Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility

The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition.

Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro

β-mercaptoethanol can induce adult adipose-derived stromal cells to rapidly and efficiently differentiate into typical neuron-like cells in vitro. Immunohistochemistry showed that neuron specific enolase and neurofilament-200 expression gradually increased with the extension of induction time, and peaked at 5 hours. By contrast, glial fibrillary acidic protein was negatively expressed at all time points. Induced cells possessed a typical Nissl body, apoptosis showing condensed chromatin in the nucleus, autophagosomes with a bilayered membrane and autolysosomes in the cytoplasm at 5 hours. TUNEL assay and immunohistochemistry and immunofluorescence demonstrated that apoptosis and caspase-3 expression increased and peaked at 8 hours. Immunohistochemistry and immunofluorescence showed that microtubuleassociated protein light chain 3 gradually increased with induction and reached a peak at 5 hours These results indicate that autophagy played an important role in protecting cells during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro.

Discovery of lacustrine shale deposits in the Yanshan Orogenic Belt,China: Implications for hydrocarbon exploration

The mechanism of formation of lacustrine deposits within stable orogenic belts and their potential for shale oil and gas exploration are frontier themes of challenge in the fields of sedimentology and petroleum exploration. Orogenic belts witness strong tectonic activities and normally cannot host stable lacustrine basins and deep shale formations. Therefore, basins in orogenic belts are considered to have no potential to form shale hydrocarbon reservoirs. Here we investigate the Luanping Basin located in the Yanshan orogenic belt where previous studies regarded rivers and fan deltas as the major main Mesozoic deposits. Based on detailed field exploration and scientific drilling, we report the finding of a large number of lacustrine shale continental deep-water deposits in the Mesozoic strata. Our finding of the occurrence of active shale oil and gas also in this basin also subvert the previous perceptions.We report SHRIMP zircon U-Pb age that define the bottom boundary of the target interval as 127.6 ± 1.7 Ma belonging to the early Cretaceous strata. Tectonics and climate are considered to be the main factors that controlled the deep-water sedimentation during this period. The drill cores revealed evidence of shale gas and the TOC of shale is 0.33%–3.60%, with an average value of 1.39% and Ro is 0.84%–1.21%, with an average value of 1.002%. The brittleness index of shale is between 52.7% and 100%. After vertical well fracturing, the daily gas production is more than 1000 m^(3). Our findings show that the basin has considerable potential for shale oil and gas. The geological resources of the shale gas in the Xiguayuan Fm. are estimated as 1110.12 × 10^(8) m^(3), with shale oil geological resources of 3340.152 × 10^(4) t. Our findings indicate that the Yanshan orogenic belt has potential exploration prospect. This work not only redefines the Luanping Basin as a rift deep-water Mesozoic Lake Basin, but also rules out the previous notion that the basin is dominated by shallow water sediments. The discovery of shale oil and gas also provides an important reference for subsequent petroleum exploration and development in this basin. Our study shows that shale oil and gas reservoirs can be found in the lacustrine basins of orogenic belts which were strongly influenced by volcanism. These results have significant implications for the sedimentology and oil exploration in the Qinling and Xingmeng Orogenic Belts of China, as well as those in other terranes of the world including the New England Orogenic Belt in Australia.

Autophagy activator promotes neuronal differentiation of adult adipose-derived stromal cells

Preliminary research from our group found altered autophagy intensity during adipose-derived stromal cell differentiation into neuronal-like cells, and that this change was associated with morphological changes in differentiated cells. This study aimed to verify the role of rapamycin, an autophagy activator, in the process of adipose-derived stromal cell differentiation into neuronal-like cells. Immunohistochemical staining showed that expression of neuron-specific enolase and neurofilament-200 were gradually upregulated in adipose-derived stromal cells after 5 mM 13-mercaptoethanol induction, and the differentiation rate gradually increased with induction time. Using transmission electron microscopy, induced cells were shown to exhibit cytoplasmic autophagosomes, with bilayer membranes, and autolysosomes. After rapamycin （200 IJg/L） induction for 1 hour, adipose-derived stromal cells began to extend long processes, similar to the morphology of neuronal-like cells, while untreated cells did not exhibit similar morphologies until 3 hours after induction. Moreover, the differentiation rate was significantly increased after rapamycin treatment. Compared with untreated cells, expression of LC3, an autophagy protein, was also significantly upregulated. Positive LC3 expression tended to concentrate at cell nuclei with increasing induction times. Our experimental findings indicate that autophagy can significantly increase the speed of adipose-derived stromal cell differentiation into neuronal-like cells.

Formation mechanism of a smooth, defectfree surface of fused silica optics using rapid CO2 laser polishing

Surface defects introduced by conventional mechanical processing methods can induce irreversible damage and reduce the service life of optics applied in high-power lasers.Compared to mechanical processing,laser polishing with moving beam spot is a noncontact processing method,which is able to form a defect-free surface.This work aims to explore the mechanism of forming a smooth,defect-free fused silica surface by high-power density laser polishing with coupled multiple beams.The underlying mechanisms of laser polishing was revealed by numerical simulations and the theoretical results were verified by experiments.The simulated polishing depth and machined surface morphology were in close agreement with the experimental results.To obtain the optimized polishing quality,the effects of laser polishing parameters(e.g.overlap rate,pulse width and polishing times)on the polishing quality were experimentally investigated.It was found that the processing efficiency of fused silica materials by carbon dioxide(CO2)laser polishing could reach 8.68 mm2 s−1,and the surface roughness(Ra)was better than 25 nm.Besides,the cracks on pristine fused silica surfaces introduced by initial grinding process were completely removed by laser polishing to achieve a defect-free surface.The maximum laser polishing rate can reach 3.88μm s−1,much higher than that of the traditional mechanical polishing methods.The rapid CO2 laser polishing can effectively achieve smooth,defect-free surface,which is of great significance to improve the surface quality of fused silica optics applied in high-power laser facilities.

Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes

Previous studies have demonstrated that nerve cells differentiated from adipose-derived stro-mal cells after chemical induction have reduced viability;however, the underlying mechanisms remained unclear. In this study, we induced the differentiation of adult adipose-derived stromal cells into astrocytes using chemical induction. 3-（4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetra-zolium bromide assay and flow cytometry showed that, with increasing induction time, the apoptotic rate gradually increased, and the number of living cells gradually decreased. Im-munohistochemical staining demonstrated that the number of glial fibrillary acidic protein-, caspase-3- and caspase-9-positive cells gradually increased with increasing induction time. Transmission electron microscopy revealed typical signs of apoptosis after differentiation. Taken together, our results indicate that caspase-dependent apoptosis is an obstacle to the differentia-tion of adipose-derived stromal cells into astrocytes. Inhibiting apoptosis may be an important strategy for increasing the efifciency of induction.

Thermal Management of Air-Cooling Lithium-Ion Battery Pack

Lithium-ion battery packs are made by many batteries, and the difficulty in heat transfer can cause many safety issues. It is important to evaluate thermal performance of a battery pack in designing process. Here, a multiscale method combining a pseudo-two-dimensional model of individual battery and three-dimensional computational fluid dynamics is employed to describe heat generation and transfer in a battery pack. The effect of battery arrangement on the thermal performance of battery packs is investigated. We discuss the air-cooling effect of the pack with four battery arrangements which include one square arrangement, one stagger arrangement and two trapezoid arrangements. In addition, the air-cooling strategy is studied by observing temperature distribution of the battery pack. It is found that the square arrangement is the structure with the best air-cooling effect, and the cooling effect is best when the cold air inlet is at the top of the battery pack. We hope that this work can provide theoretical guidance for thermal management of lithium-ion battery packs.

CT血流动力学用于乳腺癌诊断的ROC曲线分析(英文)

Objective:The aim of this study was evaluate the diagnostic value of computed tomography(CT) perfusion in breast cancer by the method of receiver operator characteristic curve(ROC) analysis.Methods:Eighty-one cases with breast masses found by health examination or mammography were scanned by multi-slice spiral CT(MSCT) perfusion and hemodynamic parameters of blood flow(BF), mean transit time(MTT) and blood volume(BV) were calculated by deconvolution arithmetic.According to the pathologic results, two groups, benign and malignant were classified and statistical analysis were performed between them.The ROC characteristics of BF, MTT, BV were compared for each and the diagnostic value of the hemodynamic parameters were confirmed.Results:In the malignant group, BF was(0.735 ± 0.440) mL/min/mL, MTT was(22.771 ± 7.647) s and BV was 0.234 ± 0.082.In the benign group, BF was(0.466 ± 0.527) mL/min/mL, MTT was(26.712 ± 12.934) s and BV was 0.179 ± 0.117.There was a significant difference for BF and BV between the benign and malignant groups.When the hemodynamic parameters were used to discriminate the breast lesions, the area under the ROC curve(AUCROC) of BF was 0.832 ± 0.086, the maximum, while AUCROC of BV was 0.695 ± 0.092.There was no significant statistical difference between BF and BV.AUCROC of MTT was 0.473 ± 0.102, which was minimal.Since the threshold of BF was 0.381 mL/min/mL, the sensitivity was 82.3%, the specificity was 73.2%, the positive likelihood ratio(LR) was 3.071 and the negative LR was 0.242.The threshold of BV was 0.190 with sensitivity 73.3%, specificity 56.5%, positive likelihood ratio 1.685 and negative LR 0.473.Conclusion:BF and BV among CT hemodynamic parameters have certain diagnostic value in breast cancer, but BF or BV can not yet be single index to confirm or deny the diagnosis.

Security Assessment of Distribution System with Distributed Photovoltaic

In order to evaluate the safe and stable operation of distribution network with the distributed photovoltaic (PV), the?security of distribution network is researched. On the basis of electricity supply security, voltage quality and network losses,?the index system of static security is established. The paper simulates the uncertainty and random characteristics of PV by OpenDSS. The typical scenes that PV accessed to the distribution network are designed.?The paper summarizes the results of voltage fluctuation and network losses and uses indices to quantify it under different scenes. Based on the index system, the paper proposes some recommendations on PV permeability, interconnected locations, dispersion degrees and power factors when the distributed PV accessed to the distribution network.

The mechanism study of low-pressure air plasma cleaning on large-aperture optical surface unraveled by experiment and reactive molecular dynamics simulation

Low-pressure air plasma cleaning is an effective method for removing organic contaminants on large-aperture optical components in situ in the inertial confinement fusion facility.Chemical reactions play a significant role in plasma cleaning,which is a complex process involving abundant bond cleavage and species generation.In this work,experiments and reactive molecular dynamics simulations were carried out to unravel the reaction mechanism between the benchmark organic contaminants of dibutyl phthalate and air plasma.The optical emission spectroscopy was used to study the overall evolution behaviors of excited molecular species and radical signals from air plasma as a reference to simulations.Detailed reaction pathways were revealed and characterized,and specific intermediate radicals and products were analyzed during experiments and simulation.The reactive species in the air plasma,such as O,HO_(2)and O_(3)radicals,played a crucial role in cleaving organic molecular structures.Together,our findings provide an atomic-level understanding of complex reaction processes of low-pressure air plasma cleaning mechanisms and are essential for its application in industrial plasma cleaning.

Molecular Dynamics Simulations of the Interface between Porous and Fused Silica

Molecular dynamics simulations are performed to gain insights into the structural and vibrational properties of interface between porous and fused silica.The Si–O bonds formed in the interface exhibit the same lengths as the bulk material, whereas the coordination defects in the interface are at an intermediate level as compared with the dense and porous structures.Clustered bonds are identified from the interface, which are associated with the reorganization of the silica surface.The bond angle distributions show that the O–Si–O bond angles keep the average value of 109°, whereas the Si–O–Si angles of the interface present in a similar manner to those in porous silica.Despite the slight structural differences, similarities in the vibrations are observed, which could further demonstrate the stability of porous silica films coated on the fused silica.

Continuous assessment of cerebral autoregulation by TCD during tilt table testing

[SUMMARY] TTTT is a non-invasive and new investigative examination,and a most important method of clinical diagnosis for many diseases,specially for orthostatic syncope,autonomic failure,intracranial hypertension,neurodegenerative diseases,CVAs and so on.At the same time,TCD technique for non-invasive monitoring of CBFV has also provided a new tool for investigating CA.In clinical circumstance,we may carry on assessment of dynamic CA by TTTT,and this kind of method has been proved to be appropriate to examine patients and monitor.we can choose different tilt positions by tilt-table according to the different demands for clinical diagnosis or researches,and record the different appearances of various index signs,we can take advantage of the technique of transfer function analysis of power spectrum between spontaneous changes in CBF and other factors(such as arterial pressure) to do research on the specific mechanism of impaired CA.

Optimal Dispatch for Flexible Uncertainty Sets in Multi-energy Systems: An IGDT Based Two-stage Decision Framework

The operational stability and economy of multi-energy systems(MES)are threatened by various uncertainties,such as variable renewable energy power,energy demands,and weather conditions.Most of the existing methods for the dispatch decisions of MES are based on the prescribed probability distribution or uncertainty sets of random variables,which have many disadvantages,such as potential infeasibility and over-conservatism.In this paper,we propose a novel dispatch model for MES that integrates dispatch decision making,uncertainty set selection,and operational cost control into a unified framework.First,the deterministic dispatch model of MES is introduced,in which the physical characteristics of district heating systems and buildings are fully considered.Then,a novel decision framework that combines the two-stage dispatch strategy and info-gap decision theory(IGDT)is proposed for MES,where the uncertainty set is flexible and can be optimized based on the operational cost budget.Finally,a revised algorithm,based on the column-and-constraint generation method,is proposed for the model.Case studies are performed on MES that includes a 33-bus distribution system and a heating network modified from a real 51-node network located in Jinlin Province,China.The results verify the effectiveness of the proposed method.

Impact of Influenza and Pneumococcal Polysaccharide Vaccination on Economic Burden from Acute Exacerbations of Chronic Obstructive Pulmonary Disease-Hebei Province,China,November 2018 to November 2020

Summary What is already known on this topic?Chronic obstructive pulmonary disease(COPD)exacerbations increase household economic burden,but there is limited evidence from prospective cohort studies in China about the impact of vaccination on economic burden.What is added by this report?This study demonstrated the economic burden of COPD exacerbations,pneumonia,and hospitalization in COPD patients in China is substantial.Influenza vaccine and 23-valent pneumococcal polysaccharide vaccine(PPSV23),separately or together,were significantly associated with decreased economic burden.What are the implications for public health practice?Our study supports evidence on recommendations that COPD patients in China are offered both influenza vaccine and PPSV23.

Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation

Background:Natural killer(NK)cells are enriched in the liver and are the main regulators in liver transplantation regarding rejection or tolerance,viral infection,or tumor recurrence.Immunosuppression consists of a triple drug standard regimen comprising tacrolimus(TAC)and corticosteroids(CS)with either mycophenolate mofetil(MMF)or sirolimus(SIR)/everolimus(EVE).The aim of this study was to evaluate the impact of trough levels of these regimens under clinical conditions and exposure on human NK-cell activity and function in order to better understand the antiviral and anti-tumor effects of mammalian target of rapamycin inhibitor(mTORI).Methods:Peripheral blood mononuclear cells(PBMCs)were collected from liver transplant recipients and healthy controls.Number and phenotypes of NK cells in vivo were analyzed by flow cytometry.In this study we simulated the immunosuppressive microenvironment in vitro.PBMCs were cultured at the clinically effective plasma concentration of drugs for 3 d to detect the effect of immunosuppressants on NK cells.Drug type and concentration:single drug[EVE,5 ng/mL;SIR,5 ng/mL;TAC,5 ng/mL;cyclosporine A(CSA),125 ng/mL;MMF,15μg/mL;CS,0.5μg/mL]and combined immunosuppressants(Group 1:TAC,5 ng/mL+MMF,15μg/mL+CS,0.5μg/mL;Group 2:TAC,5 ng/mL+SIR,5 ng/mL+CS,0.5μg/mL;Group 3:TAC,5 ng/mL+EVE,5 ng/mL+CS,0.5μg/mL).In addition,NK cells were sorted from PBMCs and treated under the above conditions to detect NK cell killing function and RNA transcription characteristics.Results:CS significantly impaired the cytolytic activity of NK cells,followed by MMF and SIR/EVE.CS and TAC/CSA significantly decreased the secretion of IFN-γand CD107a.NK cell function in liver transplant recipients was most pronouncedly inhibited by a triple immunosuppressive regimen,with CS playing the most prominent role compared with the other drugs.The MMF-containing regimen demonstrated a significant increase in the expression of suppressive genes,especially of the Siglec7/9 family.The SIR group had stronger NK cell activity compared with that of the MMF group,although liver transplantation patients have lower NK cell activity and function.Conclusions:Despite an overall comparable immunosuppressive efficiency in terms of prevention of acute rejection,a mTORIs-including regimen might be considered as having less impact on NK cell function.

Optimal Planning of AC-DC Hybrid Transmission and Distributed Energy Resource System: Review and Prospects

With the highly-extensive integration of distributed renewable energy resources(DER)into the grid,the power distribution system has changed greatly in the structure,function and operating characteristics.On this ground,An AC-DC hybrid DER system becomes necessary for effective management and control over DER.This paper first summarizes the physical characteristics and morphological evolution of AC-DC hybrid DER system.The impact of these new features on system configuration planning is analyzed with respect to its flexible networking,rich operation control modes,and tight sourcenetwork-load-storage coupling.Then,based on a review of the existing research,problems and technical difficulties are figured out in terms of converter modeling,steady-state analysis,power flow calculation,operating scenarios management,and optimization model solution.In light of the problems and difficulties,a framework for the configuration optimization of AC-DC hybrid DER systems is proposed.At last,the paper provides a prospect of key technologies from six aspects including morphology forecasting,coupling interaction analysis,uncertainty modeling,operation simulation,optimization model solving algorithm and comprehensive scheme evaluation.

A novel genetic algorithm based on all spanning trees of undirected graph for distribution network reconfiguration

Network reconfiguration is of theoretical and practical significance to guarantee safe and economical operation of distribution system.In this paper,based on all spanning trees of undirected graph,a novel genetic algorithm for electric distribution network reconfiguration is proposed.Above all,all spanning trees of simplified graph of distribution network are found.Tie branches are obtained with spanning tree subtracted from simplified graph.There is one and only one switch open on each tie branch.Decimal identity number of open switch on each tie branch is taken as the optimization variable.Therefore,the length of chromosome is very short.Each spanning tree corresponds to one subpopulation.Gene operations of each subpopulation are implemented with parallel computing method.Individuals of offspring after gene operation automatically meet with radial and connected constraints for distribution network operation.Disadvantages of conventional genetic algorithm for network reconfiguration that a large amount of unfeasible solutions are created after crossover and mutation,which result in very low searching efficiency,are completely overcome.High calculation speed and superior capability of the proposed method are validated by two test cases.

Laser performance of the SG-Ⅲ laser facility

SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here.

Integrated approach for optimal island partition and power dispatch

Operating in island mode when failure occurs in sure to maintain an uninterrupted power supply to significant loads. A two-stage approach that integrates optimal island partition and power dispatch is proposed in this paper, considering photovoltaics(PVs), batteries(BEs) and electric vehicles(EVs) as the power sources. In the first stage, energy indices are defined to describe the energy demand and the maximum energy that these distributed energy resources(DERs) can provide, and islands are partitioned based on an energy constraint. Considering the variability the loads and PVs, the energy constraint is a necessary but not sufficient condition for island operation,so in the second stage, a power dispatch model is proposed the active distribution network(ADN) is an effective mea-as a test for the island partition result. Sequential power flow is also simulated to guarantee a feasible and optimized island status. The situations when the tests are not passed are analyzed and classified, and corresponding modifications for the first stage model are provided. Multiple levels of constraints based on the energy index are established for the island partition model. The proposed approach has been validated through simulation using a modified IEEE 69-bus system which is divided into three districts with different load variability characteristics.

Fully distributed control to coordinate charging efficiencies for energy storage systems

This study proposes a novel fully distributed coordination control(DCC) strategy to coordinate charging efficiencies of energy storage systems(ESSs). To realize this fully DCC strategy in an active distribution system(ADS) with high penetration of intermittent renewable generation, a two-layer consensus algorithm is proposed and applied. It collects global information in the first layer and achieves pinning-based DCC in the second layer. Basic objectives of the proposed DCC for ESSs are: à to coordinate the ESSs and improve efficiency using associated marginal charging costs(MCCs) in a fully distributed manner; ` to reduce local power mismatch and power transmission losses; ′ to adapt to unintentional communication topology changes. The effectiveness and adaptability of the proposed DCC approach are both validated by simulation results.