A new megastigmane,rehmamegastigmane(1),together with eighteen known compounds lariciresinol(2),lariciresinol-4′-O-β-D-glucopyranoside(3),hierochin D(4),yemuoside YM1(5),darendoside B(6),decaffeoylacteoside(7),jiono...A new megastigmane,rehmamegastigmane(1),together with eighteen known compounds lariciresinol(2),lariciresinol-4′-O-β-D-glucopyranoside(3),hierochin D(4),yemuoside YM1(5),darendoside B(6),decaffeoylacteoside(7),jionoside B1(8),catalpol(9),ajugol(10),6-O-vanilloylajugol(11),6-O-E-feruloylajugol(12),rehmapicroside(13),rehmapicrogenin(14),3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid(15),vanillic acid(16),hydroferulic acid(17),threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol(18),p-hydroxyphenylethyl alcohol(19)was isolated from the fresh roots of Rehmannia glutinosa.Compounds 2–6 and 16–18 were isolated from this plant for the first time.展开更多
Although the toughening of Calcium phosphate(CaP)scaffold by the addition of fiber has been well recognized,integrated mechanical,structural and functional considerations have been neglected in the design and fabricat...Although the toughening of Calcium phosphate(CaP)scaffold by the addition of fiber has been well recognized,integrated mechanical,structural and functional considerations have been neglected in the design and fabrication of CaP scaffold implant.The emerging 3D printing provides a promising technique to construct CaP scaffold with precise size and elaborate microstructure.However,the most challenge is to extrude smoothly the CaP paste containing fibers for frequently-used extrusion-based 3D printing.In this study,frozen section and chemical dispersant(Pluronic F127,F127)were employed jointly to prepare non-aggregated polylactic-co-glycolic acid(PLGA)fibers.The injectability of CaP pastes with well dispersed PLGA fibers was more than 90%when the content of PLGA fibers was no more than 3 wt%.Meanwhile rheological property of CAP pastes with well dispersed fibers showed shear thinning,which were both beneficial to extrude CaP paste with well dispersed fibers for 3D printing.Moreover,these CaP scaffolds showed ductile fracture behavior due to the pullout and bridging effect of PLGA fibers.The cell proliferation and alkaline phosphatase(ALP)activity indicated that 3D printed CAP scaffold containing PLGA fibers possesses excellent biocompatibility and facilitate osteogenic differentiation ability.Thus,it was feasible to print CaP pastes with well dispersed PLGA fibers to construct toughening CaP scaffolds with the higher shape fidelity and complex structures,which had significant clinical potentials in osteoanagenesis due to their higher toughness and excellent biocompatibility.展开更多
The present phytochenucal study was undertaken to investigate the chemical constituents of the 95%EtOH extract of the dried roots of Rehmannia glutinosa.The compounds were isolated and purified by Diaion HP-20,Toyopea...The present phytochenucal study was undertaken to investigate the chemical constituents of the 95%EtOH extract of the dried roots of Rehmannia glutinosa.The compounds were isolated and purified by Diaion HP-20,Toyopearl HW-40,silica gel column chromatography and preparative HPLC,and the structures were identified on展开更多
基金supported by the Key Projects in the National Science&Technology Pillar Program during the Twelfth Five-Year Plan Period(2011BAI06B02)the Collaborative Innovation Center of Diagnosis,Treatment and Drug Research for Respiratory Disease,Henan province,China.
文摘A new megastigmane,rehmamegastigmane(1),together with eighteen known compounds lariciresinol(2),lariciresinol-4′-O-β-D-glucopyranoside(3),hierochin D(4),yemuoside YM1(5),darendoside B(6),decaffeoylacteoside(7),jionoside B1(8),catalpol(9),ajugol(10),6-O-vanilloylajugol(11),6-O-E-feruloylajugol(12),rehmapicroside(13),rehmapicrogenin(14),3-methoxy-2,6,6-trimethylcyclohexane-1-enecarboxylic acid(15),vanillic acid(16),hydroferulic acid(17),threo-1-(4-hydroxy-3-methoxyphenyl)-1,2,3-propanetriol(18),p-hydroxyphenylethyl alcohol(19)was isolated from the fresh roots of Rehmannia glutinosa.Compounds 2–6 and 16–18 were isolated from this plant for the first time.
基金This work was supported by the National Natural Science Foundation of China(51372210)Research Fund for the Doctoral Program of Higher Education of China(20130184110023)+1 种基金the Basic Research Founda-tion Key Project of Sichuan Province(2016JY0011)the Fundamental Research Funds for the Central Universities(2682020XG04).
文摘Although the toughening of Calcium phosphate(CaP)scaffold by the addition of fiber has been well recognized,integrated mechanical,structural and functional considerations have been neglected in the design and fabrication of CaP scaffold implant.The emerging 3D printing provides a promising technique to construct CaP scaffold with precise size and elaborate microstructure.However,the most challenge is to extrude smoothly the CaP paste containing fibers for frequently-used extrusion-based 3D printing.In this study,frozen section and chemical dispersant(Pluronic F127,F127)were employed jointly to prepare non-aggregated polylactic-co-glycolic acid(PLGA)fibers.The injectability of CaP pastes with well dispersed PLGA fibers was more than 90%when the content of PLGA fibers was no more than 3 wt%.Meanwhile rheological property of CAP pastes with well dispersed fibers showed shear thinning,which were both beneficial to extrude CaP paste with well dispersed fibers for 3D printing.Moreover,these CaP scaffolds showed ductile fracture behavior due to the pullout and bridging effect of PLGA fibers.The cell proliferation and alkaline phosphatase(ALP)activity indicated that 3D printed CAP scaffold containing PLGA fibers possesses excellent biocompatibility and facilitate osteogenic differentiation ability.Thus,it was feasible to print CaP pastes with well dispersed PLGA fibers to construct toughening CaP scaffolds with the higher shape fidelity and complex structures,which had significant clinical potentials in osteoanagenesis due to their higher toughness and excellent biocompatibility.
文摘The present phytochenucal study was undertaken to investigate the chemical constituents of the 95%EtOH extract of the dried roots of Rehmannia glutinosa.The compounds were isolated and purified by Diaion HP-20,Toyopearl HW-40,silica gel column chromatography and preparative HPLC,and the structures were identified on
