Development Status and Countermeasures of Farmers' Professional Cooperatives in Shangqiu City

Farmers' professional cooperatives develop in various forms,and with the continuous improvement of development level,social effects have gradually appear.Based on the specific situation of farmers' professional cooperatives in Shangqiu City,this paper expounded the development status of farmers' professional cooperatives in Shangqiu City,analyzed and discussed various problems encountered in the development process of farmers' professional cooperatives,and put forward some countermeasures and suggestions,such as establishing and perfecting cooperative rules and regulations,financing from multiple channels,introducing technical talents in various ways,breaking the information asymmetry restriction by various means,and giving full play to government functions,aiming to further promote standardized,large-scale,healthy and sustainable development of farmers' professional cooperatives.

Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats’ brain ischemia-reperfusion injury

Honokiol(HK)usage is greatly restricted by its poor aqueous solubility and limited oral bioavailability.We synthesized and characterized a novel phosphate prodrug of honokiol(HKP)for in vitro and in vivo use.HKP greatly enhanced the aqueous solubility of HK(127.54±15.53 mg/ml)and the stability in buffer solution was sufficient for intravenous administration.The enzymatic hydrolysis of HKP to HK was extremely rapid in vitro(T 1/2=8.9±2.11 s).Pharmacokinetics studies demonstrated that after intravenous administration of HKP(32 mg/kg),HKP was converted rapidly to HK with a time to reach the maximum plasma concentration of^5 min.The prodrug HKP achieved an improved T 1/2(7.97±1.30 h)and terminal volume of distribution(26.02±6.04 ml/kg)compared with direct injection of the equimolar parent drug(0.66±0.01 h)and(2.90±0.342 ml/kg),respectively.Furthermore,oral administration of HKP showed rapid and improved absorption compared with the parent drug.HKP was confirmed to maintain the bioactivity of the parent drug for ameliorating ischemia-reperfusion injury by decreasing brain infarction and improving neurologic function.Taken together,HKP is a potentially useful aqueous-soluble prodrug with improved pharmacokinetic properties which may merit further development as a potential drug candidate.