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IFN-γ通过调控细胞代谢和mRNA翻译促进巨噬细胞活化
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作者 王秦兰 xiaodi su +1 位作者 Yingpu Yu Yi Zhong 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2015年第5期624-624,共1页
IFN-γ可增强巨噬细胞对Toll样受体(Toll-like receptors,TLRs)触发的天然免疫反应,但IFN-γ如何增强巨噬细胞对TLR敏感性的机制研究不多。Ivashkiv等发现IFN-γ可以通过抑制TLR4触发的HES1和HEY1的表达,促进巨噬细胞释放细胞因子。此外... IFN-γ可增强巨噬细胞对Toll样受体(Toll-like receptors,TLRs)触发的天然免疫反应,但IFN-γ如何增强巨噬细胞对TLR敏感性的机制研究不多。Ivashkiv等发现IFN-γ可以通过抑制TLR4触发的HES1和HEY1的表达,促进巨噬细胞释放细胞因子。此外,研究还发现,IFN-γ致敏可以使组蛋白发生乙酰化修饰,进而促进染色体重塑,调控基因的表达。总之该研究提出了一种新型机制:IFN-γ通过调控细胞代谢和mRNA翻译促进TLR触发的巨噬细胞活化。 展开更多
关键词 巨噬细胞活化 IFN mRNA翻译 细胞代谢 天然免疫反应 细胞因子 调控基因 乙酰化修饰 TLRS 信号通路
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Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality 被引量:3
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作者 xiaodi su Laura sutarlie Xian Jun Loh 《Research》 EI CAS 2020年第1期1521-1535,共15页
In aquaculture industry,fish,shellfish,and aquatic plants are cultivated in fresh,salt,or brackish waters.The increasing demand of aquatic products has stimulated the rapid growth of aquaculture industries.How to effe... In aquaculture industry,fish,shellfish,and aquatic plants are cultivated in fresh,salt,or brackish waters.The increasing demand of aquatic products has stimulated the rapid growth of aquaculture industries.How to effectively monitor and control water quality is one of the key concerns for aquaculture industry to ensure high productivity and high quality.There are four major categories of water quality concerns that affect aquaculture cultivations,namely,(1)physical parameters,e.g.,pH,temperature,dissolved oxygen,and salinity,(2)organic contaminants,(3)biochemical hazards,e.g.,cyanotoxins,and(4)biological contaminants,i.e.,pathogens.While the physical parameters are affected by climate changes,the latter three are considered as environmental factors.In this review,we provide a comprehensive summary of sensors,biosensors,and analytical technologies available for monitoring aquaculture water quality.They include low-cost commercial sensors and sensor network setups for physical parameters.They also include chromatography,mass spectrometry,biochemistry,and molecular methods(e.g.,immunoassays and polymerase chain reaction assays),culture-based method,and biophysical technologies(e.g.,biosensors and nanosensors)for environmental contamination factors.According to the different levels of sophistication of various analytical techniques and the information they can provide(either fine fingerprint,highly accurate quantification,semiquantification,qualitative detection,or fast screening),we will comment on how they may be used as complementary tools,as well as their potential and gaps toward current demand of real-time,online,and/or onsite detection. 展开更多
关键词 qualitative latter QUALITY
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