Deformable double-shelled hollow mesoporous organosilica nanocapsules:A multi-interfacial etching strategy

Multishelled hollow structures have drawn increasing interest because of their peculiar compartmentation environments and physicochemical properties.In this work,deformable double-shelled hollow mesoporous o rganosilica nanocapsules(DDHMONs)were succes s fully synthesized by a multi-interfacial etching strategy.The obtained DDHMONs have a double-shelled structure with aninorganic-organic hybrid framework,a uniform outer layer(~320 nm)and inner layer(~180 nm),ordered mesochannels(~2.21 nm),and a large specific surface area(~1233 m^(2)/g).In vitro toxicity tests show that the DDHMONs have excellent biocompatibility when coincubated with human breast cancer cells.In addition,the anti cancer substance doxorubicin(DOX)can be highly loaded in DDHMONs(~335μg/mg).The results from flow cytometry together with confocal laser scanning microscopy show that DOX can be efficiently delivered into MCF-7 cells by DDHMONs,thus improving chemotherapeutic efficiency and demonstrating that DDHMONs have potential nanomedicine applications as anticancer agents.

Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions

The stability of periodic mesoporous organosilica(PMO) nanoparticles in physiological solutions greatly affects their potential biomedical applications. Herein, thioether-bridged PMO nanospheres with a diameter of 61 nm are synthesized. Then, the thioether-bridged PMO nanospheres are modified with different molecular weighted polyethylene glycol(PEG) via click reaction for the first time. FI-IR and thermogravimetric analysis confirm the successful modification of PEG on the PMO. The influence of PEG molecular weight on the dispersity and stability of the PMO-PEG in phosphate buffer(PBS) and Dulbecco's modified Eagle's medium(DMEM) is studied. The results show that the PEG coating increases the stability and dispersity of PMO in the biological solutions. The PMO-PEG1K, PMO-PEG2K, and PMOPEG5K have better stability in PBS solution. The PMO-PEG2K shows best stability and dispersity in DMEM. Over all, this work provides important method and knowledge to guide the modification of PMO for biomedical

Uniform hierarchical silica film with perpendicular macroporous channels and accessible ordered mesopores for biomolecule separation

Herein, we demonstrate that silica films with perpendicular macroporous channels and accessible ordered mesopores can be conveniently prepared. The hierarchical macroporous–mesoporous silica films are synthesized by using zinc oxide nanorod array as macroporous template and CTAB surfactant as mesoporous template. In basic surfactant-containing solution, ordered mesoporous silica shells homogeneously grow on the zinc oxide nanorod array. The growth of the mesostructures do not require any chemical modification for the zinc oxide nanorod, which opens a new way for preparing hierarchical silica films with perpendicular mesochannels. The prepared hierarchical macroporous–mesoporous silica films possess a uniform thickness of 2μm, large perpendicular macropores with a length of 1.8μm and a width of 80 nm, and accessible ordered mesopores. Separation experiment demonstrates that this macroporous–mesoporous film can effectively separate biomolecules with different sizes.