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Simulation and Experimental Study on Load-bearing Deformation Characteristics of 11R22.5 Vehicle Retreaded Tire
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作者 qiang WANG Li JIANG xiaojie qi 《Mechanical Engineering Science》 2020年第1期9-16,共8页
The finite element bearing deformation simulation was implemented on 11.00R22.5 retreaded tires by ANSYS software in the paper in order to further clarify the bearing deformation characteristics of retreaded tires and... The finite element bearing deformation simulation was implemented on 11.00R22.5 retreaded tires by ANSYS software in the paper in order to further clarify the bearing deformation characteristics of retreaded tires and improve the performance of retreaded tires effectively.The characteristic laws of bearing radial deformation and bearing lateral deformation of retreaded tire and new tires of the same model under different working conditions were obtained through load deformation tests.The radial deformation calculation results,simulation results and measured results of retreaded tires were comparatively analyzed.The calculation formula of bearing radial deformation of retreaded tires was proposed based on the linear regression principle.The difference of bearing deformation characteristics and ground area characteristics of retreaded tires and new tires were comparatively analyzed.The results showed that the radial and lateral deformation of retreaded tires and new tires is increased with the increase of radial load when the tire pressure was constant,and the increase trend is approximately linear.The radial stiffness of retreaded tires is similar to that of new tires under certain tire pressure and low load.The radial stiffness of retreaded tires is larger than that of new tires,and the stiffness difference is increased with the increasing of load under constant tire pressure and high load.Rubber aging phenomenon in retreaded tire carcass have an impact on the bearing deformation characteristics of retreaded tires,thereby producing great impact on the remaining service life of retreaded tires. 展开更多
关键词 vehicle retreaded tire load-bearing deformation characteristics finite element radial stiffness rubber aging
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单细胞转录组和单细胞染色质开放性图谱解析小鼠γδT细胞异质性
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作者 李振华 杨全利 +13 位作者 唐欣 陈一铭 王闪闪 齐晓杰 张亚雯 刘宗华 骆静 刘晖 巴永兵 郭练霞 吴宝剑 黄芳 曹广超 尹芝南 《Science Bulletin》 SCIE EI CSCD 2022年第4期408-426,M0004,共20页
γδT细胞具有重要的免疫监视功能,其不同亚群在维持组织稳态和局部免疫反应中发挥不同作用,但是γδT细胞的异质性尚未完全解析.本文对小鼠胸腺、脾脏和淋巴结中的γδT细胞开展了单细胞转录和染色质开放性组学分析,系统地解析了其异质... γδT细胞具有重要的免疫监视功能,其不同亚群在维持组织稳态和局部免疫反应中发挥不同作用,但是γδT细胞的异质性尚未完全解析.本文对小鼠胸腺、脾脏和淋巴结中的γδT细胞开展了单细胞转录和染色质开放性组学分析,系统地解析了其异质性.经典的γδT1(IFN-γ^(+))和γδT17(IL-17A;)亚群内部也存在显著的异质性,作者推断了其潜在调控机制.通过对胸腺γδT细胞进行拟时序分析,作者构建了其发育轨迹.有意思的是,作者发现胸腺中存在一群独立于γδT1和γδT17的新亚群—GZMA;γδT细胞,并且发现该亚群具有前体细胞特征.作者还通过转录子活性分析、转录因子识别基序富集发现了一个新的γδT17转录抑制因子—NR1D1,并利用基因敲除小鼠进行了验证.综上,本文构建了小鼠γδT单细胞转录图谱和单细胞染色质开放性图谱,为深入解析γδT细胞异质性和亚群调控机制提供了宝贵的资源库. 展开更多
关键词 γδT cell scRNA-seq scATAC-seq Innate immunity HETEROGENEITY
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