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退火解旋酶SMARCAL1在维持基因组稳定中的作用与机制 被引量:4
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作者 文雅蕾 吕柯孬 +3 位作者 徐小康 张欣 丁良 潘学峰 《遗传》 CAS CSCD 北大核心 2019年第12期1084-1098,共15页
SMARCAL1是属于SWI/SNF(SWItch/Sucrose Non-Fermentable)相关、基质相关和激动蛋白依赖的染色质调节因子家族成员ATP驱动的DNA退火解旋酶。SMARCAL1在体外和体内能催化单链结合蛋白RPA结合的DNA单链与其互补链退火成双链DNA。人Smarcal... SMARCAL1是属于SWI/SNF(SWItch/Sucrose Non-Fermentable)相关、基质相关和激动蛋白依赖的染色质调节因子家族成员ATP驱动的DNA退火解旋酶。SMARCAL1在体外和体内能催化单链结合蛋白RPA结合的DNA单链与其互补链退火成双链DNA。人Smarcal1基因的突变与Schimke免疫骨性发育不良(Schimke immuno-osseous dysplasia,SIOD)所能表现出的临床症状呈高度相关。本文对SMARCAL1在DNA损伤部位DNA复制叉的重塑、在DNA双链断裂(double-stranded DNA,dsDNA)处参与经典的非同源末端连接(non-homologous end joining,NHEJ)修复,以及在人染色体端粒完整性维护等方面的作用与机制进行了梳理,对Smarcal1基因突变类型与SIOD症状之间的对应关系进行了更新,并对SMARCAL1在三核苷酸重复序列扩增关联的神经–肌肉退行性病变过程中的可能作用进行了分析和讨论,旨在更好地理解该退火解旋酶在维持基因组稳定中的作用和机制。 展开更多
关键词 SMARCAL1 RPA DNA复制叉 SIOD 三核苷酸重复序列扩增
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Application and Modeling of Battery Energy Storage in Power Systems 被引量:11
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作者 xiaokang xu Martin Bishop +1 位作者 Donna G.Oikarinen Chen Hao 《CSEE Journal of Power and Energy Systems》 SCIE 2016年第3期82-90,共9页
This paper presents engineering experiences from battery energy storage system(BESS)projects that require design and implementation of specialized power conversion systems(a fast-response,automatic power converter and... This paper presents engineering experiences from battery energy storage system(BESS)projects that require design and implementation of specialized power conversion systems(a fast-response,automatic power converter and controller).These projects concern areas of generation,transmission,and distribution of electric energy,as well as end-energy user benefits,such as grid frequency regulation,renewable energy smoothing and leveling,energy dispatching and arbitrage,power quality and reliability improvements for connected customers,islanding operations,and smart microgrid applications.In general,a grid level BESS project sends an interconnect request to utility power grids in the project development stage.Simulation models of equipment are then sent for a system impact study(e.g.,power flow and/or stability analysis),based on utility grid code requirements.The system study then determines the connection’s technical feasibility and impact of the project on the power grid.In this paper,a set of new BESS models is presented that are configured and parameterized for use in system impact studies as well as transmission planning studies.The models,which have been recently approved and released by the U.S.Western Electricity Coordinating Council(WECC),represent the steady state and dynamic performance of the BESS in several software platforms for power system studies based on operating project performance experience.Model benchmarking results as well as a real system case study are also included in the paper to show that the parameterized and tuned models respond correctly and as expected when system operating conditions change following contingency events.Finally,this paper provides useful guidelines in the use of new models to represent a BESS for power system analysis. 展开更多
关键词 Battery energy storage CONTINGENCY frequency regulation power flow analysis power quality power reliability renewable energy smart microgrid stability analysis state of charge system impact studies transmission planning
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