基于耦合评价的甘肃省高校非学历教育-经济-社会协调发展研究

时空耦合评价可以从整体视域反映教育规模与区域经济、社会三个变量系统的协同发展水平。本研究基于甘肃省高校非学历教育与区域经济社会发展的时空耦合关系,提出了相应的协调发展对策。研究发现,高校非学历教育与经济社会发展呈现明显关联,通过提供职业培训、技能提升和科研合作等项目,对促进地区产业发展、人才培养和社会进步起到了积极的影响。基于此,本研究提出了注重教育供给与职业需求协调、人才培养与产业升级协调、人力资源培养与就业推动协调以及知识创新与社会进步协调的对策建议,旨在实现高校自身发展、经济繁荣和社会进步的共赢。

Pressure-Tuned Intrinsic Anomalous Hall Conductivity in Kagome Magnets RV_(6)Sn_(6)(R=Gd,Tb)

Exploration of exotic phenomena in magnetic topological systems is at the frontier of condensed matter physics,holding a significant promise for applications in topological spintronics.However,complex magnetic structures carrying nontrivial topological properties hinder its progresses.Here,we investigate the pressure effect on the novel topological kagome magnets GdV_(6)Sn_(6) and TbV_(6)Sn_(6) to dig out the interplay between magnetic Gd/Tb layers and nonmagnetic V-based kagome sublattice.The pressure-tuned magnetic transition temperature Tm in both the compounds exhibit a turning point at the critical pressure P_(c),accompanied with a sign reversal in anomalous Hall effect(AHE).The separation of intrinsic and extrinsic contributions using the Tian-Ye-Jin scaling model suggests that the intrinsic mechanism originating from the electronic Berry curvature holds the priority in the competition with extrinsic mechanism in AHE.The above-mentioned findings can be attributed to the combined effect of pressure-tuned band topology and magnetic interaction in segregated layers.Our results provide a practical route to design and manipulate the intrinsic AHE in magnetic topological materials.

Clinical research on Tai Chi:a review of health benefits

Tai Chi,a traditional Chinese martial art and health exercise,has gained significant global attention and recognition.The clinical benefits of Tai Chi have been studied extensively in recent decades.We conducted a systematic search of PubMed,Web of Science,EMBASE databases,and the China National Knowledge Infrastructure,identifying and reviewing 241 clinical trials on the benefits of Tai Chi from their inception to June 1,2023.Most of these studies have consistently demonstrated the positive impact of Tai Chi on balance,cognitive function,mood regulation,sleep quality,pain relief,cardiorespiratory function,and overall health.In the future,the key to fostering the ongoing development of this field lies in comprehensive research on standardized study designs and reporting,the scope of Tai Chi applications,and the core factors influencing its efficacy.

晚期胃食管胃结合部腺癌二线治疗方案疗效及安全性的回顾性研究

目的:探讨晚期胃/食管胃结合部(gastric/gastroesophageal junction,G/GEJ)腺癌适宜的二线治疗方案。方法:回顾性分析2019年1月至2021年3月于河南省肿瘤医院以紫杉醇单药和紫杉醇联合抗血管或程序性细胞死亡受体-1(programmed cell death protein 1,PD-1)单抗作为二线治疗的晚期G/GEJ腺癌的临床资料。结果:收集101例患者,中位随访时间为10.4个月,中位总生存期(overall survival,OS)为9.5个月。紫杉醇单药治疗组(43例)、紫杉类联合抗血管组(22例)和紫杉类联合免疫组(36例)客观缓解率(overall response rate,ORR)分别为9.3%、27.3%和30.6%,疾病控制率(disease control rate,DCR)分别为60.5%、86.4%和80.6%,中位无进展生存期(progression-free survival,PFS)分别为2.7个月、4.3个月和3.9个月,中位OS分别为7.0个月、12.0个月和11.0个月,差异均具有统计学意义(均P<0.05)。三组不良反应均可控,无新型不良事件发生,联合抗血管组高血压发生率为40.9%(9/22),联合PD-1单抗组免疫相关不良反应发生率为19.4%(7/36),与其他两组相比差异均具有统计学意义(均P<0.05);多因素分析显示美国东部肿瘤协作组(ECOG)评分、腹膜转移是患者OS的独立影响因素(P<0.05)。结论:紫杉类联合抗血管或PD-1单抗治疗可有效延长患者PFS及OS,临床疗效显著且安全性高,是晚期胃癌二线治疗可选择的方案。

Ultralow-temperature heat transport study of noncentrosymmetric superconductor CaPtAs

The noncentrosymmetric superconductor CaPtAs with time-reversal symmetry breaking in its superconducting state was previously proposed to host nodal superconductivity.Here,by employing ultralow-temperature thermal conductivity measurement on CaPtAs single crystal,we study its superconducting gap structure.A negligible residual linear term of thermal conductivity(κ_(0)/T)in zero magnetic field and the field dependence ofκ_(0)/T indicate that CaPtAs has multiple superconducting gaps with a dominant s-wave component.This is consistent with recent nuclear quadrupole resonance measurements on CaPtAs.Our work puts a strong constraint on the theories to describe the superconducting pairing symmetry of CaPtAs.

Sinomenine reduces iNOS expressionvia inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats

Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum. It is widely used as an immunosuppressive drug for treating rheumatic and arthritic diseases. In our previous studies, we found that sinomenine reduced cellular infiltration within the spinal cord and alleviated experimental autoimmune encephalomyelitis （EAE） in rats. In this study, we further investigated the mechanisms of sinomenine treatment in EAE rats. In EAE rats, treatment with sinomenine exerted an anti-inducible NO synthase （anti-iNOS） effect, which is related to the reductions of Thl cytokine interferon-y （IFN-7） and its transcription factor, T-bet, in spinal cords. Moreover, sinomenine treatment of splenocytes stimulated with anti-CD3 antibody and recombinant rat in- terleukin 12 reduced the expression of T-bet and IFN-y in vitro and also reduced the capability of supernatants of splenocyte culture to induce iNOS expression by primary astrocytes. However, sinomenine had no direct inhibito- ry effect on iNOS produced by astrocytes cultured with IFN-y and tumor necrosis factor α in vitro. In conclusion, the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet/IFN-y pathway.

Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling

We sought to investigate the expression of Fas and FasL on T cell surface and caspase 8 involvement in T cell apoptosis promoted by serum IL-10 in systemic lupus erythematosus （SLE） patients. Cells and sera were obtained from 35 SLE patients. Apoptosis of T cells in patients with SLE was increased and associated with the SLE disease activity index （SLEDAI）. Elevated expression of Fas and FasL on T cell surface contributed to increased apoptosis of T cells. Increased IL-10 in the sera of SLE patients was capable of inducing Fas and FasL expression on CD4^＋T cell surface, promoting apoptosis of this cell subset. Decreased IL-10 serum levels and low expression of Fas were found in 5 patients of the first follow-up group after 2-month treatment. In another group with one-year treatment, the SLEDAI declined to inactive scores. Serum IL-10 was decreased significantly, and expression of Fas and FasL on T cells was also reduced. Declined apoptosis was predominant only in CD4^＋T cell subset. When sera with high level of IL-10 were used to culture PBMCs from healthy controls, activated caspase 8 was elevated in CD3^＋T, CD4^＋T and CD8^＋T cells. The study showed that serum IL-10 induced apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling. Increased apoptosis of T cells contributes to autoantigen burden, which is pathogenic in the development of SLE.

电子自旋密度可视化在环境化学涉自由基反应教学中的应用

自由基反应是环境化学教学过程中的重点和难点。为了达到良好的教学效果,本研究以量化计算结合三维可视化的图形手段,使用“自旋密度”对自由基反应中的单电子过程进行了教学展示,结合具体教情学情进行课堂教学内容和形式的优化调整。首先,通过分子轨道理论对羟基自由基的电子结构进行分析,明确自旋密度、单电子、半充满轨道等概念;其次,通过对自旋密度可视化,对经典自由基反应进行追踪;最后,建立自旋密度与静电势之间的呼应或互补的关系,加深对环境自由基过程的理解。这种与现代化学理论的有机融合,赋予了环境自由基反应更深刻的内涵,提供了更多可供研究或操作的“手柄”,提高了学生的学习兴趣,融洽了师生关系,实现了预期教学目标。

Serum IL-10 from systemic lupus erythematosus patients suppresses the differentiation and function of monocyte-derived dendritic cells

The role played by cytokines, other than interferon （IFN）-a, in the differentiation and function of dendritic cells （DCs） in systemic lupus erythematosus （SLE）, remains unclear. Serum interleukin-10 （IL-10） levels are generally elevated in SLE patients, which might modulate the differentiation of DCs. In this study, DCs were induced from monocytes either by transendothelial trafficking or by culture with granulocyte-macrophage colony-stimulating factor （GM-CSF） ＋ IL-4 ＋ tumor necrosis factor （TNF）-a. Both systems were used to investigate the effects of elevated serum IL-10 level on DC differentiation in SLE patients. The results showed that monocyte-derived DCs induced by either SLE serum or exogenous IL-10 reduced the expression of human leukocyte antigen （HLA）-DR and CD80, decreased IL-12p40 level, and increased IL-10 level, and exhibited an impaired capacity to stimulate allogenic T-cell proliferation. These results indicate that serum IL-10 may be involved in the pathogenesis of SLE by modulating the differentiation and function of DCs.

Pathological significance and regulatory mechanism of lymphotoxin β receptor overexpression in T cells of patients with systemic lupus erythematosus

Systemic lupus erythematosus（SLE） is a typical autoimmune disease. Lymphotoxin β receptor（LTβR） signaling plays an important role in autoimmune inflammations. LTβR-Ig fusion protein, LTβR blocking agent, has been used to treat SLE, while its mechanism remains to be fully elucidated. In this study, to investigate the expression of LTβR in the T cells of SLE patients and its roles in the pathogenesis of SLE, we isolated the peripheral blood T cells of SLE patients and normal controls to detect expression of LTβR by flow cytometry and RNA assay. T cells were also stimulated with LIGHT, a ligand of LTβR, and then detected for their LTβR expressions and apoptosis by flow cytometry. Also, their expressions of inflammatory factors and receptors were determined by RNA assay. The results showed that LTβR positive cells were 22.75%±6.98% in CD3~＋ cells of SLE patients, while there were almost no LTβR positive cells in CD3~＋ cells of normal persons. Moreover, LTβR expression was remarkably higher in CD3,CD4 and CD8 positive T cells of active SLE patients than non/low active patients（all P〈0.05）, and positively correlated with increased Ig level, decreased complement level and renal damage. Moreover, the stimulation of SLE T cells with LIGHT promoted higher expression of LTβR, IL-23 R and IL-17 A, and apoptosis of T cells. In conclusion,we demonstrated a high expression of LTβR in the T cells of SLE patients which may be associated with pathogenesis of SLE.

Lactobacillus isolates from healthy volunteers exert immunomodulatory effects on activated peripheral blood mononuclear cells

As probiotics in the gut, Lactobacilli are believed to play important roles in the development and maintenance of both the mucosal and systemic immune system of the host. This study was aimed to investigate the immunomodulatory function of candiate lactobacilli on T cells. Lactobacilli were isolated from healthy human feces and the microbiological characteristics were identified by API 50 CHL and randomly amplified polymorphic DNA （RAPD） assays. Anti-CD3 antibody activated peripheral blood mononuclear cells （PBMCs） were treated by viable, heat-killed lactobacilli and genomic DNA of lactobacilli, and cytokine profiles were tested by ELISA. Isolated lactobacilli C44 and C48 were identified as L. acidophilus and L. paracacei, which have properties of acid and bile tolerance and inhibitor effects on pathogens. Viable and heat-killed C44 and C48 induced low levels of proinflammatory cytokines （TNF-a, IL-6 and IL-8） and high levels of IFN-y and IL-12p70 in PBMCs. In anti- CD3 antibody activated PBMCs, viable and heat-killed C44 increased Th2 cytokine levels （IL-5, IL-6 and IL-10）, and simultaneously enhanced Thl responses by inducing IFN-y and IL-12p70 production. Different from that of lactabacillus strains, their genomic DNA induced low levels of IL-12p70, IFN-y and proinflammatory cytokines in PBMCs with or without anti-CD3 antibody activation. These results provided in vitro evidence that the genomic DNA of strains of C44 and C48, especially C44, induced weaker inflammation, and may be potentially applied for treating allergic diseases.

High-pressure study of topological semimetals XCd_(2)Sb_(2)(X=Eu and Yb)

Topological materials have aroused great interest in recent years,especially when magnetism is involved.Pressure can effectively tune the topological states and possibly induce superconductivity.Here we report the high-pressure study of topological semimetals XCd_(2)Sb_(2)(X=Eu and Yb),which have the same crystal structure.In antiferromagnetic(AFM)Weyl semimetal EuCd_(2)Sb_(2),the Néel temperature(TN)increases from 7.4 K at ambient pressure to 50.9 K at 14.9 GPa.When pressure is above 14.9 GPa,the AFM peak of resistance disappears,indicating a non-magnetic state.In paramagnetic Dirac semimetal candidate YbCd_(2)Sb_(2),pressure-induced superconductivity appears at 1.94 GPa,then Tc reaches to a maximum of 1.67 K at 5.22 GPa and drops to zero at about 30 GPa,displaying a dome-shaped temperature–pressure phase diagram.High-pressure x-ray diffraction measurement demonstrates that a crystalline-to-amorphous phase transition occurs at about 16 GPa in YbCd_(2)Sb_(2),revealing the robustness of pressure-induced superconductivity against structural instability.Similar structural phase transition may also occur in EuCd_(2)Sb_(2),causing the disappearance of magnetism.Our results show that XCd_(2)Sb_(2)(X=Eu and Yb)is a novel platform for exploring the interplay among magnetism,topology,and superconductivity.

Discovery of Two Families of VSb-Based Compounds with V-Kagome Lattice

We report the structure and physical properties of two newly discovered compounds AV_(8)Sb_(12)and AV_(6)Sb_(6)(A=Cs,Rb),which have C_(2)(space group:Cmmm)and C_(3)(space group:R3 m)symmetry,respectively.The basic Vkagome unit appears in both compounds,but stacking differently.AV_(2)Sb_(2) layer is sandwiched between two V_(3)Sb_(5)layers in AV_(8)Sb_(12),altering the V-kagome lattice and lowering the symmetry of kagome layer from hexagonal to orthorhombic.In AV_(6)Sb_(6),the building block is a more complex slab made up of two half-V_(3)Sb_(5)layers that are intercalated by Cs cations along the c-axis.Transport property measurements demonstrate that both compounds are nonmagnetic metals,with carrier concentrations at around 10^(21)cm^(-3).No superconductivity has been observed in CsV_(8)Sb_(12)above 0.3 K under in situ pressure up to 46 GPa.Compared to CSV_(3)Sb_(5),theoretical calculations and angle-resolved photoemission spectroscopy reveal a quasi-two-dimensional electronic structure in CsV_(8)Sb_(12)with C_(2)symmetry and no van Hove singularities near the Fermi level.Our findings will stimulate more research into V-based kagome quantum materials.

Effect of Interferon-alpha in systemic lupus erthematosus (SLE) serum on the differentiation and maturation of dendritic cells derived from CD34^+ hematopoietic precursor cells

Objective： To study the effect of interferon-alpha IFN-α in the serum of SLE patients on the differentiation and maturation of dendritic cells （DCs） derived from CD34^＋ hematopoietic precursor cells （HPCs）. Methods： Serum samples from SLE patients and normal controls were collected and the concentration of IFN-α detected by ELISA. CD34^＋HPCs were purified from cord blood by a magnetic cell sorting system （MACS）, and cultured to differentiate to DCs. Normal serum, normal serum with exogenous IFN-α, SLE serum with raised levels of IFN-α, or SLE serum with anfi-IFN-α neutralizing antibody was added to the culture medium. The phenotype of DCs was analyzed by flow cytometry （FCM） and the capacity of DCs to stimulate allogenic T lymphocyte proliferation was evaluated in a mixed lymphocyte reaction by the Cell Counting Kit-8. Cytokine production was assessed by ELISA. Results： Serum levels of IFN-α were significantly higher in SLE patients than in normal controls and this correlated positively with disease activity. Cultured in SLE serum with raised levels of IFN-α, CD34^＋ HPCs could differentiate into DCs that expressed higher levels of HLA-DR, CD80 and CD86, and showed an enhanced allogenic T-cell stimulatory capacity, while producing lower levels of IL-12 and higher amounts of IL-10 compared with those DCs cultured in normal serum. Conclusion： Increased levels of IFN-α in SLE serum promotes the differentiation and maturation of DCs derived from CD34^＋ HPCs and could contribute to the pathogenesis of SLE.

GhCTSF1,a short PPR protein with a conserved role in chloroplast development and photosynthesis,participates in intron splicing of rpoC1 and ycf3-2 transcripts in cotton

Cotton is one of the most important textile fibers worldwide.As crucial agronomic traits,leaves play an essential role in the growth,disease resistance,fiber quality,and yield of cotton plants.Pentatricopeptide repeat(PPR)proteins are a large family of nuclear-encoded proteins involved in organellar or nuclear RNA metabolism.Using a virus-induced gene silencing assay,we found that cotton plants displayed variegated yellow leaf phenotypes with decreased chlorophyll content when expression of the PPR gene GhCTSF1 was silenced.GhCTSF1 encodes a chloroplast-localized protein that contains only two PPR motifs.Disruption of GhCTSF1 substantially reduces the splicing efficiency of rpoC1 intron 1 and ycf3 intron 2.Loss of function of the GhCTSF1 ortholog EMB1417 causes splicing defects in rpoC1 and ycf3-2,leading to impaired chloroplast structure and decreased photosynthetic rates in Arabidopsis.We also found that GhCTSF1 interacts with two splicing factors,GhCRS2 and GhWTF1.Defects in GhCRS2 and GhWTF1 severely affect intron splicing of rpoC1 and ycf3-2 in cotton,leading to defects in chloroplast development and a reduction in photosynthesis.Our results suggest that GhCTSF1 is specifically required for splicing rpoC1 and ycf3-2 in cooperation with GhCRS2 and GhWTF1.

社会规范对情绪感染的影响及其潜在机制

情绪感染是情绪从表达者传递到接收者并致使接收者情绪体验与表达者趋于一致的过程,适宜的情绪感染能促进社会关系和合作.情绪模仿和社会评价被认为是情绪感染的主要途径,但在社会情境中,社会评价的作用更为突出.然而,以往研究主要集中在群际关系(如内外群、竞争合作)等,而作为社会评价过程中的关键因素之一,社会规范如何影响情绪感染以及可能涉及的机制却未引起重视.本文梳理了情绪感染的含义与测量,情绪感染的心理机制,社会评价与社会规范之间的关系,社会规范的概念与分类、操纵与测量;归纳总结了社会规范影响情绪感染的相关理论基础和实证研究,提出了社会规范作用于情绪感染可能的心理机制以及该过程中可能涉及的神经基础,并对未来研究方向进行了展望.

Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis

The functional exhaustion of CD8^(+)T cells represents a fundamental hallmark of chronic viral infection and cancer and,in both scenarios,is driven by prolonged exposure to persistent cognate antigens in the context of an immunoinhibitory microenvironment.Exhausted CD8^(+)T cells upregulate the expression of a wide diversity of coinhibitory immunoreceptors(also referred to as immune checkpoint receptors),such as PD-1,Tim-3,LAG-3,and TIGIT.Concomitantly,exhausted CD8^(+)T cells lose their potential to differentiate into functional memory cells and are characterized by hierarchical loss of effector function,leading to compromised tumor control and viral eradication[1,2].

Vehicular volatile organic compounds losses due to refueling and diurnal process in China: 2010–2050

Volatile organic compounds（VOCs） are crucial to control air pollution in major Chinese cities since VOCs are the dominant factor influencing ambient ozone level, and also an important precursor of secondary organic aerosols. Vehicular evaporative emissions have become a major and growing source of VOC emissions in China. This study consists of lab tests, technology evaluation, emissions modeling, policy projections and cost-benefit analysis to draw a roadmap for China for controlling vehicular evaporative emissions. The analysis suggests that evaporative VOC emissions from China＇s light-duty gasoline vehicles were approximately 185,000 ton in 2010 and would peak at 1,200,000 ton in 2040 without control. The current control strategy implemented in China, as shown in business as usual（BAU） scenario, will barely reduce the long-term growth in emissions. Even if Stage II gasoline station vapor control policies were extended national wide（BAU ＋ extended Stage II）, there would still be over 400,000 ton fuel loss in 2050. In contrast, the implementation of on-board refueling vapor recovery（ORVR） on new cars could reduce 97.5% of evaporative VOCs by 2050（BAU ＋ ORVR/BAU ＋ delayed ORVR）. According to the results, a combined Stage II and ORVR program is a comprehensive solution that provides both short-term and long-term benefits. The net cost to achieve the optimal total evaporative VOC control is approximately 62 billion CNY in 2025 and 149 billion CNY in 2050.

Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19

COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness.