Acute myocardial infarction (AMI) has been associated with poor prognosis,even after revascularization with percutaneous coronary intervention (PCI),likely due to coronary endothelial cell dysfunction and injury.^([1,...Acute myocardial infarction (AMI) has been associated with poor prognosis,even after revascularization with percutaneous coronary intervention (PCI),likely due to coronary endothelial cell dysfunction and injury.^([1,2])Endothelin-1 (ET-1),a peptide that serves as a vasoconstrictor of smooth muscle cell proliferation,can reflect endothelial cell functional states.Due to low circulation levels and short plasma half-life time,measuring plasma ET-1 levels is difficult.In contrast,big ET-1.展开更多
Background and Objective The white blood cell count to mean platelet volume ratio(WMR)has recently been described as a predictor of cardiovascular events in patients who undergo percutaneous coronary intervention(PCI)...Background and Objective The white blood cell count to mean platelet volume ratio(WMR)has recently been described as a predictor of cardiovascular events in patients who undergo percutaneous coronary intervention(PCI).The aim of this study was to investigate the usefulness of admission WMR in predicting outcomes in patients with acute coronary syndrome(ACS).展开更多
Background and Objective Renal insufficiency(RI)is reported to be associated with increased ischemic and bleeding events after percutaneous coronary intervention(PCI),which is possibly due to high residual platelet re...Background and Objective Renal insufficiency(RI)is reported to be associated with increased ischemic and bleeding events after percutaneous coronary intervention(PCI),which is possibly due to high residual platelet reactivity(HRPR)during DAPT therapy.Therefore,we performed a large prospective observational study to evaluate the platelet reactivity and related clinical outcomes in real-world patients with different renal insufficiency stage after PCI,and to examine whether HRPR is associated with higher incidence of adverse cardiovascular events in a 2-year follow up.展开更多
Objective This study analyzed a large single-center sample in China to explain the impact of smoking state at baseline on long-term prognosis of coronary artery disease (CAD) patients who received percutaneous coronar...Objective This study analyzed a large single-center sample in China to explain the impact of smoking state at baseline on long-term prognosis of coronary artery disease (CAD) patients who received percutaneous coronary intervention (PCI).展开更多
Objective It remains undetermined whether biodegradable polymer drug-eluting stents(BP-DES)are superior to second generation drugeluting stents(G2-DES)in patients with and without diabetes mellitus(DM).The study aims ...Objective It remains undetermined whether biodegradable polymer drug-eluting stents(BP-DES)are superior to second generation drugeluting stents(G2-DES)in patients with and without diabetes mellitus(DM).The study aims to evaluate the efficacy and safety of G2-DES and BP-DES in patients with and without DM in a high-volume cardiovascular center in China.展开更多
Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients wit...Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).展开更多
Background and Objective Treatment strategy for unstable angina has underwent significant changes since the introduction of Braunwald classification of unstable angina nearly 30 years ago,yet re-evaluation of this rou...Background and Objective Treatment strategy for unstable angina has underwent significant changes since the introduction of Braunwald classification of unstable angina nearly 30 years ago,yet re-evaluation of this routinely used classification system is rarely published in recent years.We aim to re-evaluate the Braunwald unstable angina(UA)classification on its predictive value of clinical characteristics,angiographic features,and occurrence of future adverse events.展开更多
Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we desig...Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we designed a cationic aggregation-induced emission(AIE)amphiphile to self-assemble with natural DNA duplexes.As an efficient donor,the as-prepared cationic AIE amphiphile could be densely attached to the phosphate groups of natural DNA duplexes by using the smaller cationic trimethylammonium.The long alkyl chain between the cationic trimethylammonium and the AIEfluorophore allowed for avoiding the insuffi-cient binding caused by the steric hindrance of the AIEfluorophore,resulting in a remarkably high donor/acceptor ratio comparable to that of the widely developed custom DNA assemblies.The proposed self-assembly strategy provided novelflex-ible avenues for the assembling offinely controlled and efficient light-harvesting systems into natural DNA with little synthetic modifications and low cost.展开更多
基金National Clinical Research Center for Cardiovascular Diseases,Fuwai Hospital,Chinese Academy of Medical Sciences(NCRC2020013)CAMS Innovation Fund for Medical Sciences(2020-I2M-C&T-B-049)。
文摘Acute myocardial infarction (AMI) has been associated with poor prognosis,even after revascularization with percutaneous coronary intervention (PCI),likely due to coronary endothelial cell dysfunction and injury.^([1,2])Endothelin-1 (ET-1),a peptide that serves as a vasoconstrictor of smooth muscle cell proliferation,can reflect endothelial cell functional states.Due to low circulation levels and short plasma half-life time,measuring plasma ET-1 levels is difficult.In contrast,big ET-1.
文摘Background and Objective The white blood cell count to mean platelet volume ratio(WMR)has recently been described as a predictor of cardiovascular events in patients who undergo percutaneous coronary intervention(PCI).The aim of this study was to investigate the usefulness of admission WMR in predicting outcomes in patients with acute coronary syndrome(ACS).
文摘Background and Objective Renal insufficiency(RI)is reported to be associated with increased ischemic and bleeding events after percutaneous coronary intervention(PCI),which is possibly due to high residual platelet reactivity(HRPR)during DAPT therapy.Therefore,we performed a large prospective observational study to evaluate the platelet reactivity and related clinical outcomes in real-world patients with different renal insufficiency stage after PCI,and to examine whether HRPR is associated with higher incidence of adverse cardiovascular events in a 2-year follow up.
文摘Objective This study analyzed a large single-center sample in China to explain the impact of smoking state at baseline on long-term prognosis of coronary artery disease (CAD) patients who received percutaneous coronary intervention (PCI).
文摘Objective It remains undetermined whether biodegradable polymer drug-eluting stents(BP-DES)are superior to second generation drugeluting stents(G2-DES)in patients with and without diabetes mellitus(DM).The study aims to evaluate the efficacy and safety of G2-DES and BP-DES in patients with and without DM in a high-volume cardiovascular center in China.
文摘Background and Objective Elevated serum levels of lipoprotein(Lp[a]) has recently been proposed as a marker of cardiovascular risk.We aimed to determine the role of Lp(a) on long-term clinical outcomes in patients with ST elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).
文摘Background and Objective Treatment strategy for unstable angina has underwent significant changes since the introduction of Braunwald classification of unstable angina nearly 30 years ago,yet re-evaluation of this routinely used classification system is rarely published in recent years.We aim to re-evaluate the Braunwald unstable angina(UA)classification on its predictive value of clinical characteristics,angiographic features,and occurrence of future adverse events.
基金National Natural Science Foundation of China,Grant/Award Numbers:U22A20397,21974008Beijing Natural Science Foundation,Grant/Award Number:2212013Fundamental Research Funds for the Central Universities,Grant/Award Number:buctrc201820。
文摘Arranging dense donors around a single acceptor for the assembly of effi-cient light-harvesting antennas is a long-standing challenge due to the intractable aggregation-caused quenching of dense donors.Herein,we designed a cationic aggregation-induced emission(AIE)amphiphile to self-assemble with natural DNA duplexes.As an efficient donor,the as-prepared cationic AIE amphiphile could be densely attached to the phosphate groups of natural DNA duplexes by using the smaller cationic trimethylammonium.The long alkyl chain between the cationic trimethylammonium and the AIEfluorophore allowed for avoiding the insuffi-cient binding caused by the steric hindrance of the AIEfluorophore,resulting in a remarkably high donor/acceptor ratio comparable to that of the widely developed custom DNA assemblies.The proposed self-assembly strategy provided novelflex-ible avenues for the assembling offinely controlled and efficient light-harvesting systems into natural DNA with little synthetic modifications and low cost.
