Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the bloo...Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the blood-brain barrier.Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction.In this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells.We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells.However,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction.We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier.We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier.In a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation.We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation.These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.展开更多
When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ...When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of layers.To address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent network.By leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration process.The analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,respectively.The model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target plates.The maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed model.Moreover,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.展开更多
Depth estimation is an important task in computer vision.Collecting data at scale for monocular depth estimation is challenging,as this task requires simultaneously capturing RGB images and depth information.Therefore...Depth estimation is an important task in computer vision.Collecting data at scale for monocular depth estimation is challenging,as this task requires simultaneously capturing RGB images and depth information.Therefore,data augmentation is crucial for this task.Existing data augmentationmethods often employ pixel-wise transformations,whichmay inadvertently disrupt edge features.In this paper,we propose a data augmentationmethod formonocular depth estimation,which we refer to as the Perpendicular-Cutdepth method.This method involves cutting realworld depth maps along perpendicular directions and pasting them onto input images,thereby diversifying the data without compromising edge features.To validate the effectiveness of the algorithm,we compared it with existing convolutional neural network(CNN)against the current mainstream data augmentation algorithms.Additionally,to verify the algorithm’s applicability to Transformer networks,we designed an encoder-decoder network structure based on Transformer to assess the generalization of our proposed algorithm.Experimental results demonstrate that,in the field of monocular depth estimation,our proposed method,Perpendicular-Cutdepth,outperforms traditional data augmentationmethods.On the indoor dataset NYU,our method increases accuracy from0.900 to 0.907 and reduces the error rate from0.357 to 0.351.On the outdoor dataset KITTI,our method improves accuracy from 0.9638 to 0.9642 and decreases the error rate from 0.060 to 0.0598.展开更多
Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies,but studies have not fully evaluated its molecular subtypes,prognosis and response to immunotherapy of different su...Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies,but studies have not fully evaluated its molecular subtypes,prognosis and response to immunotherapy of different subtypes.The purpose of this study was to explore the molecular subtypes and the key genes associated with the prognosis of pancreas cancer patients and study the clinical phenotype,prognosis and response to immunotherapy using single-cell seq data and bulk RNA seq data,and data retrieved from GEO and TCGA databases.Methods:Single-cell seq data and bioinformatics methods were used in this study.Pancreatic cancer data were retrieved from GEO and TCGA databases,the molecular subtypes of pancreatic cancer were determined using the six cGAS-STING related pathways,and the clinical phenotype,mutation,immunological characteristics and pathways related to pancreatic cancer were evaluated.Results:Pancreatic cancer was classified into 3 molecular subtypes,and survival analysis revealed that patients in Cluster3(C3)had the worst prognosis,whereas Cluster1(C1)had the best prognosis.The clinical phenotype and gene mutation were statistically different among the three molecular subtypes.Analysis of immunotherapy response revealed that most immune checkpoint genes were differentially expressed in the three subtypes.A lower risk of immune escape was observed in Cluster1(C1),indicating higher sensitivity to immunotherapeutic drugs and subjects in this Cluster are more likely to benefit from immunotherapy.The pathways related to pancreatic cancer were differentially enriched among the three subtypes.Five genes,namely SFRP1,GIPR,EMP1,COL17A and CXCL11 were selected to construct a prognostic signature.Conclusions:Single-cell seq data were to classify pancreatic cancer into three molecular subtypes based on differences in clinical phenotype,mutation,immune characteristics and differentially enriched pathways.Five prognosis-related genes were identified for prediction of survival of pancreatic cancer patients and to evaluate the efficacy of immunotherapy in various subtypes.展开更多
Gypsum/salt beds are widely developed in petroliferous basins across the world.Most basins with gypsum/salt beds have been proven to host abundant hydrocarbon resources.Previous studies on the effects of gypsum/salt b...Gypsum/salt beds are widely developed in petroliferous basins across the world.Most basins with gypsum/salt beds have been proven to host abundant hydrocarbon resources.Previous studies on the effects of gypsum/salt beds on hydrocarbon reservoirs primarily focused on their excellent sealing property as cap rocks.However,an increasing number of exploration discoveries have shown that gypsum/salt beds have the potential to promote the formation of high-quality source rocks and hydrocarbon reservoirs.Gypsum/salt beds influence the generation,preservation and accumulation of hydrocarbons.Based on the systematic analysis of the generation of hydrocarbons in global gypsum/saltbearing sequences,the study discussed the control of gypsum/salt beds on play elements,and explore the relationship between the development of gypsum/salt beds and global large-and medium-scale hydrocarbon reservoirs.Furthermore,we analyzed the correlation between typical gypsum/saltbearing sequences and their hydrocarbon generation potentials in China.In-depth analysis shows three patterns in terms of the spatial superimposition of gypsum/salt beds and source rocks,that is,postsalt pattern,inter-salt pattern and pre-salt pattern.Among others,the source rocks of the inter-salt pattern are widely developed in salt basins and of great potential for hydrocarbon exploration.展开更多
The Global boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the uppermost of the Ordovician System) is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangj...The Global boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the uppermost of the Ordovician System) is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North section. The section is located near Wangjiawan village, 42 km north of Yichang city (western Hubei, China), at 30° 58′56″N and 111° 25′10″E. The GSSP level coincides with the first appearance of the graptolite species Normalograptus extraordinarius (Sobolevskaya). Secondary markers include the onset of a positive carbon-isotope excursion, and a slightly earlier first appearance of Normalograptus ojsuensis ( Koren and Mikhailova ). The Wangjiawan North section possesses continuity of sedimentation and biozonation with completeness of exposures, abundant and well-preserved graptolites and shelly fossils, i. e. the Hirnantia- Dalmanitina shelly fauna which is a key element for recognition of the Hirnantian Stage. The Wangjiawan North, South and Riverside sections possess favorable facies and widespread correlation potential, are free from structure complication, metamorphism and other alteration, and have good accessibility. The Riverside section in particular possesses amenability to isotopic age determination. The beginning of the Hirnantian was followed by a global episode of a major extinction event, which happened in the Diceratograptus mirus Subzone. The proposal was voted by the International Subcommission on Ordovician Stratigraphy in October, 2004, approved by the International Commission on Stratigraphy in February, 2006, and ratified by the International Union of Geological Sciences in May, 2006.展开更多
From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12th day of pregnancy, 300 mg/kg taurine was daily added ...From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12th day of pregnancy, 300 mg/kg taurine was daily added to food until spontaneous delivery occurred. Brain tissues from normal neonatal rats at 6 hours after delivery, neonatal rats with intrauterine growth restriction, and neo- natal rats with intrauterine growth restriction undergoing taurine supplement were obtained for fur- ther experiments. The terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling assay revealed that the number of apoptotic cells in the brain tissue of neonatal rats with intrauterine growth restriction significantly increased. Taurine supplement in pregnant rats reduced cell apoptosis in brain tissue from neonatal rats with intrauterine growth restriction. Immu- nohistochemical staining revealed that taurine supplement increased glial cell line-derived neuro- trophic factor expression and decreased caspase-3 expression in the cerebral cortex of intrauterine growth-restricted fetal rats. These results indicate that taurine supplement reduces cell apoptosis through the glial cell line-derived neurotrophic factor-caspase-3 signaling pathway, resulting in a protective effect on the intrauterine growth-restricted fetal rat brain.展开更多
Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehen...Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehensively present detailed information about spatial differences in terrain and is superior to single terrain factors. We applied remote sensing and geographical information system to terrain gradient, used the non-dimensional distribution index to examine spatial distribution characteristics of various landscape types, and analyzed the ecological effects of landscape were quantitatively on terrain gradients. Eco-environment quality (EEQ) was evaluated using the forestry operation area as the evaluation unit. The spatial distributions in various landscapes were significantly influenced by terrain factors, especially by bodies of water, cropland and residential land. The spatial distribution varied greatly in different terrain gradients for similar landscape types. The areas associated with good, intermediate and poor EEQ were occupied primarily by natural landscape, semi-natural and largely artificial landscapes, respectively.展开更多
Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with pr...Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.展开更多
The relationship between precipitation intensity and cloud water in typhoon systems remains unclear.This study combined time-and space-synchronized precipitation and spectral data obtained by the Precipitation Radar(P...The relationship between precipitation intensity and cloud water in typhoon systems remains unclear.This study combined time-and space-synchronized precipitation and spectral data obtained by the Precipitation Radar(PR)as well as the Visible and Infrared Scanner(VIRS)onboard the TRMM satellite,to overcome the limitations of precipitation properties and cloud parameters not being synchronized in previous studies.A merged dataset of near-surface rain rate(RR)and corresponding cloud water path(CWP)was established and used to analyze the potential correlation between cloud microphysical properties and precipitation,to deepen our understanding of the evolution of cloud to rain.In addition,25 collocated satellite overpasses of mature typhoon cases in the Northwest Pacific Ocean from 1998 to 2012 were obtained,and the relationships between the CWP and RR of 144515 pixels were analyzed in detail.The results show that the CWP and RR of mature typhoon systems with different precipitation types,precipitation cloud phases,and vertical depths of precipitation can be fitted by a notable sigmoid function,which may be useful for estimating CWP and parameterizing precipitation in models.Furthermore,the relationship was applied and tested with an independent sample to show that RR is a significant indicator of CWP.展开更多
In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se...In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se quantum dots and reduced graphene oxide(RGO) fragment-decorated ZnO nanowires was synthesized to overcome the narrow optical sensitive waveband and enhance the photo-responsivity. Due to the enrichment of the interface and heterostructure by RGO fragments being utilized, the photo-responsivity of the transistor was improved to 2000 AW^(-1) and the photo-sensitive wavelength was extended from ultraviolet to visible. In addition, a positive back-gate voltage was employed to reduce the Schottky barrier width of RGO fragments and ZnO nanowires. As a result, the amount of carriers was increased by 10 folds via the modulation of back-gate voltage. With these inherent properties, such as integrated circuit capability and wide optical sensitive waveband, the transistor will manifest great potential in the future applications in photodetectors.展开更多
Hydrous ruthenium oxide was formed by a new process. The precursor was obtained by mixing the aqueous solutions of RuCl3xH2O and NaHCO3. The addition of NaHCO3 led to the formation of an oxide with extremely fine RuO2...Hydrous ruthenium oxide was formed by a new process. The precursor was obtained by mixing the aqueous solutions of RuCl3xH2O and NaHCO3. The addition of NaHCO3 led to the formation of an oxide with extremely fine RuO2 particles forming a porous network structure in the oxide electrode. Polyethylene glycol was added as a controller to partly inhibit the sol-gel reaction. The rate capacitance of 530 F·g^-1 was measured for the powder formed at an optimal annealing temperature of 210℃. Several details concerning this new material, including crystal structure, particle size as a function of temperature, and electrochemical properties, were also reported. In addition, the rate capacitance of the composite electrode reached 800 F·g^-1 after carbon black was added. By using the modified electrode of a RuO2/carbon black composite electrode, the electrochemical capacitor exhibits high energy density and stable power characteristics. The values of specific energy and maximum specific power of 24 Wh·kg^-1 and 4 kW·kg^-1, respectively, are demonstrated for a cell voltage between 0 and 1 V.展开更多
In this article,we study some characterizations of Toeplitz operators with positive operator-valued function as symbols on the vector-valued generalized Bargmann-Fock spaces Fψ^2.Main results including Fock-Carleson ...In this article,we study some characterizations of Toeplitz operators with positive operator-valued function as symbols on the vector-valued generalized Bargmann-Fock spaces Fψ^2.Main results including Fock-Carleson condition,bounded Toeplitz operators,compact Toeplitz operators,and Toeplitz operators in the Schatten-p class are all considered.展开更多
Water resources are a basic need for social sustainable development and human existence.As an important national strategy for water resources security,spatial and temporal patterns and driving mechanisms of water yiel...Water resources are a basic need for social sustainable development and human existence.As an important national strategy for water resources security,spatial and temporal patterns and driving mechanisms of water yield ecosystem services on the Qingzang Plateau(QP)are critical for water resources management,optimal water allocation and the improvement of ecological water protection efficiency.However,only a few relevant studies are currently available.In this study,we simulated the water yield(WY)of the QP over 34 years,from 1982 to 2015,using the InVEST model and analyzed the spatiotemporal dynamic relationships between WY and climate change as well as between WY and vegetation change,using geographically weighted regression(GWR)models.The results showed that:1)from 1982 to 2015,the WY of the QP increased at an average rate of 3.8 mm/yr;2)WY presented a reduced spatial pattern from southeast to northwest;and 3)the WY driving factors have individual and spatial differences.In terms of the area percentage in promoting WY when analyzing each driving factor,precipitation(99.8%)and air pressure(53.3%)played the major roles in promoting WY,while temperature(71.9%),wind speed(57.2%),net primary productivity(87.2%),radiation(68.3%)and lake(87.7%)played negative roles.The areas where WY are dominated by temperature are the largest(41.1%),and followed by areas dominated by pressure(19.7%)and precipitation(18.5%).The results of this study provide scientific support for formulating regional water resources policy,social and economic development planning and other macro decisions for the QP.展开更多
For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue ...For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue necrosis.Therefore,the oxygen in our environment is vital for life.As a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and medicine.In recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific diseases.This review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.展开更多
Objective: To investigate whether human dendritic cells (DC) derived from peripheral blood mononuclear cells (PBMC), which were pulsed by heat shock protein 70 (HSP70) isolated from human bladder tumor cell lin...Objective: To investigate whether human dendritic cells (DC) derived from peripheral blood mononuclear cells (PBMC), which were pulsed by heat shock protein 70 (HSP70) isolated from human bladder tumor cell lines of E J, were able to induce peptide specific cytotoxic T-lymphocytes (CTL) response in vitro and give the experimental foundation for the future clinical trials of immunotherapy in bladder tumor. Methods: The E J-derived HSP70 co-cultured with DC from the healthy volunteers' PBMC, along with the crude lysate (the supematant before HSP70 purification) from EJ cells were used as the experimental groups and DC not pulsed by any tumor cells antigen were the blank control. The autologous T-lymphocytes were added into the above various DC groups, and after incubation, the stimulation indexes (SI) and interferon-y (IFN-γ) were detected to evaluate the immune activities of various DC groups. The killing effects of CTL to target cells, EJ and Hela cells, were determined with 51^Cr releasing test. Results: Both DC/HSP70 and DC/the crude lysate could effectively activate CTL in vitro and kill target cells EJ. The killing effect of DC/HSP70 to EJ was much stronger than DC/the crude lysate (the supernatant before HSP70 purification) (P 〈 0.05). DC without any tumor cell antigens had a lower killing power to EJ. Meanwhile, DC/ HSP70 had little killing power to Hela non-relevant to bladder tumor histopathologically as compared with EJ cells (P 〈 0.05). Conclusion: The DC pulsed by HSP70 derived from the autologous tumor cells could induce a peptide complexes specific CTL response to tumor cells, and the CTL response induced by the DC/HSP70 was stronger, which display the basis of the possible clinical application of DC/HSP70 for bladder tumor.展开更多
The BF3/n-BuOH complexes were investigated as active species in catalyzing n-decene polymerization reaction.The structures of BF3/n-BuOH complexes were characterized not only by modern spectrum but also by calculation...The BF3/n-BuOH complexes were investigated as active species in catalyzing n-decene polymerization reaction.The structures of BF3/n-BuOH complexes were characterized not only by modern spectrum but also by calculation at theoretical level. The results confirmed that BF3/n-BuOH complexes changed from BF3·(n-BuOH)2 complexes to BF3·n-BuOH complexes with the mass fraction of BF3 increasing. These two complexes have different catalytic activity, but BF3·n-BuOH was superior. The highest n-decene conversion could reach 99% and the most excellent selectivity of n-decene trimer and tetramer could reach up to 80% yield by a series of controlled conditions. This work can help to understand the catalytic active species of n-decene polymerization and provide support for industrialization of poly-alpha-olefins(PAOs).展开更多
基金supported by the Ningbo Public Welfare Science and Technology Program,No.2022S023(to JY)Ningbo Natural Science Foundation,No.2022J211(to JS)+2 种基金Ningbo Medical and Health Brand Discipline,No.PPXK2018-04(to XG)Ningbo Top Medical and Health Research Program,No.2022020304(to XG)Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province,No.2022E10026(to YH)。
文摘Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the blood-brain barrier.Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction.In this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells.We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells.However,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction.We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier.We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier.In a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation.We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation.These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.
文摘When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of layers.To address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent network.By leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration process.The analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,respectively.The model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target plates.The maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed model.Moreover,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.
基金the Grant of Program for Scientific ResearchInnovation Team in Colleges and Universities of Anhui Province(2022AH010095)The Grant ofScientific Research and Talent Development Foundation of the Hefei University(No.21-22RC15)+2 种基金The Key Research Plan of Anhui Province(No.2022k07020011)The Grant of Anhui Provincial940 CMC,2024,vol.79,no.1Natural Science Foundation,No.2308085MF213The Open Fund of Information Materials andIntelligent Sensing Laboratory of Anhui Province IMIS202205,as well as the AI General ComputingPlatform of Hefei University.
文摘Depth estimation is an important task in computer vision.Collecting data at scale for monocular depth estimation is challenging,as this task requires simultaneously capturing RGB images and depth information.Therefore,data augmentation is crucial for this task.Existing data augmentationmethods often employ pixel-wise transformations,whichmay inadvertently disrupt edge features.In this paper,we propose a data augmentationmethod formonocular depth estimation,which we refer to as the Perpendicular-Cutdepth method.This method involves cutting realworld depth maps along perpendicular directions and pasting them onto input images,thereby diversifying the data without compromising edge features.To validate the effectiveness of the algorithm,we compared it with existing convolutional neural network(CNN)against the current mainstream data augmentation algorithms.Additionally,to verify the algorithm’s applicability to Transformer networks,we designed an encoder-decoder network structure based on Transformer to assess the generalization of our proposed algorithm.Experimental results demonstrate that,in the field of monocular depth estimation,our proposed method,Perpendicular-Cutdepth,outperforms traditional data augmentationmethods.On the indoor dataset NYU,our method increases accuracy from0.900 to 0.907 and reduces the error rate from0.357 to 0.351.On the outdoor dataset KITTI,our method improves accuracy from 0.9638 to 0.9642 and decreases the error rate from 0.060 to 0.0598.
文摘Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies,but studies have not fully evaluated its molecular subtypes,prognosis and response to immunotherapy of different subtypes.The purpose of this study was to explore the molecular subtypes and the key genes associated with the prognosis of pancreas cancer patients and study the clinical phenotype,prognosis and response to immunotherapy using single-cell seq data and bulk RNA seq data,and data retrieved from GEO and TCGA databases.Methods:Single-cell seq data and bioinformatics methods were used in this study.Pancreatic cancer data were retrieved from GEO and TCGA databases,the molecular subtypes of pancreatic cancer were determined using the six cGAS-STING related pathways,and the clinical phenotype,mutation,immunological characteristics and pathways related to pancreatic cancer were evaluated.Results:Pancreatic cancer was classified into 3 molecular subtypes,and survival analysis revealed that patients in Cluster3(C3)had the worst prognosis,whereas Cluster1(C1)had the best prognosis.The clinical phenotype and gene mutation were statistically different among the three molecular subtypes.Analysis of immunotherapy response revealed that most immune checkpoint genes were differentially expressed in the three subtypes.A lower risk of immune escape was observed in Cluster1(C1),indicating higher sensitivity to immunotherapeutic drugs and subjects in this Cluster are more likely to benefit from immunotherapy.The pathways related to pancreatic cancer were differentially enriched among the three subtypes.Five genes,namely SFRP1,GIPR,EMP1,COL17A and CXCL11 were selected to construct a prognostic signature.Conclusions:Single-cell seq data were to classify pancreatic cancer into three molecular subtypes based on differences in clinical phenotype,mutation,immune characteristics and differentially enriched pathways.Five prognosis-related genes were identified for prediction of survival of pancreatic cancer patients and to evaluate the efficacy of immunotherapy in various subtypes.
基金This study was funded by a key project of the National Natural Science Fund of China(41930426)a key project of the Petrochemical Joint Fund(U1663201).
文摘Gypsum/salt beds are widely developed in petroliferous basins across the world.Most basins with gypsum/salt beds have been proven to host abundant hydrocarbon resources.Previous studies on the effects of gypsum/salt beds on hydrocarbon reservoirs primarily focused on their excellent sealing property as cap rocks.However,an increasing number of exploration discoveries have shown that gypsum/salt beds have the potential to promote the formation of high-quality source rocks and hydrocarbon reservoirs.Gypsum/salt beds influence the generation,preservation and accumulation of hydrocarbons.Based on the systematic analysis of the generation of hydrocarbons in global gypsum/saltbearing sequences,the study discussed the control of gypsum/salt beds on play elements,and explore the relationship between the development of gypsum/salt beds and global large-and medium-scale hydrocarbon reservoirs.Furthermore,we analyzed the correlation between typical gypsum/saltbearing sequences and their hydrocarbon generation potentials in China.In-depth analysis shows three patterns in terms of the spatial superimposition of gypsum/salt beds and source rocks,that is,postsalt pattern,inter-salt pattern and pre-salt pattern.Among others,the source rocks of the inter-salt pattern are widely developed in salt basins and of great potential for hydrocarbon exploration.
文摘The Global boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the uppermost of the Ordovician System) is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North section. The section is located near Wangjiawan village, 42 km north of Yichang city (western Hubei, China), at 30° 58′56″N and 111° 25′10″E. The GSSP level coincides with the first appearance of the graptolite species Normalograptus extraordinarius (Sobolevskaya). Secondary markers include the onset of a positive carbon-isotope excursion, and a slightly earlier first appearance of Normalograptus ojsuensis ( Koren and Mikhailova ). The Wangjiawan North section possesses continuity of sedimentation and biozonation with completeness of exposures, abundant and well-preserved graptolites and shelly fossils, i. e. the Hirnantia- Dalmanitina shelly fauna which is a key element for recognition of the Hirnantian Stage. The Wangjiawan North, South and Riverside sections possess favorable facies and widespread correlation potential, are free from structure complication, metamorphism and other alteration, and have good accessibility. The Riverside section in particular possesses amenability to isotopic age determination. The beginning of the Hirnantian was followed by a global episode of a major extinction event, which happened in the Diceratograptus mirus Subzone. The proposal was voted by the International Subcommission on Ordovician Stratigraphy in October, 2004, approved by the International Commission on Stratigraphy in February, 2006, and ratified by the International Union of Geological Sciences in May, 2006.
基金funded by the National Natural Science Foundation of China,No.81170577
文摘From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12th day of pregnancy, 300 mg/kg taurine was daily added to food until spontaneous delivery occurred. Brain tissues from normal neonatal rats at 6 hours after delivery, neonatal rats with intrauterine growth restriction, and neo- natal rats with intrauterine growth restriction undergoing taurine supplement were obtained for fur- ther experiments. The terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling assay revealed that the number of apoptotic cells in the brain tissue of neonatal rats with intrauterine growth restriction significantly increased. Taurine supplement in pregnant rats reduced cell apoptosis in brain tissue from neonatal rats with intrauterine growth restriction. Immu- nohistochemical staining revealed that taurine supplement increased glial cell line-derived neuro- trophic factor expression and decreased caspase-3 expression in the cerebral cortex of intrauterine growth-restricted fetal rats. These results indicate that taurine supplement reduces cell apoptosis through the glial cell line-derived neurotrophic factor-caspase-3 signaling pathway, resulting in a protective effect on the intrauterine growth-restricted fetal rat brain.
基金supported by National High Technology Research and Development Program 863(Grant No.2012AA102001)Natural Scientific Foundation of Heilongjiang Province(Grant No.D201410)Natural Science Foundation of Heilongjiang Province Department Education Commission(Grant No.12531513)
文摘Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehensively present detailed information about spatial differences in terrain and is superior to single terrain factors. We applied remote sensing and geographical information system to terrain gradient, used the non-dimensional distribution index to examine spatial distribution characteristics of various landscape types, and analyzed the ecological effects of landscape were quantitatively on terrain gradients. Eco-environment quality (EEQ) was evaluated using the forestry operation area as the evaluation unit. The spatial distributions in various landscapes were significantly influenced by terrain factors, especially by bodies of water, cropland and residential land. The spatial distribution varied greatly in different terrain gradients for similar landscape types. The areas associated with good, intermediate and poor EEQ were occupied primarily by natural landscape, semi-natural and largely artificial landscapes, respectively.
文摘Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.
基金the National Natural Science Foundation of China(grant no.91837310,41675041,41705011)the National Key R&D Program of China(2018YFC1507200,2017YFC1501402)+2 种基金the Key research and development projects in Anhui province(201904a07020099)the Third Tibetan Plateau Scientific Experiment:Observations for Boundary Layer and Troposphere(Grant No.GYHY201406001)CLIMATE-TPE(ID 32070)in the framework of the ESA-MOST Dragon 4 program.
文摘The relationship between precipitation intensity and cloud water in typhoon systems remains unclear.This study combined time-and space-synchronized precipitation and spectral data obtained by the Precipitation Radar(PR)as well as the Visible and Infrared Scanner(VIRS)onboard the TRMM satellite,to overcome the limitations of precipitation properties and cloud parameters not being synchronized in previous studies.A merged dataset of near-surface rain rate(RR)and corresponding cloud water path(CWP)was established and used to analyze the potential correlation between cloud microphysical properties and precipitation,to deepen our understanding of the evolution of cloud to rain.In addition,25 collocated satellite overpasses of mature typhoon cases in the Northwest Pacific Ocean from 1998 to 2012 were obtained,and the relationships between the CWP and RR of 144515 pixels were analyzed in detail.The results show that the CWP and RR of mature typhoon systems with different precipitation types,precipitation cloud phases,and vertical depths of precipitation can be fitted by a notable sigmoid function,which may be useful for estimating CWP and parameterizing precipitation in models.Furthermore,the relationship was applied and tested with an independent sample to show that RR is a significant indicator of CWP.
基金partially supported by the National Key Basic Research Program 973 (2013CB328804, 2013CB328803)the National High-Tech R&D Program 863 of China (2012AA03A302, 2013AA011004)+4 种基金the National Natural Science Foundation Project (51120125001, 61271053, 61306140, 61405033, 91333118, 61372030, 61307077 and 51202028)the Beijing Natural Science Foundation (4144076)the China Postdoctoral Science Foundation (2013M530613 and 2015T80080)the Natural Science Foundation Project of Jiangsu Province (BK20141390, BK20130629, and BK20130618)the Scientific Research Department of Graduate School in Southeast University
文摘In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se quantum dots and reduced graphene oxide(RGO) fragment-decorated ZnO nanowires was synthesized to overcome the narrow optical sensitive waveband and enhance the photo-responsivity. Due to the enrichment of the interface and heterostructure by RGO fragments being utilized, the photo-responsivity of the transistor was improved to 2000 AW^(-1) and the photo-sensitive wavelength was extended from ultraviolet to visible. In addition, a positive back-gate voltage was employed to reduce the Schottky barrier width of RGO fragments and ZnO nanowires. As a result, the amount of carriers was increased by 10 folds via the modulation of back-gate voltage. With these inherent properties, such as integrated circuit capability and wide optical sensitive waveband, the transistor will manifest great potential in the future applications in photodetectors.
文摘Hydrous ruthenium oxide was formed by a new process. The precursor was obtained by mixing the aqueous solutions of RuCl3xH2O and NaHCO3. The addition of NaHCO3 led to the formation of an oxide with extremely fine RuO2 particles forming a porous network structure in the oxide electrode. Polyethylene glycol was added as a controller to partly inhibit the sol-gel reaction. The rate capacitance of 530 F·g^-1 was measured for the powder formed at an optimal annealing temperature of 210℃. Several details concerning this new material, including crystal structure, particle size as a function of temperature, and electrochemical properties, were also reported. In addition, the rate capacitance of the composite electrode reached 800 F·g^-1 after carbon black was added. By using the modified electrode of a RuO2/carbon black composite electrode, the electrochemical capacitor exhibits high energy density and stable power characteristics. The values of specific energy and maximum specific power of 24 Wh·kg^-1 and 4 kW·kg^-1, respectively, are demonstrated for a cell voltage between 0 and 1 V.
基金Supported by National Natural Science Foundation of China(11471084,11301101,11971125)Young Innovative Talent Project of Department of Edcucation of Guangdong Province(2017KQNCX220)the Natural Research Project of Zhaoqing University(221622).
文摘In this article,we study some characterizations of Toeplitz operators with positive operator-valued function as symbols on the vector-valued generalized Bargmann-Fock spaces Fψ^2.Main results including Fock-Carleson condition,bounded Toeplitz operators,compact Toeplitz operators,and Toeplitz operators in the Schatten-p class are all considered.
基金supported by The Second Tibetan Plateau Scientific Expedition and Research(Grant No.2019QZKK0405)the Chinese Academy of Sciences through the Strategic Pilot Science and Technology Special Project(Category A)(Grant No.XDA2002040201)the Shaanxi Provincial Key Laboratory of Land Management Open Fund(Grant No.2018-ZD01).
文摘Water resources are a basic need for social sustainable development and human existence.As an important national strategy for water resources security,spatial and temporal patterns and driving mechanisms of water yield ecosystem services on the Qingzang Plateau(QP)are critical for water resources management,optimal water allocation and the improvement of ecological water protection efficiency.However,only a few relevant studies are currently available.In this study,we simulated the water yield(WY)of the QP over 34 years,from 1982 to 2015,using the InVEST model and analyzed the spatiotemporal dynamic relationships between WY and climate change as well as between WY and vegetation change,using geographically weighted regression(GWR)models.The results showed that:1)from 1982 to 2015,the WY of the QP increased at an average rate of 3.8 mm/yr;2)WY presented a reduced spatial pattern from southeast to northwest;and 3)the WY driving factors have individual and spatial differences.In terms of the area percentage in promoting WY when analyzing each driving factor,precipitation(99.8%)and air pressure(53.3%)played the major roles in promoting WY,while temperature(71.9%),wind speed(57.2%),net primary productivity(87.2%),radiation(68.3%)and lake(87.7%)played negative roles.The areas where WY are dominated by temperature are the largest(41.1%),and followed by areas dominated by pressure(19.7%)and precipitation(18.5%).The results of this study provide scientific support for formulating regional water resources policy,social and economic development planning and other macro decisions for the QP.
基金This work was supported by Grants from the National Natural Science Foundation of China(Nos.81671918 and 81372072)the Zhejiang Provincial Medical and Healthy Science Foundation of China(Nos.2021452516,2019ZD028,and 2018KY874)the National Key Research Program of China(No.2016YFC1101004).
文摘For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue necrosis.Therefore,the oxygen in our environment is vital for life.As a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and medicine.In recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific diseases.This review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.
基金Supported by a grant from the National Natural Science Foundation of China (No. 3000754).
文摘Objective: To investigate whether human dendritic cells (DC) derived from peripheral blood mononuclear cells (PBMC), which were pulsed by heat shock protein 70 (HSP70) isolated from human bladder tumor cell lines of E J, were able to induce peptide specific cytotoxic T-lymphocytes (CTL) response in vitro and give the experimental foundation for the future clinical trials of immunotherapy in bladder tumor. Methods: The E J-derived HSP70 co-cultured with DC from the healthy volunteers' PBMC, along with the crude lysate (the supematant before HSP70 purification) from EJ cells were used as the experimental groups and DC not pulsed by any tumor cells antigen were the blank control. The autologous T-lymphocytes were added into the above various DC groups, and after incubation, the stimulation indexes (SI) and interferon-y (IFN-γ) were detected to evaluate the immune activities of various DC groups. The killing effects of CTL to target cells, EJ and Hela cells, were determined with 51^Cr releasing test. Results: Both DC/HSP70 and DC/the crude lysate could effectively activate CTL in vitro and kill target cells EJ. The killing effect of DC/HSP70 to EJ was much stronger than DC/the crude lysate (the supernatant before HSP70 purification) (P 〈 0.05). DC without any tumor cell antigens had a lower killing power to EJ. Meanwhile, DC/ HSP70 had little killing power to Hela non-relevant to bladder tumor histopathologically as compared with EJ cells (P 〈 0.05). Conclusion: The DC pulsed by HSP70 derived from the autologous tumor cells could induce a peptide complexes specific CTL response to tumor cells, and the CTL response induced by the DC/HSP70 was stronger, which display the basis of the possible clinical application of DC/HSP70 for bladder tumor.
基金Support by National Key Research and Development Program of China(2017YFB0306701)State Key Laboratory Opening Project Foundation of Jilin University(2018-16).
文摘The BF3/n-BuOH complexes were investigated as active species in catalyzing n-decene polymerization reaction.The structures of BF3/n-BuOH complexes were characterized not only by modern spectrum but also by calculation at theoretical level. The results confirmed that BF3/n-BuOH complexes changed from BF3·(n-BuOH)2 complexes to BF3·n-BuOH complexes with the mass fraction of BF3 increasing. These two complexes have different catalytic activity, but BF3·n-BuOH was superior. The highest n-decene conversion could reach 99% and the most excellent selectivity of n-decene trimer and tetramer could reach up to 80% yield by a series of controlled conditions. This work can help to understand the catalytic active species of n-decene polymerization and provide support for industrialization of poly-alpha-olefins(PAOs).