The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–2020.The current work investigate...The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–2020.The current work investigates the possible mechanisms accounting for these distinct TPSC changes.Our results indicate that the decrease in W_TPSC is primarily attributed to rising temperatures,while the increase in E_TPSC is closely linked to enhanced precipitation.Local circulation analysis shows that the essential system responsible for the TPSC changes is a significant anticyclonic system centered over the northwestern TP.The anomalous descending motion and adiabatic heating linked to this anticyclone leads to warmer temperatures and consequent snowmelt over the western TP.Conversely,anomalous easterly winds along the southern flank of this anticyclone serve to transport additional moisture from the North Pacific,leading to an increase in snowfall over the eastern TP.Further analysis reveals that the anomalous anticyclone is associated with an atmospheric wave pattern that originates from upstream regions.Springtime warming of the subtropical North Atlantic(NA)sea surface temperature(SST)induces an atmospheric pattern resembling a wave train that travels eastward across the Eurasian continent before reaching the TP.Furthermore,the decline in winter sea ice(SIC)over the Barents Sea exerts a persistent warming influence on the atmosphere,inducing an anomalous atmospheric circulation that propagates southeastward and strengthens the northwest TP anticyclone in spring.Additionally,an enhancement of subtropical stationary waves has resulted in significant increases in easterly moisture fluxes over the coastal areas of East Asia,which further promotes more snowfall over eastern TP.展开更多
The current work examines the impact of the snow cover extent(SCE)of the Tibetan Plateau(TP)on the interannual variation in the summer(June−July−August)surface air temperature(SAT)over Central Asia(CA)(SAT_CA)during t...The current work examines the impact of the snow cover extent(SCE)of the Tibetan Plateau(TP)on the interannual variation in the summer(June−July−August)surface air temperature(SAT)over Central Asia(CA)(SAT_CA)during the 1979−2019 period.The leading mode of the summer SAT_CA features a same-sign temperature anomalies in CA and explains 62%of the total variance in SAT_CA.The atmospheric circulation associated with a warming SAT_CA is characterized by a pronounced high-pressure system dominating CA.The high-pressure system is accompanied by warm advection as well as descending motion over CA,favoring the warming of the SAT_CA.Analysis shows that the interannual variation in the summer SAT_CA is significantly positively correlated with the April SCE over the central-eastern TP.In April,higher than normal SCE over the central-eastern TP has a pronounced cooling effect on the column of the atmosphere above the TP and can persist until the following early summer.Negative and positive height anomalies appear above and to the west of the TP.In the following months,the perturbation forcing generated by the TP SCE anomalies lies near the western center of the Asian subtropical westerly jet(SWJ),which promotes atmospheric waves in the zonal direction guided by the Asian SWJ.Associated with this atmospheric wave,in the following summer,a significant high-pressure system dominates CA,which is a favorable condition for a warm summer SAT_CA.展开更多
Both copper/zinc superoxide dismutase (SOD; Cu/Zn-SOD, SOD1) cDNA and manganese SOD (Mn-SOD, SOD2) cDNA were cloned for the first time from the three-keeled pond turtle, Chinemys reevesii, using RT-PCR and RACE me...Both copper/zinc superoxide dismutase (SOD; Cu/Zn-SOD, SOD1) cDNA and manganese SOD (Mn-SOD, SOD2) cDNA were cloned for the first time from the three-keeled pond turtle, Chinemys reevesii, using RT-PCR and RACE methods in this work. The SOD1 cDNA was 749 bp long and consisted of a 32-bp 5'-untranslated region (UTR), a 249-bp 3'-UTR, and a 468-bp open reading frame (ORF) encoding a 155-amino-acid protein with 16.0 kDa predicted molecular mass and 5.95 theoretical isoelectric point (p/). The SOD2 cDNA was 1687 bp long and comprised 94-bp of 5'-UTR, 912-bp 3'-UTR and 681-bp ORF encoding a 226-amino-acid protein with 25.0 kDa predicted molecular mass and 8.83 pI. The deduced amino acid sequence of SOD1 showed relatively high similarity (77.4%-87.1%) and identity (65.4%-74.4%) with the published sequences of SOD1 from other vertebrate species, whereas SOD2 protein shared slightly higher similarity (83.6%-95.6%) and identity (76.1%-88.9%) with other reported vertebrates SOD2s. Phylogenetic analysis revealed that the C. reevesii SOD1 and SOD2 were separately clustered together, and were highly conserved during evolution. Both SOD mRNA expression was detected widely in the brain, liver, muscle, kidney, gut, spleen, lung and heart at variable levels. The highest expression of the two SODs was observed in muscle, and followed in brain, liver, kidney, gut and heart, whereas low transcriptional levels were found in spleen and lung. Meanwhile, high activity of SOD 1 was kept in brain, liver, muscle, kidney and heart, and followed in gut, spleen and lung. The activities of SOD2 in brain, liver, muscle, kidney, gut and heart were significantly higher than those in spleen and lung.展开更多
Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323...Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.展开更多
基金This research is funded by the National Natural Science Foundation of China(Grant No.42075050)Fundamental Research Funds for the Central Universities(Grant No.K20220232).
文摘The spring snow cover(SC)over the western Tibetan Plateau(TP)(TPSC)(W_TPSC)and eastern TPSC(E_TPSC)have displayed remarkable decreasing and increasing trends,respectively,during 1985–2020.The current work investigates the possible mechanisms accounting for these distinct TPSC changes.Our results indicate that the decrease in W_TPSC is primarily attributed to rising temperatures,while the increase in E_TPSC is closely linked to enhanced precipitation.Local circulation analysis shows that the essential system responsible for the TPSC changes is a significant anticyclonic system centered over the northwestern TP.The anomalous descending motion and adiabatic heating linked to this anticyclone leads to warmer temperatures and consequent snowmelt over the western TP.Conversely,anomalous easterly winds along the southern flank of this anticyclone serve to transport additional moisture from the North Pacific,leading to an increase in snowfall over the eastern TP.Further analysis reveals that the anomalous anticyclone is associated with an atmospheric wave pattern that originates from upstream regions.Springtime warming of the subtropical North Atlantic(NA)sea surface temperature(SST)induces an atmospheric pattern resembling a wave train that travels eastward across the Eurasian continent before reaching the TP.Furthermore,the decline in winter sea ice(SIC)over the Barents Sea exerts a persistent warming influence on the atmosphere,inducing an anomalous atmospheric circulation that propagates southeastward and strengthens the northwest TP anticyclone in spring.Additionally,an enhancement of subtropical stationary waves has resulted in significant increases in easterly moisture fluxes over the coastal areas of East Asia,which further promotes more snowfall over eastern TP.
基金the National Natural Science Foundation of China(Grant No.42075050).
文摘The current work examines the impact of the snow cover extent(SCE)of the Tibetan Plateau(TP)on the interannual variation in the summer(June−July−August)surface air temperature(SAT)over Central Asia(CA)(SAT_CA)during the 1979−2019 period.The leading mode of the summer SAT_CA features a same-sign temperature anomalies in CA and explains 62%of the total variance in SAT_CA.The atmospheric circulation associated with a warming SAT_CA is characterized by a pronounced high-pressure system dominating CA.The high-pressure system is accompanied by warm advection as well as descending motion over CA,favoring the warming of the SAT_CA.Analysis shows that the interannual variation in the summer SAT_CA is significantly positively correlated with the April SCE over the central-eastern TP.In April,higher than normal SCE over the central-eastern TP has a pronounced cooling effect on the column of the atmosphere above the TP and can persist until the following early summer.Negative and positive height anomalies appear above and to the west of the TP.In the following months,the perturbation forcing generated by the TP SCE anomalies lies near the western center of the Asian subtropical westerly jet(SWJ),which promotes atmospheric waves in the zonal direction guided by the Asian SWJ.Associated with this atmospheric wave,in the following summer,a significant high-pressure system dominates CA,which is a favorable condition for a warm summer SAT_CA.
基金supported by a grant from the National Natural Science Foundation of China (Project No. 31172383)
文摘Both copper/zinc superoxide dismutase (SOD; Cu/Zn-SOD, SOD1) cDNA and manganese SOD (Mn-SOD, SOD2) cDNA were cloned for the first time from the three-keeled pond turtle, Chinemys reevesii, using RT-PCR and RACE methods in this work. The SOD1 cDNA was 749 bp long and consisted of a 32-bp 5'-untranslated region (UTR), a 249-bp 3'-UTR, and a 468-bp open reading frame (ORF) encoding a 155-amino-acid protein with 16.0 kDa predicted molecular mass and 5.95 theoretical isoelectric point (p/). The SOD2 cDNA was 1687 bp long and comprised 94-bp of 5'-UTR, 912-bp 3'-UTR and 681-bp ORF encoding a 226-amino-acid protein with 25.0 kDa predicted molecular mass and 8.83 pI. The deduced amino acid sequence of SOD1 showed relatively high similarity (77.4%-87.1%) and identity (65.4%-74.4%) with the published sequences of SOD1 from other vertebrate species, whereas SOD2 protein shared slightly higher similarity (83.6%-95.6%) and identity (76.1%-88.9%) with other reported vertebrates SOD2s. Phylogenetic analysis revealed that the C. reevesii SOD1 and SOD2 were separately clustered together, and were highly conserved during evolution. Both SOD mRNA expression was detected widely in the brain, liver, muscle, kidney, gut, spleen, lung and heart at variable levels. The highest expression of the two SODs was observed in muscle, and followed in brain, liver, kidney, gut and heart, whereas low transcriptional levels were found in spleen and lung. Meanwhile, high activity of SOD 1 was kept in brain, liver, muscle, kidney and heart, and followed in gut, spleen and lung. The activities of SOD2 in brain, liver, muscle, kidney, gut and heart were significantly higher than those in spleen and lung.
基金supported by the Ministry of Science and Technology of China(No.2022YFC2505202)the National Natural Science Foundation of China(Nos.81970691 and 82170819)+4 种基金Shanghai Outstanding Academic Leaders Plan(No.20XD1422800)Shanghai Medical and Health Development Foundation(No.DMRFP_I_01)Clinical Research Plan of SHDC(No.SHDC2020CR3064B)Science and Technology Committee of Shanghai(No.20Y11905100)Key Medical Subject of Jiading District,Shanghai(No.2020-jdyxzdzk-01).
文摘Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.