Objective:To analyze the effectiveness of applying ShuGan JieYu Capsules(SGJYC)combined with trazodone in patients with post-stroke depression(PSD)with insomnia.Methods:60 cases of PSD with insomnia patients admitted ...Objective:To analyze the effectiveness of applying ShuGan JieYu Capsules(SGJYC)combined with trazodone in patients with post-stroke depression(PSD)with insomnia.Methods:60 cases of PSD with insomnia patients admitted to the hospital from May 2022 to May 2023 were selected and randomly divided into a reference group(trazodone)and a research group(SGJYC combined with trazodone)of 30 cases each.Statistics were analyzed using the Hamilton Depression Rating Scale(HAM-D),Pittsburgh Sleep Quality Index(PSQI),and Activities of Daily Living(ADL)scale before treatment and 4,8,and 12 weeks after treatment.Results:Before treatment,The results of HAM-D,PSQI,and ADL scale studies in the two groups before treatment were not statistically significant(P>0.05);4,8,and 12 weeks after treatment,the results of HAM-D and PSQI studies in the research group were lower than that of the reference group,and the results of ADL scale studies were higher than that of the reference group.There was a significant difference between the groups(P<0.05).The total adverse reaction rate of the research group was lower than that of the reference group,and there was a significant difference between the groups(P<0.05).Conclusion:The combination of SGJYC and trazodone reduced depression in post-stroke patients,corrected insomnia,improved sleep quality,was safe,and had a low rate of adverse reactions.展开更多
The current study demonstrated that injury of the spinal cord lateral funiculus occurs in liver cirrhosis.This study sought to compare the morphology of the thoracic and lumbar cord,the expression of functional protei...The current study demonstrated that injury of the spinal cord lateral funiculus occurs in liver cirrhosis.This study sought to compare the morphology of the thoracic and lumbar cord,the expression of functional proteins,and changes in vessels between liver cirrhosis and non-cirrhosis corpses.Results showed that in the liver cirrhosis group,the hepatic vein expanded,the gastrointestinal tract was full of coagulated blood,blood-stasis was easily seen in the veniplex of the vertebral canal and the lumbar spinal cord,and the cell bodies of the anterior horn in the thoracic and lumbar cord were smaller than those in non-cirrhosis corpses.In addition,nerve cells shrank,Nissl bodies were concentrated with obscured nuclei,and neurofilament and synapsin containing cell bodies of the anterior horn and white matter decreased in the liver cirrhosis group.These experimental findings indicate that abnormal circulation of the spinal cord,resulting from hemodynamic change of cirrhotic portal hypertension,may be the most significant cause of hepatic myelopathy.展开更多
基金Research Project on Heilongjiang Province Traditional Chinese Medicine No.ZHY2022-057。
文摘Objective:To analyze the effectiveness of applying ShuGan JieYu Capsules(SGJYC)combined with trazodone in patients with post-stroke depression(PSD)with insomnia.Methods:60 cases of PSD with insomnia patients admitted to the hospital from May 2022 to May 2023 were selected and randomly divided into a reference group(trazodone)and a research group(SGJYC combined with trazodone)of 30 cases each.Statistics were analyzed using the Hamilton Depression Rating Scale(HAM-D),Pittsburgh Sleep Quality Index(PSQI),and Activities of Daily Living(ADL)scale before treatment and 4,8,and 12 weeks after treatment.Results:Before treatment,The results of HAM-D,PSQI,and ADL scale studies in the two groups before treatment were not statistically significant(P>0.05);4,8,and 12 weeks after treatment,the results of HAM-D and PSQI studies in the research group were lower than that of the reference group,and the results of ADL scale studies were higher than that of the reference group.There was a significant difference between the groups(P<0.05).The total adverse reaction rate of the research group was lower than that of the reference group,and there was a significant difference between the groups(P<0.05).Conclusion:The combination of SGJYC and trazodone reduced depression in post-stroke patients,corrected insomnia,improved sleep quality,was safe,and had a low rate of adverse reactions.
基金the National Natural Science Foundation of China,No.30872988
文摘The current study demonstrated that injury of the spinal cord lateral funiculus occurs in liver cirrhosis.This study sought to compare the morphology of the thoracic and lumbar cord,the expression of functional proteins,and changes in vessels between liver cirrhosis and non-cirrhosis corpses.Results showed that in the liver cirrhosis group,the hepatic vein expanded,the gastrointestinal tract was full of coagulated blood,blood-stasis was easily seen in the veniplex of the vertebral canal and the lumbar spinal cord,and the cell bodies of the anterior horn in the thoracic and lumbar cord were smaller than those in non-cirrhosis corpses.In addition,nerve cells shrank,Nissl bodies were concentrated with obscured nuclei,and neurofilament and synapsin containing cell bodies of the anterior horn and white matter decreased in the liver cirrhosis group.These experimental findings indicate that abnormal circulation of the spinal cord,resulting from hemodynamic change of cirrhotic portal hypertension,may be the most significant cause of hepatic myelopathy.
