Purpose The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established.A meta-analysis was performed to evaluate the improvement of ocular surface condition in post...Purpose The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established.A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment durations.Methods Studies were performed based on 5 databases:PubMed,Cochrane Library,Web of Science,Embase,and China National Knowledge Infrastructure.Data on changes in Schirmer’s test,tear breakup time(TBUT),corneal staining score,and OSDI score were collected for meta-analysis.Results A total of 621 affected eyes from 9 independent clinical studies were included.6 studies conducted Schirmer's test after the application of 3% DQS.Meta-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application(less than or equal to 1 month)(WMD=0.14,P=0.27,95% CI:-0.11 to 0.39),but was statistically different for long-term application(longer than or equal to 3 months)(WMD=0.76,P=0.03,95% CI:0.08 to 1.45).For the corneal fluorescence staining score,the data from 6 studies indicated that the improvement was statistically significant for short-term application(WMD=-0.40,P<0.00001,95% CI:-0.72 to-0.08)and but not long-term application(WMD=-0.21,P=0.26,95% CI:-0.57 to 0.15).For TBUT,the data from 9 studies indicated that both short-term and long-term application showed significant improvement(WMD=1.70,P<0.00001,95% CI:1.38 to 2.03;WMD=1.52,P<0.00001,95% CI:1.09 to 1.95).Similar results were observed in data from 5 studies with OSDI scores,where both short-term and long-term application showed statistically significant improvements(WMD=-5.41,P<0.00001,95% CI:-7.02 to-3.81;WMD=-6.10,P<0.00001,95% CI:-8.52 to-3.67).Conclusions The application of 3% DQS in post-operative cataract patients has a positive effect on improving the ocular surface conditions.Short-term application resulted in lower corneal staining scores,prolonged TBUT,and improved OSDI scores.Long-term application improved Schirmer's test results,TBUT,and subjective symptoms.展开更多
文摘Purpose The effect of interventional time for 3% Diquafosol reatment in post-cataract surgery has not been well established.A meta-analysis was performed to evaluate the improvement of ocular surface condition in post-cataract surgery patients who received 3% DQS for various treatment durations.Methods Studies were performed based on 5 databases:PubMed,Cochrane Library,Web of Science,Embase,and China National Knowledge Infrastructure.Data on changes in Schirmer’s test,tear breakup time(TBUT),corneal staining score,and OSDI score were collected for meta-analysis.Results A total of 621 affected eyes from 9 independent clinical studies were included.6 studies conducted Schirmer's test after the application of 3% DQS.Meta-analysis showed that the difference between 3% DQS and control groups was not statistically significant for short-term application(less than or equal to 1 month)(WMD=0.14,P=0.27,95% CI:-0.11 to 0.39),but was statistically different for long-term application(longer than or equal to 3 months)(WMD=0.76,P=0.03,95% CI:0.08 to 1.45).For the corneal fluorescence staining score,the data from 6 studies indicated that the improvement was statistically significant for short-term application(WMD=-0.40,P<0.00001,95% CI:-0.72 to-0.08)and but not long-term application(WMD=-0.21,P=0.26,95% CI:-0.57 to 0.15).For TBUT,the data from 9 studies indicated that both short-term and long-term application showed significant improvement(WMD=1.70,P<0.00001,95% CI:1.38 to 2.03;WMD=1.52,P<0.00001,95% CI:1.09 to 1.95).Similar results were observed in data from 5 studies with OSDI scores,where both short-term and long-term application showed statistically significant improvements(WMD=-5.41,P<0.00001,95% CI:-7.02 to-3.81;WMD=-6.10,P<0.00001,95% CI:-8.52 to-3.67).Conclusions The application of 3% DQS in post-operative cataract patients has a positive effect on improving the ocular surface conditions.Short-term application resulted in lower corneal staining scores,prolonged TBUT,and improved OSDI scores.Long-term application improved Schirmer's test results,TBUT,and subjective symptoms.
