The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite

The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.

Design,Fabrication and Assembly of the Solar Upper Transition Region Imager(SUTRI)

The Solar Upper Transition Region Imager(SUTRI)focuses on the solar transition region to achieve dynamic imaging observation of the upper transition region.In this paper,we report the optical system design,mechanical design,ultrasmooth mirror manufacture and measurement,EUV multilayer film coating,prelaunch installation and calibration for the SUTRI payload at IPOE,Tongji University.Finally,the SUTRI carried by the SATech-01 satellite was successfully set to launch.All functions of this telescope were normal,and the observation results obtained in orbit were consistent with the design.

一例PYGM基因复合杂合突变导致糖原累积症Ⅴ型的诊断和基因检测分析

糖原累积症Ⅴ型是一种由肌糖原磷酸化酶(muscle glycogen phosphorylase,PYGM)缺陷引起的常染色体隐性遗传疾病,其临床特征为运动不耐受、再振作现象和血清肌酸激酶水平增高。本文报道了1例中国糖原累积症Ⅴ型年轻男性患者,运动后双下肢无力、血肌酸激酶升高、肌肉磁共振可见下肢近端后群肌轻度脂肪浸润,基因检测结果显示先证者具有复合杂合型PYGM致病突变,分别为来自母亲的c.308T>C (p.L103P)变异和来自父亲的c.260_261delCT (p.S87Ffs*23)变异,其中前者为新发突变。本研究丰富了PYGM致病基因突变谱,有助于提高临床医生对糖原累积症Ⅴ型的认识,并为该疾病的进一步遗传学研究提供参考。

Effect of Decanoic Acid on the Cognitive Function of AD Mice

[Objectives] To study the effect of PPARγ agonist DA on the cognitive function of AD mice as well as the mechanism.[Methods]50 Kunming male mice were randomly divided into normal control group,model group and decanoic acid administration group,the AD mice model was established by subcutaneous injection of D-galactose for 8 weeks,and the treatment group was administered orally with different doses of decanoic acid( low dose of 50 mg/kg,middle dose of 100 mg/kg,high dose of 200 mg/kg). After 8 weeks,the Morris water maze was used to detect the learning and memory capability of mice; HE staining was used to observe the morphological change of hippocampal cells in brain tissue; Western-blot and immunohistochemistry technique were used to detect the expression of PPARγ and Aβ42 protein in brain tissue; the ELISA method was used for the determination of TNF-α and i NOS level in serum. [Results]Morris water maze results showed that DA could significantly improve the learning and memory function in AD mice( P < 0. 05); HE staining showed that DA could significantly reduce degeneration in hippocampal cells; Western-blot and immunohistochemistry results showed that DA could promote the expression of PPARγ and reduce the expression of Aβ42 in brain tissue( P < 0. 05); ELISA results showed that the TNF-α,i NOS levels decreased in AD mice serum after DA treatment( P < 0. 05). [Conclusions] DA could significantly improve the cognitive function of AD mice,improve the degeneration of hippocampal cells in brain tissue,and decrease the expression of Aβ42 in brain tissue. The mechanism might be related to activation of PPARγ protein and down-regulation of expression of relevant inflammatory factors.

A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host ranges.The need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference colonies.While morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two species.Additionally,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between B.neohumeralis and B.tryoni;therefore,ambiguous samples remain undiagnosed.Here we report the first molecular marker that can consistently distinguish between B.tryoni and B.neohumeralis.Our diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene region.We confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the species.The assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in B.tryoni and the other targeting adjacent SNPs present in B.neohumeralis(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly species.Therefore,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

Outcome of bariatric surgery in patients with unexpected liver cirrhosis: A multicenter study from China

Background and aims Liver cirrhosis is a complex disease that may result in increased morbidity and mortality following bariatric surgery(BS).This study aimed to explore the outcome of BS in patients with unexpected cirrhosis,focusing on postoperative complications and the progression of liver disease.Methods A retrospective study of bariatric patients with cirrhosis from four centers in China between 2016 and 2023 was conducted,with follow-up for one year after BS.The primary outcome was the safety of BS in patients with unexpected cirrhosis,while the secondary outcome was the metabolic efficacy of BS in this group postoperatively.Results A total of 47 patients met the study criteria,including 46 cases of Child-Pugh class A cirrhosis and 1 case of Child-Pugh B.Pathological examination confirmed nodular cirrhosis in 21 patients(44.68%),pseudolobule formation in 1 patient(2.13%),lipedema degeneration with inflammatory cell infiltration in 3 patients(6.38%),and chronic hepatitis in 1 patient(2.13%).The average percentage of total weight loss was 29.73±6.53%at one year postoperatively.During the 30-day postoperative period,the complication rate was 6.38%,which included portal vein thrombosis,gastrointestinal bleeding,and intra-abdominal infection.Moreover,no cases of liver decompensation or mortality were reported during the follow-up period.The remission rates of comorbidities among 41 patients one year after surgery were as follows:dyslipidemia 100%,type 2 diabetes 82.61%,hypertension 84.62%,and obstructive sleep apnea syndrome 85.71%.Conclusions BS can be safely performed in patients with unexpected cirrhosis in the compensated stage of liver disease,with low postoperative morbidity and no mortality observed during one-year follow-up.

像差对空间激光通信系统发射光束远场分布的影响

基于菲涅耳标量衍射理论,推导了离焦状态下激光发射系统远场光斑分布的解析式,提出了一种基于相似度系数的采样间隔寻优法。用最佳采样间隔得到的数值仿真结果与解析计算结果的偏差小于0.04%。采用傅里叶变换法仿真了存在像差时的远场光斑分布情况,并分析了角位移、发散角、增益等关键参数对光场分布的影响。当激光波长为λ、指向允许偏差为3μrad、中心增益裕量为3 dB时,基于公差分配理论得到离焦、倾斜、球差、慧差、像散的容差需分别小于等于0.36λ、0.07λ、0.43λ、0.13λ、0.5λ。

Receptivity and structural sensitivity study of the wide vaneless diffuser flow with adjoint method

The stability of the flow in the vaneless diffuser of a centrifugal compressor is studied with the linear theory. The characteristics of direct and adjoint perturbation modes are investigated,and the receptivity of the instability mode to momentum forcing or mass injection is identified based on the adjoint modes. Analysis shows that the perturbation with the largest amplitude is located at the outlet of the vaneless diffuser, while the highest-receptivity region is located in the middle of the vaneless diffuser along the radial direction. The large difference between the direct and adjoint modes indicates that the instability mechanism cannot be identified from a study of either eigenmode separately. Therefore, the structural sensitivity analysis is adopted to study the feedback of the instability mode. The structural sensitivity of the eigenvalue which is proportional to the perturbation pressure and velocity is used to explain the mechanism of flow control for the vaneless diffuser.