Multivariate logistic analyses were performed to identify the risk factors for MHE.Results:In total,736 patients with cirrhosis were analyzed.The prevalence of MHE was 42.0%(n=309).The primary etiology among all patients was hepatitis B virus(HBV)-related cirrhosis(71.9%[529/736]).The prevalence of MHE was significantly higher in patients with alcoholic cirrhosis(57.1%[40/70])than in those with HBV-related cirrhosis(40.6%[215/529],p=0.009)or hepatitis C virus(HCV)-related cirrhosis(38.2%[26/68],p=0.026).Age(odds ratio[OR],1.042;95%confidence interval[CI],1.024-1.059;p<0.001),duration of education(OR,0.935;95%CI,0.899-0.971;p=0.001),etiology(OR,1.740;95%CI,1.028-2.945;p=0.039),and high MELD-Na scores(OR,1.038;95%CI,1.009-1.067;p=0.009)were independent risk factors for MHE.When patients with cirrhosis of different etiologies were analyzed separately,the results showed that age(OR,1.035;95%CI,1.014-1.057;p=0.001)and duration of education(OR,0.924;95%CI,0.883-0.966;p=0.001)were risk factors for MHE among patients with HBV-related cirrhosis,whereas age(OR,1.138;95%CI,1.033-1.254;p=0.009)and creatinine concentration(OR,16.487;95%CI,1.113-244.160;p=0.042)were risk factors for MHE in patients with HCV-related cirrhosis.No risk factors for MHE were found in patients with autoimmune cirrhosis.For patients with alcoholic cirrhosis,the platelet count(OR,1.014;95%CI,1.000-1.027;p=0.045)was a risk factor for MHE.The PHES subtest results were inconsistent among patients who had MHE with cirrhosis of different etiologies.Patients with HBV-related cirrhosis performed better on Number Connection Test B and the serial dotting test than those with alcoholic cirrhosis(p=0.007 and p<0.001),better on Number Connection Test B than those with HCV-related cirrhosis(p=0.020),and better on the line tracing test than those with autoimmune cirrhosis(p=0.037).Conclusion:The etiology of cirrhosis affected the prevalence of MHE and risk factors for MHE.The domains of major cognitive impairment varied among patients with cirrhosis of different etiologies.Further studies are required to verify these findings. 展开更多
关键词 ETIOLOGY liver cirrhosis minimal hepatic encephalopathy psychometric hepatic encephalopathy score risk factors
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Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection 被引量:19
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作者 Ying Ju Nan Hou +12 位作者 xiaoning zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2009年第1期35-43,共9页
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus (HBV) in... T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus (HBV) infection remains unknown. Here, we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes, especially on CD8^+ T cells, was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs, significantly increased IFN-γ production from hepatic CD8^+ T cells in HBV model mice was observed. Very interestingly, we found Tim-3 expression on CD8^+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover, Tim-3 knockdown influenced anti-HBs production in vivo. Collectively, our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. Cellular & Molecular Immunology. 展开更多
关键词 TIM-3 HBV CD8^+ T cell hydrodynamic injection SHRNA
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A real-time forecast of tunnel fire based on numerical database and artificial intelligence 被引量:7
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作者 Xiqiang Wu xiaoning zhang +2 位作者 Xinyan Huang Fu Xiao Asif Usmani 《Building Simulation》 SCIE EI CSCD 2022年第4期511-524,共14页
The extreme temperature induced by fire and hot toxic smokes in tunnels threaten the trapped personnel and firefighters.To alleviate the potential casualties,fast while reasonable decisions should be made for rescuing... The extreme temperature induced by fire and hot toxic smokes in tunnels threaten the trapped personnel and firefighters.To alleviate the potential casualties,fast while reasonable decisions should be made for rescuing,based on the timely prediction of fire development in tunnels.This paper targets to achieve a real-time prediction(within 1 s)of the spatial-temporal temperature distribution inside the numerical tunnel model by using artificial intelligence(Al)methods.A CFD database of 100 simulated tunnel fire scenarios under various fire location,fire size,and ventilation condition is established.The proposed Al model combines a Long Short-term Memory(LSTM)model and a Transpose Convolution Neural Network(TCNN).The real-time ceiling temperature profile and thousands of temperature-field images are used as the training input and output.Results show that the predicted temperature field 60 s in advance achieves a high accuracy of around 97%.Also,the Al model can quickly identify the critical temperature field for safe evacuation(i.e.,a critical event)and guide emergency responses and firefighting activities.This study demonstrates the promising prospects of Al-based fire forecasts and smart firefighting in tunnel spaces. 展开更多
关键词 tunnel fires smart firefighting critical event CFD deep learning LSTM/TCNN
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Root microbiota shift in rice correlates with resident time in the field and developmental stage 被引量:34
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作者 Jingying zhang Na zhang +12 位作者 Yong-Xin Liu xiaoning zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan zhang Tao Jin Chengcai Chu Yang Bai 《Science China(Life Sciences)》 SCIE CAS CSCD 2018年第6期613-621,共9页
Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota compo... Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. 展开更多
关键词 rice root microbiota time-series shift biomarker taxa residence time in the field developmental stages modeling machine learning
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Host-Associated Quantitative Abundance Profiling Reveals the Microbial Load Variation of Root Microbiome 被引量:9
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作者 Xiaoxuan Guo xiaoning zhang +11 位作者 Yuan Qin Yong-Xin Liu Jingying zhang Na zhang Kun Wu Baoyuan Qu Zishan He Xin Wang Xinjian zhang Stephane Hacquard Xiangdong Fu Yang Bai 《Plant Communications》 2020年第1期147-163,共17页
Plant-associated microbes are critical for plant growth and survival under natural environmental conditions.To date,most plant microbiome studies involving high-throughput amplicon sequencing have focused on the relat... Plant-associated microbes are critical for plant growth and survival under natural environmental conditions.To date,most plant microbiome studies involving high-throughput amplicon sequencing have focused on the relative abundance of microbial taxa.However,this technique does not assess the total microbial load and the abundance of individual microbes relative to the amount of host plant tissues.Here,we report the development of a host-associated quantitative abundance profiling(HA-QAP)method that can accurately examine total microbial load and colonization of individual root microbiome members relative to host plants by the copy-number ratio of microbial marker gene to plant genome.We validate the HAQAP method using mock experiments,perturbation experiments,and metagenomic sequencing.The HA-QAP method eliminates the generation of spurious outputs in the classical method based on microbial relative abundance,and reveals the load of root microbiome to host plants.Using the HA-QAP method,we found that the copy-number ratios of microbial marker genes to plant genome range from 1.07 to 6.61 for bacterial 16S rRNA genes and from 0.40 to 2.26 for fungal internal transcribed spacers in the root microbiome samples from healthy rice and wheat.Furthermore,using HA-QAP we found that an increase in total microbial load represents a key feature of changes in root microbiome of rice plants exposed to drought stress and of wheat plants with root rot disease,which significantly influences patterns of differential taxa and species interaction networks.Given its accuracy and technical feasibility,HA-QAP would facilitate our understanding of genuine interactions between root microbiome and plants. 展开更多
关键词 microbial load host-associated quantitative abundance profiling root microbiome
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Effects of dairy bioactive peptides and lotus seeds/lily bulb powder on flavor and quality characteristics of goat milk yogurt 被引量:1
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作者 Xinqi Zhao Ming Cheng +2 位作者 Cunfang Wang Hua Jiang xiaoning zhang 《Food Bioscience》 SCIE 2022年第3期442-449,共8页
The objective of this study was to evaluate the changes on flavor and quality characteristics of goat yogurt during storage with the addition of dairy bioactive peptides and a mixture of lotus seed and lily bulb powde... The objective of this study was to evaluate the changes on flavor and quality characteristics of goat yogurt during storage with the addition of dairy bioactive peptides and a mixture of lotus seed and lily bulb powder.Both the addition of dairy bioactive peptides and lotus seeds/lily bulb powder resulted in a fermentation time reduction,water holding capacity(WHC)improvement,and inhibition of post-acidification of goat yogurt during storage.A total of 50 volatile flavor components were detected in the goat milk yogurt samples,and the addition of the above two supplements were shown to be effective in improving the flavor and the textural properties of the goat milk yogurt during storage.The group added with lotus seeds/lily bulb powder showed the best WHC and textural properties,followed by the group added with dairy bioactive peptides alone and the group with both added.The addition of both supplements was found to be useful in making up for the two defects of goat yogurt,prolonged fermentation and soft curds.Therefore,dairy bioactive peptides and lotus seeds/lily bulb powder are recommended to be added to goat yogurt as nutritional supplements. 展开更多
关键词 Lotus seeds/lily bulb powder Dairy bioactive peptides Goat yogurt GC-IMS Texture properties
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