A novel generation of oxazole vlide and interception with sulfonamide have been well developed to construct fully substituted amidines. This copper-catalyzed four-component reaction incorporates two diazo molecules to...A novel generation of oxazole vlide and interception with sulfonamide have been well developed to construct fully substituted amidines. This copper-catalyzed four-component reaction incorporates two diazo molecules to target amidines and shows broad substrate scope, excellent functional groups tolerance and good to excellent yields.展开更多
This work developed an unprecedented strategy for the acetylation of alcohols and amines using diacetyl as both an acylation reagent and a photosensitizer.This environmentally friendly process exhibits excellent funct...This work developed an unprecedented strategy for the acetylation of alcohols and amines using diacetyl as both an acylation reagent and a photosensitizer.This environmentally friendly process exhibits excellent functional group tolerance,a wide substrate scope,operational simplicity and no need for the use of exogenous dehydrating reagents,activating reagents or photocatalysts.The potential application of this strategy to pharmaceutical chemistry was demonstrated by the late-stage modification of various drug molecules,and the process was found to be readily scalable without any loss of efficiency.Preliminary mechanistic results showed that the in situ generation of peracetic acid is responsible for the facile acylation of structurally diverse alcohols and amines using this technique.展开更多
文摘A novel generation of oxazole vlide and interception with sulfonamide have been well developed to construct fully substituted amidines. This copper-catalyzed four-component reaction incorporates two diazo molecules to target amidines and shows broad substrate scope, excellent functional groups tolerance and good to excellent yields.
基金funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)NSFC(grant numbers 21971175 and 21572148).
文摘This work developed an unprecedented strategy for the acetylation of alcohols and amines using diacetyl as both an acylation reagent and a photosensitizer.This environmentally friendly process exhibits excellent functional group tolerance,a wide substrate scope,operational simplicity and no need for the use of exogenous dehydrating reagents,activating reagents or photocatalysts.The potential application of this strategy to pharmaceutical chemistry was demonstrated by the late-stage modification of various drug molecules,and the process was found to be readily scalable without any loss of efficiency.Preliminary mechanistic results showed that the in situ generation of peracetic acid is responsible for the facile acylation of structurally diverse alcohols and amines using this technique.
