Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forec...Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells.展开更多
Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs)...Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs),which have widely interested scholars in the shipping industry due to their safety,high efficiency,and energy-saving qualities.Considering the current development of USVs,the types of USVs and applications domestically and internationally are being investigated.USVs emerged with technological developments and their characteristics show some differences from traditional vessels,which brings some problems and advantages for their application.Certain maritime regulations are not applicable to USVs and must be changed.The key technologies in the current development of USVs are being investigated.While the level of intelligence is improving,the protection of cargo cannot be neglected.An innovative approach to the internal structure of USVs is proposed,where the inner hull can automatically recover its original state in case of outer hull tilting.Finally,we summarize the development status of USVs,which are an inevitable direction of development in the marine field.展开更多
The objectives of this study were to 1) determine the variation of nutrient digestion, plasma metabolites and oxidative stress parameters triggered by induced subacute ruminal acidosis (SARA); and 2) evaluate the ...The objectives of this study were to 1) determine the variation of nutrient digestion, plasma metabolites and oxidative stress parameters triggered by induced subacute ruminal acidosis (SARA); and 2) evaluate the ability of pelleted beet pulp (BP) as a replacement for ground corn to alleviate SARA. Eight Holstein-Friesian cows were fed four diets during four successive17 day periods: 1) total mixed ration (TMR) containing 0% finely ground wheat (FGW) (WO); 2) TMR containing 10% FGW (W10); 3) TMR containing 20% FGW (W20); and 4) TMR containing 10% BP as a replacement for 10% ground corn (BP10). The SARA induction protocol reduced the mean ruminal pH from 6.37 to 5.94, and the minimum ruminal pH decreased from 5.99 to 5.41 from baseline to challenge period. Mean ruminal pH increased from 5.94 to 6.05, and minimum daily ruminal pH increased from 5.41 to 5.63, when BP was substituted for corn. The apparent digestibility of nutrients was not affected by the dietary treatments, except that the digestibility of neutral detergent fibre (NDF) and acid detergent fibre (ADF) was reduced in cows fed the W20 diet compared with cows fed the W0 and W10 diets, and cows fed the BP10 diet had higher NDF and ADF digestibility than the cows fed the W20 diet. Cows fed the W20 diet had a lower plasma concentration of 13-hydroxybutyrate (BHBA), non-esterified fatty acids (NEFA), cholesterol, triglyceride, and total antioxidative capacity (TAC), and a higher plasma concentration of glucose, insulin, malonaldehyde (MDA), super oxygen dehydrogenises (SOD), and glutathione peroxidase (GSH-Px) than cows fed the W0 diet. Substitution of BP for corn increased concentrations of plasma BHBA and TAC, but decreased concentrations of plasma MDA. Our results indicate that reduction of fibre digestion; the concomitant increase of plasma glucose and insulin; the decrease of plasma BHBA, NEFA, cholesterol, and triglyceride; and changes of plasma oxidative stress parameters are highly related to SARA induced by W20 diets. These variables may be alternative candidates for SARA diagnosis. We also suggest that the substitution of BP for corn could reduce the risk of SARA, increase fibre digestion, and improve the antioxidant status in dairy cows.展开更多
This study provides a comprehensive evaluation of historical surface soil moisture simulation(1979-2012)over Eurasia at annual and seasonal time scales between two medium-resolution versions of the Beijing Climate Cen...This study provides a comprehensive evaluation of historical surface soil moisture simulation(1979-2012)over Eurasia at annual and seasonal time scales between two medium-resolution versions of the Beijing Climate Center Climate System Model(BCC-CSM)—one that is currently participating in phase 6 of the Coupled Model Intercomparison Project(CMIP6),i.e.,BCC-CSM2-MR,and the other,BCC-CSM1.1m,which participated in CMIP5.We show that BCC-CSM2-MR is more skillful in reproducing the climate mean states and standard deviations of soil moisture,with pattern correlations increased and biases reduced significantly.BCC-CSM2-MR performs better in capturing the first two primary patterns of soil moisture anomalies,where the period of the corresponding time series is closer to that of reference data.Comparisons show that BCC-CSM2-MR performs at a high level among multiple models of CMIP6 in terms of centered pattern correlation and“amplitude of variation”(relative standard deviation).In general,the centered pattern correlation of BCC-CSM2-MR,ranging from 0.61 to 0.87,is higher than the multi-model mean of CMIP6,and the relative standard deviation is 0.75,which surmounts the overestimations in most of the CMIP6 models.Due to the vital role played by precipitation in land-atmosphere interaction,possible causes of the improvement of soil moisture simulation are further related to precipitation in BCC-CSM2-MR.The results indicate that a better description of the relationship between soil moisture and precipitation and a better reproduction of the climate mean precipitation by the model may result in the improved performance of soil moisture simulation.展开更多
Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and trea...Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went well.Conclusions: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports.展开更多
Objective This study aimed to elucidate the association between the level of preoperative serum fibrinogen(PSF)and the prognosis of patients with esophageal squamous cell carcinoma(ESCC).Methods From January 2010 to D...Objective This study aimed to elucidate the association between the level of preoperative serum fibrinogen(PSF)and the prognosis of patients with esophageal squamous cell carcinoma(ESCC).Methods From January 2010 to December 2016,all patients diagnosed with ESCC who underwent surgery in Qingdao Municipal Hospital were analyzed retrospectively.Moreover,the fibrinogen levels of all patients were assessed before surgery,and hyperfibrinogenemia was diagnosed when the fibrinogen level was≥4.0 g/L.The impact of PSF on disease-free survival(DFS)and overall survival(OS)was analyzed using the log-rank method and Cox proportional hazards regression model.P value less than 0.05 was considered statistically significant.Results A total of 336 patients were finally analyzed,and approximately 102 patients(30.36%)were diagnosed with hyperfibrinogenemia before surgery.Hyperfibrinogenemia was associated with older age(≥70 years)(P=0.012),advanced pathological T stage(P=0.003),and lymph node involvement(P=0.024).Univariate analysis showed that patients with hyperfibrinogenemia had shorter DFS(1.96 years vs.3.64 years,P=0.001)and OS(2.27 years vs.4.15 years,P<0.001)than patients without hyperfibrinogenemia.Multivariate analysis confirmed that PSF was an independent factor affecting DFS(risk ratio[RR]:1.35,95%confidence interval[CI]:1.02-1.79,P=0.038)and OS(RR:1.37,95%CI:1.03-1.83,P=0.034)in patients with ESCC.Conclusion For patients with operable ESCC,hyperfibrinogenemia had poor prognosis.Moreover,PSF is an independent prognostic factor for operable ESCC.展开更多
The Ms6.2 Dayao, Yunnan, earthquake occurred on July 21, 2003, followed by a major Ms6.1 earthquake about 88 days later in the same region. Hypocenters of the two earthquakes are almost in the same place. Based on the...The Ms6.2 Dayao, Yunnan, earthquake occurred on July 21, 2003, followed by a major Ms6.1 earthquake about 88 days later in the same region. Hypocenters of the two earthquakes are almost in the same place. Based on the P wave first motion polarities of the two aftershock sequences recorded by temporary stations, we have studied the stress field in the aftershock zone and obtained the two stress field directions in Dayao region using the new version of PKU_Grid^Test Software provided by Chunquan Yu. Assuming that the rotation of the stress field is caused by the second main shock, we estimated the crustal stress value in the focal region by using the stress value calculation method proposed by Yongge Wan. The estimated maximum, intermediate and minimum principal stresses are 166.3 MPa, 158.7 MPa and 151 MPa, respectively, before the second main shock. The normal and shear stresses projected on the fault plane of the second main shock before it occurred are 157.3 MPa, 7.4 MPa, and are 158.8 MPa, 0.2 MPa after it occurred, respectively. The perturbed input parameters experiments attest the stability of the solution. The result shows that the preseismic shear stress is larger than the post-seismic one, and their difference corresponds to the stress drop approximately. The estimated compressive stress level is very high, but the differential stress is low. The result is helpful for friction coefficient estimation, plate motion simulation and related studies.展开更多
Water transportation today has become increasingly busy because of economic globalization.In order to solve the problem of inaccurate port traffic flow prediction,this paper proposes an algorithm based on gated recurr...Water transportation today has become increasingly busy because of economic globalization.In order to solve the problem of inaccurate port traffic flow prediction,this paper proposes an algorithm based on gated recurrent units(GRUs)and Markov residual correction to pass a fixed cross-section.To analyze the traffic flow of ships,the statistical method of ship traffic flow based on the automatic identification system(AIS)is introduced.And a model is put forward for predicting the ship flow.According to the basic principle of cyclic neural networks,the law of ship traffic flow in the channel is explored in the time series.Experiments have been performed using a large number of AIS data in the waters near Xiazhimen in Zhoushan,Ningbo,and the results show that the accuracy of the GRU-Markov algorithm is higher than that of other algorithms,proving the practicability and effectiveness of this method in ship flow prediction.展开更多
In paired Fermi systems,strong many-body effects exhibit in the crossover regime between the Bardeen–Cooper–Schrieffer(BCS)and the Bose–Einstein condensation(BEC)limits.The concept of the BCS–BEC crossover,which i...In paired Fermi systems,strong many-body effects exhibit in the crossover regime between the Bardeen–Cooper–Schrieffer(BCS)and the Bose–Einstein condensation(BEC)limits.The concept of the BCS–BEC crossover,which is studied intensively in the research field of cold atoms,has been extended to condensed matters.Here by analyzing the typical superconductors within the BCS–BEC phase diagram,we find that FeSe-based superconductors are prone to shift their positions in the BCS–BEC crossover regime by charge doping or substrate substitution,since their Fermi energies and the superconducting gap sizes are comparable.Especially at the interface of single-layer FeSe on SrTiO3 substrate,the superconductivity is relocated closer to the crossover unitary than other doped FeSe-based materials,indicating that the pairing interaction is effectively modulated.We further show that hole-doping can drive the interfacial system into the phase with possible pre-paired electrons,demonstrating its flexible tunability within the BCS–BEC crossover regime.展开更多
Kagome superconductors AV3Sb5(A=Cs,V,Sb) have served as an ideal platform to unveil the intriguing competitions between charge-density-wave(CDW),superconductivity and possible nontrivial topological states.We report s...Kagome superconductors AV3Sb5(A=Cs,V,Sb) have served as an ideal platform to unveil the intriguing competitions between charge-density-wave(CDW),superconductivity and possible nontrivial topological states.We report soft point-contact spectroscopy(SPCS) studies on CsV3Sb5under pressure up to 2.5 GPa.Its superconducting transition temperature Tcand gaps for SPCS at pressure P=0.1 GPa suggest the absence of the adverse local strain effect as observed in point-contacts at ambient pressure,while the SPCS-determined Tcunder hydrostatic pressure deviates from the reported double dome feature below 2.5 GPa.Three distinct gap values in CsV3Sb5are proposed to exist through the whole pressure range with 2Δ1/kBTc≤1,2Δ2/kBTc~2.3-3.0 and 2Δ3/kBTc>3.5.The two smaller gaps for 2Δ1/kBTc≤1 and 2Δ2/kBTc~2.3-3.0 are robust under pressure,while there is no trace of the largest gap 2Δ3/kBTc>3.5 for SPCS in the c direction with P≤P1=0.7 GPa and P≥ P2=2.0 GPa and it becomes observable in the pressure range of(P1,P2),suggesting a complex relation between CDW and superconductivity between(P1,P2).展开更多
Conventional kinetics theory for diffusion-controlled phase transformation shows that the reverse transition should lag behind the temperature rise through rapid heating,i.e.,overheating is required.In this work,we fo...Conventional kinetics theory for diffusion-controlled phase transformation shows that the reverse transition should lag behind the temperature rise through rapid heating,i.e.,overheating is required.In this work,we found that theβ-transus temperature decreased by∼50℃ during studying theα→βtransformation in Ti-6Al-4V alloy via electropulsing treatment(EPT).The calculation suggests that the acceleration of transformation kinetics cannot be fully explained by Joule heat and athermal effects of the electromigration effect and electron wind theory.The microstructural evolution during EPT was systematically investigated utilizing scanning electron microscope(SEM),electron backscattered diffraction(EBSD),X-ray diffraction(XRD),transmission Kikuchi diffraction(TKD),and transmission electron micro-scope(TEM).Microscopic analysis shows that the nano-sizedωand O'phases formed in theβphase,which causes large numbers of lattice distortion regions.The defects are conducive to accelerating the bulk diffusion of alloying elements inβ.Moreover,the nanodomains limited the growth of martensite,therefore nanocrystalline martensite formed after quenching.These findings develop the understanding of the destructive effect of current on metallic crystal,which will help to guide microstructural regulation in titanium and other alloys.展开更多
Selective laser melting(SLM)is one of the most popular addi-tive manufacturing(AM)technologies.As a near-net shape man-ufacturing method,it offers many advantages from the manufac-turing perspective and has attracted ...Selective laser melting(SLM)is one of the most popular addi-tive manufacturing(AM)technologies.As a near-net shape man-ufacturing method,it offers many advantages from the manufac-turing perspective and has attracted more and more current re-search interests in fabricating the workhorse titanium alloy Ti-6Al-4 V[1].Since the high cooling rate of the molten pool and complicated thermal cycle will result in a fine and metastableαmicrostructure,generally,post-process is required to optimize the microstructure for the widespread application need.Hot iso-static pressing(HIP)and traditional heat treatment are the main post-treatments for the SLM-built Ti-6Al-4 V component[2].How-ever,HIP is a high-cost process and most heat treatments could not achieve a microstructure with high strength-ductility synergy and thermostability,e.g.,sub-transus water quenched microstruc-ture showed superior mechanical properties,but the martensite is far from thermodynamic equilibrium;the sup-transus air cooled microstructure has high thermostability but exhibits low elonga-tion[3,4].展开更多
For over a century,the structure and evolution of the nervous system have been at the center of debate among biologists.In the 19th century,Camillo Golgi first proposed that the nervous system is a syncytial continuum...For over a century,the structure and evolution of the nervous system have been at the center of debate among biologists.In the 19th century,Camillo Golgi first proposed that the nervous system is a syncytial continuum,with neurons being directly connected with shared cell membranes and cytoplasm[1].This concept is known as the reticular theory(also referred to as the syncytial theory).However,this view was later challenged by Santiago Ramon y Cajal,who put forward the neuronal doctrine[2].展开更多
This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing ...This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations.展开更多
基金supported by the Science and Technology Grant No.520120210003,Jibei Electric Power Company of the State Grid Corporation of China。
文摘Convective storms and lightning are among the most important weather phenomena that are challenging to forecast.In this study,a novel multi-task learning(MTL)encoder-decoder U-net neural network was developed to forecast convective storms and lightning with lead times for up to 90 min,using GOES-16 geostationary satellite infrared brightness temperatures(IRBTs),lightning flashes from Geostationary Lightning Mapper(GLM),and vertically integrated liquid(VIL)from Next Generation Weather Radar(NEXRAD).To cope with the heavily skewed distribution of lightning data,a spatiotemporal exponent-weighted loss function and log-transformed lightning normalization approach were developed.The effects of MTL,single-task learning(STL),and IRBTs as auxiliary input features on convection and lightning nowcasting were investigated.The results showed that normalizing the heavily skew-distributed lightning data along with a log-transformation dramatically outperforms the min-max normalization method for nowcasting an intense lightning event.The MTL model significantly outperformed the STL model for both lightning nowcasting and VIL nowcasting,particularly for intense lightning events.The MTL also helped delay the lightning forecast performance decay with the lead times.Furthermore,incorporating satellite IRBTs as auxiliary input features substantially improved lightning nowcasting,but produced little difference in VIL forecasting.Finally,the MTL model performed better for forecasting both lightning and the VIL of organized convective storms than for isolated cells.
基金Shanghai High-level Local University Innovation Team(Maritime Safety&Technical Support)the National Natural Science Foundation of China (Grant No. 42176217)
文摘Following developments in artificial intelligence and big data technology,the level of intelligence in intelligent vessels has been improved.Intelligent vessels are being developed into unmanned surface vehicles(USVs),which have widely interested scholars in the shipping industry due to their safety,high efficiency,and energy-saving qualities.Considering the current development of USVs,the types of USVs and applications domestically and internationally are being investigated.USVs emerged with technological developments and their characteristics show some differences from traditional vessels,which brings some problems and advantages for their application.Certain maritime regulations are not applicable to USVs and must be changed.The key technologies in the current development of USVs are being investigated.While the level of intelligence is improving,the protection of cargo cannot be neglected.An innovative approach to the internal structure of USVs is proposed,where the inner hull can automatically recover its original state in case of outer hull tilting.Finally,we summarize the development status of USVs,which are an inevitable direction of development in the marine field.
基金financially supported by funds from the National Key Basic Research Program of China(Project No.2011CB100801)
文摘The objectives of this study were to 1) determine the variation of nutrient digestion, plasma metabolites and oxidative stress parameters triggered by induced subacute ruminal acidosis (SARA); and 2) evaluate the ability of pelleted beet pulp (BP) as a replacement for ground corn to alleviate SARA. Eight Holstein-Friesian cows were fed four diets during four successive17 day periods: 1) total mixed ration (TMR) containing 0% finely ground wheat (FGW) (WO); 2) TMR containing 10% FGW (W10); 3) TMR containing 20% FGW (W20); and 4) TMR containing 10% BP as a replacement for 10% ground corn (BP10). The SARA induction protocol reduced the mean ruminal pH from 6.37 to 5.94, and the minimum ruminal pH decreased from 5.99 to 5.41 from baseline to challenge period. Mean ruminal pH increased from 5.94 to 6.05, and minimum daily ruminal pH increased from 5.41 to 5.63, when BP was substituted for corn. The apparent digestibility of nutrients was not affected by the dietary treatments, except that the digestibility of neutral detergent fibre (NDF) and acid detergent fibre (ADF) was reduced in cows fed the W20 diet compared with cows fed the W0 and W10 diets, and cows fed the BP10 diet had higher NDF and ADF digestibility than the cows fed the W20 diet. Cows fed the W20 diet had a lower plasma concentration of 13-hydroxybutyrate (BHBA), non-esterified fatty acids (NEFA), cholesterol, triglyceride, and total antioxidative capacity (TAC), and a higher plasma concentration of glucose, insulin, malonaldehyde (MDA), super oxygen dehydrogenises (SOD), and glutathione peroxidase (GSH-Px) than cows fed the W0 diet. Substitution of BP for corn increased concentrations of plasma BHBA and TAC, but decreased concentrations of plasma MDA. Our results indicate that reduction of fibre digestion; the concomitant increase of plasma glucose and insulin; the decrease of plasma BHBA, NEFA, cholesterol, and triglyceride; and changes of plasma oxidative stress parameters are highly related to SARA induced by W20 diets. These variables may be alternative candidates for SARA diagnosis. We also suggest that the substitution of BP for corn could reduce the risk of SARA, increase fibre digestion, and improve the antioxidant status in dairy cows.
基金supported by the National Key Research and Development Program of China(Grant Nos.2018YFC1506004 and 2016YFA0602602).
文摘This study provides a comprehensive evaluation of historical surface soil moisture simulation(1979-2012)over Eurasia at annual and seasonal time scales between two medium-resolution versions of the Beijing Climate Center Climate System Model(BCC-CSM)—one that is currently participating in phase 6 of the Coupled Model Intercomparison Project(CMIP6),i.e.,BCC-CSM2-MR,and the other,BCC-CSM1.1m,which participated in CMIP5.We show that BCC-CSM2-MR is more skillful in reproducing the climate mean states and standard deviations of soil moisture,with pattern correlations increased and biases reduced significantly.BCC-CSM2-MR performs better in capturing the first two primary patterns of soil moisture anomalies,where the period of the corresponding time series is closer to that of reference data.Comparisons show that BCC-CSM2-MR performs at a high level among multiple models of CMIP6 in terms of centered pattern correlation and“amplitude of variation”(relative standard deviation).In general,the centered pattern correlation of BCC-CSM2-MR,ranging from 0.61 to 0.87,is higher than the multi-model mean of CMIP6,and the relative standard deviation is 0.75,which surmounts the overestimations in most of the CMIP6 models.Due to the vital role played by precipitation in land-atmosphere interaction,possible causes of the improvement of soil moisture simulation are further related to precipitation in BCC-CSM2-MR.The results indicate that a better description of the relationship between soil moisture and precipitation and a better reproduction of the climate mean precipitation by the model may result in the improved performance of soil moisture simulation.
文摘Background: This study aimed to illustrate the prevalence of CHD by screening children in extremely high-altitudeareas (over 4000 m to even 5000 m above sea level) and explore an aid model for early diagnosis and treatmentfor the Tibetan population. Methods: A total of 2242 students from different schools in Ngamring County,Xigaze City, Tibet from September 2019 to September 2020 were selected for screening. The students were examinedthrough the inquiry of their current medical history and family history, cardiac auscultation and a physicalexamination, in order to screen out the suspected cases of CHD, and then the suspected cases were confirmed bycardiac color ultrasound examinations. After that, positive patients were be transferred to Shandong Province forfree treatment. Results: The prevalence of CHD among children in Ngamring County was 3.70% (83 cases),which is the highest incidence rate ever reported. The most common type of CHD was patent ductus arteriosus(PDA), accounting for 55.42% of the total number of cases screened, followed by atrial septal defect (ASD) andventricular septal defect (VSD), accounting for 28.92% and 12.05%, respectively. The prevalence of CHD in childrenat high altitude was significantly higher than that in children at low altitude. The children with CHD weretransferred to Shandong Province for surgery, the operations were successful and their recoveries went well.Conclusions: The results show that high altitude is closely related to the prevalence of CHD, and the incidencein Ngamring County is much higher than that in previous reports.
文摘Objective This study aimed to elucidate the association between the level of preoperative serum fibrinogen(PSF)and the prognosis of patients with esophageal squamous cell carcinoma(ESCC).Methods From January 2010 to December 2016,all patients diagnosed with ESCC who underwent surgery in Qingdao Municipal Hospital were analyzed retrospectively.Moreover,the fibrinogen levels of all patients were assessed before surgery,and hyperfibrinogenemia was diagnosed when the fibrinogen level was≥4.0 g/L.The impact of PSF on disease-free survival(DFS)and overall survival(OS)was analyzed using the log-rank method and Cox proportional hazards regression model.P value less than 0.05 was considered statistically significant.Results A total of 336 patients were finally analyzed,and approximately 102 patients(30.36%)were diagnosed with hyperfibrinogenemia before surgery.Hyperfibrinogenemia was associated with older age(≥70 years)(P=0.012),advanced pathological T stage(P=0.003),and lymph node involvement(P=0.024).Univariate analysis showed that patients with hyperfibrinogenemia had shorter DFS(1.96 years vs.3.64 years,P=0.001)and OS(2.27 years vs.4.15 years,P<0.001)than patients without hyperfibrinogenemia.Multivariate analysis confirmed that PSF was an independent factor affecting DFS(risk ratio[RR]:1.35,95%confidence interval[CI]:1.02-1.79,P=0.038)and OS(RR:1.37,95%CI:1.03-1.83,P=0.034)in patients with ESCC.Conclusion For patients with operable ESCC,hyperfibrinogenemia had poor prognosis.Moreover,PSF is an independent prognostic factor for operable ESCC.
基金supported by the National Natural Science Foundation of China (40874022,41074072)Public Utility Research Project (200808053)973 program (2008CB425703)
文摘The Ms6.2 Dayao, Yunnan, earthquake occurred on July 21, 2003, followed by a major Ms6.1 earthquake about 88 days later in the same region. Hypocenters of the two earthquakes are almost in the same place. Based on the P wave first motion polarities of the two aftershock sequences recorded by temporary stations, we have studied the stress field in the aftershock zone and obtained the two stress field directions in Dayao region using the new version of PKU_Grid^Test Software provided by Chunquan Yu. Assuming that the rotation of the stress field is caused by the second main shock, we estimated the crustal stress value in the focal region by using the stress value calculation method proposed by Yongge Wan. The estimated maximum, intermediate and minimum principal stresses are 166.3 MPa, 158.7 MPa and 151 MPa, respectively, before the second main shock. The normal and shear stresses projected on the fault plane of the second main shock before it occurred are 157.3 MPa, 7.4 MPa, and are 158.8 MPa, 0.2 MPa after it occurred, respectively. The perturbed input parameters experiments attest the stability of the solution. The result shows that the preseismic shear stress is larger than the post-seismic one, and their difference corresponds to the stress drop approximately. The estimated compressive stress level is very high, but the differential stress is low. The result is helpful for friction coefficient estimation, plate motion simulation and related studies.
文摘Water transportation today has become increasingly busy because of economic globalization.In order to solve the problem of inaccurate port traffic flow prediction,this paper proposes an algorithm based on gated recurrent units(GRUs)and Markov residual correction to pass a fixed cross-section.To analyze the traffic flow of ships,the statistical method of ship traffic flow based on the automatic identification system(AIS)is introduced.And a model is put forward for predicting the ship flow.According to the basic principle of cyclic neural networks,the law of ship traffic flow in the channel is explored in the time series.Experiments have been performed using a large number of AIS data in the waters near Xiazhimen in Zhoushan,Ningbo,and the results show that the accuracy of the GRU-Markov algorithm is higher than that of other algorithms,proving the practicability and effectiveness of this method in ship flow prediction.
基金Supported by the National Key R&D Program of China under Grant Nos 2017YFA0303600,2016YFA0300600 and2016YFA0202300the National Natural Science Foundation of China under Grant No 11634016+3 种基金the Strategic Priority Research Program(B)of Chinese Academy of Sciences under Grant No XDB07030100the Research Program of Beijing Academy of Quantum Information Sciences under Grant No Y18G09the Youth Innovation Promotion Association of Chinese Academy of Sciences under Grant No 2016008the Hundred Talents Program of Chinese Academy of Sciences
文摘In paired Fermi systems,strong many-body effects exhibit in the crossover regime between the Bardeen–Cooper–Schrieffer(BCS)and the Bose–Einstein condensation(BEC)limits.The concept of the BCS–BEC crossover,which is studied intensively in the research field of cold atoms,has been extended to condensed matters.Here by analyzing the typical superconductors within the BCS–BEC phase diagram,we find that FeSe-based superconductors are prone to shift their positions in the BCS–BEC crossover regime by charge doping or substrate substitution,since their Fermi energies and the superconducting gap sizes are comparable.Especially at the interface of single-layer FeSe on SrTiO3 substrate,the superconductivity is relocated closer to the crossover unitary than other doped FeSe-based materials,indicating that the pairing interaction is effectively modulated.We further show that hole-doping can drive the interfacial system into the phase with possible pre-paired electrons,demonstrating its flexible tunability within the BCS–BEC crossover regime.
基金supported by the National Key R&D Program of China(Grant No. 2017YFA0303100)the National Natural Science Foundation of China (Grant Nos. 12174333, 11974061, and 12274369)the Key R&D Program of Zhejiang Province,China (Grant No. 2021C01002)。
文摘Kagome superconductors AV3Sb5(A=Cs,V,Sb) have served as an ideal platform to unveil the intriguing competitions between charge-density-wave(CDW),superconductivity and possible nontrivial topological states.We report soft point-contact spectroscopy(SPCS) studies on CsV3Sb5under pressure up to 2.5 GPa.Its superconducting transition temperature Tcand gaps for SPCS at pressure P=0.1 GPa suggest the absence of the adverse local strain effect as observed in point-contacts at ambient pressure,while the SPCS-determined Tcunder hydrostatic pressure deviates from the reported double dome feature below 2.5 GPa.Three distinct gap values in CsV3Sb5are proposed to exist through the whole pressure range with 2Δ1/kBTc≤1,2Δ2/kBTc~2.3-3.0 and 2Δ3/kBTc>3.5.The two smaller gaps for 2Δ1/kBTc≤1 and 2Δ2/kBTc~2.3-3.0 are robust under pressure,while there is no trace of the largest gap 2Δ3/kBTc>3.5 for SPCS in the c direction with P≤P1=0.7 GPa and P≥ P2=2.0 GPa and it becomes observable in the pressure range of(P1,P2),suggesting a complex relation between CDW and superconductivity between(P1,P2).
基金in part supported by the National Natural Science Foundation of China(42041004,41991231,and U2242206)the U.S.National Science Foundation(AGS-2032542 and AGS-2032532)+1 种基金the Climate Program Office of the National Oceanic and Atmospheric Administration(NA20OAR4310380)partly supported by a fellowship from China Scholarship Council(CSC No.201906180097)。
基金Financial support from the National Key Research and Development Program of China(Nos.2020YFB008300,2020YFB008303,and 2020YFB008304)Provincial Natural Science Foundation of Shandong(No.ZR202102220408)+1 种基金National Natural Science Foundation of China(No.51701080)Talent Development Excellent Young Talents Fund Project China(No.20190103053JH).
文摘Conventional kinetics theory for diffusion-controlled phase transformation shows that the reverse transition should lag behind the temperature rise through rapid heating,i.e.,overheating is required.In this work,we found that theβ-transus temperature decreased by∼50℃ during studying theα→βtransformation in Ti-6Al-4V alloy via electropulsing treatment(EPT).The calculation suggests that the acceleration of transformation kinetics cannot be fully explained by Joule heat and athermal effects of the electromigration effect and electron wind theory.The microstructural evolution during EPT was systematically investigated utilizing scanning electron microscope(SEM),electron backscattered diffraction(EBSD),X-ray diffraction(XRD),transmission Kikuchi diffraction(TKD),and transmission electron micro-scope(TEM).Microscopic analysis shows that the nano-sizedωand O'phases formed in theβphase,which causes large numbers of lattice distortion regions.The defects are conducive to accelerating the bulk diffusion of alloying elements inβ.Moreover,the nanodomains limited the growth of martensite,therefore nanocrystalline martensite formed after quenching.These findings develop the understanding of the destructive effect of current on metallic crystal,which will help to guide microstructural regulation in titanium and other alloys.
基金supported by the National Natural Science Foundation of China (32271681)the Joint Funds of the National Natural Science Foundation of China (U2006215)+1 种基金supported by Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China)and National Ethnic Affairs Commission (KLEEMA202206)the financial assistance provided by the National Science Foundation (2145130).
基金the National Key Re-search and Development Program of China(Nos.2020YFB2008300,2020YFB2008303 and 2020YFB2008304)the Provincial Natural Science Foundation of Shandong(Grant No.ZR202102220408)+1 种基金the National Natural Science Foundation of China(Grant No.51701080)the Talent Development-Excellent Young Talents Fund Project,China(Grant No.20190103053JH).
文摘Selective laser melting(SLM)is one of the most popular addi-tive manufacturing(AM)technologies.As a near-net shape man-ufacturing method,it offers many advantages from the manufac-turing perspective and has attracted more and more current re-search interests in fabricating the workhorse titanium alloy Ti-6Al-4 V[1].Since the high cooling rate of the molten pool and complicated thermal cycle will result in a fine and metastableαmicrostructure,generally,post-process is required to optimize the microstructure for the widespread application need.Hot iso-static pressing(HIP)and traditional heat treatment are the main post-treatments for the SLM-built Ti-6Al-4 V component[2].How-ever,HIP is a high-cost process and most heat treatments could not achieve a microstructure with high strength-ductility synergy and thermostability,e.g.,sub-transus water quenched microstruc-ture showed superior mechanical properties,but the martensite is far from thermodynamic equilibrium;the sup-transus air cooled microstructure has high thermostability but exhibits low elonga-tion[3,4].
基金supported by the Ministry of Science and Technology China Brain Initiative Grant(2022ZD0204701)the Scientific Research Fund of Zhejiang Provincial Education Department(Y202147674)。
文摘For over a century,the structure and evolution of the nervous system have been at the center of debate among biologists.In the 19th century,Camillo Golgi first proposed that the nervous system is a syncytial continuum,with neurons being directly connected with shared cell membranes and cytoplasm[1].This concept is known as the reticular theory(also referred to as the syncytial theory).However,this view was later challenged by Santiago Ramon y Cajal,who put forward the neuronal doctrine[2].
基金partially funded by Blueray Medicalpartially funded by China's National Key R&D Programs(NKPs)“Digital Diagnostic and Treatment Equipment”under 2019YFC0121500Shaanxi“Key Industry Innovation Chain-Social Development”under 2018ZDXM-SF-072.
文摘This paper explores the advancement and application of high-power blue diode lasers in treating benign prostatic hyperplasia(BPH).Addressing the challenges posed by existing techniques,the study focuses on optimizing tissue removal methods.Energy platform for BPH should balance a range of factors,such as operative time,patient conditions,urinary functions,complications,durability,accessibility,and cost,all while prioritizing patient care.Blueray Medical's innovation of high-power blue diode laser systems for BPH surgery is explored,with emphasis on achieving a balance among these considerations.By illustrating the biomedical effects of lasers and their interaction with soft tissues,particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior,this study outlines the advantages of the highpower blue diode laser system.The initial laboratory experiments and clinical results consistently align with our theoretical predictions,especially in terms of tissue vaporization efficiency,tissue coagulation,and bleeding control.In conclusion,blue diode lasers hold potential to enhance surgical outcomes for BPH.Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages.Integrating blue laser technology into BPH protocols could lead to shorter hospital stays,cost savings,and expanded patient eligibility,although rigorous clinical studies are needed to fully understand their benefits and limitations.