Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the prin...Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the principle of“common but differentiated responsibilities”to facilitate a comprehensive,balanced,and effective implementation of the key elements of the Paris Agreement,such as adaptation,mitigation,finance,technology,capacity building,and transparency;how to uphold and maintain the status of China and other emerging countries as developing countries in light of the requirements of the United Nations Framework Convention on Climate Change and the historical responsibilities of these countries;and how to assess the goal of limiting the global temperature increase to 1.5℃and what constitutes an equitable carbon mitigation pathway for different types of countries.Developed countries and developing countries have drastically diverging views on carbon border adjustment measures for trade with developing countries proposed by several developed countries such as the European Union.Developed countries have demonstrated obvious intentions and actions designed to weaken and neglect the principle of“common but differentiated responsibilities”,to impose mitigation pressure on developing countries,to shift the responsibilities for emissions onto others,and to pass on the costs of mitigation.The maneuvering among different types of countries and interest groups has become increasingly intense.In response,China must maintain its strategic focus,adhere to the goals and principles established by the Paris Agreement,stick to its strategic positioning as a developing country,solidify strategic support from the developing world,and safeguard the legitimate rights and interests of developing countries.China played a conducive role in facilitating the Paris Agreement and has become an active participant,contributor,and leader in global climate governance.China must continue to follow Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and its conception of ecological civilization and the concept of building a community of common destiny,to actively lead the cooperation process in the construction of a global climate governance system characterized by equity,justice,and win-win collaborations,and to promote compliance with the Paris Agreement.At the same time,China should accelerate the green,low-carbon,circular transformation of its economy;accelerate the coordinated governance of the economy,environment,and climate change;and formulate and implement a long-term low-carbon development strategy.By the middle of the 21st century,while achieving the goal of building a great modern socialist country,China can also achieve a deep decarbonization development path that is in line with the goal of limiting the global temperature increase to well below 2°C and pursuing efforts to limit the increase to 1.5℃.展开更多
Light is a powerful environmental factor influencing diverse brain functions.Clinical evidence supports the beneficial effect of light therapy on several diseases,including depression,cognitive dysfunction,chronic pai...Light is a powerful environmental factor influencing diverse brain functions.Clinical evidence supports the beneficial effect of light therapy on several diseases,including depression,cognitive dysfunction,chronic pain,and sleep disorders.However,the precise mechanisms underlying the effects of light therapy are still not well understood.In this review,we critically evaluate current clinical evidence showing the beneficial effects of light therapy on diseases.In addition,we introduce the research progress regarding the neural circuit mechanisms underlying the modulatory effects of light on brain functions,including mood,memory,pain perception,sleep,circadian rhythm,brain development,and metabolism.展开更多
Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"...Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"1+N"policy framework has been built to guide the implementations.Scientific and technological innovation has been emphasized as one of the key strategies to establish an innovation system,strengthen research,and promote applications of green and low-carbon technologies[1].Despite numerous studies and policies on decarbonization technologies,studies focusing on technological development pathways for China’s carbon neutrality are needed[2].展开更多
Background Future distribution of dengue risk is usually predicted based on predicted climate changes using general circulation models(GCMs).However,it is difficult to validate the GCM results and assess the uncertain...Background Future distribution of dengue risk is usually predicted based on predicted climate changes using general circulation models(GCMs).However,it is difficult to validate the GCM results and assess the uncertainty of the predictions.The observed changes in climate may be very different from the GCM results.We aim to utilize trends in observed climate dynamics to predict future risks of Aedes albopictus in China.Methods We collected Ae.albopictus surveillance data and observed climate records from 80 meteorological stations from 1970 to 2021.We analyzed the trends in climate change in China and made predictions on future climate for the years 2050 and 2080 based on trend analyses.We analyzed the relationship between climatic variables and the prevalence of Ae.albopictus in different months/seasons.We built a classification tree model(based on the average of 999 runs of classification and regression tree analyses)to predict the monthly/seasonal Ae.albopictus distribution based on the average climate from 1970 to 2000 and assessed the contributions of different climatic variables to the Ae.albopictus distribution.Using these models,we projected the future distributions of Ae.albopictus for 2050 and 2080.Results The study included Ae.albopictus surveillance from 259 sites in China found that winter to early spring(November–February)temperatures were strongly correlated with Ae.albopictus prevalence(prediction accuracy ranges 93.0–98.8%)—the higher the temperature the higher the prevalence,while precipitation in summer(June–September)was important predictor for Ae.albopictus prevalence.The machine learning tree models predicted the current prevalence of Ae.albopictus with high levels of agreement(accuracy>90%and Kappa agreement>80%for all 12 months).Overall,winter temperature contributed the most to Ae.albopictus distribution,followed by summer precipitation.An increase in temperature was observed from 1970 to 2021 in most places in China,and annual change rates varied substantially from-0.22℃/year to 0.58℃/year among sites,with the largest increase in temperature occurring from February to April(an annual increase of 1.4–4.7℃ in monthly mean,0.6–4.0℃ in monthly minimum,and 1.3–4.3℃ in monthly maximum temperature)and the smallest in November and December.Temperature increases were lower in the tropics/subtropics(1.5–2.3℃ from February–April)compared to the high-latitude areas(2.6–4.6℃ from February–April).The projected temperatures in 2050 and 2080 by this study were approximately 1–1.5℃ higher than those projected by GCMs.The estimated current Ae.albopictus risk distribution had a northern boundary of north-central China and the southern edge of northeastern China,with a risk period of June–September.The projected future Ae.albopictus risks in 2050 and 2080 cover nearly all of China,with an expanded risk period of April–October.The current at-risk population was estimated to be 960 million and the future at-risk population was projected to be 1.2 billion.Conclusions The magnitude of climate change in China is likely to surpass GCM predictions.Future dengue risks will expand to cover nearly all of China if current climate trends continue.展开更多
Tear film hyperosmolarity plays a core role in the development of dry eye disease(DED)by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium.In this study,th...Tear film hyperosmolarity plays a core role in the development of dry eye disease(DED)by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium.In this study,the mechanisms involving the hyperosmolar microenvironment,glycolysis mediating metabolic reprogramming,and pyroptosis were explored clinically,in vitro,and in vivo.Data from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genes,including PKM2 and GSDMD,was significantly upregulated and that the secretion of IL-1βsignificantly increased.In vitro,the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells(HCECs)was used to discuss the interaction among cells.The hyperosmolar environment was found to greatly induce HCECs’metabolic reprogramming,which may be the primary cause of the subsequent inflammation in macrophages upon the activation of the related gene and protein expression.2-Deoxy-d-glucose(2-DG)could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosis of macrophages.In vivo,2-DG showed potential efficacy in relieving DED activity and could significantly reduce the overexpression of genes and proteins related to glycolysis and pyroptosis.In summary,our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis.展开更多
The yak(Bos grunniens),an indigenous herbivore raised at altitudes between 3,000 and 5,000 m above sea level,is closely linked to more than 40 ethnic communities and plays a vital role in the ecological stability,live...The yak(Bos grunniens),an indigenous herbivore raised at altitudes between 3,000 and 5,000 m above sea level,is closely linked to more than 40 ethnic communities and plays a vital role in the ecological stability,livelihood security,socio-economic development,and ethnic cultural traditions in the Asian highlands.They provide the highlanders with meat,milk,fibres,leather and dung(fuel).They are also used as pack animals to transport goods,for travel and ploughing,and are important in many religious and traditional ceremonies.The Asian highlands are known for an extremely,harsh environment,namely low air temperature and oxygen content and high ultraviolet light and winds.Pasture availability fluctuates greatly,with sparse pasture of poor quality over the long seven-month cold winter.After longterm natural and artificial selections,yaks have adapted excellently to the harsh conditions:1)by genomics,with positively selected genes involved in hypoxia response and energy metabolism;2)anatomically,including a short tongue with a weak sense of taste,and large lung and heart;3)physiologically,by insensitivity to hypoxic pulmonary vasoconstriction,maintaining foetal haemoglobin throughout life,and low heart rate and heat production in the cold season;4)behaviourlly,by efficient grazing and selecting forbs with high nutritional contents;5)by low nitrogen and energy requirements for maintenance and low methane emission and nitrogen excretion,namely,‘Low-Carbon’and‘Nitrogen-Saving’traits;6)by harboring unique rumen microbiota with a distinct maturation pattern,that has coevolved with host metabolism.This review aims to provide an overview of the comprehensive adaptive strategies of the yak to the severe conditions of the highlands.A better understanding of these strategies that yaks employ to adapt to the harsh environment could be used in improving their production,breeding and management,and gaining benefits in ecosystem service and a more resilient livelihood to climate change in the Asian highlands.展开更多
Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly e...Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly encapsulated in the interlayer space of DLHCs with a high loading of 75% （weight percentage） and serves as the active component for lithium storage. The presence of Se in the composite and the carbon framework not only alleviate the shuttling of polysulfide, but also improve the conductivity of electrodes. Migration of active materials from the interlayer void to the hollow cavity of DLHCs after cycling, which further mitigates the loss of active materials and the shuttle effect, is observed. As a result, the SeS2/DLHC composite delivers a high specific capacity （930 mA.h.g-1 at 0.2 C） and outstanding rate capability （400 mA.h.g-1 at 6 C）, which is much better than those of SeS2/single-layered hollow carbon sphere, Se/DLHC, and S/DLHC composites. Notably, the SeS2/DLHC composite shows an ultralong cycle life with 89% capacity retention over 900 cycles at 1 C, or only 0.012% capacity decay per cycle. Our study reveals that both SeS2 and the double-layered structures are responsible for the excellent electrochemical performance.展开更多
The thermal environment and thermal comfort of a building are greatly affected by the desig n of the build ing interface form. Most con temporary architectural designs con sider only the relations between architectura...The thermal environment and thermal comfort of a building are greatly affected by the desig n of the build ing interface form. Most con temporary architectural designs con sider only the relations between architectural form and architectural beauty. Few studies on the correlati on of architectural form and thermal comfort address the in flue nee of architectural form on thermal comfort and thermal environment. These studies are particularly important for gymnasium architectures located in hot and humid areas, which have high requirements for thermal comfort. This paper presents an experimental investigati on and an an alysis of the effect of the building in terface form of gymnasiums on thermal comfort in hot and humid subtropical regions during summer. Results showed that the influence of the top interface forms on thermal comfort is mainly dominated by the mea n radiant temperature, which could be con trolled to improve thermal comfort. The in fluence of side interface forms on thermal comfort is mainly domi nated by air velocity, and thermal comfort could be improved by promoting natural ventilation on the side interface form design to reduce indoor heat. This research enhanced our understanding of the relation between the in terface form and the thermal comfort of gymnasiums. In addition, this paper provides a theoretical reference for the sustainable design of gymnasiums in hot and humid climates.展开更多
The rational design of nano-carriers is critical for modem enzyme immobilization for advanced biocatalysis. Herein, we report the synthesis of octadecylalkyl- modified mesoporous-silica nanoparticles （C18-MSNs） with...The rational design of nano-carriers is critical for modem enzyme immobilization for advanced biocatalysis. Herein, we report the synthesis of octadecylalkyl- modified mesoporous-silica nanoparticles （C18-MSNs） with a high C18 content （-19 wt.%） and tunable pore sizes （1.6--13 nm）. It is demonstrated that the increased hydrophobic content and a tailored pore size （slightly larger than the size of lipase） are responsible for the high performance of immobilized lipase. The optimized C18-MSNs exhibit a loading capacity of 711 mg/g and a specific activity 5.23 times higher than that of the free enzyme. Additionally, 93% of the initial activity is retained after reuse five times, which is better than the best performance reported to date. Our findings pave the way for the robust immobilization of lipase for biocatalytic applications.展开更多
Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbi...Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbic dopamine system,and then progresses to other cortical regions[1,2].展开更多
The effects of the diameter of SiO2 nanopillars,the diameter of Ag nanospheres,the arrays’period,and the medium environment on the plasmonic lattice resonance(PLR)formed by Ag nanospheres on SiO2 nanopillar arrays ar...The effects of the diameter of SiO2 nanopillars,the diameter of Ag nanospheres,the arrays’period,and the medium environment on the plasmonic lattice resonance(PLR)formed by Ag nanospheres on SiO2 nanopillar arrays are systematically investigated.Larger diameters of SiO2 nanopillars with other parameters kept constant will widen the PLR peak,redshift the PLR wavelength,and weaken the PLR intensity.Larger diameters of Ag nanospheres with other parameters kept constant will widen the PLR peak,redshift the PLR wavelength,and strengthen the PLR intensity.Larger array periods or larger refractive index of medium environment corresponds to larger PLR wavelengths.展开更多
This article reports a study on the China-Canada-United States English Immersion(CCUEI)Moral Education and Social Studies(MESS)curriculum materials for elementary classes(Grades 3-6)with the aim of learning how the cu...This article reports a study on the China-Canada-United States English Immersion(CCUEI)Moral Education and Social Studies(MESS)curriculum materials for elementary classes(Grades 3-6)with the aim of learning how the curriculum addressed the dual goals of MESS content and English language learning.An analysis comparing the CCUEI third grade MESS textbook with an equivalent level Chinese textbook demonstrates how China’s national standards in MESS and English education can be met,and drawbacks encountered in the process.The CCUEI textbook was found to embrace grade level MESS content standards,but showed a varied degree of depth of content across standards.The textbook addressed all of the general goals of Level One English language learning(Grades 3-4)and most of the language skills indicators(16 out of 20).An additional in-depth teacher survey provided a user’s perspective on MESS materials.The teachers rated the textbook highly for its activity-centered format and knowledge-rich content.They emphasized the importance of teaching English language as preparation for the MESS content teaching,and asked for more systematic support in language teaching from curriculum materials.展开更多
基金This research was supported by the Ministry of Science and Technology of the People’s Republic of China[Grant number.2018YFC 1509001]the National Natural Science Foundation of China[Grant number.72174105]by Tsinghua University-INDITEX Sustainable Development Fund[Grant number.TISD201909].
文摘Presently,the full implementation of the negotiations and collaborations under the Paris Agreement faces new key problems and severe challenges.These problems and challenges include the following:how to honor the principle of“common but differentiated responsibilities”to facilitate a comprehensive,balanced,and effective implementation of the key elements of the Paris Agreement,such as adaptation,mitigation,finance,technology,capacity building,and transparency;how to uphold and maintain the status of China and other emerging countries as developing countries in light of the requirements of the United Nations Framework Convention on Climate Change and the historical responsibilities of these countries;and how to assess the goal of limiting the global temperature increase to 1.5℃and what constitutes an equitable carbon mitigation pathway for different types of countries.Developed countries and developing countries have drastically diverging views on carbon border adjustment measures for trade with developing countries proposed by several developed countries such as the European Union.Developed countries have demonstrated obvious intentions and actions designed to weaken and neglect the principle of“common but differentiated responsibilities”,to impose mitigation pressure on developing countries,to shift the responsibilities for emissions onto others,and to pass on the costs of mitigation.The maneuvering among different types of countries and interest groups has become increasingly intense.In response,China must maintain its strategic focus,adhere to the goals and principles established by the Paris Agreement,stick to its strategic positioning as a developing country,solidify strategic support from the developing world,and safeguard the legitimate rights and interests of developing countries.China played a conducive role in facilitating the Paris Agreement and has become an active participant,contributor,and leader in global climate governance.China must continue to follow Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era and its conception of ecological civilization and the concept of building a community of common destiny,to actively lead the cooperation process in the construction of a global climate governance system characterized by equity,justice,and win-win collaborations,and to promote compliance with the Paris Agreement.At the same time,China should accelerate the green,low-carbon,circular transformation of its economy;accelerate the coordinated governance of the economy,environment,and climate change;and formulate and implement a long-term low-carbon development strategy.By the middle of the 21st century,while achieving the goal of building a great modern socialist country,China can also achieve a deep decarbonization development path that is in line with the goal of limiting the global temperature increase to well below 2°C and pursuing efforts to limit the increase to 1.5℃.
基金supported by grants from the National Natural Science Foundation of China(32171010 and 32100820)STI2030-Major Projects(2021ZD0203100)the Guangdong Basic and Applied Basic Research Foundation(2023B1515040010).
文摘Light is a powerful environmental factor influencing diverse brain functions.Clinical evidence supports the beneficial effect of light therapy on several diseases,including depression,cognitive dysfunction,chronic pain,and sleep disorders.However,the precise mechanisms underlying the effects of light therapy are still not well understood.In this review,we critically evaluate current clinical evidence showing the beneficial effects of light therapy on diseases.In addition,we introduce the research progress regarding the neural circuit mechanisms underlying the modulatory effects of light on brain functions,including mood,memory,pain perception,sleep,circadian rhythm,brain development,and metabolism.
基金support on data research and technological deployment provided by the Administrative Centre for China’s Agenda 21,Ministry of Science and Technology of the People’s Republic of Chinathe funding provided by the National Natural Science Foundation of China(72140005 and 51621003)。
文摘Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement.China has pledged to peak CO_(2) emissions before 2030 and achieve carbon neutrality before 2060,and a"1+N"policy framework has been built to guide the implementations.Scientific and technological innovation has been emphasized as one of the key strategies to establish an innovation system,strengthen research,and promote applications of green and low-carbon technologies[1].Despite numerous studies and policies on decarbonization technologies,studies focusing on technological development pathways for China’s carbon neutrality are needed[2].
文摘Background Future distribution of dengue risk is usually predicted based on predicted climate changes using general circulation models(GCMs).However,it is difficult to validate the GCM results and assess the uncertainty of the predictions.The observed changes in climate may be very different from the GCM results.We aim to utilize trends in observed climate dynamics to predict future risks of Aedes albopictus in China.Methods We collected Ae.albopictus surveillance data and observed climate records from 80 meteorological stations from 1970 to 2021.We analyzed the trends in climate change in China and made predictions on future climate for the years 2050 and 2080 based on trend analyses.We analyzed the relationship between climatic variables and the prevalence of Ae.albopictus in different months/seasons.We built a classification tree model(based on the average of 999 runs of classification and regression tree analyses)to predict the monthly/seasonal Ae.albopictus distribution based on the average climate from 1970 to 2000 and assessed the contributions of different climatic variables to the Ae.albopictus distribution.Using these models,we projected the future distributions of Ae.albopictus for 2050 and 2080.Results The study included Ae.albopictus surveillance from 259 sites in China found that winter to early spring(November–February)temperatures were strongly correlated with Ae.albopictus prevalence(prediction accuracy ranges 93.0–98.8%)—the higher the temperature the higher the prevalence,while precipitation in summer(June–September)was important predictor for Ae.albopictus prevalence.The machine learning tree models predicted the current prevalence of Ae.albopictus with high levels of agreement(accuracy>90%and Kappa agreement>80%for all 12 months).Overall,winter temperature contributed the most to Ae.albopictus distribution,followed by summer precipitation.An increase in temperature was observed from 1970 to 2021 in most places in China,and annual change rates varied substantially from-0.22℃/year to 0.58℃/year among sites,with the largest increase in temperature occurring from February to April(an annual increase of 1.4–4.7℃ in monthly mean,0.6–4.0℃ in monthly minimum,and 1.3–4.3℃ in monthly maximum temperature)and the smallest in November and December.Temperature increases were lower in the tropics/subtropics(1.5–2.3℃ from February–April)compared to the high-latitude areas(2.6–4.6℃ from February–April).The projected temperatures in 2050 and 2080 by this study were approximately 1–1.5℃ higher than those projected by GCMs.The estimated current Ae.albopictus risk distribution had a northern boundary of north-central China and the southern edge of northeastern China,with a risk period of June–September.The projected future Ae.albopictus risks in 2050 and 2080 cover nearly all of China,with an expanded risk period of April–October.The current at-risk population was estimated to be 960 million and the future at-risk population was projected to be 1.2 billion.Conclusions The magnitude of climate change in China is likely to surpass GCM predictions.Future dengue risks will expand to cover nearly all of China if current climate trends continue.
基金supported by the National Natural Science Foundation of China(Nos.81870624 and 82171013)Major Science and Technology Projects of Zhejiang Province(No.2022C03173).
文摘Tear film hyperosmolarity plays a core role in the development of dry eye disease(DED)by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epithelium.In this study,the mechanisms involving the hyperosmolar microenvironment,glycolysis mediating metabolic reprogramming,and pyroptosis were explored clinically,in vitro,and in vivo.Data from DED clinical samples indicated that the expression of glycolysis and pyroptosis-related genes,including PKM2 and GSDMD,was significantly upregulated and that the secretion of IL-1βsignificantly increased.In vitro,the indirect coculture of macrophages derived from THP-1 and human corneal epithelial cells(HCECs)was used to discuss the interaction among cells.The hyperosmolar environment was found to greatly induce HCECs’metabolic reprogramming,which may be the primary cause of the subsequent inflammation in macrophages upon the activation of the related gene and protein expression.2-Deoxy-d-glucose(2-DG)could inhibit the glycolysis of HCECs and subsequently suppress the pyroptosis of macrophages.In vivo,2-DG showed potential efficacy in relieving DED activity and could significantly reduce the overexpression of genes and proteins related to glycolysis and pyroptosis.In summary,our findings suggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation by mediating pyroptosis.
基金supported by the STI2030-Major Projects(2021ZD0203100)the National Natural Science Foundation of China(31922030,32171010,31771170,31900720,and 32171009)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(2023B1515040010,2021B1515020035,2019A1515011598,and 2023A1515010478)the Science and Technology Program of Guangdong(2018B030334001)the Science and Technology Program of Guangzhou(202007030012)the Programme of Introducing Talents of Discipline to Universities(B14036).
基金the National Natural Science Foundation of China(32072757 and U21A20250).
文摘The yak(Bos grunniens),an indigenous herbivore raised at altitudes between 3,000 and 5,000 m above sea level,is closely linked to more than 40 ethnic communities and plays a vital role in the ecological stability,livelihood security,socio-economic development,and ethnic cultural traditions in the Asian highlands.They provide the highlanders with meat,milk,fibres,leather and dung(fuel).They are also used as pack animals to transport goods,for travel and ploughing,and are important in many religious and traditional ceremonies.The Asian highlands are known for an extremely,harsh environment,namely low air temperature and oxygen content and high ultraviolet light and winds.Pasture availability fluctuates greatly,with sparse pasture of poor quality over the long seven-month cold winter.After longterm natural and artificial selections,yaks have adapted excellently to the harsh conditions:1)by genomics,with positively selected genes involved in hypoxia response and energy metabolism;2)anatomically,including a short tongue with a weak sense of taste,and large lung and heart;3)physiologically,by insensitivity to hypoxic pulmonary vasoconstriction,maintaining foetal haemoglobin throughout life,and low heart rate and heat production in the cold season;4)behaviourlly,by efficient grazing and selecting forbs with high nutritional contents;5)by low nitrogen and energy requirements for maintenance and low methane emission and nitrogen excretion,namely,‘Low-Carbon’and‘Nitrogen-Saving’traits;6)by harboring unique rumen microbiota with a distinct maturation pattern,that has coevolved with host metabolism.This review aims to provide an overview of the comprehensive adaptive strategies of the yak to the severe conditions of the highlands.A better understanding of these strategies that yaks employ to adapt to the harsh environment could be used in improving their production,breeding and management,and gaining benefits in ecosystem service and a more resilient livelihood to climate change in the Asian highlands.
基金The authors acknowledge the financial support from the Australian Research Council, the Queensland Government, the CAS/SAFEA International Partnership Program for Creative Research Teams, the Australian National Fabrication Facility and the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland. L. Z. acknowledges the financial support from the National Natural Science Foundation of China （No. 51502226）.
文摘Selenium sulfide/double-layered hollow carbon sphere （SeS2/DLHC） composites have been designed as high-performance cathode materials for novel Li-SeS2 batteries. In the constructed composite, SeS2 is predominantly encapsulated in the interlayer space of DLHCs with a high loading of 75% （weight percentage） and serves as the active component for lithium storage. The presence of Se in the composite and the carbon framework not only alleviate the shuttling of polysulfide, but also improve the conductivity of electrodes. Migration of active materials from the interlayer void to the hollow cavity of DLHCs after cycling, which further mitigates the loss of active materials and the shuttle effect, is observed. As a result, the SeS2/DLHC composite delivers a high specific capacity （930 mA.h.g-1 at 0.2 C） and outstanding rate capability （400 mA.h.g-1 at 6 C）, which is much better than those of SeS2/single-layered hollow carbon sphere, Se/DLHC, and S/DLHC composites. Notably, the SeS2/DLHC composite shows an ultralong cycle life with 89% capacity retention over 900 cycles at 1 C, or only 0.012% capacity decay per cycle. Our study reveals that both SeS2 and the double-layered structures are responsible for the excellent electrochemical performance.
文摘The thermal environment and thermal comfort of a building are greatly affected by the desig n of the build ing interface form. Most con temporary architectural designs con sider only the relations between architectural form and architectural beauty. Few studies on the correlati on of architectural form and thermal comfort address the in flue nee of architectural form on thermal comfort and thermal environment. These studies are particularly important for gymnasium architectures located in hot and humid areas, which have high requirements for thermal comfort. This paper presents an experimental investigati on and an an alysis of the effect of the building in terface form of gymnasiums on thermal comfort in hot and humid subtropical regions during summer. Results showed that the influence of the top interface forms on thermal comfort is mainly dominated by the mea n radiant temperature, which could be con trolled to improve thermal comfort. The in fluence of side interface forms on thermal comfort is mainly domi nated by air velocity, and thermal comfort could be improved by promoting natural ventilation on the side interface form design to reduce indoor heat. This research enhanced our understanding of the relation between the in terface form and the thermal comfort of gymnasiums. In addition, this paper provides a theoretical reference for the sustainable design of gymnasiums in hot and humid climates.
文摘The rational design of nano-carriers is critical for modem enzyme immobilization for advanced biocatalysis. Herein, we report the synthesis of octadecylalkyl- modified mesoporous-silica nanoparticles （C18-MSNs） with a high C18 content （-19 wt.%） and tunable pore sizes （1.6--13 nm）. It is demonstrated that the increased hydrophobic content and a tailored pore size （slightly larger than the size of lipase） are responsible for the high performance of immobilized lipase. The optimized C18-MSNs exhibit a loading capacity of 711 mg/g and a specific activity 5.23 times higher than that of the free enzyme. Additionally, 93% of the initial activity is retained after reuse five times, which is better than the best performance reported to date. Our findings pave the way for the robust immobilization of lipase for biocatalytic applications.
基金supported by grants from the Postdoctoral Foundation of Jiangsu Province,China(1601180B)a Project of the Postdoctoral Science Foundation of China(2016M601841)
文摘Drug addiction results in long-term synaptic potentiation at excitatory synapses in the brain reward circuitry,especially in the ventral tegmental area（VTA）and nucleus accumbens（NAc）,central parts of the mesolimbic dopamine system,and then progresses to other cortical regions[1,2].
基金supported by the Primary Research&Development Plan of Jiangsu Province(No.BE2016175)the Chinese Postdoctoral Science Foundation(No.2017M621581)。
文摘The effects of the diameter of SiO2 nanopillars,the diameter of Ag nanospheres,the arrays’period,and the medium environment on the plasmonic lattice resonance(PLR)formed by Ag nanospheres on SiO2 nanopillar arrays are systematically investigated.Larger diameters of SiO2 nanopillars with other parameters kept constant will widen the PLR peak,redshift the PLR wavelength,and weaken the PLR intensity.Larger diameters of Ag nanospheres with other parameters kept constant will widen the PLR peak,redshift the PLR wavelength,and strengthen the PLR intensity.Larger array periods or larger refractive index of medium environment corresponds to larger PLR wavelengths.
基金provided by two anonymous reviewers of an earlier version of this article.
文摘This article reports a study on the China-Canada-United States English Immersion(CCUEI)Moral Education and Social Studies(MESS)curriculum materials for elementary classes(Grades 3-6)with the aim of learning how the curriculum addressed the dual goals of MESS content and English language learning.An analysis comparing the CCUEI third grade MESS textbook with an equivalent level Chinese textbook demonstrates how China’s national standards in MESS and English education can be met,and drawbacks encountered in the process.The CCUEI textbook was found to embrace grade level MESS content standards,but showed a varied degree of depth of content across standards.The textbook addressed all of the general goals of Level One English language learning(Grades 3-4)and most of the language skills indicators(16 out of 20).An additional in-depth teacher survey provided a user’s perspective on MESS materials.The teachers rated the textbook highly for its activity-centered format and knowledge-rich content.They emphasized the importance of teaching English language as preparation for the MESS content teaching,and asked for more systematic support in language teaching from curriculum materials.
