Alzheimer's disease(AD)is the most prevalent neurodegenerative disease featuring progressive cognitive impairment.Although the etiology of late-onset AD remains unclear,the close association of AD with apolipoprot...Alzheimer's disease(AD)is the most prevalent neurodegenerative disease featuring progressive cognitive impairment.Although the etiology of late-onset AD remains unclear,the close association of AD with apolipoprotein E(APOE),a gene that mainly regulates lipid metabolism,has been firmly established and may shed light on the exploration of AD pathogenesis and therapy.However,various confounding factors interfere with the APOE-related AD risk,raising questions about our comprehension of the clinical findings concerning APOE.In this review,we summarize the most debated factors interactingwith theAPOEgenotype and ADpathogenesis,depict the extent to which these factors relate to APOEdependent AD risk,and discuss the possible underlying mechanisms.展开更多
Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually death.Symptomatic treatments such as inhibition of salivati...Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually death.Symptomatic treatments such as inhibition of salivation,alleviation of muscle cramps,and relief of spasticity and pain still play an important role in enhancing the quality of life.To date,riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few countries.While there is adequate consensus on the modest efficacy of riluzole,there are still open questions concerning the efficacy of edaravone in slowing the disease progression.Therefore,identification of novel therapeutic strategies is urgently needed.Impaired autophagic process plays a critical role in ALS pathogenesis.In this review,we focus on therapies modulating autophagy in the context of ALS.Furthermore,stem cell therapies,gene therapies,and newly-developed biomaterials have great potentials in alleviating neurodegeneration,which might halt the disease progression.In this review,we will summarize the current and prospective therapies for ALS.展开更多
基金This work was supported by the Chengdu Science and Technology Bureau(2019-YF05-00655-SN)Key Project of the Medical Science Department,University of Electronic Science and Technology,of China(ZYGX2020ZB035)Guangdong Provincial Key R&D Program(2018B030337001).
文摘Alzheimer's disease(AD)is the most prevalent neurodegenerative disease featuring progressive cognitive impairment.Although the etiology of late-onset AD remains unclear,the close association of AD with apolipoprotein E(APOE),a gene that mainly regulates lipid metabolism,has been firmly established and may shed light on the exploration of AD pathogenesis and therapy.However,various confounding factors interfere with the APOE-related AD risk,raising questions about our comprehension of the clinical findings concerning APOE.In this review,we summarize the most debated factors interactingwith theAPOEgenotype and ADpathogenesis,depict the extent to which these factors relate to APOEdependent AD risk,and discuss the possible underlying mechanisms.
基金This review work was supported by funding from the National Nature Research Foundation(81671241,81771521)Shanghai Shuguang Plan Project(18SG15)Shanghai outstanding young scholars Project。
文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease involving both upper and lower motor neurons,leading to paralysis and eventually death.Symptomatic treatments such as inhibition of salivation,alleviation of muscle cramps,and relief of spasticity and pain still play an important role in enhancing the quality of life.To date,riluzole and edaravone are the only two drugs approved by the Food and Drug Administration for the treatment of ALS in a few countries.While there is adequate consensus on the modest efficacy of riluzole,there are still open questions concerning the efficacy of edaravone in slowing the disease progression.Therefore,identification of novel therapeutic strategies is urgently needed.Impaired autophagic process plays a critical role in ALS pathogenesis.In this review,we focus on therapies modulating autophagy in the context of ALS.Furthermore,stem cell therapies,gene therapies,and newly-developed biomaterials have great potentials in alleviating neurodegeneration,which might halt the disease progression.In this review,we will summarize the current and prospective therapies for ALS.
