Cyclodextrin metal-organic framework(CD-MOF)as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol(STV).The solubility of STV was lower than20.00 ng/mL at pH 1.0 and ...Cyclodextrin metal-organic framework(CD-MOF)as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol(STV).The solubility of STV was lower than20.00 ng/mL at pH 1.0 and pH 4.5,whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and129.58 ng/mL in water with a significant pH-dependence.The in vitro release profiles of STV from STV@CD-MOF(0.5:1)were pH-independent in distinct pH media and closed to be thoroughly released but no such release profiles were observed for STV@CD-MOF(1:1)owing to nanoclusters formation.The bioavailability of STV@CD-MOF(1:1)in rats was 8.67-fold higher than that of STV,and was1.32-and 1.27-fold higher than that of STV@CD and STV@CD-MOF(0.5:1).Our results indicated that the inclusion mechanism played a primary role when STV in CD-MOF was at a low loading ratio,while the increasement in bioavailability at a high loading ratio,which was attributed to the nanocluster mechanism.This was confirmed by molecular simulation.In conclusion,CD-MOF is a promising system for STV loading,overcoming the insolubility and to improve the bioavailability of this natural compound.展开更多
Butterfly wings are closely related to the premature failure of rolling element bearings.In this study,butterfly formation is investigated using the developed semi-analytical three-dimensional(3D)contact model incorpo...Butterfly wings are closely related to the premature failure of rolling element bearings.In this study,butterfly formation is investigated using the developed semi-analytical three-dimensional(3D)contact model incorporating inclusion and material property degradation.The 3D elastic field introduced by inhomogeneous inclusion is solved by using numerical approaches,which include the equivalent inclusion method(EIM)and the conjugate gradient method(CGM).The accumulation of fatigue damage surrounding inclusions is described using continuum damage mechanics.The coupling between the development of the damaged zone and the stress field is considered.The effects of the inclusion properties on the contact status and butterfly formation are discussed in detail.The model provides a potential method for quantifying material defects and fatigue behavior in terms of the deterioration of material properties.展开更多
基金financial support from the National Science Foundation for Young Scientists of China(No.81803441)the National Science and Technology Major Projects for the Major New Drugs Innovation and Development(No.2018ZX09721002-009,China)+1 种基金the National Natural Science Foundation of China(No.81873019)the University Synergy Innovation Program of Anhui Province(GXXT-2020-025)
文摘Cyclodextrin metal-organic framework(CD-MOF)as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol(STV).The solubility of STV was lower than20.00 ng/mL at pH 1.0 and pH 4.5,whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and129.58 ng/mL in water with a significant pH-dependence.The in vitro release profiles of STV from STV@CD-MOF(0.5:1)were pH-independent in distinct pH media and closed to be thoroughly released but no such release profiles were observed for STV@CD-MOF(1:1)owing to nanoclusters formation.The bioavailability of STV@CD-MOF(1:1)in rats was 8.67-fold higher than that of STV,and was1.32-and 1.27-fold higher than that of STV@CD and STV@CD-MOF(0.5:1).Our results indicated that the inclusion mechanism played a primary role when STV in CD-MOF was at a low loading ratio,while the increasement in bioavailability at a high loading ratio,which was attributed to the nanocluster mechanism.This was confirmed by molecular simulation.In conclusion,CD-MOF is a promising system for STV loading,overcoming the insolubility and to improve the bioavailability of this natural compound.
基金This project is supported by National Natural Science Foundation of China(Nos.52005057 and 51975063)the Fundamental Research Funds for the Central Universities(Nos.2020CDJQY-A069 and 2021CDJGXB 008).
文摘Butterfly wings are closely related to the premature failure of rolling element bearings.In this study,butterfly formation is investigated using the developed semi-analytical three-dimensional(3D)contact model incorporating inclusion and material property degradation.The 3D elastic field introduced by inhomogeneous inclusion is solved by using numerical approaches,which include the equivalent inclusion method(EIM)and the conjugate gradient method(CGM).The accumulation of fatigue damage surrounding inclusions is described using continuum damage mechanics.The coupling between the development of the damaged zone and the stress field is considered.The effects of the inclusion properties on the contact status and butterfly formation are discussed in detail.The model provides a potential method for quantifying material defects and fatigue behavior in terms of the deterioration of material properties.
