Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common cause for dementia.There are many hypotheses about AD,including abnormal deposit of amyloidβ(Aβ)protein in the extracellular sp...Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common cause for dementia.There are many hypotheses about AD,including abnormal deposit of amyloidβ(Aβ)protein in the extracellular spaces of neurons,formation of twisted fibers of tau proteins inside neurons,cholinergic neuron damage,inflammation,oxidative stress,etc.,and many anti-AD drugs based on these hypotheses have been developed.In this review,we will discuss the existing and emerging hypothesis and related therapies.展开更多
基金This review was supported by“Personalized Medicines-Molecular Signature based Drug Discovery and Development”,Strategic Priority Research program of Sciences,Grants No.XDA12040101.
文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common cause for dementia.There are many hypotheses about AD,including abnormal deposit of amyloidβ(Aβ)protein in the extracellular spaces of neurons,formation of twisted fibers of tau proteins inside neurons,cholinergic neuron damage,inflammation,oxidative stress,etc.,and many anti-AD drugs based on these hypotheses have been developed.In this review,we will discuss the existing and emerging hypothesis and related therapies.
