Objective The study aimed to detect the expression of estrogen receptors(ERs) in thyroid cancer and investigate the correlation between their expression and clinical features and different pathological types.Methods T...Objective The study aimed to detect the expression of estrogen receptors(ERs) in thyroid cancer and investigate the correlation between their expression and clinical features and different pathological types.Methods The expression of ERs in 56 samples of thyroid cancer tissues was detected by an immunochemical approach. The expression of ERs in thyroid cancer tissues and different pathological types were analyzed using the χ~2 test. Results The number of cases with positive expression of ER in thyroid cancer tissues was 36. The number of papillary thyroid cancers(PTCs) was 48, with positive expression of ERs in 32 cases. The number of follicular thyroid cancers was 4, with positive expression of ERs in 2 cases. The number of medullary thyroid cancers was 4, with negative expression of ERs in all cases. The difference between the expression and different pathological types showed statistical significance. The expression of ERs showed no correlation with sex, age, or TNM stage, with no statistical significance. However, the expression of ERs was correlated with metastasis of lymph nodes, which had statistical significance. The expression of ERs was negatively correlated with pathological types and metastasis of lymph nodes. The correlated coefficient index was –0.313 and –0.334, respectively. Conclusion The expression of ERs showed no correlation with sex, age, or TNM stage, but was negatively correlated with pathological types and metastasis of lymph nodes.展开更多
In Bazhong City,Sichuan Province,China,top dieback symptoms were found on many pine trees(Pinus thunbergii Parl).The tips of old needles first turned grayish-green and then developed into brown bands in the field.Phyl...In Bazhong City,Sichuan Province,China,top dieback symptoms were found on many pine trees(Pinus thunbergii Parl).The tips of old needles first turned grayish-green and then developed into brown bands in the field.Phylogenetic analysis of concatenated ITS and EF1-αindicated the pathogen of this dieback disease as Diplodia neojuniperi.Additionally,effects of temperature,pH and medium on the mycelial growth were also characterized.The most favorable temperature and pH level for mycelial growth are 25°C and 8,respectively.The optimal medium for mycelial growth is PDA medium.To our knowledge,this is the first report of D.neojuniperi causes Diplodia top dieback on Pinus thunbergii.Our results provide fundamental information for monitoring and preventing such disease in the future.展开更多
In a recent paper published in Science,Konieczny et al.describe that IL-17A produced by RORγt+γδT cells governs wound epithelial cell hypoxic adaptation,which is required for cell migratory activity and efficient r...In a recent paper published in Science,Konieczny et al.describe that IL-17A produced by RORγt+γδT cells governs wound epithelial cell hypoxic adaptation,which is required for cell migratory activity and efficient re-epithelization.展开更多
A recent study by Czimmerer et al.published in Immunity reveals that exposure to interleukin-4(IL-4),which is an alternative signal,remodels the macrophage epigenetic landscape,including chromatin structure and the bi...A recent study by Czimmerer et al.published in Immunity reveals that exposure to interleukin-4(IL-4),which is an alternative signal,remodels the macrophage epigenetic landscape,including chromatin structure and the binding of transcriptional regulators to their dedicated enhancers.This allows for a synergistic interaction with toll-like receptor(TLR)ligand-mediated inflammatory stimuli,consequently enabling these cells to have an exaggerated inflammatory response[1].展开更多
文摘Objective The study aimed to detect the expression of estrogen receptors(ERs) in thyroid cancer and investigate the correlation between their expression and clinical features and different pathological types.Methods The expression of ERs in 56 samples of thyroid cancer tissues was detected by an immunochemical approach. The expression of ERs in thyroid cancer tissues and different pathological types were analyzed using the χ~2 test. Results The number of cases with positive expression of ER in thyroid cancer tissues was 36. The number of papillary thyroid cancers(PTCs) was 48, with positive expression of ERs in 32 cases. The number of follicular thyroid cancers was 4, with positive expression of ERs in 2 cases. The number of medullary thyroid cancers was 4, with negative expression of ERs in all cases. The difference between the expression and different pathological types showed statistical significance. The expression of ERs showed no correlation with sex, age, or TNM stage, with no statistical significance. However, the expression of ERs was correlated with metastasis of lymph nodes, which had statistical significance. The expression of ERs was negatively correlated with pathological types and metastasis of lymph nodes. The correlated coefficient index was –0.313 and –0.334, respectively. Conclusion The expression of ERs showed no correlation with sex, age, or TNM stage, but was negatively correlated with pathological types and metastasis of lymph nodes.
基金supported by the National Natural Science Foundation of China 31800543(X.D).
文摘In Bazhong City,Sichuan Province,China,top dieback symptoms were found on many pine trees(Pinus thunbergii Parl).The tips of old needles first turned grayish-green and then developed into brown bands in the field.Phylogenetic analysis of concatenated ITS and EF1-αindicated the pathogen of this dieback disease as Diplodia neojuniperi.Additionally,effects of temperature,pH and medium on the mycelial growth were also characterized.The most favorable temperature and pH level for mycelial growth are 25°C and 8,respectively.The optimal medium for mycelial growth is PDA medium.To our knowledge,this is the first report of D.neojuniperi causes Diplodia top dieback on Pinus thunbergii.Our results provide fundamental information for monitoring and preventing such disease in the future.
文摘In a recent paper published in Science,Konieczny et al.describe that IL-17A produced by RORγt+γδT cells governs wound epithelial cell hypoxic adaptation,which is required for cell migratory activity and efficient re-epithelization.
基金the National Natural Science Foundation of China(No.82272278).
文摘A recent study by Czimmerer et al.published in Immunity reveals that exposure to interleukin-4(IL-4),which is an alternative signal,remodels the macrophage epigenetic landscape,including chromatin structure and the binding of transcriptional regulators to their dedicated enhancers.This allows for a synergistic interaction with toll-like receptor(TLR)ligand-mediated inflammatory stimuli,consequently enabling these cells to have an exaggerated inflammatory response[1].
