基于MXenes的功能纤维的制备及其在智能可穿戴领域的应用

在电子信息和物联网技术的推动下,人类对可穿戴电子器件和智能织物的需求愈发突出,功能纤维作为智能可穿戴设备的重要载体,近年来获得快速发展。功能纤维的性能很大程度上取决于纤维的基础构筑单元。过渡金属碳/氮化物(MXenes)作为一种新兴的二维材料,凭借其高电导率、优异的可加工性能、可调节的表面特性以及出色的机械强度等优点,受到了极大的关注,也逐渐成为构筑功能纤维的重要单元。本文将主要综述MXenes的湿化学、熔融盐、无氟试剂刻蚀等方法和力学、电学、光学和化学稳定性等性能,阐述基于该材料制备的功能纤维在传感、储能以及其他智能领域的应用,最后讨论了基于MXenes材料的功能纤维的未来应用前景和技术挑战。

Application of non-small cell lung cancer pleural effusion cell blocks in molecular pathological detection

Objective: The tumor tissues used in molecular pathological detection were usually obtained by surgery, which would cause trauma and may not be suitable for the terminal cancer patients. This paper evaluated the value of the non-small cell lung cancer(NSCLC) pleural effusion cell blocks as tumor tissues replacement materials in the application of molecular pathological detection. Methods: Tumor cells were made into cell blocks through stratified centrifugal from 30 NSCLC patients with the pleural effusion. The immunohistochemistry, fluorescence in situ hybridization(FISH) and gene sequencing methods were employed in our experiments. Results: The tumor cells of cell block section were rich and could keep part of histological structure. Immunohistochemistry staining could assist diagnosis and tumor parting. Epidermal growth factor receptor(EGFR) FISH-positive was found in 33.33% of the group, high polysomy in 6 cases, amplification in 4 cases. EGFR gene mutations were found in 8 cases of 30 samples, with an incidence of 26.67%, 6 cases were detected in the exon 19, and 2 cases were detected in the exon 21. Conclusion: The NSCLC pleural effusion cell blocks are useful for the diagnosis and determining the primary source of tumor, instructed targeted therapy.

Effects of Bacterial Manure from Cassava Alcohol Fermentation Mash on Yield and Starch Content of Cassava

In order to provide a scientific basis for the utilization of cassava alcohol fermentation mash and the high-yield and high-efficiency cultivation of cassava,compound microbial inoculum was inoculated into the cassava alcohol fermentation mash to prepare bacterial manure,which was then applied to two cassava varieties,Nanzhi 199 and SC 205 to explore the optimum application amount,application method and application concentration. The results showed that when the inoculation amount of the compound microbial inoculum was 2‰ of the mass of the mash,the requirements of industrial production of liquid bacterial manure and agricultural application can be met,saving costs. After the emergence of cassava seedlings,if they were drenched with the bacterial manure of cassava alcohol fermentation mash through roots once according to the amount of 67. 5 t/ha and irrigated with the bacterial manure once every 15 d under drought conditions,both the yield and quality of cassava can be improved significantly. The yield and starch content of Nanzhi 199 reached 26 196. 23 kg/ha and 30. 32%,36. 57% and4. 75 percentage points higher than those of CK. The yield and starch content of SC 205 reached 41 126. 06 kg/ha and 23. 74%,99. 25% and3. 19 percentage points higher than those of CK. Under the application modes of foliar spray,root irrigation and foliar spray + root irrigation,the fertilization effect was more obvious. When undiluted bacterial manure of cassava alcohol fermentation mash was applied according to the amount of 52. 5 t/( ha·time),the fertilization effect of the application mode of foliar spray + root irrigation was the best. The bacterial manure from cassava alcohol fermentation mash can be directly applied without dilution,and the fertilizer efficiency will be reduced significantly after dilution.

血清脂联素与胎盘亮氨酸氨肽酶对妊娠期糖尿病患者妊娠结局的影响

目的探讨血清脂联素、胎盘亮氨酸氨肽酶(P-LAP)水平,对妊娠期糖尿病(GDM)患者妊娠结局的影响。方法选择2019年12月至2022年1月无锡市妇幼保健院,江南大学附属妇产医院收治的143例GDM患者为研究对象。采用回顾性分析方法,根据GDM患者妊娠结局,将其分别纳入良好组(n=115)与不佳组(n=28)。对2组患者于孕龄为24孕周时,进行空腹血糖(FBG),1、2 h 75 g口服葡萄糖耐量试验(OGTT),糖化血红蛋白(HbA1c)及血清脂联素与P-LAP水平检测,并采用成组t检验进行统计学分析。采用多因素非条件logistic回归分析,对GDM患者妊娠结局影响因素进行分析。采用受试者工作特征(ROC)曲线,分析血清脂联素及P-LAP水平对GDM患者妊娠结局的预测价值。本研究遵循的程序符合无锡市妇幼保健院,江南大学附属妇产医院伦理委员会制定的伦理学标准,并得到该伦理委员会批准(审批文号:2018-003-02)。2组患者年龄、孕前人体质量指数(BMI)、孕次、产次等一般临床资料比较,差异均无统计学意义(P>0.05)。结果不佳组GDM患者分娩孕龄与血清脂联素、P-LAP水平,均显著低于良好组,而血糖控制不佳占比与HbA1c水平,则均显著高于良好组,并且差异均有统计学意义(t=3.89、P<0.001,t=8.22、P<0.001,t=2.57、P=0.025,χ^(2)=101.54、P<0.001,t=3.95、P<0.001)。2组患者FPG及1、2 h OGTT血糖浓度等分别比较,差异均无统计学意义(P>0.05)。多因素非条件logistic回归分析结果显示,分娩孕龄及HbA1c水平、血清脂联素与P-LAP水平及血糖控制不佳,均为GDM患者妊娠结局的独立影响因素(OR=3.307、0.216、3.846、3.099、0.552,95%CI:1.401~7.806、0.091~0.509、1.629~9.079、1.313~7.315、0.416~0.783,P=0.017、0.014、0.017、0.014、0.025)。ROC曲线分析结果显示,血清脂联素与P-LAP水平单一指标及其联合预测GDM患者妊娠结局的曲线下面积(AUC)分别为0.709(95%CI:0.594~0.825,P=0.002),0.706(95%CI:0.584~0.821,P=0.001),0.791(95%CI:0.679~0.897,P=0.003)。结论血清脂联素、P-LAP水平降低,均为GDM患者不良妊娠结局的独立影响因素,可用于辅助预测GDM患者妊娠结局。