Objective:The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy(PHx)are not entirely known,but bile acids(BAs)and fibroblast growth factor 15(Fgf15)that are highly expressed i...Objective:The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy(PHx)are not entirely known,but bile acids(BAs)and fibroblast growth factor 15(Fgf15)that are highly expressed in the mouse ileum could promote hepatocyte proliferation.Fgf15 strongly suppresses the synthesis of BAs,and emerging evidence indicates that Fgf15 is important for liver regeneration.展开更多
The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. ...The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve safety of drug therapy.展开更多
The developments of a series of wheel or CADF contact functions are briefly described. profile computer aided methods based on the RRDF Since 2001 the implementations of these methods are carded out according to diffe...The developments of a series of wheel or CADF contact functions are briefly described. profile computer aided methods based on the RRDF Since 2001 the implementations of these methods are carded out according to different requirements for tramway vehicles, metro vehicles, and main line EMU vehicles etc. It is found that the main advantage of these new methods in wheel profile design is obtaining the proper wheel profiles to efficiently reduce the wears of wheel and rail and to improve the performances of both stability and curving performances. Moreover, post process of transfering a profile with discrete points to a profile with arc and line combinations is studied with a high precision.展开更多
文摘Objective:The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy(PHx)are not entirely known,but bile acids(BAs)and fibroblast growth factor 15(Fgf15)that are highly expressed in the mouse ileum could promote hepatocyte proliferation.Fgf15 strongly suppresses the synthesis of BAs,and emerging evidence indicates that Fgf15 is important for liver regeneration.
基金supported by the National Institute of Health,National Institute of General Medical Sciences (No.R01GM087376)National Institute of Health,National Institute for Environmental Health Sciences (No.R01ES-019487)
文摘The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications that do not involve changes in DNA sequence. Examples of such modifications include DNA methylation, histone modifications, and non-coding RNAs. This review examines the widespread effect of epigenetic regulations on genes involved in drug metabolism, and also suggests a network perspective of epigenetic regulation. The epigenetic mechanisms have important clinical implications and may provide insights into effective drug development and improve safety of drug therapy.
基金support provided by National Key Technology R&D Program(No.2007BAG02A04)
文摘The developments of a series of wheel or CADF contact functions are briefly described. profile computer aided methods based on the RRDF Since 2001 the implementations of these methods are carded out according to different requirements for tramway vehicles, metro vehicles, and main line EMU vehicles etc. It is found that the main advantage of these new methods in wheel profile design is obtaining the proper wheel profiles to efficiently reduce the wears of wheel and rail and to improve the performances of both stability and curving performances. Moreover, post process of transfering a profile with discrete points to a profile with arc and line combinations is studied with a high precision.
