蛋白质糖基化修饰在结直肠癌中的研究进展

结直肠癌作为中国最常见的恶性肿瘤之一,涉及多种复杂的病理生理过程。随着糖组学的深入研究,揭露了蛋白质糖基化修饰与结直肠癌的发生、进展、转移及多药耐药的密切关系,糖基化的改变作为重要的生物标志物,为早期诊断及干预治疗提供了新的靶点。本文综述了蛋白质糖基化修饰在结直肠癌中最新研究进展,希望可以通过靶向相关糖基化修饰位点,改善患者预后及耐药性。

媒体在流行病暴发事件中的干预作用:基于传染病模型理论和新型冠状病毒疫情案例的分析

本文从流行病传播动力学的角度探讨媒体在应对突发公共卫生事件中的干预作用。我们首先分析传染病模型中的基本要素,并指出干预传染病传播速率和范围的关键环节,包括降低疾病传染率、减少易感人群基数和增加收治率等。然后,我们结合2020年新型冠状病毒流行事件中的一些实际案例来分析和评价媒体在这些环节中起到的正面和负面的干预效果。研究发现,从传染病学的角度审视媒体的干预行为,有助于深入地评价干预效果和理解产生效果的原因。本文认为,在应对以突发公共卫生事件为代表的社会危机时,媒体需要在科学的指导下开展工作:首先理解危机的发展过程和可能的干预环节,然后明确自身在各环节中的定位和潜在作用,才能精准地发挥公共影响力,产生正面的干预效果。

The Regression Analysis between the Meteorological Synthetic Index Sequence and PM2.5 Concentration

Adapting daily meteorological data provided by China International Exchange Station, and using principal component analysis of meteorological index for dimension reduction comprehensive, the regression analysis model between PM2.5 and comprehensive index is established, by making use of Eviews time series modeling of the comprehensive principal component, finally puts forward opinions and suggestions aim at the regression analysis results of using artificial rainfall to ease haze.

The Research of Performance Comparison of Displacement and Mixing Ventilation System in Catering Kitchen

A commercial kitchen is a complicated environment where multiple components of a ventilation system including hood exhaust, conditioned air supply, and makeup air systems work together but not always in unison. And the application of an appropriate ventilation system is extremely vital to keep the catering kitchen comfortable, which consequently promotes the productivity and gains. Application of two systems (traditional mixing ventilation system and thermal displacement ventilation system) is compared in a typical kitchen environment using computational fluid dynamics modeling which was used to investigate the difference between mixing and displacement ventilation (DV). It was reported in two parts, one on thermal comfort and the other one on indoor air quality. The results show that DV can maintain a thermally comfortable environment that has a low air velocity, a small temperature difference between the head and ankle level, and a low percentage of dissatisfied people, and may provide better IAQ in the occupied zone. So it was persuasive that using thermal displacement ventilation in kitchen environment allows for a reduction in space temperature without increasing the air-conditioning system capacity.

The Research of Performance Comparison of Displacement and Mixing Ventilation System in Catering Kitchen

A commercial kitchen is a complicated environment where multiple components of a ventilation system including hood exhaust, conditioned air supply, and makeup air systems work together but not always in unison. And the application of an appropriate ventilation system is extremely vital to keep the catering kitchen comfortable, which consequently promotes the productivity and gains. Application of two systems (traditional mixing ventilation system and thermal displacement ventilation system) is compared in a typical kitchen environment using computational fluid dynamics modeling which was used to investigate the difference between mixing and displacement ventilation (DV). It was reported in two parts, one on thermal comfort and the other one on indoor air quality. The results show that DV can maintain a thermally comfortable environment that has a low air velocity, a small temperature difference between the head and ankle level, and a low percentage of dissatisfied people, and may provide better IAQ in the occupied zone. So it was persuasive that using thermal displacement ventilation in kitchen environment allows for a reduction in space temperature without increasing the air-conditioning system capacity.

BSKCN and BSAML: blind signatures from the module lattice and the asymmetric module lattice

1 Introduction Blind signature allows a user to obtain the signature of a message from a signer without revealing the information of the message,as well as defending against forgery.In recent years,there have been increased efforts to design post-quantum blind signature schemes,since it is known that classical cryptography assumptions(e.g.,integer factoring problem and discrete logarithm problem)are not secure against attacks carried out using quantum computers[1].One popular approach is to design blind signature schemes using lattice.The first lattice-based blind signature scheme is proposed by Rückert[2],who also presented a general process of constructing lattice-based blind signature influenced by Lyubashevskys’s secure framework[3].Rückert’s approach achieves both blindness and one-more unforgeability in the random oracle model.Since then,many other blind signature schemes have extended Rückert signature scheme.For example,based on Crystals-Dilithium[4](one of the NIST post-quantum signature standardization),Le et al.[5]created a blind signature from module lattices.

跨学科创新能力培养的学理机制与模式重构

在学科融合趋势日益迅猛的时代背景下,机器人教育、创客教育、STEM教育等跨学科教育成为学生创新能力培养的重要途径。基于跨学科教育培养学生创新能力的实践,离不开有效教学模式的构建。有两条线索较为关键,一是"跨学科大概念"为学生跨学科创新能力的培养提供了基础和抓手,二是逆向教学思路可与当前盛行的逆向工程教学法结合,进一步细化跨学科创新能力的培养路径。借此,本文在前期提出的4C教学模式的基础上,重新构建和解读了培养学生跨学科创新能力的4C教学模式。

Assessment of water-based cutting fluids with green additives in broaching

In order to improve the cutting performance in broaching,the lubrication and cleaning effects offered by water-based cutting fluids with green additives need to be studied from the viewpoint of green manufacturing.Therefore,water-based solutions with castor oil,surfactant(linear alkylbenzene sulfonate,LAS),and nanographite were prepared by ultrasonic agitation and sprayed into the zone of broaching via atomization.The performances of the cutting fluids,in terms of the viscosity,specific heat,wetting angle,and droplet size,were evaluated to discuss their effects on the broaching load.Among the fluids,the addition of LAS into oil-in-water(WO-S),where its cutting fluid with 10 wt.%castor oil and 1.5 wt.%surfactant,exhibited the lowest broaching force.With regard to the lubricating and cleaning mechanisms,WO-S has good wettability and permeability,and hence,can lubricate the cutting edge of the tool to decrease the cutting load,cool the cutting edge to keep it sturdy,and clean the surface of the cutting edge to keep it sharp.The results reveal that the simultaneous addition of castor oil and LAS had remarkable effects on the lubrication and cleaning,and resulted in a broaching load reduction of more than 10%compared to commercial cutting fluids.However,the addition of nanographite could not improve the lubrication owing to its agglomeration.

Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes

Dear Editor,The pandemic of COVID-19,a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2;previously known as 2019-n Co V),has placed an enormous burden on health authorities in 213 countries and territories.At the time of writing,over 26 million cases have been recorded across the world,with more than 870 k associated deaths(www.worldometers.info/coronavirus/).World Bank warns COVID-19 pandemic risks dramatic rise in poverty,with the majority of economies expecting to suffer from falling levels of GDP in 2020.

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Wearing masks is an easy way to operate and popular measure for preventing epidemics.Although masks can slow down the spread of viruses,their efficacy in gathering environments involving heterogeneous person-to-person contacts remains unknown.Therefore,we aim to investigate the epidemic prevention effect of masks in different real-life gathering environments.This study uses four real interpersonal contact datasets to construct four empirical networks to represent four gathering environments.The transmission of COVID-19 is simulated using the Monte Carlo simulation method.The heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be different from the baseline efficacy in general society.Furthermore,the heterogeneity of gathering environments causes the epidemic prevention effect of masks to differ.Wearing masks can greatly reduce the probability of clustered epidemics and the infection scale in primary schools,high schools,and hospitals.However,the use of masks alone in primary schools and hospitals cannot control outbreaks.In high schools with social distancing between classes and in workplaces where the interpersonal contact is relatively sparse,masks can meet the need for prevention.Given the heterogeneity of individual behavior,if individuals who are more active in terms of interpersonal contact are prioritized for mask-wearing,the epidemic prevention effect of masks can be improved.Finally,asymptomatic infection has varying effects on the prevention effect of masks in different environments.The effect can be weakened or eliminated by increasing the usage rate of masks in high schools and workplaces.However,the effect on primary schools and hospitals cannot be weakened.This study contributes to the accurate evaluation of mask efficacy in various gathering environments to provide scientific guidance for epidemic prevention.

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies.Umbilical cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune disorders.This prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory ITP.The research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion phase.Adverse events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up period.Ultimately,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,respectively.Thirteen patients(13/18,72.2%)experienced one or more treatment emergent adverse events.Serious adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion phase.The overall response rate was 44.4%(8/18)among all enrolled patients.To sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(ClinicalTrials.gov ID:NCT04014166).