阿尔茨海默病(Alzheimer’s disease,AD)是以认知记忆不可逆性恶化为特征的神经变性疾病。AD致病机理多样,主要病理特征是β-淀粉样蛋白多肽(β-amyloid polypeptide,Aβ)沉积和tau蛋白纤维缠结。近年来,炎症机制亦被AD研究者所关注。2...阿尔茨海默病(Alzheimer’s disease,AD)是以认知记忆不可逆性恶化为特征的神经变性疾病。AD致病机理多样,主要病理特征是β-淀粉样蛋白多肽(β-amyloid polypeptide,Aβ)沉积和tau蛋白纤维缠结。近年来,炎症机制亦被AD研究者所关注。2023年阿尔茨海默病协会国际会议(Alzheimer's association international conference,AAIC)修订AD诊断框架,扩增传统的ATN框架为ATNIVS,其中I为炎症机制,提示神经炎症可以作为AD疾病诊断或药物治疗的靶向策略。目前炎症与AD的关系复杂,一方面炎症因子可以作为生物标志物预测临床前AD的发生,另一方面可以改善或加剧AD神经病变。因此本文将对炎症因子在AD疾病进展中的临床价值和作为早期诊断生物标志物的相关研究进行论述,包括炎症因子种类(白介素、肿瘤坏死因子及趋化因子等)和功能、炎症与神经胶质细胞及神经元的关系,炎症作为AD早期诊断生物标志物等,深入探讨神经炎症与AD疾病进程之间的关系,对系统了解神经炎症在AD中的作用具有一定的意义。展开更多
Background:COVID-19 has seriously affected people’s mental health and changed their behaviors.Previous studies for mental state and behavior promotion only targeted limited people or were not suitable for daily activ...Background:COVID-19 has seriously affected people’s mental health and changed their behaviors.Previous studies for mental state and behavior promotion only targeted limited people or were not suitable for daily activity restrictions.Therefore,we decided to explore the effect of health education videos on people’s mental state and health-related behaviors.Methods:Based on WeChat,QQ,and other social media,we conducted an online survey by snowball sampling.Spearman’s non-parametric method was used to analyze the correlation related to mental health problems and health-related behaviors.Besides,we used binary logistic regression analyses to examine mental health problems and health-related behaviors’predictors.We performed SPSS macro PROCESS(model 4 and model 6)to analyze mediation relationships between exposure to health education videos and depression/anxiety/health-related behaviors.These models were regarded as exploratory.Results:Binary logistic regression analyses indicated that people who watched the health education videos were more likely to wear masks(OR 1.15,p<0.001),disinfect(OR 1.26,p<0.001),and take temperature(OR 1.37,p<0.001).With higher level of posttraumatic growth(PTG)or perceived social support(PSS),people had lower percentage of depression(For PSS,OR 0.98,p<0.001;For PTG,OR 0.98,p<0.01)and anxiety(For PSS,OR 0.98,p<0.001;For PTG,OR 0.98,p=0.01)and better health behaviors.The serial multiple-mediation model supported the positive indirect effects of exposure to health education videos on the depression and three health-related behaviors through PSS and PTG(Depression:B[SE]=−0.0046[0.0021],95%CI−0.0098,−0.0012;Mask-wearing:B[SE]=0.0051[0.0023],95%CI 0.0015,0.0010;Disinfection:B[SE]=0.0059[0.0024],95%CI 0.0024,0.0012;Temperature-taking:B[SE]=0.0067[0.0026],95%CI 0.0023,0.0013).Conclusion:Exposure to health education videos can improve people’s self-perceived social support and inner growth and help them cope with the adverse impact of public health emergencies with better mental health and health-related behaviors.展开更多
文摘阿尔茨海默病(Alzheimer’s disease,AD)是以认知记忆不可逆性恶化为特征的神经变性疾病。AD致病机理多样,主要病理特征是β-淀粉样蛋白多肽(β-amyloid polypeptide,Aβ)沉积和tau蛋白纤维缠结。近年来,炎症机制亦被AD研究者所关注。2023年阿尔茨海默病协会国际会议(Alzheimer's association international conference,AAIC)修订AD诊断框架,扩增传统的ATN框架为ATNIVS,其中I为炎症机制,提示神经炎症可以作为AD疾病诊断或药物治疗的靶向策略。目前炎症与AD的关系复杂,一方面炎症因子可以作为生物标志物预测临床前AD的发生,另一方面可以改善或加剧AD神经病变。因此本文将对炎症因子在AD疾病进展中的临床价值和作为早期诊断生物标志物的相关研究进行论述,包括炎症因子种类(白介素、肿瘤坏死因子及趋化因子等)和功能、炎症与神经胶质细胞及神经元的关系,炎症作为AD早期诊断生物标志物等,深入探讨神经炎症与AD疾病进程之间的关系,对系统了解神经炎症在AD中的作用具有一定的意义。
基金received funding from the Zhejiang University Education Foundation(2020XGZX003)Soft Science Project of Science Technology Department of Zhejiang Province of China(2019C35025)+1 种基金the National Natural Science Foundation of China(71974170)Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01007).
文摘Background:COVID-19 has seriously affected people’s mental health and changed their behaviors.Previous studies for mental state and behavior promotion only targeted limited people or were not suitable for daily activity restrictions.Therefore,we decided to explore the effect of health education videos on people’s mental state and health-related behaviors.Methods:Based on WeChat,QQ,and other social media,we conducted an online survey by snowball sampling.Spearman’s non-parametric method was used to analyze the correlation related to mental health problems and health-related behaviors.Besides,we used binary logistic regression analyses to examine mental health problems and health-related behaviors’predictors.We performed SPSS macro PROCESS(model 4 and model 6)to analyze mediation relationships between exposure to health education videos and depression/anxiety/health-related behaviors.These models were regarded as exploratory.Results:Binary logistic regression analyses indicated that people who watched the health education videos were more likely to wear masks(OR 1.15,p<0.001),disinfect(OR 1.26,p<0.001),and take temperature(OR 1.37,p<0.001).With higher level of posttraumatic growth(PTG)or perceived social support(PSS),people had lower percentage of depression(For PSS,OR 0.98,p<0.001;For PTG,OR 0.98,p<0.01)and anxiety(For PSS,OR 0.98,p<0.001;For PTG,OR 0.98,p=0.01)and better health behaviors.The serial multiple-mediation model supported the positive indirect effects of exposure to health education videos on the depression and three health-related behaviors through PSS and PTG(Depression:B[SE]=−0.0046[0.0021],95%CI−0.0098,−0.0012;Mask-wearing:B[SE]=0.0051[0.0023],95%CI 0.0015,0.0010;Disinfection:B[SE]=0.0059[0.0024],95%CI 0.0024,0.0012;Temperature-taking:B[SE]=0.0067[0.0026],95%CI 0.0023,0.0013).Conclusion:Exposure to health education videos can improve people’s self-perceived social support and inner growth and help them cope with the adverse impact of public health emergencies with better mental health and health-related behaviors.
